Agilent Technologies 708-DS Installation guide

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
P/N: xx-xxxx
- 1 -
AGILENT 708-DS DISSOLUTION APPARATUS
TRAINING MANUAL
Table of Contents
1.1. The Apparatus..........................................................................................................................- 5 -
1.2. The Firmware............................................................................................................................- 6 -
1.3. Optional Configurations........................................................................................................- 6 -
2. INSTRUMENT SETUP ............................................................................. - 7 -
2.1. Physical Setup .........................................................................................................................- 7 -
2.1.1. Unpacking Equipment / Accessories .......................................................................- 7 -
2.1.2. Heater / Circulator Setup .............................................................................................- 8 -
2.1.3. Communication / Power Cord Installation ..............................................................- 8 -
2.1.4. Instrument Power Up....................................................................................................- 9 -
2.1.5. Leveling the Apparatus................................................................................................- 9 -
2.1.6. Heater / Circulator Power Up....................................................................................- 10 -
2.1.7. Dissolution Vessel Installation.................................................................................- 11 -
2.1.8. Manifold Installation....................................................................................................- 11 -
2.1.9. Shaft / Evaporation Cover / DDM Installation.......................................................- 12 -
2.1.10. Setting Paddle / Basket Heights ..............................................................................- 14 -
2.2. Firmware Setup – Instrument Settings............................................................................- 15 -
2.2.1. Apparatus ID Numbers, LCD Settings....................................................................- 15 -
2.2.2. Setting the Date / Time...............................................................................................- 16 -
2.2.3. Calibrating the Touch Screen...................................................................................- 16 -
2.2.4. Instrument Tolerances, Vessel Size, Enable Alarms/DDMs .............................- 17 -
2.2.5. Manifold Configuration (Vessel Numbering)........................................................- 17 -
2.2.6. Print Options.................................................................................................................- 18 -
3. MEASUREMENT OF PHYSICAL PARAMETERS................................. - 18 -
3.1. RPM, Wobble, Centering, Level, Verticality (Shaft and Vessel) ................................- 18 -
3.1.1. RPM / Wobble................................................................................................................- 19 -
3.1.2. Centering .......................................................................................................................- 20 -
3.1.3. Vessel Table Level.......................................................................................................- 20 -
3.1.4. Shaft / Vessel Verticality............................................................................................- 21 -
3.2. Temperature(s).......................................................................................................................- 21 -
3.2.1. External Vessel Temperature (EVT) Probe............................................................- 21 -
3.2.2. AutoTemp - Vessel Temperatures...........................................................................- 22 -
3.3. Manual Operation (from Diagnostics)..............................................................................- 23 -
3.3.1. Verification of Apparatus Operation.......................................................................- 23 -

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
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4. BASIC OPERATION .............................................................................. - 24 -
4.1. Dissolution Medium – Filling Vessels, Media Change / Addition .............................- 24 -
4.2. Manual Sampling, Evaporation Cover Options .............................................................- 25 -
4.3. LCD Display (Touch Screen)..............................................................................................- 26 -
4.3.1. Operations from Main Screen...................................................................................- 26 -
4.3.2. Alphanumeric / Numeric / Date & Time Entries....................................................- 27 -
5. OPTION DESCRIPTION (BASED ON CONFIGURATION)................... - 28 -
5.1. Lift Mechanism.......................................................................................................................- 28 -
5.1.1. Automated .....................................................................................................................- 28 -
5.1.2. Manual ............................................................................................................................- 28 -
5.2. Auto Sampling........................................................................................................................- 29 -
5.2.1. Load / Eject Manifold ..................................................................................................- 29 -
5.2.2. Removing or Adjusting Cannulas / Probes...........................................................- 30 -
5.2.3. Programming Manifold Depth ..................................................................................- 30 -
5.3. AutoTemp................................................................................................................................- 31 -
5.3.1. Enabling Temperature Measurements ...................................................................- 31 -
5.3.2. Setting Tolerances ......................................................................................................- 31 -
5.3.3. Manifold Down Lead Time / Manifold Down Duration........................................- 32 -
5.4. Dosage Delivery Modules (DDM).......................................................................................- 32 -
5.4.1. Automated DDM...........................................................................................................- 33 -
5.4.2. Manual DDM..................................................................................................................- 33 -
5.5. 708-DS Reports......................................................................................................................- 34 -
5.6. Alarms......................................................................................................................................- 34 -
6. METHOD SETUP AND EXECUTION WITH THE 708-DS ..................... - 36 -
6.1. 708-DS Method Setup (Stored) ..........................................................................................- 36 -
6.2. 708-DS Test Execution (Stored Method).........................................................................- 40 -
6.3. 708-DS Method Setup and Execution (Manual).............................................................- 41 -
6.4. Screen Lock / Unlock ...........................................................................................................- 42 -
6.5. Pause / Resume Test ... Media Change ...........................................................................- 43 -
7. DIALOG, WARNING, AND POPUP ERROR SCREENS....................... - 44 -
8. CLEANING / MAINTENANCE / TROUBLESHOOTING ........................ - 44 -

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
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8.1. Maintenance Due Icon (Calibration / PM due date alarms).........................................- 44 -
8.2. Rinse Cups (for use with VK 8000)...................................................................................- 45 -
8.3. Vessels (TruAlign), Shafts, Evaporation Covers ........................................................- 45 -
8.4. Touch Screen Alignment Procedure................................................................................- 46 -

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
P/N: xx-xxxx
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Table of Figures
FIGURE 1-1. 708-DS DISSOLUTION APPARATUS.............................................................................. - 5-
FIGURE 1-2. MAIN SCREEN ............................................................................................................ - 6-
FIGURE 2-1. 708-DS HEATER /CIRCULATOR .................................................................................. - 8-
FIGURE 2-2. BUILT-IN SELF TEST SCREEN ...................................................................................... - 9-
FIGURE 2-3. LEVEL ADJUSTMENT SCREWS ..................................................................................... - 9-
FIGURE 2-4. 708-DS LEVEL ADJUSTMENT .................................................................................... - 10 -
FIGURE 2-6. TRUALIGN VESSEL ORIENTATION .............................................................................. - 11 -
FIGURE 2-7. SAMPLE TUBING FASTENER....................................................................................... - 12 -
FIGURE 2-8. DOSAGE DELIVERY MODULE ..................................................................................... - 13 -
FIGURE 2-9. COVER ALIGNER....................................................................................................... - 13 -
FIGURE 2-10. 708-DS ACCESSORY INSTALLATION ........................................................................ - 13 -
FIGURE 2-11. SETTING PADDLE /BASKET HEIGHTS....................................................................... - 14 -
FIGURE 2-12. INSTRUMENT SETTINGS SCREEN 1 .......................................................................... - 15 -
FIGURE 2-13.DATE AND TIME SCREEN......................................................................................... - 16 -
FIGURE 2-14. TOUCH SCREEN CALIBRATION................................................................................. - 16 -
FIGURE 2-15. MANIFOLD CONFIGURATION SCREEN....................................................................... - 17 -
FIGURE 2-16. 708-DS PRINTER ................................................................................................... - 18 -
FIGURE 3-1. RPM AND WOBBLE MEASUREMENT ON A 708-DS...................................................... - 19 -
FIGURE 3-2. LEVEL VERIFICATION -TORPEDO LEVEL..................................................................... - 20 -
FIGURE 3-4. 708-DS SAMPLE TEMPERATURE BUTTON.................................................................. - 21 -
FIGURE 3-5. SAMPLE TEMPERATURES SCREEN............................................................................. - 22 -
FIGURE 3-6. DIAGNOSTICS SCREEN 1........................................................................................... - 23 -
FIGURE 3-7. DIAGNOSTICS SCREEN 2........................................................................................... - 24 -
FIGURE 4-1. FILLING THE VESSEL OF A 708-DS............................................................................. - 25 -
FIGURE 4-2. TAKING A MANUAL SAMPLE....................................................................................... - 25 -
FIGURE 4-3. 708-DS STANDARD EVAPORATION COVER ................................................................ - 26 -
FIGURE 4-4. MAIN SCREEN .......................................................................................................... - 26 -
FIGURE 4-5. ALPHANUMERIC AND NUMERIC DATA ENTRY SCREENS............................................... - 27 -
FIGURE 5-1. 708-DS MANUAL LIFT KNOB ..................................................................................... - 28 -
FIGURE 5-2. INSTALLATION OF THE MANIFOLD............................................................................... - 29 -
FIGURE 5-3. PADDLES/BASKETS SAMPLING DEPTH SCREEN.......................................................... - 30 -
FIGURE 5-4. METHOD PROPERTIES SCREEN 3 .............................................................................. - 31 -
FIGURE 5-5. TOLERANCE SETTINGS.............................................................................................. - 32 -
FIGURE 5-6. INSTRUMENT SETTINGS SCREEN 2 ............................................................................ - 33 -
FIGURE 5-7. 708-DS DDM –MANUAL.......................................................................................... - 33 -
FIGURE 5-8. REPORT OPTIONS..................................................................................................... - 34 -
FIGURE 6-1. METHOD PROPERTIES SCREEN 1 .............................................................................. - 36 -
FIGURE 6-2. METHOD PROPERTIES SCREEN 2 .............................................................................. - 37 -
FIGURE 6-3. METHOD PROPERTIES SCREEN 3 .............................................................................. - 38 -
FIGURE 6-4. METHOD PROPERTIES SCREEN 4 .............................................................................. - 39 -
FIGURE 6-5. TIMEPOINT PROPERTIES SCREEN.............................................................................. - 39 -
FIGURE 6-6. TEST START SCREEN................................................................................................ - 40 -
FIGURE 6-7. MANUAL OPERATION SCREEN................................................................................... - 41 -
FIGURE 6-8. UNLOCK INSTRUMENT SCREEN.................................................................................. - 43 -
FIGURE 6-9. PAUSE METHOD SCREEN.......................................................................................... - 43 -
FIGURE 8-1. REGULATORY CALIBRATION DATE SCREEN................................................................ - 44 -
FIGURE 8-2. 708-DS RINSE CUP.................................................................................................. - 45 -

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
P/N: xx-xxxx
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Agilent 708-DS Overview
1.1. The Apparatus
Agilent’s 708-DS Dissolution Apparatus has been carefully designed to provide
an accurate, fast, flexible, and safe instrument to execute a variety of
dissolution methods. The apparatus is capable of traditional Basket (USP
Apparatus 1) and Paddle (USP 2) test methods, as well as Paddle over Disk
(USP 5) and Rotating Cylinder (USP 6) experiments.
Figure 1-1. 708-DS Dissolution Apparatus

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
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Beyond the scope of compendial devices, other vessel sizes and drug delivery
mechanisms may be used with the 708-DS. These include 200, and 2000mL
vessels sizes complete with appropriately scaled accessories. Also, stationary
baskets and enhancer cells may be configured.
The apparatus itself has many different configuration possibilities. The 708-DS
is available with a manual or automated lift mechanism to control the drive unit.
Other additional options include: AutoTemp, Auto Sampling, Dosage Delivery
Modules (DDM) and a Printer. Each of these will be explained in greater detail
throughout this manual.
1.2. The Firmware
Setup and operation of the instrument is controlled via the LCD touch screen
on the front of the unit. The Main screen, displayed after initialization occurs,
provides the current status of several instrument parameters as well as a
variety of “hotspots” and buttons to initiate operation.
Figure 1-2. Main Screen
Press the ‘Menu...’button from the Main screen to display the primary System
Menu. From this screen, the user has the ability to configure the apparatus to
their exact specifications. These options include method setup, instrument
settings, diagnostic tests, and more.
1.3. Optional Configurations
As mentioned previously, the apparatus has an assortment of configurable
options. While many of these are selected at the time of ordering, most may be
added at a later time if and when laboratory testing needs change.
A manual or automated Head Lift mechanism is used to raise and lower the
apparatus’ drive unit.

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Training Manual
Revision A September 2010
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For automated sample collection, the Auto Sampling option is available which
is comprised of a sampling manifold with sampling and return cannulas. The
manifold may also include the AutoTemp option which includes individual
temperature probes for each dissolution vessel.
For a hands-free test start, the newly designed Dosage Delivery Module (DDM)
allows for simultaneous or sequential introduction of dosage forms. Lastly, a
Printer may be included to document all critical apparatus settings and events.
2. Instrument Setup
2.1. Physical Setup
Once the 708-DS dissolution apparatus has been delivered to the laboratory
where setup and installation will occur, the steps to begin unpacking and any
applicable qualification begin. The following sections will proceed naturally
through various procedures to ensure a smooth and methodical setup.
2.1.1. Unpacking Equipment / Accessories
Upon delivery of the equipment, some portions of the apparatus will
require some simple assembly. It is important to first inspect all pieces to
ensure no damage has occurred during shipment. The following table
includes many, if not all, of the accessories shipped with the unit:
708-DS Dissolution Apparatus Heater / Circulator
Power Cords 6-pin Cable for Heater / Circulator
Bath Temperature Probe External Vessel Temperature (EVT) Probe
Dissolution Vessels Evaporation Covers
TruAlign™ Blank Vessel Position Covers Evaporation Cover Plugs
DDM Assemblies Basket Shaft Assemblies
Cover Aligners Paddle Shaft Assemblies
DDM Alignment Shafts Vessel Centering Tool
Shaft Locking Collars Thermal Printer Paper
17-mm Open End Wrench 90° Allen Key (for Level Adjustment)
7/64” T-Handle Allen Wrench Stainless Steel Tubing Clamps
Length of Plastic Tubing (1/2” OD) 25-mm Spheres
Clip-on Basket Height Gauge Bubble Level
Technical Documentation CD Rinse Cups

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
P/N: xx-xxxx
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2.1.2. Heater / Circulator Setup
The 708-DS utilizes a water bath to heat and maintain temperature within
the dissolution vessels. The water in the bath is heated and circulated by
a Heater / Circulator (H/C) that is positioned behind the water bath. The
H/C should be installed beneath the back of the vessel plate with the
power outlet facing the rear and legs inserted into the holes of the base
plate.
Figure 2-1. 708-DS Heater / Circulator
NOTE: To prevent damage to the heating elements, the unit should not be powered ON
until the all tubing connections have been verified and the bath has been filled with water.
2.1.3. Communication / Power Cord Installation
Before turning the apparatus ON, the communication cables and power
cords are installed. The 708-DS and its’ accompanying H/C each have a
power cord requiring connection to an outlet of the appropriate voltage.
The H/C communication cable is a 6-pin cable that connects the H/C to
the position marked BATH HEATER on the rear of the apparatus. Also,
the Bath Temperature probe is connected to the BATH TEMP port on the
rear of the 708-DS and the probe is inserted into the hole in the center of
the vessel plate (between the back middle vessel positions).
A unit not equipped with AutoTemp may include an additional External
Vessel Temperature (EVT) Probe. This probe is inserted into the VESSEL
TEMP jack on the rear of the apparatus drive unit. The other end of the
probe is placed in the hole in the left side of the vessel plate toward the
back.

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
P/N: xx-xxxx
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2.1.4. Instrument Power Up
Once the cables have been connected, the apparatus is powered ON
using the switch on the left side of the drive unit. Upon initialization, the
instrument undergoes a brief “Self-Test” to ensure proper operation. At
this time, the serial number, firmware version, firmware release date, and
LCD version are displayed. A green check mark indicates the test was
successful. A red “X” appears if any of the system components fail the
test along with the status of each component. The error screen will
appear until the condition is resolved and the internal routine completes
successfully.
Figure 2-2. Built-in Self Test Screen
2.1.5. Leveling the Apparatus
Adjustment of the vessel plate level is performed by using the 90° Allen
Key and the 17-mm open-end wrench supplied with the apparatus. The
first step is to remove the black caps that cover the level adjustment
screws on the front and rear of the base plate (see Figure 2-3).
Figure 2-3. Level Adjustment Screws
Raise the stability feet located toward the back on either side of the base
plate so they are not touching the laboratory bench.
NOTE: It may be necessary to use the open-end wrench to loosen the nut(s) beneath the
base plate to allow for adjustment of the leveling screws.

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
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Adjust the two front leveling feet of the apparatus, while monitoring the
vessel plate level, to achieve left-to-right level within tolerance. Then,
adjust the leveling foot at the rear of the apparatus, while monitoring the
vessel plate level, to achieve front-to-back level within tolerance. Once
satisfactory level is attained, use the open-end wrench to tighten the
nut(s) beneath the base plate. Lower the stability feet located toward the
back on either side of the base plate until they touch the laboratory
bench. Do not over-tighten to ensure level is maintained.
Figure 2-4. 708-DS Level Adjustment
The water bath is filled at this time – be sure to allow for displacement of
the water when the vessels are installed. After filling the water bath to the
appropriate height, re-verify the level front-to-back and left-to-right to
ensure the previous setting has been maintained.
2.1.6. Heater / Circulator Power Up
With the water bath of the 708-DS filled to the appropriate height, turn on
the power to the Heater / Circulator. The flow of water should begin
immediately. If air is trapped in the loop, however, the unit may need to
be primed.
NOTE: See the label on the rear of the H/C for instructions on priming – a tilt of the unit
(arrow pointing down) should be sufficient to purge any air from the system.
If the red Heater Error LED is illuminated, it may be necessary to turn the
unit OFF and back ON to re-initiate the internal pump. Once proper flow is
established, examine all tubing connections in the loop to ensure no leaks
are present. The Pump On LED should be lit up green indicating the
pump is operating properly. The Heater On LED will be illuminated green
if the water is being heated. As the water temperature approaches the
target temperature, this LED will naturally cycle on / off.

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
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2.1.7. Dissolution Vessel Installation
The 708-DS utilizes the TruAlign™ dissolution vessels. To install the
vessels, raise the drive unit of the apparatus. Locate the vessels and
carefully insert them into each position of the vessel plate. Rotate the two
diagonal clips for each position over the vessel rim to secure it in place. If
desired, use the point on the vessel collar (see Figure 2-6) to orient the
vessels identically for each test.
Figure 2-6. TruAlign Vessel Orientation
For any unused vessel positions, locate the TruAlign blank vessel position
covers. Place a cover over the vessel plate openings and rotate the two
clips over the rim of the cover to secure it in place.
2.1.8. Manifold Installation
For an instrument configured with Auto Sampling or AutoTemp, the use of
a manifold is required. To install the manifold, lift the drive unit of the 708-
DS to its fully raised position. From the Main screen, press Menu >
Diagnostics. Position the manifold so the center screw is aligned with the
center receptor on the underside of the drive unit. Ensure the left and
right alignment cylinders are also positioned correctly. Push the manifold
up into the drive unit until resistance is met. While gently lifting upward,
press Load from within the Manifold Control box on the touch screen. The
internal drive slowly lifts the manifold to its fully raised position.
If the AutoTemp option is installed, attach the two 9-pin RS232 cables to
the appropriate locations on the underside of the drive unit. If the manifold
is configured with tubing and cannulas for Auto Sampling, locate the black
tubing fasteners and attach them to the sample tubing wrap.

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
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Affix a fastener to the bottom of the drive unit on either side of the center
drive unit lift (see Figure 2-7). Attach the tubing to the clips located toward
the back on the underside of the apparatus drive unit.
Figure 2-7. Sample Tubing Fastener
2.1.9. Shaft / Evaporation Cover / DDM Installation
Once the vessels and manifold have been installed, the remaining
accessories are put into place on the apparatus. Locate the appropriate
pieces to be configured as part of the apparatus: evaporation covers,
DDMs / Cover Aligners / Evaporation Cover Plugs, receptor shafts,
paddle or basket shafts, and shaft locking collars.
Lift the drive unit to its fully raised position. Insert a receptor shaft into
each active spindle location. Place a shaft locking collar on the top of
each shaft and slide it down until it rests on top of the spindle assembly
on top of the drive unit. Slide an evaporation cover over the shafts
(Basket or Paddle) to be installed and attach them to the already installed
receptor shafts at each applicable position.
Locate the DDM assemblies, Cover Aligners, or Evaporation Cover Plugs
to be installed.

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
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Figure 2-8. Dosage Delivery Module Figure 2-9. Cover Aligner
For all applicable positions, insert a DDM or Cover Aligner into the DDM
Alignment Shaft hanging from the underside of the drive unit.
Attach the DDM or Cover Aligner to the evaporation cover by aligning the
notch with the locking pin of the cover and pushing until fully seated.
Ensure that the sampling
port of the evaporation
cover is aligned properly
with the cannulas and
probes of the manifold, if
applicable.
For units without DDM
Alignment Shafts, insert
an Evaporation Cover
Plug into the appropriate
location of each cover.
Figure 2-10. 708-DS Accessory Installation

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
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2.1.10. Setting Paddle / Basket Heights
To complete the 708-DS accessory installation, it is necessary to properly
set the Basket or Paddle shaft height – 25 ± 2mm from the bottom of the
dissolution vessel.
If basket shafts have been installed, locate the clip-on basket height
gauge. Clip the gauge onto the bottom of the basket shaft. Place the drive
unit in its operating position (fully lowered). With the shaft locking collar
loose, carefully lower the shaft until the bottom of the basket height gauge
rests against the bottom of the vessel. Ensure the shaft locking collar is
flush against the top of the spindle assembly by rotating the shaft until
resistance is met. Tighten the shaft locking collar securely with the 7/64”
T-handle allen wrench. Repeat for all active vessel positions.
Figure 2-11. Setting Paddle / Basket Heights
For units with paddle shafts installed, locate the 25-mm height spheres.
Place a sphere in each vessel. Place the drive unit in its operating
position (fully lowered). With the shaft locking collar loose, carefully lower
the shaft until the bottom of the paddle blade rests against the height
sphere. Ensure the shaft locking collar is flush against the top of the
spindle assembly by rotating the shaft until resistance is met. Tighten the
shaft locking collar securely with the 7/64” T-handle allen wrench. Repeat
for all active vessel positions.

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Training Manual
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2.2. Firmware Setup – Instrument Settings
Once the apparatus’ accessory set up is complete, the instrument firmware is
configured to best meet the needs of the laboratory. The following sections will
proceed naturally through various screens to program specific settings and
parameters.
2.2.1. Apparatus ID Numbers, LCD Settings
From the Main screen, press Menu > Instrument. The screen shown in
Figure 2-12 is displayed:
Figure 2-12. Instrument Settings Screen 1
From this screen, the following actions are performed:
Touch anywhere inside the Tester ID box to enter a unique
identification number for the 708-DS.
Touch anywhere inside the Comm ID box and enter an
appropriate communication identification number (default is 01).
Place a check in the All Position Spin box to allow for spindle
rotation with the drive unit raised (useful for RPM / wobble
verification with some measurement devices).
Adjust the LCD settings by pressing the up / down arrows to
adjust the brightness of the screen and the volume when buttons
are pressed.

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2.2.2. Setting the Date / Time
From the Instrument Settings screen shown above in Figure 2-12, press
the Date / Time box to set the current date and time.
Figure 2-13. Date and Time Screen
Enter the current date by pressing anywhere in the Datebox. Press Ok
when finished. Press the format button (MM/DD/YYYY) to toggle between
alternate date formats. Select the format that is most appropriate. Enter
the current time by pressing anywhere in the Time box. Press Ok when
finished.
2.2.3. Calibrating the Touch Screen
To calibrate the LCD touch screen of the 708-DS dissolution apparatus,
press the Align Screen button from the Instrument Settings screen
shown in Figure 2-12. Follow the on-screen prompts to execute this
routine by pressing the 3 circles displayed in succession. Verify the
screen calibration values by pressing the 4 different circles in the screen
corners.
Figure 2-14. Touch Screen Calibration

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When complete, the calibration values are stored in non-volatile memory
for further use. If the Align Screen button was pressed inadvertently, the
calibration routine will abort after 5 seconds if the screen is not touched.
2.2.4. Instrument Tolerances, Vessel Size, Enable Alarms/DDMs
From the Instrument Settings screen shown in Figure 15, press Next.
From this screen, the following actions are performed:
Press anywhere inside the Temperature Tolerances box to enter a
temperature tolerance (in °C). Press Ok when finished.
Press anywhere inside the Speed Tolerance box to enter a speed
tolerance (in RPM). Press Ok when finished.
Select the size of the vessels (in mL) configured as part of the
dissolution apparatus by pressing the appropriate circle.
Press anywhere inside the Number Active box to indicate the
number of active vessel positions. Press Ok when finished.
Place a check in the Enable Alarms box to activate the alarms of
the apparatus.
Place a check in the Enable DDM box if the apparatus is
configured with dosage delivery modules and their use is desired
when running programs.
Each of the tolerances programmed on this screen will trigger the
appropriate error messages and warnings to display when deviations
greater than these occur. The settings are stored and applied to each
method executed with the apparatus.
2.2.5. Manifold Configuration (Vessel Numbering)
From the Instrument Settings
screen shown in Figure 2-12,
press Next twice. The Manifold
Configuration screen displays.
This screen offers the user two
options to number the vessel
positions for all tests conducted
with the 708-DS.
Select the desired option by
touching the appropriate circle.
Figure 2-15. Manifold Configuration Screen
Press Finish > Main when complete to return to the Main screen.

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2.2.6. Print Options
If the instrument includes a Printer, press Menu >Reports from the Main
screen. This screen allows the user to print the results of the last test, the
contents of stored methods, or the current instrument settings. The printer
is also enabled or disabled from this screen by using the Enable Printer
check box.
Figure 2-16. 708-DS Printer
To print the results of the most recently executed method, ensure there is
a check in the Enable Printer box and press Last Run Results.
To print the parameters of any of the stored methods, ensure there is a
check in the Enable Printer box and press Print Method. Select the
number that corresponds to the method to be printed. Available methods
have a name associated with them. Methods yet to be configured have a
series of dashes (------) in the name field.
To print the current 708-DS instrument settings, ensure there is a check
in the Enable Printer box and press Print Instrument Settings. All the
instrument configuration parameters and their current values are
documented on the printout.
3. Measurement of Physical Parameters
3.1. RPM, Wobble, Centering, Level, Verticality (Shaft and Vessel)
Periodic verification of certain physical parameters is critical for all dissolution
apparatus. Each laboratory has specific guidelines and procedures to follow that
detail the frequency of these measurements. The following sections will suggest
how to perform these steps with the 708-DS dissolution apparatus. The primary
tools used in these descriptions will be Agilent’s QA II Station and/or VK 5010.
Other similar calibrated devices may also be utilized.

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3.1.1. RPM / Wobble
To measure and record the RPM and Wobble, the All Position Spin
feature is enabled. This allows for the spindles to rotate while the drive
unit is in a raised position. Press Menu > Instrument from the Main
screen. To enable this function, place a check in the All Position Spin
box.
Figure 3-1. RPM and Wobble Measurement on a 708-DS
Raise the shaft to an appropriate level by pulling up on the shaft locking
collar of the vessel position to be measured. If necessary, the evaporation
covers may be lifted out of the way. To do this, raise the DDM alignment
shaft until the o-ring is inside the drive unit. This keeps the covers from
interfering with the RPM / Wobble measurement.
Place the QA II Station RPM / Wobble gauge (with the Ease Align adapter
attached) on the vessel rim. It is necessary to orient the gauge so that the
corner cutouts of the Ease Align adapter are positioned where the vessel
rim clips are. Attach the RPM clip to the shaft in front of the RPM sensor.
Place the pointer of the wobble gauge on the lower rim of the basket or
just above the paddle blade depending on the apparatus installed.
Activate the spindles at the desired RPM and record the values.
Spindle rotation may be initiated in a variety of ways including:
From the Main screen, press the RPM hotspot, enter the desired
spindle speed and press Ok.
From the Main screen, press Menu > Diagnostics. Touch
anywhere inside the RPM box, enter the desired spindle speed,
press Ok, and then press Run.

Agilent 708-DS Dissolution Apparatus
Training Manual
Revision A September 2010
P/N: xx-xxxx
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Move the RPM / Wobble gauge and repeat this procedure for all
applicable vessel positions for each spindle speed desired.
3.1.2. Centering
To verify the shaft of each active position of the apparatus is in the
“center” of each vessel, place the appropriate gauge on the shaft at the
desired vessel position. Locate the gauge on the shaft at the point where
centering is to be verified – ensure the gauge remains on the cylindrical
portion of the vessel.
Agilent’s VK 5010 can be utilized for this measurement and provides a
printout with the distance from the centerline (in mm). The Vessel
Centering Tool included with the 708-DS can be used for a quick “go / no-
go” verification with the help of the Ease Align adapter (QA II Station
accessory).
Move the centering gauge and repeat this procedure for all applicable
vessel positions.
3.1.3. Vessel Table Level
Adjustment of the vessel table level for the unit has been discussed in
Section 2.1.5. Verification of the level can be performed by placing a
digital or bubble level in the middle of the vessel plate.
If a non-quantitative level is used (e.g. torpedo level), the front-to-back
level, as well as the right-to-left level should be verified.
Figure 3-2. Level Verification - Torpedo Level