Agilent Technologies 8453 Wiring diagram

Agilent Technologies
Agilent 8453 Dissolution
Testing System
Installing and Operating
Manual

Agilent 8453 Dissolution Testing System Installing and Operating Manual
Notices
© Agilent Technologies, Inc. 2004, 2008
No part of this manual may be reproduced in
any form or by any means (including elec-
tronic storage and retrieval or translation
into a foreign language) without prior agree-
ment and written consent from Agilent
Technologies, Inc. as governed by United
States and international copyright laws.
Manual Part Number
G1127-90003
Edition
09/2008
Printed in Germany
Agilent Technologies
Hewlett-Packard-Strasse 8
76377 Waldbronn
Research Use Only
Not for use in Diagnostic Procedures.
Warranty
The material contained in this docu-
ment is provided “as is,” and is sub-
ject to being changed, without notice,
in future editions. Further, to the max-
imum extent permitted by applicable
law, Agilent disclaims all warranties,
either express or implied, with regard
to this manual and any information
contained herein, including but not
limited to the implied warranties of
merchantability and fitness for a par-
ticular purpose. Agilent shall not be
liable for errors or for incidental or
consequential damages in connec-
tion with the furnishing, use, or per-
formance of this document or of any
information contained herein. Should
Agilent and the user have a separate
written agreement with warranty
terms covering the material in this
document that conflict with these
terms, the warranty terms in the sep-
arate agreement shall control.
Technology Licenses
The hardware and/or software described in
this document are furnished under a license
and may be used or copied only in accor-
dance with the terms of such license.
Restricted Rights Legend
If software is for use in the performance of a
U.S. Government prime contract or subcon-
tract, Software is delivered and licensed as
“Commercial computer software” as
defined in DFAR 252.227-7014 (June 1995),
or as a “commercial item” as defined in FAR
2.101(a) or as “Restricted computer soft-
ware” as defined in FAR 52.227-19 (June
1987) or any equivalent agency regulation or
contract clause. Use, duplication or disclo-
sure of Software is subject to Agilent Tech-
nologies’ standard commercial license
terms, and non-DOD Departments and
Agencies of the U.S. Government will
receive no greater than Restricted Rights as
defined in FAR 52.227-19(c)(1-2) (June
1987). U.S. Government users will receive
no greater than Limited Rights as defined in
FAR 52.227-14 (June 1987) or DFAR
252.227-7015 (b)(2) (November 1995), as
applicable in any technical data.
Safety Notices
CAUTION
A CAUTION notice denotes a haz-
ard. It calls attention to an operat-
ing procedure, practice, or the like
that, if not correctly performed or
adhered to, could result in damage
to the product or loss of important
data. Do not proceed beyond a
CAUTION notice until the indicated
conditions are fully understood and
met.
WARNING
A WARNING notice denotes a
hazard. It calls attention to an
operating procedure, practice, or
the like that, if not correctly per-
formed or adhered to, could result
in personal injury or death. Do not
proceed beyond a WARNING
notice until the indicated condi-
tions are fully understood and
met.

Agilent 8453 Dissolution Testing System Installing and Operating Manual 3
Introduction
This section introduces you to Agilent dissolution testing software and
explains how to use this handbook to install the hardware and software.
What is Dissolution Testing?
The dissolution testing software for the Agilent 8453 UV-visible
spectrophotometer and Agilent ChemStation automates totally the process of
measuring the rates of release of active ingredients from formulations into
solutions. Your dissolution testing software is provided on CD-ROM to install
and operate in the graphic environment of the supported Microsoft Windows
operating system(s). For details see the Specifications for your Agilent
ChemStation for UV-visible Spectroscopy Systems. The software automates
the sampling, measuring, data processing, and reporting of the dissolution
test. The dissolution testing software requires that you develop your own
specific testing method for either single-component or multicomponent
analysis. The software provides all the necessary features for developing a test
method.
The dissolution testing software samples and measures your samples
automatically in the Agilent 8453 UV-visible spectrophotometer. The software
compares the absorbance measurements with previously measured known
standards. The software calculates the concentration of component in your
samples and calculates dissolution results automatically.
You choose in your test method the dissolution results that you want reported.
The dissolution testing software calculates the following choices of dissolution
results for the ingredient of interest:
• % Dissolved or released
• Weight dissolved or released per tablet
• Weight dissolved or released per weight of tablet
These results are based on label weight or on tablet weight.

4 Agilent 8453 Dissolution Testing System Installing and Operating Manual
What To Do
You use this handbook to set up your dissolution testing system. This is what
you do:
• follow the instructions in this handbook,
• refer to other handbooks when necessary, then
• return to the next step in this handbook for completion of setting up.
What You Need
Your dissolution testing system comprises the following components:
See your packing check list for your system options. You use the system with
your dissolution vessels and bath.
What You Install
• Agilent 8453 UV-visible spectroscopy system
• Dissolution sampling system
The chapters that follow describe the installation procedures for dissolution
sampling systems.
Spectrophotometer Agilent 8453 UV-visible spectrophotometer.
Sample Introduction System 8-port valve and single channel pump, multicell transport with
multichannel pump, or multicell transport with eight-port valve and
two single-channel pumps.
Personal Computer PC with Microsoft Windows operating system and printer.
Application Software Agilent ChemStation general purpose software and dissolution
testing software for UV-visible spectroscopy.

Agilent 8453 Dissolution Testing System Installing and Operating Manual 5
In This Guide…
This handbook provides you with instructions for installing your Agilent
dissolution testing system.
1 Site Requirements and Specifications
This chapter describes the site requirements and contains the specifications
for all units applied.
2SettingUp
This chapter describes how to set up your Agilent 8453 UV-visible
spectroscopy system and dissolution sampling system.
3 Using the Peristaltic Pumps 1VS and 8VS
This chapter describes how to install, operate, maintain and service the
peristaltic pumps.
4 Using the Valve Unit and Valve-pump Controller
This chapter describes how to install, operate, maintain and service the valve
unit and valve-pump controller.
5 Parts for Dissolution Testing
This chapter contains lists of parts and their numbers you need for the
different configurations of dissolution testing systems.
A Safety Information
This chapter contains relevant safety information.

6 Agilent 8453 Dissolution Testing System Installing and Operating Manual

Agilent 8453 Dissolution Testing System Installing and Operating Manual 7
Contents
1 Site Requirements and Specifications 11
Site Requirements 12
Site Requirements 12
General Considerations 12
Power Consideration 12
Power Cords 13
Bench Space 13
Environment 14
Specifications 15
Peristaltic Pumps 1VS and 8VS 15
Valve Pump Controller 17
Valve unit 19
2SettingUp21
Setting Up Your Spectrophotometer 22
Setting Up Your Sampling System 23
Naming Parts 23
Dissolution Bath 26
Installing a Multicell-transport-based Sampling System 27
Installing Your Eight-position Multicell Transport 28
Installing Your Peristaltic Pump 8VS 28
Connecting Multicell System Tubing 31
Troubleshooting 34
Part Numbers 35
Installing a Valve-based Sampling System 36
Setting Up Your Valve-pump Controller 38

8 Agilent 8453 Dissolution Testing System Installing and Operating Manual
Contents
Setting Up Your Valve Unit 42
Connecting Cables 44
Installing Your Peristaltic Pump 1VS 46
Connecting Valve System Tubing 49
Replacing Tubing 50
Troubleshooting 51
Part Numbers 52
Installing Your Multibath System 53
Installing Your Multicell Transport 54
Setting Up Your Valve-pump Controller 55
Setting Up Your Valve Units 58
Connecting Cables 60
Installing Your Peristaltic Pump 1VS 62
Connecting Valve System Tubing 65
Replacing Tubing 66
Troubleshooting 67
Part Numbers 68
3 Using the Peristaltic Pumps 1VS and 8VS 69
Installing Your Pump 70
Viewing the Pump 70
Operating Your Pump 73
Adjusting Flow Rate 73
Maintaining Your Pump 74
Removing the Tubing Cassette 75
Changing the Pressure-wheel Assembly 75
Changing the Drive Belt 77
Changing the Fuse 79
Servicing Your Pump 80
Electronics Description 80
Checking Remote Operation 82

Contents
Agilent 8453 Dissolution Testing System Installing and Operating Manual 9
4 Using the Valve Unit and Valve-pump Controller 85
Operating Your Valve System 86
Operating Your Valve Unit 86
Operating Your Pump 87
Troubleshooting Your Valve System 88
Checking the Problem 88
Solving Your Problem 91
Part Numbers 96
Servicing Your Valve System 98
Electronics Overview 99
Troubleshooting 106
Cables and Connectors 110
5 Parts for Dissolution Testing 113
Parts for Dissolution Testing 114
A Safety Information 119
Safety Information 120
General 120
Operation 120
Safety Symbols 121
Agilent Technologies on Internet 123
Index 125

10 Agilent 8453 Dissolution Testing System Installing and Operating Manual
Contents