RR Mechatronics Interrliner XN1 FRL User manual

Instructions for Use
Interrliner
MRN-164_2-EN Version 2.02

Contents
- Application. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
- Document history overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
1 - Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
1.1 - - Intended use of device. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
1.2 - - Indication for use of device. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
1.3 - - Instrument overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
1.4 - - Explanation of symbols. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
1.5 - - Starrsed line of ESR instruments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
1.6 - - Explanation of available documentation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
1.7 - - EQAS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
1.8 - - Sedimentation measurement principle. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
1.9 - - Dilution principle. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
2 - Instrument description. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
2.1 - - PC Operation and User Interface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
2.2 - - Technical specifications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
2.3 - - Used reagents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
2.3.1 - - Starrsed Rinse solution. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
2.3.2 - - Starrsed Saline. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
2.3.3 - - Starrsed Diluent. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
2.3.4 - - Deionized water. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
2.3.5 - - Starrsed Disinfectant. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
2.3.6 - - Starrsed Cleaning Agent. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
3 - Installation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
3.1 - - Main power connections. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
4 - General safety information. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
4.1 - - Safety warning. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
4.2 - - Moving parts protection. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
5 - Starrsed program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
5.1 - - Software version. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24
5.2 - - Sample screen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24
Contents
MRN-164_2-EN Version 2.02 Interrliner 3

5.2.1 - - Main screen sections. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
5.2.2 - - Main screen with keyboard. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
5.2.3 - - Pipette information. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28
5.3 - - History screen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
5.3.1 - - Display pipette data. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
5.3.2 - - Display Sample history. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
5.3.2.1 - - Display patient results. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33
5.3.3 - - Display rack history. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34
5.3.3.1 - - Display rack status. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
5.3.4 - - ESR Statistics screens. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36
5.3.5 - - QC Results screens. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36
5.3.5.1 - - QC Normal results (table). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
5.3.5.2 - - QC abnormal results (table). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38
5.3.5.3 - - QC abnormal results (graph). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
5.3.5.4 - - QC abnormal results screen extended. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40
5.3.5.5 - - Display sample history (QC). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
5.3.5.6 - - Linked QC IDs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
5.3.5.7 - - QC Result analysis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42
5.3.6 - - Set start/end date. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
5.3.7 - - History sample analyse option. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
5.3.8 - - History analyse results. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
5.4 - - Reagents screen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46
5.4.1 - - Display reagent history. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
5.4.2 - - New reagent input. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48
5.4.2.1 - - New reagent input (cont). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48
5.5 - - Maintenance screen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
5.5.1 - - Prime / Clean. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50
5.5.1.1 - - Fill and Clean screen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
5.5.1.2 - - End-of-day-wash procedure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52
5.5.2 - - Check sensors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52
5.5.3 - - Display error history. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54
5.5.4 - - Display maintenance history. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
5.5.5 - - Maintenance info. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
5.5.6 - - Close . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56
5.5.7 - - End-of-day-wash options. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56
5.5.8 - - End-of-day-wash schedule settings. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
5.6 - - Settings screen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
5.7 - - Service screen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
Contents
4MRN-164_2-EN Version 2.02 Interrliner

6 - Operation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58
6.1 - - Quick start-up. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58
6.1.1 - - Check list. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58
6.1.2 - - Start-pool. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58
6.1.3 - - Power up sequence. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58
6.1.4 - - ESR Unit check. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
6.1.5 - - Priming the fluid system. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
6.2 - - Fill procedure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
6.2.1 - - Liquid levels. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60
6.3 - - Checks during operation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60
6.4 - - Turn off. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60
6.4.1 - - End-of-day-wash procedure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60
6.4.2 - - Turn off sequence. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61
7 - Reporting. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62
7.1 - - Result Printout. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62
7.1.1 - - Report 60-Minute mode. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
7.1.2 - - Report 30 Minute mode. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64
7.2 - - ESR Error. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64
7.2.1 - - ESR Error and Warning code messages. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64
7.3 - - Limit error settings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
7.4 - - Reporting range. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
7.5 - - Aspect Hazy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
8 - Quality control. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
8.1 - - Control pipettes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
8.2 - - Monitoring measurement quality with Starrsed Control. . . . . . . . . . . . . . . . . . . . . . . . . . 67
8.2.1 - - Limitations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
8.2.2 - - Expected value range. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
8.2.3 - - Temperature correction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68
Contents
MRN-164_2-EN Version 2.02 Interrliner 5

8.2.4 - - Usage options. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68
8.2.5 - - Quality control procedure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68
8.2.6 - - QC Results. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
8.2.6.1 - - QC Error messages. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
8.2.6.2 - - QC Result analysis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70
9 - Waste disposal. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
9.1 - - Replacing the waste container. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
10 - Data safety management. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72
10.1 - - Power failure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72
11 - Troubleshooting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
11.1 - - Errors 183 and 193. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
11.2 - - Errors 165-171 and 210-214. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
11.3 - - Errors 181-185 and 193-201. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74
11.4 - - Flushing liquids. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74
11.5 - - Reagents alarm. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74
11.6 - - Separator error. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
11.7 - - Fill time-out error. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
11.8 - - Hazy reports. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76
11.9 - - Leaking pipettes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
11.10 - - Liquid level sensor not sensing. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
11.11 - - Air bubbles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
11.11.1 - - Foam in column. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78
11.11.2 - - Pipette looks like zebra crossing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78
11.11.3 - - One air bubble about 5 mm under meniscus. . . . . . . . . . . . . . . . . . . . . . . . . . . . 79
11.11.4 - - One air bubble rising in pipette. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79
11.11.5 - - Small air bubbles rising in pipette. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80
11.11.6 - - Random air bubbles in pipette. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80
11.12 - - Quality control troubleshooting. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80
12 - Troubleshooting Interrliner transport. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
12.1 - - Errors 24-26, 38, 42-43, 62, 67, 70-75, 80. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
12.2 - - Errors 33 and 37. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
12.3 - - Errors 40 and 81. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
13 - General Maintenance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Contents
6MRN-164_2-EN Version 2.02 Interrliner

13.1 - - Daily. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86
13.2 - - Weekly. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86
13.2.1 - - Check the sensors in service mode. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86
13.2.2 - - Cleaning waste separator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86
13.3 - - Level 4 maintenance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
13.3.1 - - Pump tube replacement. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
13.3.2 - - Replace bacterial filters. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
13.3.3 - - Fill-nozzle O-ring replacement. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
13.3.4 - - Fill and clean procedure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
13.4 - - Level 3 maintenance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90
13.5 - - Check or replace sample probe or outer needle. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
13.6 - - Reagents installation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92
13.7 - - Cleaning Touch screen display. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
14 - Appendix for Interrliner. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94
14.1 - - Appendix - Error list Interrliner ESR analyser unit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95
14.2 - - Maintenance schedule. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104
15 - Work instruction Interrliner. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
16 - Glossary of Terms. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131
- Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
Contents
MRN-164_2-EN Version 2.02 Interrliner 7

Application
fff
fff
This manual, MRN-164_2, is applicable for the following instruments:
EHST109621 Interrliner XN1 FRL
EHST109622 Interrliner XN2 FRL
EHST109623 Interrliner XN3 FRL
with Software version V6.xx
Application
8MRN-164_2-EN Version 2.02 Interrliner

Document history overview
MRN-164_2-EN
Published date Thursday, 26 August 2021
Issue No Date Revised Section(s) Changes Authorised
2.02 Sept. 2021 Program • Options number of retry
aspiration and disable pipette
added
• Entering Reagent information
mandatory
H. Schavemaker
2.01 jan. 2020 • Update and publication H. Schavemaker
2.00 June 2017 Instrument description
Safety
Program
Maintenance
• Technical specifications
additions
• Explanation of symbols
• Introduction of robot cover
lock
• Updated maintenance
instructions and maintenance
information
• Introduction new software
layout
H. Schavemaker
1.00 Dec. 2014 First issue H. Schavemaker
Document history overview
MRN-164_2-EN Version 2.02 Interrliner 9

1
Introduction
1.1 - Intended use of device
Automated analyser for in vitro determination of the Erythrocyte Sedimentation Rate (ESR) of human blood
samples in conformity with the Westergren standard.
For professional use in medical laboratories only. To be used for all patient populations, not restricted by age
or any other anatomical or physiological particulars.
1.2 - Indication for use of device
For screening and follow-up of patients with (suspected) inflammatory conditions.
1.3 - Instrument overview
The Starrsed Blood Sedimentation Rate Instrument (hereafter called Interrliner) is an in vitro diagnostic
medical device that automatically carries out the erythrocyte sedimentation rate (ESR) analysis according to
the Westergren method, conforming to CLSI approved standard H02-A51 and recommended by the ICSH2,
using closed sample tubes filled with citrate or EDTA blood.
The Interrliner is an advanced ESR system that offers many unique features and benefits over the traditional
ESR procedures. Automating this method has the following advantages:
▪ The Westergren pipettes are always filled to the correct level.
▪ Using closed sample tubes reduces the possibility of contamination for the user and environment.
▪ Standard glass Westergren pipettes are used, in which the measurement can be corrected to a constant
temperature (18 °C Celsius). Even small abnormalities can be detected over a longer period of time,
irrespective of where and when the blood sample was taken.
▪ Sample ID's are read by the barcode reader and each sedimentation measurement is linked to the
identified sample, so that a manual work sheet is unnecessary.
▪ In the EDTA mode , the dilution of EDTA blood with citrate is considerably more accurate than manual
dilution achieved either by "tipping off" or using evacuated blood collection tubes pre-filled with citrate
solution.
▪ The data can be send to your Lab Information System (LIS/LIMS)
▪ The used sedimentation pipettes are automatically washed and dried.
▪ Minimum sample volume is 1.4 ml for the Interrliner.
▪ The Interrliner integrates with the Sysmex HST - XN line.
This model Interrliner is delivered with a front return line and uses the Sysmex sample racks.
The advanced software allows the Interrliner to communicate with the Sysmex Lab Comm host computer
systems.
References:
(1) CLSI Procedures for the Erytrhocyte Sedimentation Rate Test: Approved Standard - Fifth edition H02-A5,
VOl. 31 No 11; 2011
Introduction
10 MRN-164_2-EN Version 2.02 Interrliner

(2) ICSH review of the measurement of the Erythrocyte sedimentation rate / J. M. Jou, Int. Journal of
Laboratory Hematology 2011 (33), p .125-132
Note:
Some details are not described in this manual; if applicable, they might be found in the following
manuals:
Interrliner Installation manual MRN-023.
Interrliner Service manual MRN-125.
1.4 - Explanation of symbols
The following symbols can be used in this manual and for the instrument:
Warning sign to prevent personal injury due to biohazard.
Warning sign to prevent personal injury due to rotating parts.
Warning sign to prevent personal injury due to sharp objects.
Warning sign to prevent personal injury due to hot surfaces.
Warning sign to prevent personal injury due to electrical shocks.
General warning.
Introduction
MRN-164_2-EN Version 2.02 Interrliner 11

General note.
This symbol indicates a reference to this or other product documentation
1.5 - Starrsed line of ESR instruments
The Starrsed line of ESR automated instruments is unique by the fact that it has automated the Westergren
Method and fully complies with the published reference method, including working with diluted EDTA blood.
The Starrsed line offers several types of ESR analyzers. Our solutions range from tube-based to rack-based
to track-based, the latter resulting in the highest level of automation possible. Laboratories that operate
different Starrsed instruments in different capacities are assured that correlations are precise and fully
reliable.
1.6 - Explanation of available documentation
Manuals for the Interrliner are available on three levels: for the operator, the supervisor and the service
engineer.
The following manuals are available:
1. Instructions for Use (IFU)
Intended for the operator: Contains instructions for normal operation, safety, preventive maintenance and
troubleshooting procedures to solve the most common problems. Available in several languages.
2. User Manual (UM)
(If available) Intended for the lab supervisor. Contains information from the IFU and additional
information concerning settings, service, higher maintenance levels and troubleshooting procedures to
solve more complicated problems. Only available in English.
3. Service Manual (SM)
Intended for trained service engineers. Describes maintenance, servicing and repair of the instrument in
detail. Contains detailed descriptions of parts, assembly drawings, modifications, extended
troubleshooting, flow diagrams etc. Only available in English.
4. Installation Manual (IM)
Intended for trained service engineers. Contains instructions and procedures for installation and start-up.
Only available in English.
Manuals are available in PDF and HTML-format and can be downloaded from support.rrmechatronics.com.
1.7 - EQAS
EQAS is RR Mechatronics' comprehensive tool to periodically assess the performance of the Starrsed
instrument at your lab. Through EQAS, the test results of the instrument, obtained with Starrsed Control are
objectively compared with a worldwide peer group using the same type of instrument. Each customer can
sign up for our portal, available through our website .
Introduction
12 MRN-164_2-EN Version 2.02 Interrliner

1.8 - Sedimentation measurement principle
The automatic reading of the Westergren sedimentation pipettes is performed by moving an optical sensor
along the pipettes. While the sensor is moving, it is taking a reading every 0.25 mm. The sensor is reading
the absorption of infrared light through the Westergren pipette filled with blood. From these readings, values
at a number of absorption levels are determined. All absorption figures are relative to the darkest and
lightest reading (darkest = 100 % and the lightest = 0 % absorption respectively).
By definition the levels are:
87.5% Cells/ plasma separation
75.0% Hazy detection
50.0% Meniscus detection
Graphic showing typical absorption values of a sample
1.9 - Dilution principle
The principle of adding Diluent to a flow of whole blood is unique. The Interrliner has the capability of
monitoring the air displacement during the aspiration cycle. This is called on-line dilution. The CPU receives
data from the airflow sensor and calculates the syringe speed. Diluter accuracy is ± 3%.
The citrate dilution (4:1) takes place to reduce the influence of HCt (Hematocrit) on the sedimentation
process. Dilution brings the Hct level from 0.45 (considered as a normal level) to 0.36. The ICSH (1993)
recommended the use of EDTA samples with a Hct of 0.35 or less. Dilution errors up to 25% results in a 5%
variation in Hct of the prepared sample. This is within the natural variation in Hct between individual humans
and will not have significant influence on the accuracy of the ESR measurement.
Introduction
MRN-164_2-EN Version 2.02 Interrliner 13

2
Instrument description
The Interrliner consists of the following main modules:
Start-pool
▪ Loading of racks through belt-driven transport system
▪ Capability of holding 21 Sysmex racks
▪ Keyboard (in drawer)
Tube handling and transport
▪ Indexer unit, initialising racks and reading the barcode of the sample tubes and sample racks.
▪ Sample robot unit, mixing the sample tubes and placing successively each sample tube on the ESR
analyser unit for aspiration.
▪ Conveyor belt, running from the Start pool.
▪ Front Return line, for transport of racks back to Sysmex HST - XN after sampling.
▪ Protection hood.
ESR analyser unit
▪ ESR measuring instrument with a belt holding 84 precision's bore glass Westergren pipettes.
▪ Automated aspiration of the sample tube.
▪ Automated dilution of EDTA blood sample with citrate.
▪ Automated measurement of ESR after 30 or 60 minutes.
▪ Automated cleaning and drying of pipettes.
Instrument description
14 MRN-164_2-EN Version 2.02 Interrliner

Reagents cabinet
▪ Swing door for easy access
▪ Capable of storage of all needed reagents
PC with touch screen LCD monitor
▪ Windows based platform
▪ Dedicated instrument software
▪ Optional network connections
▪USB port
Option:
External barcode reader, which can be connected to the USB port of the ESR analyser unit. This barcode
reader can be used for reagent handling and for ID-input in sample history search.
2.1 - PC Operation and User Interface
The entire operation of the Interrliner is driven by a personal computer with Windows operating system. The
user interface is intuitive and can be activated via the keyboard or the optional touch screen. All the data
from each sample, including the raw measuring data and a pictorial representation of the pipette, is stored
and may be retrieved later if needed.
The Main screen shows which pipettes are in use. The section in the middle of the layout gives the sample
number and status for each pipette including "time to go" before the result is due.
A pictorial representation of the pipette at the measuring position and a graph of the optical density over the
length of the entire pipette is shown on the side. This data is retained in memory for subsequent retrieval if
required.
Instrument description
MRN-164_2-EN Version 2.02 Interrliner 15

2.2 - Technical specifications
Instrument models Model name
Interrliner XN1 FRL
Interrliner XN2 FRL
Interrliner XN3 FRL
Catalogue number (REF)
EHST109621
EHST109622
EHST109623
ESR method Westergren method
ICSH J. M. Jou; Int. Journal of Laboratory Hematology 2011;
33: 125-132
CLSI Procedures for the Erythrocyte Sedimentation Rate Test;
Approved Standard- Fifth Edition H02-A5, Vol. 31 No. 11; 2011
Temperature compensation
method
R.W. Manley: J. clin Path (1957), 10, 354
30 minute method R. Rogers: Medical Laboratory World 1994
Allowed blood specimen types For EDTA mode : Whole blood with < 1% EDTA anticoagulant.
Automatic dilution 4 vols. blood + 1 vol. Starrsed Diluent
Reported result mm after 1 hour
Throughput (100% filled) single double triple
30 minute method 140/hour 240/hour 360/hour
60 minute method 75/hour 140/hour 215/hour
Reagents:
Reagents used QRR 010931 Starrsed Diluent
QRR 010947 Starrsed Disinfectant
QRR 010933 Starrsed Saline
QRR 010934 Starrsed Rinse Solution
De-ionized water
Blood volume:
Aspirated blood volume per
sample
1.4 ml in EDTA mode
Rack and tube types:
Rack type Sysmex sample rack (low profile)
Instrument description
16 MRN-164_2-EN Version 2.02 Interrliner

Sample tube types Most commonly used brands/types.
Closed tubes with concentric cap only.
Barcode reader:
Barcode reader type CCD.
Reading capabilities Most common barcode labels
Code39, ITF, Industrial 2 or 5, CodaBar,EAN/UPC, CODE128
Environment:
Sound level Less than 65 dBA
Environment temperature 18 - 28 °C
Relative humidity 10-90%
Total power specifications
Mains voltage 115/230VAC, 50/60 Hz
Fuse (20 x 5 mm)
Per ESR Unit Slow blow 230V 2.5 Amp / 115V 5 Amp
Transport Unit Slow blow 230V 1.6 Amp / 115V 3.15 Amp
XN1 XN2 XN3
Power consumption Standby 90 VA 2x90VA 3x90VA
Maximum 650 VA 2x1000 VA 3x1500 VA
Heat output Standby 86 Watt 2x86 Watt 3x86 Watt
Operation 460 Watt 2x460 Watt 3x460 Watt
Dimensions XN1 FRL XN2 FRL XN3 FRL
Width 1400 mm 2500 mm 3600 mm
Height 1530 mm 1530 mm 1530 mm
Depth 1150 mm 1150 mm 1150 mm
Total Weight (empty) 238 kg 519 kg 740 kg
al
Weight (components)
ESR analyser unit 45 kg
Instrument description
MRN-164_2-EN Version 2.02 Interrliner 17

Start pool 63 kg
Conveyer/robot unit incl. Front Return
unit 160 kg
Protection hood 12 kg
Back panels 18 kg (single), 22 kg (double), 26 (triple)
LIS connectivity:
Communication Ethernet and serial, bi-directional according various protocols
Data storage:
Storage medium Hard disk on external PC
Storage capacity indication approx. 5 Mb per 1000 samples (results and raw data)
Instrument description
18 MRN-164_2-EN Version 2.02 Interrliner

2.3 - Used reagents
NOTE:
The latest version of the Material Safety Data Sheet (MSDS) of the used reagents can
be found on our web site rrmechatronics.com
2.3.1 - Starrsed Rinse solution
Starrsed Rinse solution is a dedicated IVD product, developed exclusively for automatic rinsing of the
Westergren pipettes in Starrsed ESR analyzers.
This reagent is supplied in a 20- liter container (QRR 010934).
2.3.2 - Starrsed Saline
Starrsed Saline is a dedicated IVD product, developed exclusively for the automatic cleaning of the needle
and fill-nozzle assembly in Starrsed ESR analyzers. Approximately 1 ml of saline is used for each sample.
This reagent is supplied in a 5-liter container (QRR 010933).
2.3.3 - Starrsed Diluent
Starrsed Diluent is a dedicated IVD product, developed exclusively for the automatic dilution of blood
samples in Starrsed ESR analyzers.
▪ Approximately 0.5 ml Diluent is used for each sample.
▪ Approximately 2.5 ml is used for one Prime cycle.
The diluent container is a 5-liter container (QRR 010931).
2.3.4 - Deionized water
After each aspiration, the fill nozzle is flushed with de-ionized water. The water container is a 5-liter
container and must be filled up when empty.
2.3.5 - Starrsed Disinfectant
Starrsed Disinfectant is a dedicated IVD product, developed exclusively for automatic disinfection of the
waste system of Starrsed ESR analyzers.
This reagent is delivered in a 5-liter container (QRR 010947).
2.3.6 - Starrsed Cleaning Agent
Starrsed Cleaning Agent is used to remove protein deposition from the Westergren pipettes of Starrsed ESR
analyzers.
Starrsed Cleaning Agent needs to be prepared for a cleaning procedure which is used in level 4
maintenance.
Starrsed Cleaning agent is supplied in 100 ml bottles.
QRR010905: 1 bag of 2 bottles
Instrument description
MRN-164_2-EN Version 2.02 Interrliner 19

3
Installation
The instrument must be unpacked, installed and checked by a trained engineer prior to first operation.
Detailed installation instructions are given in the Interrliner Installation manual.
Connect the instrument only to a properly earthed power connection.
3.1 - Main power connections
The main switch for the ESR analyser unit is located at the left side of this instrument.
The main switch for the Interrliner rack transport units is located in the cabinet beneath the Start-Pool.
Attention: The sample robot unit is powered by the ESR analyzers power supply. Switching the
transport units OFF will not switch OFF the sample robot!
A central power distribution block to connect all units and auxiliary devices to is located at one of the rear
support legs near the Start-pool. This distribution block has a main switch and an indicator light showing the
status ON or OFF.
Check if all the power cables from the ESR analyser unit(s) and printer(s) are connected to the distribution
block.
Note: Do not switch the Interrliner OFF during normal operation!
Installation
20 MRN-164_2-EN Version 2.02 Interrliner