Agilent Technologies 100 User manual

100 Automated Disintegration Apparatus
Operator’s Manual

Notices
Manual Part Number
70-9066 Rev E
February 2020
Copyright
© Agilent Technologies, Inc. 2020
No part of this manual may be
reproduced in any form or by any means
(including electronic storage and retrieval
or translation into a foreign language)
without prior agreement and written
consent from Agilent Technologies, Inc.
as governed by United States and
international copyright laws.
Agilent Technologies, Inc.
3501 Stevens Creek Blvd.
Santa Clara, CA 95052 USA
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The material contained in this document
is provided “as is,” and is subject to being
changed, without notice, in future
editions. Further, to the maximum extent
permitted by applicable law, Agilent
disclaims all warranties, either express or
implied, with regard to this manual and
any information contained herein,
including but not limited to the implied
warranties of merchantability and fitness
for a particular purpose. Agilent shall not
be liable for errors or for incidental or
consequential damages in connection
with the furnishing, use, or performance
of this document or of any information
contained herein. Should Agilent and the
user have a separate written agreement
with warranty terms covering the
material in this document that conflict
with these terms, the warranty terms in
the separate agreement shall control.
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in this document are furnished under a
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accordance with the terms of such
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Safety Notices
CAUTION
A CAUTION notice denotes a
hazard. It calls attention to an
operating procedure, practice, or
the like that, if not correctly
performed or adhered to, could
result in damage to the product or
loss of important data. Do not
proceed beyond a CAUTION
notice until the indicated
conditions are fully understood
and met.
WARNING
A WARNING notice denotes a
hazard. It calls attention to an
operating procedure, practice, or
the like that, if not correctly
performed or adhered to, could
result in personal injury or death.
Do not proceed beyond a
WARNING notice until the
indicated conditions are fully
understood and met.

100 Operator’s Manual 3
Content
1Safety 7
Electrical Hazards 9
Warning 10
Caution 10
Note 10
Information Symbols 11
2 Introduction 13
Conventions Used in this Manual 15
Serial Number Format 15
3 Setting Up the 100 17
Unpacking Your 100 18
Environmental Requirements for Installation 19
Setting up the Water Bath 20
Initial Power Up 21
Electrical Connections 21

Content
4100 Operator’s Manual
Installing the Temperature Probe 23
Water Bath Status LEDs 24
Setting the Date / Time Clock 25
Mounting Baskets and Filling Beakers 26
Draining the Water Bath 26
Hidden Key Functions 27
4 Operating the 100 29
Setting Water Bath Temperature 30
Setting Print Frequency for the Report Center Printer 30
Adjusting Basket Height 31
Placing Dosage Units in the Baskets 32
Selecting Operating Mode 32
Single-basket Operation 32
Multi-basket Operation 33
Three-Basket Operation 36
Printer Operation During Manual or Program Operation (Optional) 36
5 Troubleshooting and Maintenance 37
Preventive Maintenance 38
Weekly Maintenance 38
Monthly Maintenance 38
Every Six Months Maintenance 39
Yearly Maintenance 39
Disintegration Basket Care 40
Water Bath / Acrylic Care 41
Visual Checks 42
Water Bath Temperature Probe Accuracy Test 43
Report Center Impact Printer 45
Installing the Cartridge Ribbon 45

Content
100 Operator’s Manual 5
Replacing the Paper Roll 46
Toggling Your Printer Online 47
Printer Self Test 48
Printer Configuration 49
Troubleshooting 51
Obtaining Warranty and Other Services 52

Content
6100 Operator’s Manual
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100 Operator’s Manual 7
1Safety
Electrical Hazards 9

1Safety
8100 Operator’s Manual
The Agilent 100 has been designed and tested so that when used properly you
have an accurate, fast, flexible, and safe instrument.
If the equipment is used in a manner not specified by the manufacturer, the
protection provided by the equipment may be impaired.
The Agilent 100 is operated in conjunction with equipment that uses aqueous
liquids. Unskilled, improper, or careless use of this instrument can create shock
hazards, fire hazards, or other hazards which can cause death, serious injury to
personnel, or severe damage to equipment and property.
Information on safety practices is provided with your instrument and operation
manuals. Before using your instrument or accessories, you must thoroughly read
these safety practices.
Observe all relevant safety practices at all times.

1Safety
100 Operator’s Manual 9
Electrical Hazards
The Agilent 100 contains electrical circuits, devices, and components operating
at dangerous voltages. Contact with these circuits, devices, and components can
cause death, serious injury, or painful electric shock.
Panels or covers that are retained by fasteners which require the use of a tool for
removal may be opened only by Agilent-trained, Agilent-qualified, or
Agilent-authorized service engineers. Consult the manuals or product labels
supplied with the 100 to determine which parts are operator-accessible.
Application of the wrong supply voltage, connection of the instrument to an
incorrectly wired supply outlet, or lack of proper electrical grounding can create a
fire hazard or a potentially serious shock hazard and could seriously damage the
instrument and any attached ancillary equipment.
Always use a three-wire outlet with ground connection which is adequately rated
for the load. The installation must comply with local, state, and federal safety
regulations.
Do not connect the instrument to the main power supply until you have made
sure that the operating voltage is correctly set for the main power supply in the
specific outlet in your laboratory to which the equipment will be connected.

1Safety
10 100 Operator’s Manual
Warning
WARNING
A ‘Warning’ message appears in the manual when failure to observe instructions
or precautions could result in death or injury.
Read all warnings and cautions carefully and observe them at all times.
Caution
CAUTION
A ‘Caution’ message appears in the manual when failure to observe instructions
could result in damage to equipment (Agilent supplied and / or other associated
equipment).
Note
NOTE
A ‘Note’ appears in the manual to give advice or information.

1Safety
100 Operator’s Manual 11
Information Symbols
I Switches main power on
0 Switches main power off
Indicates single-phase alternating current
Indicates the product complies with the
requirements of one or more European Union
(EU) directives.
Indicates specific equipment meets
standards of safety. These products are safe
for use in the workplace for North America.
Indicates that this product must not be
disposed of as unsorted municipal waste.
All Agilent products that are subject to the
WEEE directive shipped after August 13,
2005 are compliant with the WEEE marking
requirements. Such products are marked
with the “crossed out wheelie bin” WEEE
symbol in accordance with European
Standard EN 50419.
For more information on collection, reuse,
and recycling systems, please contact your
local/regional waste administration, your
local distributor, or Agilent.
Indicates the product complies with
regulatory compliance requirements of New
Zealand and Australia.

1Safety
12 100 Operator’s Manual
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100 Operator’s Manual 13
2Introduction
Conventions Used in this Manual 15
Serial Number Format 15

2Introduction
14 100 Operator’s Manual
The 100 is designed to provide versatility and reliability, while meeting all current
USP testing requirements. Its three basket positions can be programmed to dip
together or independently, allowing up to three different tests to be run at the
same time. In addition to the standard six-tube USP-approved basket rack, a
variety of optional basket racks are available for large and bolus tablets. The 100
is used for disintegration testing in accordance with current USP requirements.
The optional built-in Report Center Printer provides hard-copy documentation of
the instrument operation for the highest degree of confidence.
The apparatus is fully programmable by simply entering the time duration of the
test. Baskets automatically lift from the beaker at the end of the test in the pass /
fail mode. The 100 also has individual digital time displays for each basket and
the water bath temperature is displayed continuously on the front panel.
CAUTION
Panels or covers that are retained by fasteners which require the
use of a tool for removal may be opened only by Agilent-trained,
Agilent-qualified, or Agilent-authorized service engineers. See
“Obtaining Warranty and Other Services” on page 52..

2Introduction
100 Operator’s Manual 15
Conventions Used in this Manual
•Items you are asked to press are in bold. For example, “press Hon the
keypad”.
Serial Number Format
The serial number contains 10 characters and follows this syntax:
CC1234xxxx
Syntax Code Meaning Description
CC Country of origin 2 alpha characters matching the required trade designation for the
country of origin
12 Year of manufacture ‘09’ for 2009, ‘10’ for 2010, etc.
34 Week of manufacture ‘01’ for week 1 to ‘52’ for week 52

2Introduction
16 100 Operator’s Manual
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100 Operator’s Manual 17
3 Setting Up the 100
Unpacking Your 100 18
Setting up the Water Bath 20
Initial Power Up 21
Installing the Temperature Probe 23
Water Bath Status LEDs 24
Setting the Date / Time Clock 25
Mounting Baskets and Filling Beakers 26
Draining the Water Bath 26
Hidden Key Functions 27

3SettingUpthe100
18 100 Operator’s Manual
Unpacking Your 100
1Open each carton and check the contents for damage which may have
occurred during shipping. Shipping damage rarely occurs, but if it does
contact both the carrier who delivered the instruments and the Dissolution
Systems Service Department. Though claims for damage should be filed with
the carrier, we can help you file a claim.
2Carefully remove the 100 from its shipping carton. Hold the unit firmly to
prevent it from dropping.
3Check for items which may have come loose during shipping. Be sure to
remove all parts before discarding or storing the packaging.
4Place the unit on a clean, dry, level section of the bench top or table. At least
four inches of space should be open for the rear panel power connections and
for access to the rear panel power switch.
WARNING
Hold the unit only by the base. Do not hold by the reciprocating
shafts to avoid damage.
WARNING
The electrical connection at the back of the apparatus is the
primary disconnect for the instrument. The apparatus should be
positioned to allow accessibility to the power cords for easy
disconnection.

3SettingUpthe100
100 Operator’s Manual 19
Environmental Requirements for Installation
•Humidity: max relative humidity 80% for temperatures up to 31 ºC decreasing
linearly to 50% relative humidity at 40ºC
•Indoor use only
•Pollution Degree: 2
•Installation Category: II
•Altitude: 2000m
•Temperature: 5 ºC to 40 ºC
•Power: 115 V/60 Hz, 230 V/50 Hz, 10 A
Main supply voltage fluctuations are not to exceed ± 10% of the nominal
supply voltage

3SettingUpthe100
20 100 Operator’s Manual
Setting up the Water Bath
1Ensure the 100 is not plugged in.
2Place the water bath on the 100 with the lower quick-connect fitting
positioned on the left side of the apparatus. Use the locator holes on the water
bath and the locator pins on the 100 to ensure proper placement.
3Locate the two tubes with quick-connect fittings and insert them into the
appropriate quick-connect fittings on the 100 water bath (see Figure 1, “Water
Bath Connections,” below).
Figure 1. Water Bath Connections
4Ensure the cover is in place on the water bath with the small hole toward the
front. Ensure the disintegration beakers are not in place in the cover.
5Fill the water bath through any one of the three beaker holes in the cover.
6Check the water bath and all connecting tubing for leaks. When satisfied that
no leaks are present, proceed to “Installing the Temperature Probe” on
page 23.
NOTE
Initially fill the water bath no higher than 2.5 inches (6.4 cm) from
the top, to allow for displacement by the beakers when they are
inserted.