Agilent Technologies 708-DS User manual

Agilent Technologies
708-DS
Dissolution Apparatus
Operator’s Manual

708-DS Operator’s Manual
Notices
© Agilent Technologies, Inc. 2016
No part of this manual may be reproduced
in any form or by any means (including
electronic storage and retrieval or transla-
tion into a foreign language) without prior
agreement and written consent from Agi-
lent Technologies, Inc. as governed by
United States and international copyright
laws.
Manual Part Number
70-9058
Edition
Rev E, February 2016
Agilent Technologies, Inc.
3501 Stevens Creek Blvd.
Santa Clara, CA 95052 USA
Warranty
The material contained in this doc-
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subject to being changed, without
notice, in future editions. Further,
to the maximum extent permitted
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Safety Notices
CAUTION
A CAUTION notice denotes a
hazard. It calls attention to an
operating procedure, practice, or
the like that, if not correctly per-
formed or adhered to, could result
in damage to the product or loss
of important data. Do not proceed
beyond a CAUTION notice until
the indicated conditions are fully
understood and met.
WARNING
A WARNING notice denotes a
hazard. It calls attention to an
operating procedure, practice,
or the like that, if not correctly
performed or adhered to, could
result in personal injury or
death. Do not proceed beyond a
WARNING notice until the
indicated conditions are fully
understood and met.

708-DS Operator’s Manual 3
Contents
Figures 7
1Safety 11
Electrical Hazards 12
Warning 13
Caution 13
Note 13
Information Symbols 14
2 Introduction 15
Conventions Used in this Manual 17
Serial Number Format 18
3 Setting Up the 708-DS 19
Initial Setup 20
Unpacking Procedure 20
Environmental Requirements for Installation 22
Clearance 22
Equipment, Parts, and Accessories As Shipped 23
Parts and Accessories 23
Tubing / Cable Connections 24
708-DS Heater / Circulator Setup 24
Instrument Level / Water Bath Setup 25
Level Instrument 25
Bath Temperature Probe Installation 28
Handheld Probe Installation 29

4 708-DS Operator’s Manual
Contents
Power Cord Connections 29
708-DS Initial Power Up 29
Filling the Water Bath 30
Level Instrument - Re-verification 31
Heater / Circulator Power-up 31
Agilent 708-DS Setup 32
Vessel Installation 32
Sample Manifold Installation 32
Accessory Installation 36
Setting Basket (Apparatus 1) Heights 42
Setting Paddle (Apparatus 2) Heights 43
4 Operating the 708-DS 45
Main Screen - Options 46
Main Screen - Display Parameters 46
Main Screen - Sample Temperatures 47
Main Screen - Run 48
Main Screen - Stop 55
Main Screen - Drive Unit Up / Down 58
Manual Drive Unit Up / Down 58
Manual Sampling 59
Main Screen - Manifold Up / Down 60
Main Screen - Lock 61
Main Screen - Unlock 62
Main Screen - Remote Control 63
Main Screen - Alarms 64
Main Screen - Maintenance Due Icon 64
Menu Screen - System Menu 65
Menu Screen - Method Editor 66
Menu Screen - Reports 75
Menu Screen - Alarms 78
Menu Screen - Instrument 79

Contents
708-DS Operator’s Manual 5
Menu Screen - Calibration 84
Menu Screen - Diagnostics 87
Menu Screen - User Access 90
General 708-DS Conventions 91
Alphanumeric Data Entry 91
Numeric and Time / Date Entry 92
Parameter Limits / Ranges 93
Agilent 708-DS Notifications 95
Main Screen - Error Conditions 95
Dialog Screens (Green / Blue) 97
Warning Screens (Yellow) 99
Error Screens (Red) 103
5 Maintenance and Troubleshooting 107
Preventive Maintenance 108
Weekly Maintenance 108
Monthly Maintenance 108
Bi-Annual Maintenance 108
Sample Line / Paddle / Basket Care 109
Shafts 109
Baskets 110
Rinsing Sample Lines 111
Rinse Cups (Optional) 112
Vessels and Evaporation Covers 113
Water Bath and Temperature Probes 113
Water Bath Care 113
Water Bath Temperature Probe Accuracy Test 114
Removing or Adjusting Cannulas / Probes 116
Manifold Maintenance 116
Removing the Manifold 116

6 708-DS Operator’s Manual
Contents
Accessing the Top Cover 117
Removing Top Cover 117
Replacing the Top Cover 117
Printer Maintenance 118
Removing a Thermal Paper Roll 118
Inserting a Thermal Paper Roll (5095-0307) 121
Thermal Printer Test 124
Obtaining Warranty and Other Services 124

708-DS Operator’s Manual 7
Figures
Figure 1. Unpacking 20
Figure 2. Removing the Apparatus 21
Figure 3. BATH HEATER Connector 24
Figure 4. Levelers and Stability Feet 25
Figure 5. Level-Adjustment Screw Caps 26
Figure 6. Raising the Stability Feet 27
Figure 7. BATH TEMP Connector 28
Figure 8. Positioning the Temperature Probe 28
Figure 9. Filling the Water Bath 30
Figure 10. Positioning the Manifold for Installation 33
Figure 11. Connecting AutoTemp 34
Figure 12. Affixing the Fasteners 35
Figure 13. Proper Sample Tubing Position 36
Figure 14. Installing Evaporation Covers on Shafts 37
Figure 15. Shaft Locking Collars 37
Figure 16. Dosage Delivery Module and Alignment Post 38
Figure 17. Inserting DDM into DDM Alignment Shaft 39
Figure 18. Attaching DDM to Alignment Post 40
Figure 19. Accessory Installation 41
Figure 20. Tightening the Shaft Locking Collar 42
Figure 21. Inserting Height Spheres 43
Figure 22. Main Screen - Display Parameters 46
Figure 23. Sample Temperatures 47
Figure 24. Select Start Type 48
Figure 25. Select Method 49
Figure 26. Start Options 50
Figure 27. Manual Operation 52
Figure 28. Data Entry 53
Figure 29. Main Screen - Stop 55

8 708-DS Operator’s Manual
Figures
Figure 30. Pause Method 55
Figure 31. Method Paused 56
Figure 32. Pause Duration Alarm 57
Figure 33. Manual Lift Knob 58
Figure 34. Taking a Manual Sample 59
Figure 35. Agilent 708-DS Standard Evaporation Cover 60
Figure 36. Lock the Instrument 61
Figure 37. Unlock the Instrument 62
Figure 38. Remote Control 63
Figure 39. Alarm Time Expired 64
Figure 40. System Menu 65
Figure 41. Method Editor 66
Figure 42. Method Properties Screen 1 67
Figure 43. Method Properties Screen 2 68
Figure 44. Method Properties Screen 3 70
Figure 45. Method Properties Screen 4 72
Figure 46. Timepoint Properties 72
Figure 47. Are You Sure? 74
Figure 48. Reports 75
Figure 49. Select Method to Print 76
Figure 50. Reports 77
Figure 51. Alarms 78
Figure 52. Menu Screen - Instrument Settings Screen 1 79
Figure 53. Menu Screen - Instrument Settings Screen 2 81
Figure 54. Menu Screen - Instrument Settings Screen 3 82
Figure 55. Menu Screen - Instrument Settings Screen 4 83
Figure 56. Paddles/Baskets Sampling Depth 84
Figure 57. Regulatory Calibration Date 86
Figure 58. Diagnostics Screen 1 87
Figure 59. Menu Screen - Diagnostics Screen 2 89
Figure 60. User Level Settings 90
Figure 61. Data Entry 91
Figure 62. Time / Date Entry 92

708-DS Operator’s Manual 9
Figures
Figure 63. Main Screen with Red Error Conditions 95
Figure 64. Rinse Cup 112
Figure 65. Resistance Value of Temperature Probe 115
Figure 66. Near-empty Paper Roll 118
Figure 67. Accessing the Printer Handle 119
Figure 68. Open Printer Chamber 119
Figure 69. Removing the Thermal Paper Roll 120
Figure 70. Inserting a Thermal New Paper Roll 121
Figure 71. Leading Paper and Closing the Lid 122
Figure 72. Closing the Printer Chamber 122
Figure 73. Feeding Paper 123
Figure 74. Printer Test 124

10 708-DS Operator’s Manual
Figures
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11
Agilent Technologies
708-DS Dissolution Apparatus
Operator’s Manual
1
Safety
Electrical Hazards 12
The Agilent 708-DS has been designed and tested so that when used
properly you have an accurate, fast, flexible, and safe instrument.
If the equipment is used in a manner not specified by the manufacturer,
the protection provided by the equipment may be impaired.
Operation of an Agilent 708-DS involves the use of aqueous liquids and
various pharmaceutical dosage forms. Unskilled, improper, or careless
use of this instrument can create shock hazards, fire hazards, or other
hazards which can cause death, serious injury to personnel, or severe
damage to equipment and property.
Information on safety practices is provided with your instrument and
operation manuals. Before using your instrument or accessories, you
must thoroughly read these safety practices.
Observe all relevant safety practices at all times.

12 708-DS Operator’s Manual
1Safety
Electrical Hazards
The dissolution apparatus contains electrical circuits, devices, and
components operating at dangerous voltages. Contact with these
circuits, devices, and components can cause death, serious injury, or
painful electric shock.
Panels or covers that are retained by fasteners which require the use of a
tool for removal may be opened only by Agilent-trained,
Agilent-qualified, or Agilent-authorized service engineers. Consult the
manuals or product labels supplied with the dissolution apparatus to
determine which parts are operator-accessible.
Application of the wrong supply voltage, connection of the instrument
to an incorrectly wired supply outlet, or lack of proper electrical
grounding can create a fire hazard or a potentially serious shock hazard
and could seriously damage the instrument and any attached ancillary
equipment.
Always use a three-wire outlet with ground connection which is
adequately rated for the load. The installation must comply with local,
state, and federal safety regulations.
Do not connect the instrument to the main power supply until you have
made sure that the operating voltage is correctly set for the main power
supply in the specific outlet in your laboratory to which the equipment
will be connected.

Safety 1
708-DS Operator’s Manual 13
Warning
WARNING
A ‘Warning’ message appears in the manual when failure to observe
instructions or precautions could result in death or injury.
Read all warnings and cautions carefully and observe them at all times.
Caution
CAUTION
A ‘Caution’ message appears in the manual when failure to observe
instructions could result in damage to equipment (Agilent supplied and /
or other associated equipment).
Note
NOTE
A ‘Note’ appears in the manual to give advice or information.

14 708-DS Operator’s Manual
1Safety
Information Symbols
I Switches main power on
0 Switches main power off
Indicates single-phase alternating current
Indicates the product complies with the
requirements of one or more European Union
(EU) directives.
Indicates specific equipment meets standards of
safety. These products are safe for use in the
workplace for North America.
Indicates that this product must not be disposed
of as unsorted municipal waste.
All Agilent products that are subject to the
WEEE directive shipped after August 13, 2005
are compliant with the WEEE marking
requirements. Such products are marked with the
“crossed out wheelie bin” WEEE symbol in
accordance with European Standard EN 50419.
For more information on collection, reuse, and
recycling systems, please contact your
local/regional waste administration, your local
distributor, or Agilent.
Indicates the product complies with regulatory
compliance requirements of New Zealand and
Australia.

15
Agilent Technologies
708-DS Dissolution Apparatus
Operator’s Manual
2
Introduction
Conventions Used in this Manual 17
Serial Number Format 18

16 708-DS Operator’s Manual
2 Introduction
Agilent’s 708-DS Dissolution Apparatus is designed for dissolution
testing of a variety of pharmaceutical products, including tablets,
capsules, and transdermal patches. Interaction with the instrument is
simplified with an intuitive, color touchscreen interface. Temperature
control is achieved using traditional water bath vessel heating. This
apparatus can be tailored to support several innovative features designed
to allow unattended dissolution testing, including Dosage Delivery
Module (DDM), AutoTemp, and Auto Sampling.
WARNING
The dissolution apparatus contains electrical circuits, devices,
and components operating at dangerous voltages. Contact with
these circuits, devices and components can cause death, serious
injury, or painful electric shock.
CAUTION
Panels or covers that are retained by fasteners which require the use
of a tool for removal may be opened only by Agilent-trained,
Agilent-qualified, or Agilent-authorized service engineers

Introduction 2
708-DS Operator’s Manual 17
Conventions Used in this Manual
•Items you are asked to press are in bold. For example, “press H on
the keypad”.
•Key sequences you are asked to press appear like this: MENU >7.

18 708-DS Operator’s Manual
2 Introduction
Serial Number Format
The serial number contains 10 characters and follows this syntax:
CC1234xxxx
Syntax Code Meaning Description
CC Country of origin 2 alpha characters matching the required trade designation for
the country of origin
12 Year of manufacture ‘09’ for 2009, ‘10’ for 2010, etc.
34 Week of manufacture ‘01’ for week 1 to ‘52’ for week 52

19
Agilent Technologies
708-DS Dissolution Apparatus
Operator’s Manual
3
Setting Up the 708-DS
Initial Setup 20
Equipment, Parts, and Accessories As Shipped 23
Tubing / Cable Connections 24
Instrument Level / Water Bath Setup 25
Agilent 708-DS Setup 32

20 708-DS Operator’s Manual
3 Setting Up the 708-DS
Initial Setup
Complete the following sections to unpack the Agilent 708-DS and
ensure it is set up in an appropriate location.
Unpacking Procedure
Figure 1 Unpacking