Buchi Inert Loop S-395 User manual

Inert Loop S-395
Operation Manual
11594358 | A en

Imprint
Product Identification:
Operation Manual (Original) Inert Loop S-395
11594358
Publication date: 08.2022
Version A
BÜCHI Labortechnik AG
Meierseggstrasse 40
Postfach
CH-9230 Flawil 1
E-Mail: [email protected]
BUCHI reserves the right to make changes to the manual as deemed necessary in the light of experience,
especially with respect to structure, illustrations and technical details.
This manual is copyrighted. Information from it may neither be reproduced, distributed, or used for
competitive purposes, nor made available to third parties. The manufacture of any component with the
aid of this manual without prior written agreement is also prohibited.

Büchi Labortechnik AG Table of contents
Operation Manual Inert Loop S-395 iii
Table of contents
1 About this document...........................................................................................................5
1.1 Mark-ups and symbols ..........................................................................................................5
1.2 Connected instruments..........................................................................................................5
1.3 Trademarks ...........................................................................................................................5
2 Safety....................................................................................................................................6
2.1 Proper use .............................................................................................................................6
2.2 Use other than that intended .................................................................................................6
2.3 Staff qualification ...................................................................................................................6
2.4 Personal protective equipment ..............................................................................................7
2.5 Warning notices in this document..........................................................................................7
2.6 Residual risks ........................................................................................................................7
2.6.1 Faults during operation.............................................................................................8
2.6.2 Glass breakage ........................................................................................................8
2.7 Modifications..........................................................................................................................8
2.8 Oxygen sensor ......................................................................................................................8
3 Product description.............................................................................................................9
3.1 Description of function ...........................................................................................................9
3.2 Configuration .......................................................................................................................10
3.2.1 Front view ...............................................................................................................10
3.2.2 Rear view................................................................................................................11
3.2.3 Control elements ....................................................................................................11
3.2.4 Type plate...............................................................................................................11
3.3 Scope of delivery .................................................................................................................12
3.4 Technical data .....................................................................................................................12
3.4.1 Inert Loop S-395.....................................................................................................12
3.4.2 Ambient conditions .................................................................................................14
3.4.3 Materials .................................................................................................................14
3.4.4 Installation site........................................................................................................15
4 Transport and storage ......................................................................................................16
4.1 Transport .............................................................................................................................16
4.2 Storage ................................................................................................................................16
4.3 Moving the instrument .........................................................................................................16
5 Installation..........................................................................................................................17
5.1 Before installation ................................................................................................................17
5.2 Establishing electrical connections......................................................................................17
5.3 Installing the exhaust gas hose ...........................................................................................17
5.4 Installing the solvent receiving vessel .................................................................................18
5.5 Installing the oxygen sensor for the first time ......................................................................19
5.6 Installations for a spray drying mode...................................................................................19

Table of contents Büchi Labortechnik AG
iv Operation Manual Inert Loop S-395
6 Operation............................................................................................................................20
6.1 Preparing the instrument .....................................................................................................20
6.2 Starting the instrument ........................................................................................................20
6.3 Tasks during spray drying ...................................................................................................21
6.4 Shutting down the instrument ..............................................................................................21
6.5 Switching off the instrument ................................................................................................21
6.6 Setting condenser temperature ...........................................................................................21
7 Cleaning and servicing .....................................................................................................22
7.1 Regular maintenance work..................................................................................................22
7.2 Empty the solvent receiving vessel .....................................................................................22
7.3 Cleaning the housing...........................................................................................................23
7.4 Cleaning the ventilation slots...............................................................................................23
7.5 Calibrating the oxygen analyzer ..........................................................................................23
7.6 Checking the controller of the oxygen sensor .....................................................................27
7.7 Changing the oxygen sensor...............................................................................................27
7.7.1 Removing the oxygen sensor .................................................................................27
7.7.2 Installing the oxygen sensor ...................................................................................28
8 Help with faults ..................................................................................................................30
8.1 Error messages ...................................................................................................................30
9 Taking out of service and disposal..................................................................................31
9.1 Taking out of service ...........................................................................................................31
9.2 Refrigerant...........................................................................................................................31
9.3 Disposal...............................................................................................................................31
9.4 Returning the instrument .....................................................................................................31
10 Appendix ............................................................................................................................32
10.1 Spare parts ..........................................................................................................................32

Büchi Labortechnik AG About this document | 1
Operation Manual Inert Loop S-395 5/34
1 About this document
This operation manual is applicable for all variants of the instrument.
Read this operation manual before operating the instrument and follow the
instructions to ensure safe and trouble-free operation.
Keep this operation manual for later use and pass it on to any subsequent user or
owner.
BÜCHI Labortechnik AG accepts no liability for damage, faults and malfunctions
resulting from not following this operation manual.
If you have any questions after reading this operation manual:
uContact BÜCHI Labortechnik AG Customer Service.
https://www.buchi.com/contact
1.1 Mark-ups and symbols
NOTE
This symbol draws attention to useful and important information.
RThis character draws attention to a requirement that must be met before the
instructions below are carried out.
uThis character indicates an instruction that must be carried out by the user.
ðThis character indicates the result of a correctly carried out instruction.
Mark-up Explanation
Window
Software Windows are marked-up like this.
Tab
Tabs are marked-up like this.
Dialog
Dialogs are marked-up like this.
[Button] Buttons are marked-up like this.
[Field names] Field names are marked-up like this.
[Menu / Menu item] Menus or menu items are marked-up like this.
Status Status is marked-up like this.
Signal Signals are marked-up like this.
1.2 Connected instruments
In addition to this operation manual, follow the instructions and specifications in the
documentation for the connected instruments.
1.3 Trademarks
Product names and registered or unregistered trademarks that are used in this
document are used only for identification and remain the property of the owner in
each case.

2 | Safety Büchi Labortechnik AG
6/34 Operation Manual Inert Loop S-395
2 Safety
2.1 Proper use
The instrument is designed and built for laboratories.
The instrument can be used for the following tasks:
Condense organic solvent from the drying gas from BUCHI spray dryer.
2.2 Use other than that intended
The use of the instrument other than described in proper use and specified in
technical data is use other than that intended.
The operator is responsible for damages or hazards that are caused by use other
than that intended.
Specially the following uses are not permitted:
Use of the instrument in areas which require explosion-safe instruments.
Use the instrument with non-BUCHI instruments.
Use of the instrument for processing substances outside of research and
development.
Use of the instrument with gases with unknown chemical composition.
Use of the instrument with samples containing peroxides.
Use of the instrument with samples that can form peroxides.
Use of the instrument with samples which produce oxygen during the processing.
Use of the instrument with toxic substances without appropriate safety measures.
Use of the instrument with biohazardous materials such as viruses or bacteria.
Use of the instrument with substances which might explode or ignite because of
the processing.
Use of the instrument with corrosive samples.
2.3 Staff qualification
Unqualified persons are unable to identify risks and are therefore exposed to greater
dangers.
The instrument may only be operated by suitably qualified laboratory staff.
These operating instructions are aimed at the following target groups:
Users
Users are persons that meet the following criteria:
They have been instructed in the use of the instrument.
They are familiar with the contents of these operating instructions and the
applicable safety regulations and apply them.
They are able on the basis of their training or professional experience to assess
the risks associated with the use of the instrument.

Büchi Labortechnik AG Safety | 2
Operation Manual Inert Loop S-395 7/34
Operator
The operator (generally the laboratory manager) is responsible for the following
aspects:
The instrument must be correctly installed, commissioned, operated and serviced.
Only suitably qualified staff may be assigned the task of performing the
operations described in these operating instructions.
The staff must comply with the local applicable requirements and regulations for
safe and hazard-conscious working practices.
Safety-related incidents that occur while using the instrument should be reported
to the manufacturer ([email protected]).
BUCHI service technicians
Service technicians authorized by BUCHI have attended special training courses and
are authorized by BÜCHI Labortechnik AG to carry out special servicing and repair
measures.
2.4 Personal protective equipment
Depending on the application, hazards due to heat and/or corrosive chemicals may
arise.
uAlways wear appropriate personal protective equipment such as safety goggles,
protective clothing and gloves.
uMake sure that the personal protective equipment meets the requirements of
the safety data sheets for all chemicals used.
2.5 Warning notices in this document
Warning notices warn you of dangers that can occur when handling the instrument.
There are four danger levels, each identifiable by the signal word used.
Signal word Meaning
DANGER Indicates a danger with a high level of risk which could result in
death or serious injury if not prevented.
WARNING Indicates a danger with a medium level of risk which could result in
death or serious injury if not prevented.
CAUTION Indicates a danger with a low level of risk which could result in mi-
nor or medium-severity injury if not prevented.
NOTICE Indicates a danger that could result in damage to property.
2.6 Residual risks
The instrument has been developed and manufactured using the latest technological
advances. Nevertheless, risks to persons, property or the environment can arise if
the instrument is used incorrectly.
Appropriate warnings in this manual serve to alert the user to these residual
dangers.

2 | Safety Büchi Labortechnik AG
8/34 Operation Manual Inert Loop S-395
2.6.1 Faults during operation
If an instrument is damaged, sharp edges, glass splinters, moving parts or exposed
electrical wires can cause injuries.
uRegularly check instruments for visible damage.
uIf faults occur, switch off the instrument immediately, unplug the power cord and
inform the operator.
uDo not continue to use instruments that are damaged.
2.6.2 Glass breakage
WARNING
In the rare case of an abrupt massive leakage like a glass breakage a deflagration
can happen.
Risk of injury from flying glass splinters.
uLeave the instrument immediately.
uStay in a safe distance for 1 minute.
uDo not switch off or unplug the instrument.
uWait until the instrument changed independently into a safe state to get back.
2.7 Modifications
Unauthorized modifications can affect safety and lead to accidents.
uUse only genuine BUCHI accessories, spare parts and consumables.
uCarry out technical changes only with prior written approval from BUCHI.
uOnly allow changes to be made by BUCHI service technicians.
BUCHI accepts no liability for damage, faults and malfunctions resulting from
unauthorized modifications.
2.8 Oxygen sensor
The instrument is equipped with an oxygen measurement sensor to ensure a safe
operation when spraying combustible solvent. The inertization of the instrument is
continuously monitored. In case of an oxygen concentration above 6% the
instrument is able to immediately stop the solvent spraying. A safe state will be
reached with a maximum time delay of 15 to 25s. The actual time delay depends on
the drying gas flow rate.
The used sensor is SIL capable.

Büchi Labortechnik AG Product description | 3
Operation Manual Inert Loop S-395 9/34
3 Product description
3.1 Description of function
The instrument is an accessory for BUCHI Spray Drying Instruments. It enables the
safe use of organic solvents in closed loop mode.
The spray drying process in closed loop mode generates an inert gas stream loaded
with solvent vapors. The instrument is used to condense these solvent vapors from
the gas stream and to monitor its oxygen concentration.
The gas flow enters the instrument and passes the pre-heat exchanger where it is
cooled before entering the condenser. After solvent vapor condensation, the gas
stream is reheated by the pre-heater before being returned to the spray drying
process. The excess inert gas leaves the instrument via the exhaust and the
condensed solvent vapors are collected in a closed bottle.
The following spray drying modes are available:
Spray drying mode Solvent composition
Closed mode with Inert Loop
(When using Ultrasonic Package acces-
sory inert gas adapter is necessary)
between 90 % - 100 % organic solvent
Closed mode with Inert Loop and Dehu-
midifier
(When using Ultrasonic Package acces-
sory inert gas adapter is necessary)
between 20 % - 80 % organic solvent

3 | Product description Büchi Labortechnik AG
10/34 Operation Manual Inert Loop S-395
3.2 Configuration
3.2.1 Front view
4
5
6
3
9
1
2
7
8
Fig.1: Front view
1 Control elements
(See Control elements)
2 Oxygen analyzer
(Front cover oxygen analyzer)
3 Communication cable 4 Exhaust connection
(marked: Exhaust)
5 Process gas out
(marked: OUT)
6 Process gas in
(marked: IN)
7 Ventilation area 8 Solvent receiving vessel
9 Castor wheels

Büchi Labortechnik AG Product description | 3
Operation Manual Inert Loop S-395 11/34
3.2.2 Rear view
3
4
1
2
5
Fig.2: Rear view
1 Type plate 2 Power connection
3 Fuses 4 Ventilation area
5 Ventilation area
3.2.3 Control elements
1234
5
6
7
8
9
Fig.3: Control elements
1 Display 2 Set temperature up
3 Switch on 4 Signal lamp power
5 Signal lamp pressure 6 Signal lamp oxygen
7 Signal lamp operation 8 Switch off
9 Set temperature down
3.2.4 Type plate
The type plate identifies the instrument. The type plate is located at the rear side of
the instrument. See Side connections

3 | Product description Büchi Labortechnik AG
12/34 Operation Manual Inert Loop S-395
Büch Labortechnik AG
Meierseggstrasse 40 CH - 9230 Flawil / Switzerland
Made in Germany
10
9
1
2
11
12
3
8
4
5
6
714
13
Fig.4: Type plate
1 Instrument name 2 Serial number
3 Article number 4 Refrigerant details
Filling capacity
5 Global warming potential 6 Input voltage range
Frequency
7 Power consumption maximum 8 Fuse type
9 High-pressure system design pres-
sure
10 Low-pressure system design pressure
11 Year of manufacture 12 Company name and address
13 Approvals 14 Symbol for "Do not dispose of as
household waste"
3.3 Scope of delivery
NOTE
The scope of delivery depends of the configuration of the purchase order.
Accessories are delivered as per the purchase order, order confirmation, and
delivery note.
3.4 Technical data
3.4.1 Inert Loop S-395
Specification Inert Loop
S-395
200 V
50 Hz
Inert Loop
S-395
230 V
50 Hz
Inert Loop
S-395
200 V
60 Hz
Inert Loop
S-395
240 V
60 Hz
Inert Loop
S-395
220 V
60 Hz
Dimensions
(W x D x H)
705 x 660 x
687 mm
705 x 660 x
687 mm
705 x 660 x
687 mm
705 x 660 x
687 mm
705 x 660 x
687 mm

Büchi Labortechnik AG Product description | 3
Operation Manual Inert Loop S-395 13/34
Specification Inert Loop
S-395
200 V
50 Hz
Inert Loop
S-395
230 V
50 Hz
Inert Loop
S-395
200 V
60 Hz
Inert Loop
S-395
240 V
60 Hz
Inert Loop
S-395
220 V
60 Hz
Weight 96.7 kg 91 kg 96.7 kg 96.7 kg 91 kg
Power con-
sumption
max. 1700
VA
max. 1700
VA
max. 2000
VA
max. 2000
VA
max. 2000
VA
Frequency 50 Hz 50 Hz 60 Hz 60 Hz 60 Hz
Connection
voltage
200 V ± 10 % 230 V ± 10 % 200 V ± 10 % 240 V ± 10 % 220 V ± 10 %
Primary fuse 10 A 10 A 14 A 14 A 12 A
Secondary
fuse
10 A - 12 A 12 A -
IP Code IP20 IP20 IP20 IP20 IP20
Overvoltage
category
II II II II II
Pollution de-
gree
II II II II II
Protection
degree
IIIII
Rate of cool-
ing*
800 W at 0
°C
800 W at 0
°C
920 W at 0
°C
920 W at 0
°C
920 W at 0
°C
Refrigerant R449A R449A R449A R449A R449A
CO-equiva-
lent
1.369 t 1.369 t 1.369 t 1.369 t 1.369 t
Filling
amount of
refrigerant
0.98 kg 0.98 kg 0.98 kg 0.98 kg 0.98 kg
Safety Group
Refrigerants
(ASHRAE)
A1 (lower
toxicity, no
flame propa-
gation)
A1 (lower
toxicity, no
flame propa-
gation)
A1 (lower
toxicity, no
flame propa-
gation)
A1 (lower
toxicity, no
flame propa-
gation)
A1 (lower
toxicity, no
flame propa-
gation)
Maximum al-
lowable
pressure (PS)
[Low pres-
sure side]
22 bar 22 bar 22 bar 22 bar 22 bar
Maximum al-
lowable
pressure (PS)
[High pres-
sure side]
26 bar 26 bar 26 bar 26 bar 26 bar

3 | Product description Büchi Labortechnik AG
14/34 Operation Manual Inert Loop S-395
Specification Inert Loop
S-395
200 V
50 Hz
Inert Loop
S-395
230 V
50 Hz
Inert Loop
S-395
200 V
60 Hz
Inert Loop
S-395
240 V
60 Hz
Inert Loop
S-395
220 V
60 Hz
Min. process
gas tempera-
ture
-30 °C -30 °C -30 °C -30 °C -30 °C
Max. process
gas tempera-
ture
8 °C 8 °C 8 °C 8 °C 8 °C
Minimum
clearance on
all sides
300 mm 300 mm 300 mm 300 mm 300 mm
*The max. cooling capacity is only guaranteed up to 5% undervoltage.
3.4.2 Ambient conditions
For indoor use only.
Max. altitude above sea level 2000 m
Ambient temperature 5‒35 °C
Maximum relative humidity 80 % for temperatures up to 31 °C
decreasing linearly to 50 % relative hu-
midity at 35 °C
Storage temperature max. 40 °C
3.4.3 Materials
Component Materials of construction
Hose connections, tubing, weld-on nipple Stainless steel 1.4571
Pre-heat exchanger, condensate separa-
tor
Stainless steel 1.4301
Plate heat exchanger Stainless steel 1.4401
Screw connections, Ball valve Stainless steel 1.4408
Sealing ball valve PTFE
Pipe elbow Stainless steel 1.4307
Pressure switch PVDF, Viton, NBR/aramid fiber composite
Oxygen sensor PA, PPS, PTFE, stainless steel
Black hoses EPDM
Drain tube PVC
Woulff bottle Glass
Plate heat exchanger Stainless steel solder

Büchi Labortechnik AG Product description | 3
Operation Manual Inert Loop S-395 15/34
3.4.4 Installation site
The installation site meets the safety requirements. See Chapter2 "Safety",
page6
The installation site has a firm, level and nonslip surface.
The installation site has no obstacles (e.g. water taps, drains, etc.).
The installation site has an own mains outlet socket for the instrument.
The installation site is not exposed to external thermal loads, such as direct solar
radiation.
The installation site has enough space that cables / tubes can be routed safely.
The installation site meets the requirements for the connected devices. See
related documentation
The installation site meets the specifications according to the technical data (e.g.
weight, dimension, etc.). See Chapter3.4 "Technical data", page12
The installation site allows that the power supply can be disconnected at any time
in an emergency.
The installation site fits basic electromagnetic environment / Emission Class B.
Make sure there is free flow of air to the side of the instrument.
Do not place loose papers or cloths below or to the sides of the instrument, as
these could impede the air circulation if drawn in.
Put the instrument on the castors directly on the floor, do not use a pad.
Make sure the castor brakes are locked.
Place only BUCHI spray dryer on the instrument.
Do not place the instrument near vibration-sensitive devices.

4 | Transport and storage Büchi Labortechnik AG
16/34 Operation Manual Inert Loop S-395
4 Transport and storage
4.1 Transport
NOTICE
Risk of breakage due to incorrect transportation
uMake sure that all parts of the instrument are safely packed in such a way as to
prevent breakage, ideally in the original box.
uAvoid sharp movements during transit.
uAfter transportation, check the instrument for damage.
uDamage that has occurred in transit should be reported to the carrier.
uKeep packing for future transportation.
4.2 Storage
uMake sure that the ambient conditions are complied with (see Chapter3.4
"Technical data", page12).
uWherever possible, store the instrument in its original packaging.
uAfter storage, check the instrument, all seals and tubing for damage and replace
if necessary.
4.3 Moving the instrument
uRelease the castor breaks.
uMove the instrument to the designated place.
uLock the castor breaks.

Büchi Labortechnik AG Installation | 5
Operation Manual Inert Loop S-395 17/34
5 Installation
5.1 Before installation
NOTICE
Instrument damaged if switched on too early.
After transporting, wait twelve hours before switching on the instrument. The fluid
in the cooling system requires twelve hours to collect in the refrigerant compressor.
5.2 Establishing electrical connections
NOTICE
Risk of instrument damage because of not suitable power supply cables.
Not suitable power supply cables can cause bad performance or an instrument
damage
uUse only BUCHI power supply cables.
Precondition:
RThe electrical installation is as specified on the
type plate.
RThe electrical installation is equipped with a
proper grounding system.
RThe electrical installation is equipped with
suitable fuses and electrical safety features.
RThe installation site is as specified in the
technical date. See Chapter3.4 "Technical
data", page12
uConnect the power supply cable to the
connection on the instrument. See Chapter3.2
"Configuration", page10
uConnect the mains plug to an own mains outlet
socket.
5.3 Installing the exhaust gas hose
CAUTION
Risk of overpressure due to clogged exhaust.
Overpressure can damage the instrument or impact the safety of the user.
uDo not bend, fold or squeeze tubes that are connected to the exhaust.

5 | Installation Büchi Labortechnik AG
18/34 Operation Manual Inert Loop S-395
uInstall the exhaust tube onto the exhaust
connection.
uAttach the tube in place with a hose clamp.
uPlace the other end of the tubing to a fume
hood.
5.4 Installing the solvent receiving vessel
uPut the PTFE hose connection on the bottle.
uPut the solvent receiving vessel in place.
uInstall the PTFE hose onto the condensate drain
valve.
uOpen the condensate drain valve.

Büchi Labortechnik AG Installation | 5
Operation Manual Inert Loop S-395 19/34
uMake sure that the lever of the condensate
drain valve is in the position indicated.
5.5 Installing the oxygen sensor for the first time
The primary installation of the oxygen sensor for a new instrument will be guided by
a BUCHI service technician. For further information see Chapter7.7 "Changing the
oxygen sensor", page27.
5.6 Installations for a spray drying mode
For installations for a spray drying mode, see separate installation manuals.
"MiniSprayDryer S-300 in closed mode with Dehumidifier and Inert Loop"
"MiniSprayDryer S-300 in closed mode with Inert Loop"
"MiniSprayDryer S-300 in open pressure mode"
"MiniSprayDryer S-300 in open suction mode"

6 | Operation Büchi Labortechnik AG
20/34 Operation Manual Inert Loop S-395
6 Operation
6.1 Preparing the instrument
Precondition:
RAll commissioning operations have been completed. See Chapter5 "Installation",
page17
uPress the button Switch off.
6.2 Starting the instrument
NOTICE
Too frequent switching on the instrument
Too frequent switching on the instrument can cause an instrument damage.
uWait 10 minutes before restarting the instrument.
NOTE
The correct oxygen value is between 20 - 21 %.
If this value is not reached.
uCalibrate the oxygen sensor. See Chapter7.5 "Calibrating the oxygen analyzer",
page23
ðIf a calibration of at least 20.5 % can not be reached replace the sensor. See
Chapter7.7 "Changing the oxygen sensor", page27.
Precondition:
RThe instrument is prepared. See Chapter6.1 "Preparing the instrument",
page20.
RMake sure that the solvent receiving vessel is empty. See Chapter7.2 "Empty the
solvent receiving vessel", page22.
uSwitch on the connected spray dryer. See Operation manual of the connected
spray dry.
ðThe signal lamp oxygen is on.
ðThe signal lamp pressure is on.
uConnect the communication cable.
uCheck the oxygen value. See Chapter3.2.1 "Front view", page10.
uSet condenser temperature. See Chapter6.6 "Setting condenser temperature",
page21.
uPress the Switch on button. See Chapter3.2.3 "Control elements", page11.
uMake sure, that the compressor is working.
uSwitch on the aspirator. See Operation manual of the connected spray dryer.
ðThe signal lamp pressure is off.
uSwitch on the spray gas.
uWait until the oxygen level is less than 6 %.
ðThe signal lamp oxygen is off.