Buchi Lyovapor L-200 Pro User manual

LyovaporTM L-200 / L-200 Pro
Operation Manual
11593861D en

Imprint
Product Identification:
Operation Manual (Original) LyovaporTM L-200 / L-200 Pro
11593861
Publication date: 09.2017
BÜCHI Labortechnik AG
Meierseggstrasse 40
Postfach
CH-9230 Flawil 1
E-Mail: [email protected]
BUCHI reserves the right to make changes to the manual as deemed necessary in the light of experi-
ence, especially with respect to structure, illustrations and technical details.
This manual is copyrighted. Information from it may neither be reproduced, distributed, or used for com-
petitive purposes, nor made available to third parties. The manufacture of any component with the aid of
this manual without prior written agreement is also prohibited.

BÜCHI Labortechnik AG Contents
Operation Manual LyovaporTM L-200 / L-200 Pro iii
Contents
1 About this document...........................................................................................................7
1.1 Connected devices .............................................................................................................................. 7
1.2 Warning notices in this document........................................................................................................ 7
1.3 Symbols............................................................................................................................................... 7
1.3.1 .................................................................................................................................................7
1.3.2 Mandatory directive symbols ...................................................................................................7
1.3.3 Mark-ups and symbols.............................................................................................................8
1.4 Available languages............................................................................................................................. 8
1.5 Trademarks.......................................................................................................................................... 8
2 Safety....................................................................................................................................9
2.1 Proper use ........................................................................................................................................... 9
2.2 Use other than that intended ............................................................................................................... 9
2.3 Staff qualification ................................................................................................................................. 9
2.4 Location of warning signs on the product .......................................................................................... 10
2.5 Residual risks .................................................................................................................................... 10
2.5.1 Faults during operation ..........................................................................................................10
2.5.2 Damage to the ice condenser................................................................................................10
2.5.3 Glass and acrylic breakage....................................................................................................10
2.5.4 Low internal pressure.............................................................................................................11
2.5.5 Cold and hot surfaces............................................................................................................11
2.6 Personal protective equipment .......................................................................................................... 11
2.7 Modifications...................................................................................................................................... 11
3 Product description...........................................................................................................12
3.1 Description of function ....................................................................................................................... 12
3.1.1 Freezing phase ......................................................................................................................12
3.1.2 Main drying phase..................................................................................................................12
3.1.3 Secondary-drying phase........................................................................................................13
3.2 Configuration ..................................................................................................................................... 14
3.2.1 Front view ..............................................................................................................................14
3.2.2 Rear view ...............................................................................................................................14
3.2.3 Connections on the rear side.................................................................................................15
3.2.4 Control panel..........................................................................................................................15
3.2.5 Pro control panel....................................................................................................................16
3.3 Type plate.......................................................................................................................................... 16
3.4 Refrigerant Specification.................................................................................................................... 16
3.5 Specifications supplied ...................................................................................................................... 17
3.6 Technical Data................................................................................................................................... 17
3.6.1 Lyovapor™ L-200 ..................................................................................................................18
3.6.2 Ambient conditions.................................................................................................................18
3.6.3 Materials ................................................................................................................................18
4 Transport and storage ......................................................................................................19
4.1 Transport ........................................................................................................................................... 19
4.2 Storage .............................................................................................................................................. 19
4.3 Lifting the instrument ......................................................................................................................... 19

Contents BÜCHI Labortechnik AG
iv Operation Manual LyovaporTM L-200 / L-200 Pro
5 Installation..........................................................................................................................21
5.1 Installation site................................................................................................................................... 21
5.2 Securing against earthquakes ........................................................................................................... 21
5.3 Putting the instrument in operation.................................................................................................... 22
5.3.1 Preparing the instrument........................................................................................................22
5.3.2 Establishing electrical connections ........................................................................................22
5.3.3 Assembling the cross fitting (optional accessory)..................................................................24
5.3.4 Assembling the main valve (optional accessory)...................................................................25
5.3.5 Assembling pressure sensor PPG010 (optional accessory)..................................................27
5.3.6 Assembling the venting valve (optional accessory) ...............................................................28
5.3.7 Assembling the pressure regulating valve (optional accessory)............................................ 29
5.3.8 Assembling the alternative pressure sensor (optional accessory).........................................30
5.3.9 Preparing the condensate drain hose.................................................................................... 31
5.4 Commissioning the vacuum pump..................................................................................................... 32
5.5 Assembling the drying attachments................................................................................................... 32
5.5.1 Fitting the 300 mm dia. O-ring ...............................................................................................32
5.5.2 Fitting the acrylic drying chamber ..........................................................................................33
5.5.3 Fitting the manifold acrylic drying chamber............................................................................ 34
5.5.4 Fitting the stopper acrylic drying chamber .............................................................................35
5.5.5 Assembling the manifold drying rack .....................................................................................36
5.5.6 Fitting the non-heatable shelf.................................................................................................37
5.5.7 Fitting heatable shelves .........................................................................................................39
5.5.8 Assembling manifold valves................................................................................................... 42
6 Operating the control panel..............................................................................................45
6.1 Layout of the control panel ................................................................................................................ 45
6.2 Function bar....................................................................................................................................... 45
6.3 Menu bar............................................................................................................................................ 46
6.3.1 Start menu .............................................................................................................................47
6.3.2 Favourites menu ....................................................................................................................47
6.3.3 Configuration menu................................................................................................................47
6.3.4 Messages menu.....................................................................................................................50
6.4 Status bar .......................................................................................................................................... 50
6.5 Carrying out freeze-drying ................................................................................................................. 52
6.5.1 Preparing the instrument........................................................................................................52
6.5.2 Starting freeze-drying.............................................................................................................52
6.5.3 Editing parameters while the process is running ...................................................................52
6.5.4 Ending freeze-drying..............................................................................................................53
6.5.5 Shutting down the instrument ................................................................................................53

BÜCHI Labortechnik AG Contents
Operation Manual LyovaporTM L-200 / L-200 Pro v
7 Operating Pro control panel .............................................................................................54
7.1 Layout of Pro control panel................................................................................................................ 54
7.2 Function bar....................................................................................................................................... 54
7.3 Menu bar............................................................................................................................................ 56
7.3.1 Start menu .............................................................................................................................56
7.3.2 Favourites menu ....................................................................................................................56
7.3.3 Method menu.........................................................................................................................57
7.3.4 Configuration menu................................................................................................................57
7.3.5 Messages menu.....................................................................................................................60
7.4 Status bar .......................................................................................................................................... 60
7.5 Editing a method................................................................................................................................ 62
7.5.1 Creating a new method..........................................................................................................62
7.5.2 Changing the name of a method............................................................................................62
7.5.3 Setting the sample collapse temperature............................................................................... 62
7.5.4 Setting the gas type ...............................................................................................................63
7.5.5 Setting the shelf loading temperature ....................................................................................63
7.5.6 Setting the steps of a method ................................................................................................63
7.5.7 Setting the phases of a method .............................................................................................65
7.6 Deleting a method.............................................................................................................................. 67
7.7 Setting end point definitions............................................................................................................... 67
7.7.1 Pressure difference test.........................................................................................................67
7.7.2 Temperature difference test...................................................................................................68
7.8 Performing freeze-drying using a method [Pro control panel] ........................................................... 69
7.8.1 Preparing the instrument........................................................................................................69
7.8.2 Selecting a method ................................................................................................................69
7.8.3 Starting freeze-drying.............................................................................................................70
7.8.4 Ending freeze-drying..............................................................................................................71
7.8.5 Shutting down the instrument ................................................................................................71
7.9 Performing freeze-drying manually [Pro control panel]...................................................................... 71
7.9.1 Preparing the instrument........................................................................................................71
7.9.2 Starting freeze-drying.............................................................................................................72
7.9.3 Editing parameters while the process is running ...................................................................72
7.9.4 Ending freeze-drying..............................................................................................................73
7.9.5 Shutting down the instrument ................................................................................................73
8 Mobile connection .............................................................................................................74
8.1 Setting up BUCHI Connect Solution.................................................................................................. 74
8.2 Handling data..................................................................................................................................... 75
8.3 Connecting the instrument to the LAN............................................................................................... 75
8.4 Requirements for local network settings............................................................................................ 75
8.5 Assigning a dynamic IP address........................................................................................................ 76
8.6 Enabling the control panel on the BUCHI Cloud................................................................................ 76
8.7 Downloading the BUCHI Monitor app................................................................................................ 76
8.8 Layout of BUCHI Monitor app............................................................................................................ 77
8.9 Connecting the instrument and app using a QR code....................................................................... 77
8.9.1 Generating a QR code...........................................................................................................77
8.9.2 Scanning the QR code...........................................................................................................78
8.10 Connecting the instrument and app using a password...................................................................... 79
8.10.1 Generating a password..........................................................................................................79
8.10.2 Entering the password ...........................................................................................................79
8.11 Removing the instrument from the app.............................................................................................. 80
8.12 Enabling notifications......................................................................................................................... 80
8.13 Remotely retrieving process data ...................................................................................................... 81

Contents BÜCHI Labortechnik AG
vi Operation Manual LyovaporTM L-200 / L-200 Pro
9 Cleaning and servicing .....................................................................................................82
9.1 Regular maintenance work................................................................................................................ 82
9.2 Performing a leak test........................................................................................................................ 84
9.3 Performing a vacuum test.................................................................................................................. 84
10 Help with faults ..................................................................................................................86
10.1 Troubleshooting................................................................................................................................. 86
10.2 Faults, possible causes and remedies............................................................................................... 86
11 Taking out of service and disposal..................................................................................88
11.1 Disposal............................................................................................................................................. 88
11.2 Returning the instrument ................................................................................................................... 88
12 Appendix ............................................................................................................................89
12.1 Spare parts and accessories ............................................................................................................. 89
12.1.1 Top-mount drying rack accessories.......................................................................................89
12.1.2 Accessories............................................................................................................................91
12.1.3 Further accessories ...............................................................................................................92
12.1.4 Spare parts ............................................................................................................................93

BÜCHI Labortechnik AG About this document | 1
Operation Manual LyovaporTM L-200 / L-200 Pro 7/96
1 About this document
These operating instructions describe the Lyovapor™ L-200 at the time supplied.
They are an integral part of the product and contain important information that is nec-
essary for safe operation and maintenance.
These operating instructions apply to all variants of the Lyovapor™ L-200.
uTo ensure safe and trouble-free operation, read these operating instructions be-
fore starting up the device and follow the guidance they contain.
uKeep the operating instructions somewhere near to the device.
uPass on the operating instructions to any subsequent owner or user.
BÜCHI Labortechnik AG accepts no liability whatsoever for any faults or damages
that result from the failure to follow these operating instructions.
uIf you still have any questions after reading these operating instructions, please
contact BÜCHI Labortechnik AG Customer Service. Contact details for your local
agents can be found on the back cover of these operating instructions or on the In-
ternet at http://www.buchi.com.
1.1 Connected devices
In addition to these operating instructions, you should also follow the instructions and
specifications in the documentation for the connected devices.
1.2 Warning notices in this document
Warning notices warn you of dangers that can occur when handling the device. There
are four danger levels, each identifiable by the signal word used.
Signal word Meaning
DANGER Indicates a danger with a high level of risk which could result in
death or serious injury if not prevented.
WARNING Indicates a danger with a medium level of risk which could result in
death or serious injury if not prevented.
CAUTION Indicates a danger with a low level of risk which could result in mi-
nor or medium-severity injury if not prevented.
IMPORTANT Indicates a danger that could result in damage to property.
1.3 Symbols
The following symbols may be displayed in this instruction manual or on the device:
1.3.1
1.3.2 Mandatory directive symbols
Symbol Meaning Symbol Meaning
Wear safety goggles Wear protective clothing
Wear protective gloves Heavy load, do not lift with-
out assistance

1 | About this document BÜCHI Labortechnik AG
8/96 Operation Manual LyovaporTM L-200 / L-200 Pro
1.3.3 Mark-ups and symbols
NOTE
This symbol draws attention to useful and important information.
RThis character draws attention to a requirement that must be met before the in-
structions below are carried out.
uThis character indicates an instruction that must be carried out by the user.
5This character indicates the result of a correctly carried out instruction.
Mark-up Explanation
Window Software Windows are marked-up like this.
Tab Tabs are marked-up like this.
Dialog Dialogs are marked-up like this.
Button Buttons are marked-up like this.
Field names Field names are marked-up like this.
Menu / Menu item Menus or menu items are marked-up like this.
Status Status is marked-up like this.
Signal Signals are marked-up like this.
1.4 Available languages
These operating instructions were originally produced in German and have been
translated into several other languages. The translations are available on the en-
closed CD or can be obtained as a PDF file via http://www.buchi.com.
1.5 Trademarks
Product names and registered or unregistered trademarks that are used in this in-
struction manual are used only for identification and remain the property of the owner
in each case.

BÜCHI Labortechnik AG Safety | 2
Operation Manual LyovaporTM L-200 / L-200 Pro 9/96
2 Safety
2.1 Proper use
The Lyovapor™ L-200 is used for freeze-drying solid materials in ampoules, vials,
dishes, round-neck or wide-neck flasks and is exclusively intended for that purpose.
The Lyovapor™ L-200 can be used in laboratories for the following tasks:
Sublimating and condensing water
2.2 Use other than that intended
Use of any kind other than that described in the section Chapter2.1 "Proper use",
page9 and any application that does not comply with the technical specifications
(see Technical data) constitutes use other than that intended.
In particular, the following applications are not permissible:
Use of the instrument in an environment with a potential risk of explosion or areas
which require explosion-safe apparatus.
Use of the instrument for processing substances outside of research and develop-
ment.
Production and processing of substances that can lead to spontaneous reactions,
such as explosives, metal hydrides or solvents that can form peroxides.
Processing with explosive gas mixtures.
Damage or hazards attributable to use of the product other than as intended are en-
tirely at the risk of the operator alone.
2.3 Staff qualification
Unqualified persons are unable to identify risks and are therefore exposed to greater
dangers.
The device may only be operated by suitably qualified laboratory staff.
These operating instructions are aimed at the following target groups:
Users
Users are persons that meet the following criteria:
They have been instructed in the use of the device.
They are familiar with the contents of these operating instructions and the applica-
ble safety regulations and apply them.
They are able on the basis of their training or professional experience to assess
the risks associated with the use of the device.
Operator
The operator (generally the laboratory manager) is responsible for the following as-
pects:
The device must be correctly installed, commissioned, operated and serviced.
Only suitably qualified staff may be assigned the task of performing the operations
described in these operating instructions.
The staff must comply with the local applicable requirements and regulations for
safe and hazard-conscious working practices.
Safety-related incidents that occur while using the device should be reported to the
manufacturer ([email protected]).

2 | Safety BÜCHI Labortechnik AG
10/96 Operation Manual LyovaporTM L-200 / L-200 Pro
BUCHI service technicians
Service technicians authorized by BUCHI have attended special training courses and
are authorized by BÜCHI Labortechnik AG to carry out special servicing and repair
measures.
2.4 Location of warning signs on the product
The following warning symbols are present on the instrument.
Fig.1: Location of warning signs on the product
General warning
2.5 Residual risks
The device has been developed and manufactured using the latest technological ad-
vances. Nevertheless, risks to persons, property or the environment can arise if the
device is used incorrectly.
Appropriate warnings in this manual serve to alert the user to these residual dangers.
2.5.1 Faults during operation
If a device is damaged, sharp edges or exposed electrical wires can cause injuries.
uRegularly check device for visible damage.
uIf faults occur, switch off the device immediately, unplug the power cord and in-
form the operator.
uDo not continue to use devices that are damaged.
2.5.2 Damage to the ice condenser
Damage to the ice condenser leads to coolant leakage and failure of the instrument.
uWait until the ice is completely thawed.
uDo not use mechanical means to remove ice from the ice condenser.
2.5.3 Glass and acrylic breakage
Broken glass and acrylic can cause severe cuts.
Damaged glass and acrylic components may implode if subjected to a vacuum.
Minor damage to the ground joints impairs the sealing effect and may therefore dimin-
ish sublimination capacity.