cytiva PRT-DPM-3T User manual

MidJet pressure
display unit
Instructions for use
cytiva.com

Table of Contents
1 Introduction ......................................................................................................................................... 3
2 Pressure display unit ........................................................................................................................... 6
3 Setup and operation ............................................................................................................................ 8
4 Maintenance and calibration .............................................................................................................. 12
5 Specifications ...................................................................................................................................... 15
6 Parts and accessories .......................................................................................................................... 16
Index ............................................................................................................................................................ 18
Table of Contents
2 MidJet pressure display unit Instructions for use 18117465 AD

1 Introduction
About this user guide
This user guide describes how to use the CytivaMidJet pressure display unit PRT-DPM-3T. Topics
include a product description, assembly instructions, operation instructions, and maintenance
procedures.
Audience
This user guide addresses the needs of scientists, process engineers, and technicians who operate
laboratory-scale cross-flow systems. The level of information presented in this guide assumes the
user possesses basic laboratory and technical skills, and has the knowledge and documentation to
safely operate any user supplied equipment connected to the pressure display unit. If you need assis-
tance with the instructions in this guide, contact Cytiva for more information.
Where to find more information
You can download technical documents and learn more about Cytiva cross-flow systems by visiting
our website, cytiva.com.
Safety
Anyone who works with the pressure display unit should read, understand, and follow the instruc-
tions in this user guide. If any operator does not understand an instruction, they should stop working
with the pressure display unit and contact Cytiva for guidance. You should save these instructions
and make them available to all users of the pressure display unit.
Cytiva designed the pressure display unit for displaying the pressure readings from pressure trans-
ducers installed into laboratory-scale, cross-flow filtration systems under the conditions stated in
this user guide. If you use the pressure display unit and pressure transducers in a manner not speci-
fied by Cytiva, you may impair the protection provided by the pressure display unit and pressure
transducers.
When using any laboratory equipment, the potential exists for personal injury unless you follow
established safety procedures. When installing and using Cytiva cross-flow systems, you should
follow good engineering practices as well as OSHA, federal, state, local, and your company’s safety
regulations and codes. You should follow your company’s safety regulations and the specific safety
instructions provided in this user guide.
Only qualified personnel who are adequately trained and who understand the operating instructions
should install, operate, maintain, and inspect the pressure display unit.
1 Introduction
MidJet pressure display unit Instructions for use 18117465 AD 3

Warnings, cautions, and tips
This user guide uses symbols and blocks of text to provide you with safety warnings and other impor-
tant information:
WARNING
WARNING indicates a hazardous situation which, if not avoided,
could result in death or serious injury. It is important not to proceed
until all stated conditions are met and clearly understood.
CAUTION
CAUTION indicates a hazardous situation which, if not avoided,
could result in minor or moderate injury. It is important not to
proceed until all stated conditions are met and clearly understood.
Tip: A tip contains useful information that can improve or optimize your procedures.
WARNING
If a pressure transducer leaks, it can release potentially hazardous
process or cleaning fluids and cause bodily harm. To prevent leaks
and the release of potentially hazardous fluids, limit system pres-
sure to 2 barg (30 psig), periodically check pressure transducer
connections for proper assembly and wear. Isolate and depressu-
rize your system before installing, removing, and checking pressure
transducers. Wear the appropriate personal protection devices and
clothing when operating and cleaning the system.
WARNING
Mishandling potentially hazardous process and cleaning solutions
can cause bodily harm. To safely handle potentially hazardous
process, cleaning, and storage solutions, read the material safety
data sheets for the solutions you use. Follow the material safety
data sheet instructions for safe handling and use the personal
protection equipment required by your company, and local, state,
and federal laws.
1 Introduction
4 MidJet pressure display unit Instructions for use 18117465 AD

WARNING
If you autoclave or use hot caustic cleaning solution (0.5 N NaOH) to
clean the pressure transducers, the transducers can fail causing
leaks of potentially hazardous cleaning or process fluid and bodily
harm. To avoid leaks of potentially hazardous solutions, do not
autoclave the pressure transducers. Limit exposure to caustic solu-
tion (0.5 N NaOH) to room temperature and only for short periods
(30 to 60 minutes) of time. Rinse all caustic thoroughly from the
transducers after exposure.
WARNING
If water or other liquids enter the pressure display unit, equipment
damage and electrical shock (bodily harm) can occur. Locate the
pressure display unit where it will not be exposed to water and
other fluids. Prevent water or other liquids from entering the unit.
Product labeling
The pressure display unit labeling, located on the back of the housing, provides key identification and
specification information (see the Figure below).
Figure 1.1: The PRT-DPM-3T pressure display unit labeling
1 Introduction
MidJet pressure display unit Instructions for use 18117465 AD 5

2 Pressure display unit
Package contents
Your pressure display unit arrives packaged in a cardboard box. The box includes these components:
Contents of PRT-DPM-3T
•display unit
•Three pressure transducers
•One temperature sensor
•Power cord (U.S.)
•User guide
•Certificates of compliance for pressure display unit
System overview
The PRT-DPM-3T pressure display unit includes three pressure displays and a temperature display
(see the Figure below).
Figure 2.1: The PRT-DPM-3T pressure display unit
Transducers
Each pressure display unit includes a set of pressure tranducers. Additional pressure transducers
can be purchased separately in packs of one or two.
The transducers use Luer-Lok™ connectors for connecting to your lab system tubing and an elec-
trical jack for connecting the electrical wire to the back of the pressure display unit.
2 Pressure display unit
6 MidJet pressure display unit Instructions for use 18117465 AD

WARNING
If you autoclave or use hot caustic cleaning solution (0.5 N NaOH) to
clean the pressure transducers, the transducers can fail causing
leaks of potentially hazardous cleaning or process fluid and bodily
harm. To avoid leaks of potentially hazardous solutions, do not
autoclave the pressure transducers. Limit exposure to caustic solu-
tion (0.5 N NaOH) to room temperature and only for short periods
(30 to 60 minutes) of time. Rinse all caustic solution thoroughly
from the transducers after exposure.
Thermocouple
The temperature signal is sent to the pressure display using a J-type thermocouple set in a
maleLuer-Lok fitting. The 5-foot length of signal wire ends in a standard 2-pin plug that plugs into the
back of the display unit. The thermocouple is calibrated by the manufacturer for digital displays.
The LED temperature display indicates temperature in °C.
2 Pressure display unit
MidJet pressure display unit Instructions for use 18117465 AD 7

3 Setup and operation
To setup your system you must integrate the pressure transducers in to your cross-flow system and
connect the transducer signal cables to the back of the pressure display unit.
Typical transducer placement in a cross-flow
filtration system
Monitoring the feed and retentate pressure—and sometimes the permeate pressure—enables the
safe and precise control of a cross-flow filtration system. Therefore, pressure transducers are
mounted on the feed and retentate lines (Fig. 3.1, on page 9). For cross-flow systems that can
benefit from monitoring the permeate pressure, a third pressure transducer (model PRT-DPM-3T)
can be mounted on the permeate line.
Temperature probe (thermocouple)
Monitoring the temperature in the reservoir or permeate collection vessel can be helpful. Pressure
display unit PRT-DPM-3T includes a temperature probe and LED temperature display that indicates
the temperature in °C.
CAUTION
If you overtighten the locking nut when installing transducers using
Luer-Lok connectors, you can damage the transducer. Often the
damage occurs when trying to loosen an overtightened connec-
tion. When you join the male and female components of a Luer-Lok,
a tight connection is essentially made. Rotating the nut prevents
the components from coming apart—it does not make the connec-
tion tighter. To prevent damaging pressure transducers, use only
light fingertip pressure to tighten the Luer-Lok’s rotating nut.
3 Setup and operation
8 MidJet pressure display unit Instructions for use 18117465 AD

Clamp
Tubing Pinch
Retentate
Feed
Temperature
Probe
Feed
Reservoir
Pump
Transducer
Signal
Pressure Display Unit
Cable
Blanked Off
Cross-Flow
Permeate Port
Cartridge
Line
Permeate
Collection
Permeate
Vessel
Figure 3.1: Typical transducer placement in a cross-flow system
Installing the transducers
CAUTION
The pressure display unit is calibrated at the factory with the
installed transducers. If you swap the transducers by plugging
them into different terminals on the back of the pressure display
unit, the accuracy of the pressure reading will be compromised. To
maintain the accuracy of the pressure display unit, do not swap the
transducers by plugging them into different terminals on the back
of the pressure display unit. Recalibrate the pressure display unit
when you install new pressure transducers.
Connect pressure transducers to the feed, retentate, and one of the permeate ports of your cross-
flow cartridge. Connect the transducer signal cables to the appropriate jacks—Inlet (or feed), Outlet
(or retentate and Permeate—on the back of the display unit. Plug the temperature sensor signal
cable into the jack on the back of the display unit. Place the temperature probe in the feed reservoir,
permeate collection vessel, or integrate it into the retentate line using a tee adaptor andLuer-Lok
connectors.
3 Setup and operation
MidJet pressure display unit Instructions for use 18117465 AD 9

WARNING
If a pressure transducer leaks, it can release potentially hazardous
process or cleaning fluids and cause bodily harm. To prevent leaks
and the release of potentially hazardous fluids, limit system pres-
sure to 2 barg (30 psig), periodically check pressure transducer
connections for proper assembly and wear. Isolate and depressu-
rize your system before installing, removing, and checking pressure
transducers. Wear the appropriate personal protection devices and
clothing when operating and cleaning the system.
Figure 3.2: A MidJet system and a pressure and temperature display unit
Powering up the display
Connect the pressure display unit power cord to a fuse-protected, electrical outlet of the proper
voltage (110 to 220 VAC, 50 to 60 Hz).
If you need to order a power cord for use outside the United States and Canada, see the part list in
Ordering parts, on page 16.
After making all the connections, power up the pressure display unit using the On/Off switch located
on the back panel of the unit.
3 Setup and operation
10 MidJet pressure display unit Instructions for use 18117465 AD

WARNING
If water or other liquids enter the pressure display unit, equipment
damage and electrical shock (bodily harm) can occur. Locate the
pressure display unit where it will not be exposed to water and
other fluids. Prevent water or other liquids from entering the unit.
Tip: If the display does not illuminate when you power up the unit, or if one of displays does not
seem to work properly, you may have to reset the system by switching it off and back on
again. This enables the display unit to reset the memory much like rebooting a computer.
Tip: The pressure display units can be integrated into various cross-flow systems using a
number of different fittings and adaptors. See the part list in Ordering parts, on page 16
for a list of the available fittings, adaptors, and cross-flow system components.
Operation
After powering up the pressure display, the pressure in pounds per square inch (or bar) will be
displayed for each transducer. The LED temperature display indicates temperature in °C as meas-
ured by the temperature probe.
To shut the unit down, move the power switch to the Off position.
3 Setup and operation
MidJet pressure display unit Instructions for use 18117465 AD 11

4 Maintenance and calibration
Inspection
Routine maintenance is not required on the pressure display unit. You should visually inspect the
pressure transducers for leaks periodically.
Based on usage (run hours, process fluid chemistry, cleaning cycles), develop a schedule for the
routine replacement of transducers before performance is affected or leaks develop.
Calibration of temperature LED display
The temperature LED display does not require calibration. Periodically test the accuracy of the ther-
mocouple and display using a standard. Replace the thermocouple if needed.
Calibration of LCD pressure displays
Only a trained and qualified instrument technician or metrologist should calibrate the pressure
displays. Calibrate the pressure display unit whenever you change a pressure transducer. Once cali-
brated, you should not switch transducer connections on the back of the unit.
Following calibration, the pressure display units should provide an accuracy of ±2 percent over the
range of calibration. For example, if you calibrate the unit using a pressure range of 2.5 to 15 psig, you
will achieve ±2 percent accuracy over that range. If you calibrate the unit from 15 to 30 psig, you will
achieve ±2 percent accuracy over that range.
The LCD displays may have different internal appearances, but the model number, performance, and
calibration procedure are the same.
Calibration of the three-transducer pressure display
unit (PRT-DPM-3T)
Follow the steps below to calibrate the three-transducer pressure display unit:
Equipment needed
Gather these materials:
•A hand-held tester with a pressure standard. The standard should be traceable to NIST for the
most precise calibration.
•Very small flathead screwdriver and small Philips head screwdriver
•Tubing and Luer-Lok fittings to connect all transducers in series to the pressure tester
4 Maintenance and calibration
12 MidJet pressure display unit Instructions for use 18117465 AD

Removing the pressure display unit cover
Follow these steps to remove the LCD display unit’s cover:
Step Action
1 Disconnect the power cord from the electrical power source.
2 Remove the four screws that hold the rubber feet to the bottom of the cabinet, and
remove the top half of the cabinet.
3 Plug the power cable in, power up the unit, and allow it to warm up for 20 minutes.
Calibrating the LCD displays
You should calibrate the unit over a 15-psig range that covers the pressures anticipated during
processing. This procedures provides instructions for calibrating between 2.5 and 15 psig. If,
however, you anticipate that most of your process pressures will be from 15 to 30 psig, modify the
test pressures to cover that range.
Follow these steps to calibrate the LCD displays:
Step Action
1 Connect the feed (inlet) and retentate (outlet) and permeate transducers in series to the
pressure tester. Blank off the open end of the last transducer and pressurize the trans-
ducer circuit to 15 psig. Allow the displays to equilibrate.
2 Rotate the adjustment screw on each LCD display until the displays indicate the exact
pressure shown on the pressure tester.
3 Repeat steps 1 through 2 in this section at pressures of 2.5, 5, and 10 psig.
4 Repeat steps 1 through 3 in this section two more times.
Qualification and acceptance
Follow these steps to qualify and accept the calibration of the unit:
Step Action
1 Pressurize the transducers to 2.5 psig using the pressure tester and record the actual
pressure displayed on the pressure tester and the indicated readings of the pressure
display unit. Repeat this step at 5, 7.5, 10, 12.5, and 15 psig.
2 If more than six of the pressure readings are outside the actual pressure applied by ± 0.3
psig , repeat the calibration and qualification and acceptance procedures again.
4 Maintenance and calibration
MidJet pressure display unit Instructions for use 18117465 AD 13

Assembly
Follow these steps to assemble the pressure display unit after calibrating it:
Step Action
1 Power down the pressure unit and unplug its power cord.
2 Decompress the transducer circuit and remove the pressure tester from the trans-
ducers.
3 Replace the top cover on the pressure display unit and reinstall the four rubber feet and
screws to hold the cover in place.
Transducer and system disposal
To dispose of a transducer, clean potentially hazardous solutions from it with a water flush, unplug
the transducer from the back of the pressure display unit, and dispose of the transducer in the trash.
When the pressure display unit reaches the end of its service life, dispose of the unit in accordance
with the government and environmental regulations that pertain to your location.
4 Maintenance and calibration
14 MidJet pressure display unit Instructions for use 18117465 AD

5 Specifications
Pressure display unit PRT-DPM-3T
Size and dimensions
Dimensions, approximate (W × D × H)—26 × 18.5 × 7.5 cm (10.3 × 7 × 3 in)
Weight, approximate: 1.5 kg (3 lbs)
Operating parameters
Ambient operating temperature range: 5-50°C
Recommended maximum operating pressure: 2 barg (30 psig)
Accuracy: ±2 percent over the 15 psig range to which it is calibrated
Power requirements: 110 to 220 VAC, 50 to 60 Hz
Thermocouple
Thermocouple: type J thermocouple, -210 to 1200°C (display range is limited to -99 to 999.9°C, limit
of error of 2.2°C
Pressure transducers
Operating parameters
Recalibrate the pressure display after installing new transducers
Recommended maximum operating pressure—2 barg (30 psig)
Material of construction—polycarbonate shell
Connection to process lines—male and female Luer-Lok connectors
Connection to pressure display—RJ15 phone jack
5 Specifications
MidJet pressure display unit Instructions for use 18117465 AD 15

6 Parts and accessories
Ordering parts
Cytiva can supply you with spare parts and accessories for your pressure display unit (see the Table
below).
Table 6.1: Pressure display unit part numbers
Code number Model number Description
56-4106-11 PRT-DPM-3T Pressure display unit with three pressure trans-
ducers and temperature thermocouple (included)
56-4110-25 PRT-DPM-3T150 Same as part PRT-DPM-3T, 220V. Power cord must
be ordered separately.
56-4109-47 PC01-CH Power Cord, China
56-4109-48 PC02-EU Power Cord, Europe
56-4109-49 PC03-IN Power Cord, India
56-4109-50 PC04-UK Power Cord, United Kingdom
56-4106-14 PT-109-01 Replacement pressure transducer (single)
56-4106-15 PT-109-02 Replacement pressure transducers (pair)
56-4110-05 TC-1308-01 Thermocouple—type J, -210 to 1200°C
56-4106-16 PTSL02-10 Size 14 tubing, 1/16-in (1.6 mm) ID, 3.1m L (silicone)
56-4106-17 PTSL03-10 Size 16 tubing, 1/8-in (3.1 mm) ID, 3.1m L (silicone)
56-4107-19 RB12-MLPC 1.5-in TC (polysulfone) x male Luer-Lok (polycar-
bonate
56-4107-02 RB4-MLPC 0.5-in TC (polysulfone) x male Luer-Lok (polycar-
bonate)
56-4105-75 RBFL-1 Female Luer-Lok x 1/8-in tubing barb (nylon), pkg. of
10
56-4105-76 RBFL-2 Female Luer-Lok x 3/32-in tubing barb (nylon), pkg. of
10
56-4105-77 RBFL-ML Female Luer-Lok x male Luer-Lok adaptor (nylon),
pkg. of 10
56-4105-78 RBFL-SC Female Luer-Lok x solid cap (nylon), pkg. of 10
56-4107-06 T4M-L-2PS 0.5-in TC x 0.25-in tubing barb (polysulfone) x male
Luer-Lok (polycarbonate)
56-4105-80 MRV-030 MidGee™ reservoir, 30 ml
56-4105-81 MRV-120 MidGee reservoir, 120 ml
56-4105-85 MRV-175A MidGee reservoir, 175 ml, autoclavable
6 Parts and accessories
16 MidJet pressure display unit Instructions for use 18117465 AD

Code number Model number Description
56-4105-83 KMRV-030 MidGee reservoir kit, including: 12 polystyrene reser-
voirs, 30 ml non-autoclavable, 12 caps, 2 sets of caps
with fittings, 12 sets of internal tubing
56-4105-84 KMRV-120 MidGee reservoir kit, including: 12 polystyrene reser-
voirs, 120 ml, non-autoclavable, 12 caps, 2 sets of
caps with fittings, 12 sets of internal tubing
56-4105-86 KMDG-175R01A Autoclavable MidGee reservoir kit, including: 6 poly-
carbonate conical bottom reservoirs, 175 ml, 3 solid
caps, 6 sets of caps with fittings, 3 bases to fit MidJet
system 1 standard base
56-4105-87 KMDG-175R02A Autoclavable Replacement MidGee reservoir kit,
including: 3 polycarbonate conical bottom reser-
voirs, 175 ml, , 3 solid caps, 3 sets of caps with fittings
56-4105-79 KMDG-1 MidGee starter kit (for use with standard peristaltic
pump such as PRP-09WM), including: PTSL02-10,
PTSL03-10, KMRV-030, KMRV-120, RBFL-1, RBFL-2,
RBFL-SC
56-4105-82 KMDG-2 MidJet system accessory kit; includes: PTSL02-10,
PTSL03-10, KMRV-030, KMRV-120, RBFL-1, RBFL-2,
RBFL-SC
56-4106-37 MDG-3SP Basic MidJet System, includes: miniature peristaltic
pump with exchangeable saddles for size 14 and size
16 tubing, (single speed, maximum recirculation rate
of 50 ml/min with size 14 tubing and 140 ml/min with
size 16 tubing); KMDG-2 MidJet accessory kit
56-4106-38 MDG-4SP Advanced MidJet system, includes: MDG-3SP basic
MidJet system, PRT-DPM-3T pressure display unit
with three pressure transducers
56-4106-53 PRP-09WM Peristaltic pump, Watson Marlow 323S, dual voltage
110/220V
6 Parts and accessories
MidJet pressure display unit Instructions for use 18117465 AD 17

Index
A
Accessories, 16
Assembly, 14
Audience, 3
C
Calibration, 12
Calibration of the three-transducer pressure
display unit (PRT-DPM-3T, 12
Caution, 4
D
Display unit accessories, 16
Display unit ordering parts, 16
Disposing of transducers and display unit, 14
E
Electrical cord connecting, 10
H
Help, 4
I
Inspecting the display unit, 13
L
Labeling, product, 5
Luer-Loks connecting without breaking, 8
M
Maintenance, 12
N
NaOH, 5, 7
O
Operating parameters, 15
Operating the unit, 8
Operation, 11
resetting the unit, 11
shut down, 11
Operator qualifications, 3
P
Package contents, 6
Parts, 16
Parts included with pressure display unit, 6
Power cord, 16
Powering up the display, 10
Pressure display unit calibration, 13
Pressure transducers, 6, 8, 12
calibration, 8, 12
where to install, 8
Product labels, 5
Proper use of the pressure display unit, 6
S
Safety, 3, 5, 6, 11
chemical compatibility, 3, 6
cleaning solutions, 6
leaks, 3, 11
NaOH, 3, 6
pressure transducers, 6
preventing shock hazard, 3, 11
product labels, 5
Setting up the system, 8
Setup electrical connections, 10
Shutting off the display unit, 10
Spare parts, 16, 17
Specifications transducers, 15
System overview, 6
T
Technical support, 3
Temperature probe, 7, 8
calibration, 7
Temperature sensor, 9, 12
calibration, 12
installing, 9
Thermocouple, 7, 8
calibration, 7
installing, 8
Tip, 4
Transducers, 6, 9, 12, 15
connecting without breaking, 9
maintaining accuracy, 12
operating parameters, 15
U
User guide introduction, 3
User guides, 3
W
Warning, 4, 9, 10
Warnings, cautions, and tips, 4
Web site, 4
Index
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cytiva.com
Cytiva and the Drop logo are trademarks of Global Life Sciences IP Holdco LLC or an affiliate.
MidGee is a trademark of Global Life Sciences Solutions USA LLC or an affiliate doing business as Cytiva.
Luer-Lok is a trademark of Becton, Dickinson and Company
All other third-party trademarks are the property of their respective owners.
© 2020–2021 Cytiva
All goods and services are sold subject to the terms and conditions of sale of the supplying company operating within the Cytiva business. A copy of those terms and conditions is available on
request. Contact your local Cytiva representative for the most current information.
For local office contact information, visit cytiva.com/contact
18117465 AD V:4 06/2021