Omega Bio-Tek MagBinder Fit24 User manual
MagBinder® Fit24
Nucleic Acid Purication
System Operation Manual
Manual Date: December 2023
Manual Revision: v1.0
For Research use only
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QMF27.0352.B1-001-24 Revision 1.0
Thank you for purchasing the MagBinder®Fit24 Nucleic Acid Purication
System.
For proper use of the instrument, please carefully read this manual before
operation and keep for future reference.
Opening Inspection
Please check the instrument when you rst open the package. If you nd
Omega Bio-tek
400 Pinnacle Way, Suite 450
Norcross, GA 30071
Phone: +1-770-931-8400
Email: [email protected]
Website: www.omegabiotek.com
Foreword
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Equipment Contents
Item Quantity
Main Unit 1
Power Cord 1
Tray 1
Tray Supports 2
Mouse 1
Allen Wrench, 2.5 mm 1
Allen Wrench, 3.0 mm 1
USB 1
Qualication Kit11
1MagBinder®Fit24 Qualication Kit is included with purchased equipment
however the kit is shipped separately.
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Safety Warnings and Guidelines
1. General safety
Please read this user manual carefully in its entirety before operation.
Prior to operating the instrument, thoroughly review this
user manual. Neglecting to read, comprehend, and adhere to
the manual’s instructions could lead to instrument damage,
potential harm to operator, or suboptimal instrument
performance.
Caution heavy. Use two person lift techniques to move the
equipment.
2. Safety tips
The operation, maintenance, and repair of the instrument should comply
with the basic guidelines and cautions listed below. Pay close attention
to all “Warning,”“Caution, “ and“Note” statements, as well as safety
symbols and markings found on the instrument and within this manual.
Improper use of the instrument may cause damage to the system,
inaccurate results, and/or potentially nullify warranties.
This instrument is a benchtop instrument which conforms to
class Iof IEC 61010-1 standard and IEC 61326 standard.
To minimize the risk of injury, biohazard contamination, re, or
electric shock, always adhere to fundamental safety measures
and local safety protocols when using this instrument.
The operator should not open or repair the instrument without
the company’s authorization. Failure to comply may result in
potential damages to the instrument, personnel injuries, and
aect the warranty.
Prior to powering up the instrument, ensure that the voltage
matches the instrument’s requirements and that the maximum
rated load can adequately support it. In case of power
cord damage, replace it with a cord that matches the same
specications.
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Ensure that the power cord remains unobstructed and is
positioned away from high trac areas while in operation.
When disconnecting the plug from the outlet, be certain to
grasp the plug securely and refrain from exclusively tugging on
the power cord.
The heat block surfaces can reach high temperatures during
operation. To avoid potential injury, do not touch these
surfaces when the instrument is in use.
Keep the instrument in an environment free from dust,
water, direct sunlight or strong light source, any heat sources,
corrosive gases, and strong magnetic interferences. Ensure
proper ventilation with low humidity levels. If using multiple
instruments, maintain a separation distance of 10 cm or greater
between them.
To ensure the instrument’s optimal reliability, it is essential to
diligently follow the preventative maintenance instructions. An
instrument that is not well-maintained may not deliver optimal
results.
Be sure to turn o the instrument after operation. If the
instrument will not be used for long periods of time, unplug
it from the outlet. Cover the instrument to prevent from
collecting dust.
Immediately unplug the instrument in the following scenarios
and contact the vendor:
• Liquid is leaking into the instrument
• Instrument gets wet or is scorched/burned
• Instrument is behaving abnormally such as abnormal
sound or smell
• Instrument is dropped and/or outer cover is damaged
• Instrument has malfunctioned
Safety Warnings and Guidelines
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This instrument contains permanent magnets. Operators
wearing a pacemaker or metallic prostheses should not use this
instrument. Close contact with a magnetic eld may damage or
aect the pacemaker or prostheses.
Avoid placing the MagBinder®Fit24 in proximity to magnetic
tapes, computer media, or other magnetic storage devices
as the magnetic eld generated by the instrument rods can
potentially cause damage to them. Exercise caution to prevent
accidentally damaging the magnets during the cleaning
process.
The MagBinder®Fit24 comes equipped with a UV lamp for
decontaminating the process chamber. Please be aware that
opening the front door will automatically deactivate the UV
lamp.
Indicates instructions for disposal.
DO NOT dispose of this instrument into unsorted municipal
waste when this instrument has reached end of life. Follow
local municipal waste ordinances for proper disposal.
Safety Warnings and Guidelines
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Safety Warnings and Guidelines
3. Preventative maintenance
To ensure consistent daily performance, maintain the instrument in an
environment free from dust and liquid spills. Avoid the use of abrasive
cleaning agents, as they are prone to cause damage to the instrument.
When necessary, clean the external surfaces or covers of the instrument
using a cloth dampened with water or a mild detergent. Clean magnetic
rods by using a soft cloth or disposable task wipe soaked in mild
detergent solution, a soap solution, or alcohol when needed. Follow the
manufacturer’s recommendations for diluting the cleaning agent.
Promptly remove spilled saline solutions, solvents, acids, or alkaline
solutions from external surfaces. Prolonged exposure to these
solutions may cause damage. If any surfaces become contaminated
with biohazardous material, apply a mild decontamination solution, as
mentioned previously, to the aected area.
Do not use any cleaning agent containing bleach as it can react
with guanidine-based chaotropic agents and form a highly reactive
compound.
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4. Transportation and storage guidlines
Ambient temperature range: 10°C – 35°C
Relative humidity: ≤ 70%
Atmospheric range: 500 – 1060 hpa
Well-ventilated area with no exposure to corrosive gas
5. Warranty and service
5.1 Content
Omega Bio-tek will replace the instrument for defects in materials and
manufacturing discovered within one month of delivery date. The warrenty
period is 12 months from the delivery date for any instrument failure caused
by material and manufacturing defects. During this warranty period, Omega
Bio-tek will either repair or replace the instrument if proven to be defective
depending on the severity of the issue.
The user will send products under warranty to the maintenance department
designated by Omega Bio-tek. The user will pay for freight delivery of the
instrument to the company, and the company will pay for the return.
more information.
5.2 Coverage
The above warranty is not applicable to the damage caused by improper use
and maintenance by the user, use of non-conforming practices by the user,
unauthorized maintenance, and/or instrument modification.
Safety Warnings and Guidelines
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Foreword...........................................................................................i
Equipment Contents....................................................................ii
Safety Warnings and Guidelines............................................iii
1. General safety..................................................................iii
2. Safety tips.........................................................................iii
3. Preventative Maintenance..........................................vi
4. Transportation and storage guidelines.................vii
5. Warranty and service...................................................vii
Chapter1Introduction.................................................................1
1.1 Intended Use....................................................................1
1.2 Manufacturer’s Warranty..............................................1
1.3 Features.............................................................................2
Chapter 2 Specications.............................................................3
2.1 Normal Operating Guidelines....................................3
2.2 Basic Parameters & Performance...............................3
2.3 Overall Dimensions........................................................4
Chapter 3 Product Schematic...................................................5
3.1 Structure............................................................................5
3.2 Operation Panel...............................................................6
Chapter 4 Installation..................................................................7
4.1 Before Unpacking Instrument....................................7
4.2 Unpacking the Instrument..........................................8
4.3 Placing Tray Supports....................................................9
4.4 Connecting Power..........................................................9
4.5 Running the Qualication Kit......................................9
4.6 Preparing the Reagents..............................................10
4.7 Inserting/Removing Tip Combs...............................11
Table of Contents
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Table of Contents
Chapter 5 Operation..................................................................12
5.1 Start-up Interface.........................................................12
5.2 Run Program...................................................................13
5.3 Program Management...............................................16
5.4 System Settings.............................................................23
5.5 UV Decontamination..................................................26
5.6 Help................................................................................27
5.7 Exit Program/Power O Instrument.......................27
Chapter 6 Troubleshooting.....................................................28
Chapter 7 Abbreviations & Symbols.....................................30
7.1 Abbreviations........................................................30
7.2 Symbols.............................................................31
Contact Information..................................................................33
Ordering Information................................................................34
Revision History...........................................................................35
Manual Date: December 2023
Manual Revision: v1.0
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Chapter 1 Introduction
The MagBinder®Fit24 Nucleic Acid Purication System uses magnetic rods in
unison to adsorb, transfer, and release magnetic particles in reagent cartridge
wells for the purication of DNA and RNA. The instrument can accommodate
1 to 24 samples simultaneously with the use of magnetic bead-based nucleic
acid extraction kits from a variety of sample types.
1.1 Intended Use
The MagBinder®Fit24 is a magnetic bead processing instrument intended for
the automation of laboratory workows including nucleic acid purication
for subsequent laboratory use.
The MagBinder®Fit24 is intended for professional use in a laboratory
environment.
The MagBinder®Fit24 comes with preloaded protocols designed to work
with Omega Bio-tek kits. Please reference specic kits for instructions on
how to run the preloaded protocols. Should there be any questions about
Please be advised that the user is responsible for verifying performance
characteristics for any procedure not covered by Omega Bio-tek’s
performance evaluation studies. The user is also responsible for establishing
performance metrics necessary for their downstream application of choice.
1.2 Manufacturer’s warranty
The manufacturer’s warranty of the instrument is 12 months from ship date.
more information.
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1.3 Features
• Easy-to-use touch screen interface
• 3 shortcut keys and/or mouse operation
• Heat function available
• UV light for instrument decontamination
• Quiet operation with minimal vibration
• Minimal interaction once samples running on instrument
Chapter 1 Introduction
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2.1 Normal operating guidelines
Environmental temperature: 10°C – 35°C
Relative humidity: ≤ 70%
Input: AC 100 – 240 V, 50 Hz/60 Hz
2.2 Basic Parameters & Performance
Table 1 Basic Parameters & Performance
Parameter Model: MagBinder®Fit24
Principle Magnetic bead-based processing
Throughput 1–24 samples
Plasticware 5 mL or 10 mL reagent cartridges + 2 mL elution tube
Sample volume (µL) 50 µL – 10,000 µL
Heat block Ambient temperature to 100°C
Temperature accuracy ±1°C
Electrical safety
Conforms to the following requirements:
EN IEC 61326-1
EN IEC 61326-2-6
EN IEC 61010-1
EN IEC 61010-2-101
Operation interface 7-inch touch screen, 3 shortcut keys and mouse is available
Internal memory Up to 8 protocols in shortcut screen with the ability to store
up to 100 protocols
Protocol import Standard USB
Protocol management Ability to create new, edit, delete, and/or save protocols
Decontamination UV light
Exhaust Internal fan
Max input power 450W
Dimension (W x D x H) 400 mm x 530 mm x 480 mm
Weight (kg) 34 kg
Chapter 2 Specications
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2.3 Overall Dimensions
Chapter 2 Specications
Dimension (WxDxH)
MagBinder®Fit24: 400 mm x 530 mm x 480 mm
D
H
W
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This section covers the instrument schematic and location of critical
instrument features only.
3.1 Structure
3.1.1 Front
3.1.2 Back
Chapter 3 Product Schematic
Socket
Fuse
Power Switch
Fan
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3.1.3 MagBinder®Fit24 inside view
3.2 Operation panel
Display screen: Touch screen operated or connect mouse to front USB port
TAB: Select for the shortcut protocol
RUN: Select to start the shortcut protocol
STOP: Abort operations
Chapter 3 Product Schematic
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Chapter 4 Installation
4.1 Before unpacking the instrument
The MagBinder® Fit24 must be installed on a stable, level surface that can
accommodate the weight (34 kg) and overall dimensions (400 mm x 530
mm x 480 mm) of the instrument. Ensure that the dedicated work area is
clean, uncluttered and free of any obstructions that may interfere with the
operation of the instrument.
Tools are provided with the instrument to release the door, sliding deck,
and the magnetic arms before powering on. Check and conrm the correct
voltage of the instrument before plugging in. The instrument must be
connected to a dedicated electrical circuit capable of supplying 100-240V AC
power, 50/60 Hz with a minimum of 5 A.
The installation site should be well-ventilated to ensure adequate air
circulation around the instrument. Ensure that the installation site
temperature and humidity are within the recommended ranges: ambient
temperature between 10°C to 35°C and relative humidity at ≤ 70%. The
ambient temperature of the installation site should be maintained between
10°C to 35°C (50°F to 95°F) to ensure optimal performance of the instrument.
The relative humidity of the installation site should be maintained at ≤
70%. If necessary, use a temperature and humidity sensor to monitor these
conditions.
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Chapter 4 Installation
4.2 Unpacking the instrument
Carefully remove the instrument from its packaging and place it on a stable,
level surface. The MagBinder®Fit24 weighs approximately 34 kg, and it is
recommended that two persons lift the instrument together. Ensure that all
components are present (refer to “Equipment Contents”on Page ii). Remove
the tape holding the door closed. Open the instrument door and remove the
foam to slide out the deck (Figure 1). Using the 3 mm allen wrench included,
remove the screws, and take out the red support that is screwed into the
deck (see red arrow, Figure 2) to release the magnetic arm.
Note: Be careful when unpacking to prevent damaging the magnetic rods.
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4.3 Placing tray supports
Slide out the deck and place the tray supports as seen in Figure 3. Place the
numbered support on the left side and the numbered on the right side
of the deck.
Chapter 4 Installation
4.4 Connecting power
Connect one end of power cord to the instrument socket and the other to
the power outlet (AC100~240 V). Turn on the power switch located in the rear
of the instrument.
4.5 Running the MagBinder®Fit24 Qualication Kit
The MagBinder®Fit24 Qualication Kit (shipped separately) is used to ensure
that the instrument is operating properly. Open the kit and follow the
directions as stated in the protocol.
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Chapter 4 Installation
4.6 Preparing the reagents
Place the reagent cartridges and elution tubes in the tray to the
corresponding positions (Figure 4). Ensure the elution tubes are positioned
open with caps oriented to the right of the tube and pressed down as shown
in Figure 4. Open the door, slide out the deck, and place the tray on the
deck. Firmly press the cartridges and elution tubes to ensure they t snugly
in the heat block on the deck (Figure 5). Slowly slide the deck back into the
instrument.
Table of contents
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