Labconco FreeZone 70061 6L -50C Series User manual

Original instructions
Models
70061**** 6L -50C Series
71061**** 6L -84C Series
70121**** 12L -50C Series
71121**** 12L -84C Series
70181**** 18L -50C Series

Original instructions
Copyright © 2018 Labconco Corporation. The information contained in this manual and the accompanying
products are copyrighted and all rights reserved by Labconco Corporation. Labconco Corporation reserves
the right to make periodic design changes without obligation to notify any person or entity of such change.
Returned or Damaged Goods
Do not return goods without the prior authorization from Labconco. Unauthorized returns will not be
accepted. If your shipment was damaged in transit, you must file a claim directly with the freight carrier.
Labconco Corporation and its dealers are not responsible for shipping damages.
The United States Interstate Commerce Commission rules require that claims be filed with the delivery
carrier within fifteen (15) days of delivery.
Limitation of Liability
The disposal and/or emission of substances used in connection with this equipment may be governed by
various federal, state, or local regulations. All users of this equipment are required to become familiar with
any regulations that apply in the user’s area concerning the dumping of waste materials in or upon water,
land, or air and to comply with such regulations. Labconco Corporation is held harmless with respect to
user’s compliance with such regulations.
Contacting Labconco Corporation
If you have questions that are not addressed in this manual, or if you need technical assistance, contact
Labconco’s Customer Service Department or Labconco’s Product Service Department at 1-800-821-5525
or 1-816-333-8811, between the hours of 7:30 a.m. and 5:30 p.m., Central Standard Time.
Part #7343200, Rev. E
ECO L433
Warranty
Labconco Corporation provides a warranty to the original buyer for the repair or replacement of parts and
reasonable labor as a result of normal and proper use of the equipment with compatible chemicals. Broken
glassware and maintenance items, such as filters, gaskets, light bulbs, finishes and lubrication are not
warranted. Excluded from warranty are products with improper installation, erratic electrical or utility supply,
unauthorized repair and products used with incompatible chemicals.
The warranty for FreeZone®Freeze Dry Systems will expire one year from date of installation or two years
from date of shipment from Labconco, whichever is sooner. Warranty is non-transferable and only applies to
the owner (organization) of record.
Buyer is exclusively responsible for the set-up, installation, verification, decontamination or calibration of
equipment. This limited warranty covers parts and labor, but not transportation and insurance charges. If the
failure is determined to be covered under this warranty, the dealer or Labconco Corporation will authorize
repair or replacement of all defective parts to restore the unit to operation. Repairs may be completed by 3rd
party service agents approved by Labconco Corporation. Labconco Corporation reserves the rights to limit this
warranty based on a service agent’s travel, working hours, the site’s entry restrictions and unobstructed access
to serviceable components of the product.
Under no circumstances shall Labconco Corporation be liable for indirect, consequential, or special damages
of any kind. This warranty is exclusive and in lieu of all other warranties whether oral, or implied.

Original instructions
TABLE OF CONTENTS
CHAPTER 1: INTRODUCTION 1
Intended Use 1
Freeze Dry Process 1
Freeze Dry Rates 2
Freeze Dry Capacity 3
Samples Containing Volatile Substances 4
About This Manual 4
Typographical Conventions 5
CHAPTER 2: PREREQUISITES 6
Electrical Requirements 6
Location Requirements 7
Vacuum Pump Requirements 7
Chamber or Manifold Requirements 7
CHAPTER 3: GETTING STARTED 8
Unpacking Your Freeze Dryer 8
Freeze Dryer Components 9
Setting Up Your Freeze Dryer 9
Component Identification 10
Vacuum Pump Connection 11
Electrical Connection 12
Baffle Installation 12
Drying Chamber or Manifold Installation 14
Chemical Resistance of Freeze Dryer Components 15
Solvent Safety Precautions 16
CHAPTER 4: LYO-WORKS™OPERATING SYSTEM 17
Control Panel 17
Initial Power Up 18
Touch Screen Operation 18
Home Screen 18
Main Menu Icons 19
Moving Between Menu Screens 19
Function Indicator Bar 19
System Parameters Display 19
Operation Buttons 20

Original instructions
Programs Screen 21
Data Logging Screen 23
Settings Screen 24
Language 24
Time & Date 24
Units 25
Security 25
Alerts 25
Configure Email Settings 26
Maintenance 28
Vacuum Pump Settings 28
Refrigeration System Settings 28
Freeze Dryer Line Voltage Offset 28
Vacuum Pump Protection 28
Calibration 29
Display 30
Network 31
Sensors Screen 31
Drying Accessory Screen 32
End Point Detection Screen 33
Help Screen 34
Diagnostics 34
User’s Manual 34
About 34
CHAPTER 5: USING YOUR FREEZE DRYER 35
Operation Checklist 35
Vacuum Pump Ballast Setting 36
Purge Valve (optional feature) 36
Operating the Freeze Dryer 36
Auto Start-Up (without Purge Valve option) 36
Auto Start-Up (with Purge Valve option) 37
Manual Start-Up 37
Setting the Operating Vacuum Level 37
Pre-Freezing Samples 38
Adding Sample 38
Starting a Program 39
Shut Down 40
Defrosting 40
Operating the Shell Freezer (optional feature) 41
Operating the Mini Chamber (optional feature) 42
Alerts 43
Power Fail 43
Line Voltage Range 43
Collector Temp 43
Collector Moisture 43
Service Vacuum Pump 44
Vacuum Leak 44

Original instructions
Vacuum Set Point 44
Status Email Messages 44
End Point Detection 44
System Temp Variation 44
System Temp Set Point 44
Shelf Temp Variation 44
Shelf Temp Set Point 45
Power Fail 45
Program Complete 45
Copy (export) a Data Log File 45
Downloading Data Log Files via Ethernet 45
Copy a Program 46
CHAPTER 6: MAINTAINING YOUR FREEZE DRYER 47
Service Safety Precautions 47
Routine Maintenance Schedule 47
CHAPTER 7: TROUBLESHOOTING 49
Vacuum Pump 49
Gaskets, Tubing, Connections, Sample Valves 50
System Components & Collector Chamber Isolation 52
Refrigeration Module Operation 54
APPENDIX A: FREEZE DRYER COMPONENTS 55
APPENDIX B: FREEZE DRYER DIMENSIONS 60
APPENDIX C: FREEZE DRYER SPECIFICATIONS 61
Electrical Specifications 61
Environmental Conditions 62
APPENDIX D: FREEZE DRYER ACCESSORIES 63

Product Service 816-333-8811 or 1-800-522-7658
1
Original instructions
CHAPTER 1
INTRODUCTION
Congratulations on your purchase of a Labconco FreeZone® Freeze Dry System,
which is designed for laboratory lyophilization procedures. The refrigerant used in
the refrigeration system is HCFC-free so it will not endanger the environment.
The unit is easy to install and maintain. Proper care and maintenance of this
product will result in many years of dependable service.
Intended Use
The Labconco Freeze Dryers described in this manual are intended for laboratory
use to facilitate the lyophilization process.
Freeze Dry Process
Freeze drying is an important process in sample preparation and for the preservation
and storage of biologicals, pharmaceuticals and foods. Of the various methods of
dehydration, freeze drying (lyophilization) is especially suited for substances that are
heat sensitive. Other than food processing (e.g., coffee, whole dinners), freeze drying
has been extensively used in the development of pharmaceuticals (e.g., antibiotics) and
preservation of biologicals (e.g., proteins, plasma, viruses and cell lines). The
nondestructive nature of this process has been demonstrated by the retention of
viability in freeze dried viruses and microorganisms.
Freeze drying is a process whereby water or other solvent is removed from frozen
material by converting the frozen water directly into vapor without the
intermediate formation of liquid water. The basis for this sublimation process
involves the absorption of heat by the frozen sample in order to vaporize the ice;
the use of a vacuum pump to enhance the removal of water vapor from the surface
of the sample; the transfer of water vapor to a collector; and the removal of heat by
the collector in order to condense the water vapor. In essence, the freeze dry
process is a balance between the heat absorbed by the sample to vaporize the
ice and the heat removed from the collector to convert the water vapor into ice.

Chapter 1: Introduction
Product Service 816-333-8811 or 1-800-522-7658
2
Original instructions
Freeze Dry Rates
The efficiency of the Freeze Drying process is dependent upon the surface area and
the thickness of the sample, the collector temperature and vacuum obtained, the
eutectic point and solute concentration of the sample. It is important to remember
these factors when trying to obtain efficient utilization of your Freeze Dry system.
A listing of selected materials and their approximate drying times are shown in
Table 1 for your reference.
SAFE TEMPERATURE AND DRYING TIMES
FOR SELECTED MATERIALS
Material
10mm Thick
Safe
Temperature
°C
Collector
Temperature
°C
Hours
(Approx.)
Milk
-5
-40
10
Urea
-7
-40
10
Blood Plasma
-10 to -25
-40
16
Serum
-25
-40
18
Vaccinia
-30 to -40
-50
22
Influenza Vaccine
-30
-50
24
Human Tissue
-30 to -40
-50
48
Vegetable Tissue
-50
-80
60
*Total sample quantities are contingent on various freeze dryer capacities.
Up to the point of overloading the system, the greater the surface area of the
sample, the faster the rate of freeze drying. By contrast, for a given surface area,
the thicker the sample the slower the rate of freeze drying. This is based on the
fact that the heat of sublimation is usually absorbed on one side of the frozen
sample and must travel through the frozen layer to vaporize water at the other
surface. In addition, as the sample is freeze dried, the water vapor must travel
through the layer of dried material. The thicker the sample, the greater the chance
that the dried layer may collapse which would cause an additional decrease in the
rate of freeze drying.
The surface area and thickness of the sample can usually be ignored when each
sample contains only a few milliliters. However, for larger volumes, the samples
should be shell frozen to maximize the surface area and minimize the thickness of
the sample. The volume of the freeze dry flask should be two to three times the
volume of the sample.
In order for lyophilization to occur, ice must be removed from the frozen sample
via sublimation. This is accomplished by the collector and the vacuum pump. The
collector, which should be at least 15 to 20°C colder than the eutectic temperature
(melting temperature) of the sample, traps vapor as ice. Since the vapor pressure
at the collector is lower than that of the sample, the flow of water vapor is from the
sample to the collector. Since this vapor diffusion process occurs very slowly
under normal atmospheric conditions, a good vacuum is essential to maintain an
Table 1

Chapter 1: Introduction
Product Service 816-333-8811 or 1-800-522-7658
3
Original instructions
efficient rate. In many applications, the maintenance of a vacuum of 0.133 mbar
or less is recommended.
The rate of freeze drying is directly proportional to the vapor pressure and the
vapor pressure is dependent upon both eutectic temperature and solute
concentration of the sample. For example, a solution of sodium chloride and water
would freeze dry at a slower rate than pure water. The eutectic temperature of a
sodium chloride solution is about –21°C and at this temperature the vapor pressure
is about 1/16 that of water at 0°C. Although the eutectic temperature is not
dependent upon the concentration of sodium chloride, the vapor pressure of the
water would decrease as the concentration of sodium chloride increased. This is
due to the fact that as the solute concentration increases, less of the surface area of
the frozen sample is occupied by water. In general, most solutions or biological
samples will have a eutectic temperature of –10 to –25°C. However, if the sample
contains a simple sugar such as glucose or if the sample is animal or plant tissue,
the eutectic temperature may be as low as –30° to –50°C.
Freeze Dry Capacity
The volume of a sample that can be freeze dried at one time is related to factors
discussed previously and the size and design of the freeze dry system. With any
given instrument, the capacity is based on the surface area of the sample; the
eutectic temperature and concentration of the sample; and the rate and amount of
heat transferred to the frozen sample. Of these factors, the eutectic temperature is
the most important factor in determining the amount of sample that can be freeze
dried at one time, particularly when flasks are used. This is because as the eutectic
temperature decreases, the vapor pressure decreases but the rate of heat absorption
by the sample does not change. This tends to promote melting of the sample,
which leads to a marked increase in vapor pressure and ultimately overloads the
collector and vacuum pump. Samples that have eutectic temperatures of –20°C or
lower should be placed on the freeze dry system one flask at a time so that the
vacuum in the system may recover before adding another sample to the system. If
the vacuum does not recover, the capacity of the freeze dry system has been
exceeded and the sample should be removed.
If there is a problem with a particular type of sample melting when placed on the
freeze dry system, dilution of the sample with more water or providing some
insulation around the flask to decrease the rate of heat absorption by the sample
may help. If the eutectic temperature of the sample is –40 to –60°C, the freeze dry
system selected for use must be equipped with cascade type refrigeration so that
the collector temperature can be cooled to below –75°C, or a dry ice/solvent trap
may be used between the collector and the vacuum pump.

Chapter 1: Introduction
Product Service 816-333-8811 or 1-800-522-7658
4
Original instructions
Samples Containing Volatile Substances
In certain cases the solvent in a sample to be freeze dried may contain volatile
components such as acetonitrile, methanol, acetic acid, formic acid or pyridine. In
addition to these substances having an effect on the eutectic temperature, they may
increase the vapor pressure at the surface of the sample. Also, compared to water,
they will require the absorption of less heat for sublimation to occur. Hence,
samples that contain volatile substances will have a greater tendency to melt,
particularly when placed in flasks or exposed to room temperature. If a sample
containing a volatile substance tends to melt when placed on a freeze dry system,
dilution of the sample with more water will help keep the sample frozen. For
example, a 0.2M solution of acetic acid is much easier to freeze dry than a 0.5M
solution.
About This Manual
This manual is designed to help you learn how to install, use, and maintain your
Freeze Dryer. Instructions for performing routine maintenance and making minor
modifications to your Freeze Dryer are also included.
Chapter 1: Introduction provides a brief overview of the Freeze Dryer, explains
the organization of the manual, and defines the typographical conventions used in
the manual.
Chapter 2: Prerequisites explains what you need to do to prepare your site before
you install your Freeze Dryer. Electrical requirements are discussed.
Chapter 3: Getting Started contains the information you need to properly unpack,
inspect and install your Freeze Dryer.
Chapter 4: Lyo-Works Operating System describes the display screens and user
interface software that controls the Freeze Dryer.
Chapter 5: Using Your Freeze Dryer discusses the basic operation of your Freeze
Dryer. Information on how to attach samples and run the Freeze Dryer is included.
Chapter 6: Maintaining Your Freeze Dryer explains how to perform routine
maintenance on your Freeze Dryer.
Chapter 7: Troubleshooting contains a table of problems you may encounter while
using your Freeze Dryer, including the probable causes of the problems, and
suggested corrective actions.
Appendix A: Freeze Dryer Components contains labeled diagrams of the
components of the Freeze Dryer.
Appendix B: Freeze Dryer Dimensions contains diagrams showing the dimensions
for the Freeze Dryer.

Chapter 1: Introduction
Product Service 816-333-8811 or 1-800-522-7658
5
Original instructions
Appendix C: Freeze Dryer Specifications contains product specifications.
Appendix D: Freeze Dryer Accessories see www.labconco.com for a complete list
of Freeze Dry accessories.
Typographical Conventions
Recognizing the following typographical conventions will help you understand and
use this manual:
Book, chapter, and section titles are shown in italic type (e.g., Chapter 3:
Getting Started).
Steps required to perform a task are presented in a numbered format.
Comments located in the margins provide suggestions, reminders, and
references.
Critical information is presented in boldface type in paragraphs that are
preceded by the exclamation icon. Failure to comply with the information
following an exclamation icon may result in injury to the user or permanent
damage to your Freeze Dryer.
Important information is presented in capitalized type in paragraphs that are
preceded by the pointer icon. It is imperative that the information contained in
these paragraphs be thoroughly read and understood by the user.
!


Product Service 816-333-8811 or 1-800-522-7658
6
Original instructions
CHAPTER 2
PREREQUISITES
Before you install your Freeze Dryer, you need to prepare your site for installation.
Carefully examine the location where you intend to install your Freeze Dryer. You
must be certain that the area is level and of solid construction. An electrical source
must be located near the installation site.
Carefully read this chapter to learn:
Electrical supply requirements.
Vacuum pump requirements.
Refer to Appendix C: Freeze Dryer Specifications for complete Freeze Dryer
electrical and environmental conditions, specifications and requirements.
Electrical Requirements
115V models
o20 Amp dedicated single phase circuit.
oProperly grounded receptacle for
NEMA 5-20P plug.
230V models
o15 Amp dedicated single phase circuit.
oProperly grounded receptacle that matches the plug supplied with
the unit, (230V models are supplied with one of the following
plugs):
US EU China UK India
(NEMA 6-15P)
oIf the plug does not match the available receptacle, remove the plug
and replace it with an approved plug of the suitable style.
US
NEMA 5-20P

Chapter 2: Prerequisites
Product Service 816-333-8811 or 1-800-522-7658
7
Original instructions
Do not use any detachable power cord that is not adequately
rated for the unit.
Frequency must agree with the serial tag rating.
Improper frequency will damage the compressor.
ADDITIONAL APPLIANCES ON THE SAME CIRCUIT MAY
CAUSE THE CURRENT TO EXCEED THE RATING OF THE
CIRCUIT BREAKER OR FUSE.
Location Requirements
The Freeze Dryer should be located in an area that provides an unobstructed flow
of air around the cabinet. This air cools the refrigeration system. The refrigeration
system draws air through the side panels and exhausts it through the back panel. A
minimum of 3" must be allowed between the back and both sides of the Freeze
Dryer and adjacent wall surfaces. Restriction of airflow during operation could
adversely affect performance.
Refer to Appendix B: Freeze Dryer Dimensions for dimensional drawings of the
Freeze Dryer.
Vacuum Pump Requirements
A vacuum pump must be provided by the user. A vacuum pump with a
displacement of 98 liters per minute and 0.007 mbar ultimate pressure is adequate
for most samples. The inlet fitting on the vacuum pump must be suitable for 3/4"
ID vacuum hose, which is provided. It is recommended that the vacuum pump is
equipped with an exhaust filter to minimize oil mist exhausting from the vacuum
pump. The operating vacuum level may be set on the Freeze Dryer. The higher
the vacuum set point, the more likely it is that oil mist will be exhausted.
Vacuum pumps used with 115V models should be equipped with a 115V, 15 Amp
NEMA 5-15P plug. Vacuum pumps used with 230V models should be equipped
with a reverse IEC plug (included with 230V pumps purchased from Labconco).
This will allow the vacuum pump to be plugged into the receptacle on electrical
box located within the Freeze Dryer cabinet.
Chamber or Manifold Requirements
A freeze drying chamber or manifold is not included and must be purchased
separately. These accessories allow samples to be attached to the Freeze Dryer.
See Chapter 3: Getting Started for installation instruction.

!
!

Product Service 816-333-8811 or 1-800-522-7658
8
Original instructions
CHAPTER 3
GETTING STARTED
Now that the site for your Freeze Dryer is properly prepared, you are ready to
unpack, inspect, install and test your Freeze Dryer. Read this chapter to learn how
to:
Unpack and move your Freeze Dryer.
Set up your Freeze Dryer.
Connect the electrical supply source to your Freeze Dryer.
Properly exhaust your Freeze Dryer.
Safely use solvents with your Freeze Dryer.
The FreeZone Console Freeze Dryer may weigh up to 330 lbs
(150 kg) depending on the model. If you must lift the Freeze
Dryer manually, use at least two (2) persons and follow safe
lifting guidelines.
Unpacking Your Freeze Dryer
Carefully unpack your Freeze Dryer and inspect it for damage that may have
occurred in transit. If your Freeze Dryer is damaged, notify the delivery carrier
immediately and retain the entire shipment intact for inspection by the carrier.
DO NOT RETURN GOODS WITHOUT THE PRIOR
AUTHORIZATION OF LABCONCO. UNAUTHORIZED RETURNS
WILL NOT BE ACCEPTED.
IF YOUR FREEZE DRYER WAS DAMAGED IN TRANSIT, YOU
MUST FILE A CLAIM DIRECTLY WITH THE FREIGHT CARRIER.
LABCONCO CORPORATION AND ITS DEALERS ARE NOT
RESPONSIBLE FOR SHIPPING DAMAGE.
!
The United
States
Interstate
Commerce
Commission
rules require
that claims be
filed with the
delivery carrier
within fifteen
(15) days of
delivery.



Chapter 3: Getting Started
Product Service 816-333-8811 or 1-800-522-7658
9
Original instructions
DO NOT DISCARD THE CARTON OR PACKING MATERIAL FOR
YOUR FREEZE DRYER UNTIL YOU HAVE CHECKED ALL OF
THE COMPONENTS AND INSTALLED AND TESTED THE FREEZE
DRYER.
Freeze Dryer Components
Verify that the components listed below are present and undamaged.
(1) Freeze Dryer
(1) Collector Chamber Lid Assembly
oAcrylic Lid Assembly for -50C models
oStainless Steel Lid Assembly for -84C models
(1) Mini Chamber Lid (if equipped)
(1) Shell Freezer Lid (if equipped)
6L
12L
18L
Part #
Description
Comments
1
1
1
1089005
User’s Manual
USB Flash Drive
1
1
1
Power Cord
See parts list (Appendix A)
1
1
1
7373436
Vacuum Hose
2
2
2
1488800
Hose Clamp
1
7213200
Baffle 6L (SSTL)
-84C SSTL Models
1
7213201
Baffle 6L (PTFE)
-84C PTFE Models
1
7213300
Baffle 12L (SSTL)
-84C SSTL Models
1
7213301
Baffle 12L (PTFE)
-84C PTFE Models
1
7390700
Baffle 18L (SSTL)
-50C SSTL Models
1
7390703
Baffle 18L (Polypro)
-50C PTFE Models
1
1
1
7205304
Drain Hose
If you did not receive one or more of the components listed for your Freeze Dryer,
or if any of the components are damaged, contact Labconco Corporation
immediately for further instructions.
Setting Up Your Freeze Dryer
After you verify receipt of the proper components, move your Freeze Dryer to the
location where you want to install it. Then, follow the steps listed below.


Chapter 3: Getting Started
Product Service 816-333-8811 or 1-800-522-7658
10
Original instructions
Component Identification
USB port
Vacuum Pump
Viewing Window
Power Inlet
Vacuum Pump Outlet
Quick-Connect drain coupling(s)
Upper = Shell Freezer (if equipped)
Lower = Collector Chamber
Circuit Breaker Reset
Touch Screen Display
On/Standby Button
& LED Indicator
Serial Tag (& Elect. Rating)
Collector Chamber
& Coil
3” Vacuum Port
Shell Freezer or
Mini Chamber
(if equipped)

Chapter 3: Getting Started
Product Service 816-333-8811 or 1-800-522-7658
11
Original instructions
Vacuum Pump Connection
A vacuum pump (as described in Chapter 2: Prerequisites) is required to operate
your Freeze Dryer properly. The Freeze Dryer is equipped with a 3/4" ID vacuum
hose for connecting the collector chamber to the vacuum pump.
Make certain that the oil in the vacuum pump is at the proper
level.
1. Remove the front left stainless steel panel and
lower rear panel from the Freeze Dryer.
2. Remove protective caps from inlet and outlet
ports of vacuum pump.
3. Place the vacuum pump inside the console
Freeze Dryer.
4. Some vacuum pumps have inlet fittings that
clamp to the pump. Place the centering ring
with filter screen on the inlet fitting.
5. Place the hose barb fitting on top of the
centering ring and secure with the clamp.
6. CHECK THE VACUUM PUMP OIL LEVEL.
Fill the pump with oil so the level is between
the lines on the sight gauge on the end of the
pump housing.
7. Attach one end of the vacuum hose to the port
inside the Freeze Dryer and the other end to the
inlet port of the vacuum pump with the hose
clamps provided. If necessary, cut the hose to
proper length to allow for gentle bends without
kinks.
!
Hose Barb
Clamp
Inlet Fitting
Vacuum Pump
Inlet Port
Console
Inlet Port
Connection

Chapter 3: Getting Started
Product Service 816-333-8811 or 1-800-522-7658
12
Original instructions
8. VERIFY THE VACUUM PUMP VOLTAGE SETTING AGREES WITH
THE FREEZE DRYER VOLTAGE SHOWN ON THE SERIAL
NUMBER LABEL. Reconfigure if necessary (see vacuum pump
instructions).
9. Connect the vacuum pump power cord to the receptacle labeled “vacuum
pump” on electrical box at the rear right hand side of the Freeze Dryer.
Models rated for use on 230V have a reverse IEC receptacle for attaching
the vacuum pump power cord.
10. If the vacuum pump has an ON/OFF switch, turn the switch ON. The
vacuum pump will be controlled by the Freeze Dryer.
IT IS HIGHLY RECOMMENDED THAT AN OIL MIST
EXHAUST FILTER BE INSTALLED ON ROTORY VANE
VACUUM PUMPS TO MINIMIZE OIL MIST EXITING THE
PUMP. AN OIL RETURN KIT CAN ALSO BE USED IN
CONJUNCTION WITH THE EXHAUST FILTER TO RETURN
TRAPPED OIL BACK TO THE VACUUM PUMP.
Electrical Connection
Make sure that the outlet that you intend to use meets the voltage and amperage
requirements listed on the serial tag of the Freeze Dryer. Plug the power cord into
the receptacle on the back of the Freeze Dryer and plug the other end into a
suitable power outlet. It will take approximately 90 seconds for the operating
system to fully load.
Baffle Installation
A baffle is shipped with 6 & 12L -84C Freeze Dryers and 18L -50C Freeze Dryers
(Models 71061xxxx, 70121xxxx & 70181xxxx). The 6 & 12L models come with
a 2 piece baffle (stainless steel cylinder with a plastic top). The 18L models come
with a one piece baffle (either stainless steel or polypropylene). The baffles are
designed to evenly distribute collected ice over the entire collector coil. Proper
positioning of the baffle is required to achieve maximum ice loading capabilities.
6 & 12L Baffle
1. Place the baffle into the collector chamber. The cylinder should be
concentric (centered) with the collector chamber.
2. Align the 1.75” hole in the rear channel of the baffle with the 1.5” vacuum
port in the side wall of the collector chamber.


Chapter 3: Getting Started
Product Service 816-333-8811 or 1-800-522-7658
13
Original instructions
18L Baffle
1. Place the baffle into the collector chamber.
2. Position the baffle so that the arrow points directly toward the front.
18L Baffle Top View
Align hole in baffle channel
with rear vacuum port
Properly Installed
6 & 12L Baffle

Chapter 3: Getting Started
Product Service 816-333-8811 or 1-800-522-7658
14
Original instructions
Drying Chamber or Drying Manifold Installation
The drying chamber or drying manifold, purchased separately, may be positioned
directly above the 3-inch port on the top of the Freeze Dryer. Follow the
instructions supplied with the selected accessory.
4 or 8 Port Manifold Installation
12 or 16 Port Drying Chamber Installation
7307300 GASKET
7307300 GASKET
7742800 SPACER
7206400 THUMB SCREW MANIFOLD
CONSOLE
FREEZE DRYER
7202300 SADDLE BRACKET
GASKET
DRYINGCHAMBER
SPACER(SSTL)
LATCH
DRYINGCHAMBER
LID

Chapter 3: Getting Started
Product Service 816-333-8811 or 1-800-522-7658
15
Original instructions
Chemical Resistance of Freeze Dryer
Components
The FreeZone Freeze Dry System is designed to be chemically resistant to most
compounds that are commonly used in freeze drying processes. However, by
necessity, the freeze dryer is comprised of a number of different materials, some of
which may be attacked and degraded by certain chemicals. The degree of
degradation is dependent on the concentration and exposure duration. Some of the
major components of the FreeZone Freeze Dry System that are susceptible to
degradation are as follows:
Acids
Buffers
Solvents
Component
Material
Acetic Acid 20%
Formic Acid
Trifluoroacetic Acid (TFA)
Calcium Chloride
Sodium Phosphate
Acetone
Acetonittirle
Carbon Tetrochloride
Cyclohexane
Dioxane
Methyl t-Butyl Ether (BTBE)
Pyridine
Valve Stem
Acetal
C
D
D
D
D
Collector
Lid
Acrylic
D
D
D
D
Hoses,
Gaskets &
Valve
Bodies
Neoprene
C
D
D
C
C
D
D
D
C
D
Flask Top
Silicon
Rubber
C
D
D
D
D
D
C
D
Chamber &
Fittings
Stainless
Steel
C
C –Moderate degradation; Limited use
D –Severe degradation; infrequent use recommended; immediate thorough
cleaning required.
Most common compounds used in freeze drying processes, if allowed to enter
the vacuum pump, will degrade the oil and cause damage to the vacuum pump.
Sugars and proteins typically will have minimal negative effect on any of the
materials of construction.
When using compounds in the Freeze Dryer that are hostile to the materials of
construction, it is imperative the equipment is thoroughly cleaned after use.
Rubber and plastic components that have been exposed to damaging
compounds should be removed and flushed with water.