Franklin IC-145 User manual

FOLD
User’s Manual
HANDBOOK
OF
ADVERSE
DRUG
INTERACTIONS
Rx
The Medical Letter

DIGITAL BOOK F
IC-145


Electronic Publishers
For Use with the Franklin
Digital Book System

Electronic Publishers

1
READ THIS LICENSE AGREEMENT BEFORE USING THE
DIGITAL BOOK. YOUR USE OF THE DIGITAL BOOK DEEMS
THAT YOU ACCEPT THE TERMS OF THIS LICENSE. IF YOU
DO NOT AGREE WITH THESE TERMS, YOU MAY RETURN
THIS PACKAGE WITH PURCHASE RECEIPT TO THE DEALER
FROM WHICH YOU PURCHASED THE DIGITAL BOOK AND
YOUR PURCHASE PRICE WILL BE REFUNDED. DIGITAL BOOK
means the software product and documentation found in this
package and FRANKLIN means Franklin Electronic Publishers, Inc.
LIMITED USE LICENSE
All rights in the DIGITAL BOOK remain the property of FRANKLIN.
Through your purchase, FRANKLIN grants you a personal and
nonexclusive license to use the DIGITAL BOOK on a single
FRANKLIN Digital Book System at a time. You may not make any
copies of the DIGITAL BOOK or of the data stored therein, whether
in electronic or print format. Such copying would be in violation of
applicable copyright laws. Further, you may not modify, adapt,
disassemble, decompile, translate, create derivative works of, or in
any way reverse engineer the DIGITAL BOOK. You may not export
or re-export, directly or indirectly, the DIGITAL BOOK without
compliance with appropriate governmental regulations. The
DIGITAL BOOK contains Franklin’s confidential and propriety
information which you agree to take adequate steps to protect from
unauthorized disclosure or use. This license is effective until
terminated. This license terminates immediately without notice from
FRANKLIN if you fail to comply with any provision of this license.
This digital book was developed for use by medical professionals.
No other use of this digital book can substitute for consultation with
yourphysician.
LicenseAgreement

2
Contents
Introduction .......................................................3
Overview of Operation......................................5
Installing the Digital Book ................................7
Viewing a Demonstration .................................9
Selecting Drugs................................................10
Correcting Misspellings ..................................12
Finding Brands, Generics, Groups ................14
Finding Interactions........................................ 16
Between Many Drugs ..................................16
For a Single Drug........................................ 18
Viewing References ........................................ 20
Sending Words to Other Books..................... 22
Digital Book System®.......................................23
Limited Warranty............................................. 25
Product Specifications ................................... 26
Key Guide .........................................................27
Index..................................................................30

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This handbook offers a quick guide to possible adverse effects
of drug interactions, with brief recommendations for precaution-
ary measures. References are given to original reports that
provide more complete discussions of each interaction.
This book— lists adverse drug interactions, their mechanisms,
and recommendations for clinical management. These listings
are usually based on clinical reports in humans.
Reports of interactions between more than two drugs are
appearing in the medical literature with increasing frequency.
Where these have been documented, they are noted as
comments under interacting pairs of drugs. Interactions listed
for groups of drugs (such as “cephalosporins” or “antidepres-
sants, tricyclic”) may not have been reported for every drug in
the group; known exceptions to the interaction are noted.
It is not possible to determine the frequency of most interac-
tions. When an interaction is documented by one or two case
reports rather than by clinical studies or reports in many
patients, the year of each report is given as some indication of
frequency.
Omissions—Drugs for which we have no documented
interaction are not included. New adverse interactions are
continually being reported; the absence of an interaction does
not necessarily mean that drugs will not interact when given
concurrently. Interactions between general anesthetics and
drugs likely to be administered during surgery, such as
autonomic drugs and local anesthetics, are not included here.
Interactions useful in therapy, such as increased plasma
concentration of penicillin with concurrent use of probenecid,
are also not included.
Common additive effects, such as occur with the use of two
Introduction

4
antihypertensive agents or two central-nervous-system
depressants, are generally not included. Effects expected from
the mechanism of a drug’s action, such as that of potassium on
digitalis glycosides or calcium on calcium-entry blockers, and
useful antagonist effects, such as that between a poison and an
antidote, are not listed. Most interactions of drugs with foods,
beverages, or other nutrients are not included, but foods
interacting with monoamine oxidase inhibitors are included.
Mechanisms of Interaction—Genetic differences can affect
drug metabolism and interactions. Drugs can interact by
changing the metabolism of other drugs, either through
inhibition or induction of any of several hepatic enzyme
activities or through alterations in hepatic blood flow; by altering
the binding of other drugs to plasma proteins or tissue
receptors; by altering the distribution of drugs to active receptor
sites; by delaying or enhancing excretion; or by causing additive
or synergistic effects.
Recommendations—Monitoring is most important when one of
the interacting drugs is stopped or started. Some experienced
clinicians may prefer to monitor the patient’s clinical status
rather than follow serum concentration of drugs.
Important Notice: The Medical Letter Drug Interactions
Program reports interactions occurring in people, which
can be documented primarily by published reports.
These may not include interactions mentioned in other
sources, such as the manufacturer’s package insert,
which are extrapolated from animal studies or interac-
tions reported for related drugs.
Introduction

5
Overview of Operation
What the Handbook Can Do
The Medical Letter®Handbook ofAdverse Drug
Interactions
is a powerful reference. Using this
digital book, you can. . .
• find brand name drugs, generic drugs, drug
groups, and food groups,
• correct drug name misspellings,
• find foods that interact with MAO inhibitors,
• select up to 20 drugs and view a list of the
interactions between them,
• select a single drug and view a list of the drugs
with which it interacts,
• read descriptions and references about drug
interactions, and
• look up drugs and words in related digital books.
Read this User’s Manual to learn how.

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ENTER
ENTER
ENTER
ENTER
CLEAR
How the Handbook Works
The Handbook is easy to use. Here are the basics.
Highlight the HADI symbol and press .
At the main drug list, As you type, the drug
type a drug name. name is highlighted.
Then press .
Type another drug You see a message
name. Press . to “
SHOW INTERACTIONS. ”
Press . You see the interactions,
if any, between the drugs.
Press . You see a description of
the interaction.
Press . You’re ready to find
other interactions.
Overview of Operation
✓About Illustrations in this Manual
Some screen shots in this User’s Manual may
vary slightly from what you see on screen. These
variations do not mean that this digital book or
your Digital Book System is malfunctioning.
ENTER

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Before you can use this digital book, you must install
it. Warning: If you install a digital book
while the
Digital Book System on, information that you entered
in other currently installed digital books may be erased.
1. Turn the Digital Book System off.
2. Install the digital book into a slot on the
back of the Digital Book System.
Align the tabs on the digital book with the notches
in the slot. Make sure its metal contacts face down.
3. Press .
4. Turn the wheel on the side of the Digital Book
System to adjust the screen contrast.
5. Press .
6. Press or to highlight the HADI symbol.
ON/OFF
CARD
Installing the Digital Book

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7. Press .
This is the main drug list, where you select drugs
to find interactions.
Installing the Digital Book
ENTER
✓Resuming Where You Left Off
While using this digital book, you can turn off
the Digital Book System at any time. When you
turn the Digital Book System on again, the
screen that you last viewed appears. Any drugs
entered in your query list are saved, too.
✓Clearing the Main Drug List
You can always return to the main drug list by
pressing .
Note: When you do, the
drugs in your query list are also cleared.
You can return to the previous screen without
clearing your query list by pressing .
CLEAR
BACK

9
Viewing a Demonstration
ENTER
CLEAR
Before you start using this digital book, you may
want to view a brief demonstration of what it can do.
1. Press at the main drug list.
2. Press to highlight “Demo.”
3. Press to start the demonstration.
4. Press to stop the demonstration.
✓ Help is Always at Hand
Except during the demonstration, you can view
a help message at any screen by pressing .
To read the help message, press . To exit it,
press .
HELP
BACK
MENU

10
Selecting Drugs
The main drug list contains brand and generic drugs,
foods, as well as drug and food groups. You select
an item from the main drug list by typing it and then
pressing . Usually you need to type only a
few letters to highlight an item. Try this example.
1. Type “META” at the main drug list.
To erase a letter, press .
2. Press to select the drug
and add it to the query list.
3. Press to clear the query.
ENTER
ENTER
CLEAR
BACK
✓Drug Selecting Tips
You do not need to type capital letters or
punctuation. However, you can type numbers at
the main drug list.
Note: In this User’s Manual,
“drug” refers to any item on the main drug list.

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Selecting Drugs
✓Using the Direction Keys
You can use these keys to move up and down
the main drug list, the query list, and other lists.
To. . . Press. . .
Scroll up and down Hold or
Page up and down UP or DN
Zoom to the top or + or *
bottom of a list
* Hold while pressing the other key, or
press and then the other key. The second
method displays a G at the bottom of the
screen.
✓ Follow the Arrows
The flashing arrows at the top right of the
screen indicate which direction keys you can
press to move around the screen.

12
Correcting Misspellings
Don’t worry if you misspell a word. The spell-
correction mode automatically appears. Try this.
1. Type “PSEUDOFED” at the main drug list.
To exit spell-correction, press repeatedly.
2. Press .
3. Press to highlight a drug.
4. Press to select the drug
and add it to the query list.
5. Press to add the related drug.
6. Press to clear the query.
BACK
ENTER
ENTER
Y
ENTER

13
Correcting Misspellings
ENTER
ENTER
? *SHIFT
✓Finding Letters in Words
If you are not sure how to spell a word, type a
question mark in place of each unknown letter
or an asterisk in place of a series of unknown
letters. Here are two examples.
• Type “CIM?T?DINE” and press .
The correct spelling, CIMETIDINE, appears.
• Type “CORTI*.” To type the asterisk, hold
and press . Then press .
a list of drug and group names beginning with
“CORTI” appears.
Note: You can type more than one question
mark or asterisk in a word, and you can type
both in one word. However, you cannot type two
consecutive asterisks in a word.

14
Finding Brands,Generics,Groups
By highlighting a drug name on the main drug list
and pressing , you can see its generic or
brand names and any drug or food groups to which it
belongs. In this example, we’ll find the brand names
and drug group of penicillin G.
1. Type “PENICILLIN G” at the main drug list.
2. Press .
3. Press repeatedly to view the brands.
Or hold and press .
At the bottom of the list, notice that penicillin G be-
longs to the drug group, penicillins.
SPEC
SPEC

15
4. Press to view the drugs in the group.
5. Press to scroll down.
6. Press twice to go back
to the main drug list.
Finding Brands, Generics, Groups
ENTER
BACK
✓Finding MAO Inhibitor Interactions
When you highlight a food name on the main
drug list, pressing shows if that food
interacts with MAO inhibitors. Try this example.
1. Type “AVOCADOS”.
2. Press . “MAO Inhibitor info” is
highlighted.
3. Press . A description of
avocados and MAO inhibitors appears.
SPEC
SPEC
ENTER

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You can find adverse interactions by selecting drugs
from the main drug list and then pressing
at “✻SHOW INTERACTIONS✻.” Then you can view a
description of each interaction.
Between Many Drugs
You can select up to 20 drugs at time to find interac-
tions between them. In this example, we’ll find the
interactions between alcohol and acetaminophen.
1. Select “ALCOHOL” from the main drug list.
2. Select “ACETAMINOPHEN.”
3. Press to view the interactions. Or
press and select “Query interactions.”
Finding Interactions
ENTER
ENTER
MENU

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Finding Interactions
4. If more than one interaction is listed,
press to highlight one.
Note: You can return to the main drug list now by
pressing .
5. Press at a highlighted interaction.
This is an interaction description. The hand points
to a comment or recommendation.
6. Press or the DN key to move down.
To. . . Press. . .
View the drug names of then
the interaction description
View the next or previous + UP or DN
description, if any
Return to the interactions
7. Press to clear the queries.
CLEAR
ENTER
SPEC
BACK
BACK
BACK

18
For a Single Drug
You can select a single drug from the main drug list
and quickly find the drugs with which it interacts. In
this example, we’ll find the interactions for heparin.
1. Type “HEPARIN” at the main drug list.
2. Press .
3. Press to view your query list.
4. Press . Or press and select
“Other interacting items.”
These are the interactions for heparin.
Finding Interactions
ENTER
LIST
OMENU

19
5. Press to highlight an interaction.
6. Press to view its description.
Finding Interactions
ENTER
✓Using the Query List
Whenever you select a drug from the main drug
list, it is saved in the query list. To view your
queries, press . Once at the query list,
you can use these keys.
To. . . Press. . .
Delete a highlighted item
View the interactions
between all the items
View all the interactions
for a highlighted item
Go to main drug list
and
save your queries
Go to main drug list
and
clear your queries
Note: Your queries are saved between sessions
unless you reset the Digital Book System or
remove its batteries.
A
O
Q
D
CLEAR
LIST