Qiagen TissueLyser III User manual

Sample to Insight
May 2023
TissueLyser III Safety Instructions and
Quick-Start Guide

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TissueLyser III Safety Instructions and Quick Start Guide 05/2023
Contents
EN 3
Introduction ..................................................................................................... 3
Safety Information ............................................................................................ 3
Installation Procedures..................................................................................... 15
Reference ...................................................................................................... 19
DE 20
Einleitung ...................................................................................................... 20
Sicherheitshinweise......................................................................................... 20
Installationsverfahren ...................................................................................... 36
Referenzen .................................................................................................... 40
FR 41
Introduction ................................................................................................... 41
Informations de sécurité................................................................................... 41
Symboles sur le TissueLyser III .......................................................................... 54
Procédures d’installation.................................................................................. 56
Référence ...................................................................................................... 60
Document Revision History......................................................................................... 61

TissueLyser III Safety Instructions and Quick Start Guide 05/2023
3
EN
Introduction
Thank you for choosing the TissueLyser III system.
Before using the TissueLyser III, it is essential you read this quick-start guide carefully and pay
particular attention to the safety information. The instructions and safety information in this
guide must be followed to ensure safe operation of the TissueLyser III and to maintain the
TissueLyser III in a safe condition. For more detailed information and instructions, visit the
product page of the TissueLyser III on qiagen.com and download the
TissueLyser III
User Manual
.
Safety Information
This instrument is intended for professional use.
The TissueLyser III is to be used only by personnel specifically instructed and trained in biology
laboratory techniques and familiar with this technology.
Before using the TissueLyser III, it is essential that you read this quick-start guide carefully. The
instructions and safety information in the quick-start guide must be followed to ensure safe
operation of the instrument and to maintain the instrument in a safe condition.

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TissueLyser III Safety Instructions and Quick Start Guide 05/2023
The following types of safety information appear throughout the TissueLyser III Safety
Instructions and Quick Start Guide
.
WARNING
The term WARNING is used to inform you about situations that could
result in personal injury to you or others.
Details about these circumstances are given in a box like this one.
CAUTION
The term CAUTION is used to inform you about situations that could
result in damage to an instrument or other equipment.
Details about these circumstances are given in a box like this one.
The guidance provided in this guide is intended to supplement, not supersede, the normal
safety requirements prevailing in the user’s country.
Please be aware that you may be required to consult your local regulations for reporting
serious incidents that have occurred in relation to the device to the manufacturer and/or its
authorized representative (only applicable for CE-marked devices with an authorized
representative established in the EU) and the regulatory authority in which the user and/or the
patient is established.

TissueLyser III Safety Instructions and Quick Start Guide 05/2023
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Proper use
WARNING
Risk of personal injury and material damage
Improper use of the TissueLyser III may cause personal injuries or
damage to the instrument. Do not attempt to move the TissueLyser III
during operation.
The TissueLyser III should only be operated by qualified personnel
who have been appropriately trained.
Servicing of the TissueLyser III should only be performed by
QIAGEN®or an authorized agent (service technicians). Do not carry
out any modifications of the instrument.
QIAGEN shall not be held responsible for any injuries or damages
resulting from nonobservance of the instructions and safety
information in this guide.
WARNING
The sound level may be high depending on the type of material, the
number of balls used, the set grinding frequency, and the grinding
time. Excess noise in terms of intensity and duration can lead to
impairments or permanent damage to hearing. Wear hearing
protection.
Excess noise can also lead to acoustic warning signals of other
instruments not being heard. Add visual signals if necessary.
CAUTION
Damage to the instrument
Use of adapters and plasticware other than those described in the
TissueLyser III User Manual may lead to damage to the clamps of the
TissueLyser III.

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TissueLyser III Safety Instructions and Quick Start Guide 05/2023
CAUTION
Damage to the instrument
Avoid spilling water or chemicals onto the TissueLyser III. Damage
caused by water or chemical spillage will void your warranty.
CAUTION
Damage to the instrument
Operation of the TissueLyser III with the transport security device
installed, or transport of the TissueLyser III without the transport
security device installed, can lead to damage to the mechanical
components of the instrument.
CAUTION
Damage to the instrument
Operation of the TissueLyser III at a temperature and humidity outside
the range specified may lead to damage to its electronic and
mechanica
l components as well as a reduction in instrument
performance.
WARNING
Risk of personal injury and material damage through falling of the
instrument
Improper handling of the TissueLyser III during transport and
installation can lead to user injury. Particularly when lifting the
instrument above head height, the instrument can fall and lead to
serious injury.
Do not transport the instrument alone. Transport the instrument close
to the floor and avoid lifting above the head.
Install the instrument on a sufficiently large, solid, and stable surface
that is protected against oscillations. Ensure that all instrument feet
are sitting stably and evenly on the surface.

TissueLyser III Safety Instructions and Quick Start Guide 05/2023
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Electrical safety
WARNING
Electrical hazard
Any interruption of the protective conductor (earth/ground lead)
inside or outside the TissueLyser III or disconnection of the protective
conductor terminal is likely to make the TissueLyser III dangerous.
Intentional interruption is prohibited.
Take note of the values for voltage and frequency on the TissueLyser
III type plate and only connect the TissueLyser III to a fitting power
grid.
Only connect the TissueLyser III to the power grid with the enclosed
power cable and to a power outlet with protective conductor
(earth/ground).
Before each usage, check the power cord and the plug for damage.
Never use the instrument with damaged power cord or plug.
Lethal voltages inside the TissueLyser III.
When the TissueLyser III is connected to line power, terminals may
be live and opening the TissueLyser III or removing parts is likely to
expose live parts.
Install the instrument in a way that allows easy access to the power
cord connector and the power switch.
To ensure satisfactory and safe operation of the TissueLyser III, follow the advice below:
The line power cord must be connected to a line power outlet that has a protective
conductor (earth/ground).
Do not adjust or replace internal parts of the TissueLyser III.
Do not operate the TissueLyser III with any covers or parts removed.
If liquid has spilled inside the TissueLyser III, switch off the TissueLyser III, disconnect it
from the power outlet, and contact QIAGEN Technical Services.

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TissueLyser III Safety Instructions and Quick Start Guide 05/2023
If the TissueLyser III becomes electrically unsafe, prevent other personnel from operating
it, and contact QIAGEN Technical Services; the TissueLyser III may be electrically unsafe
when:
It or the line power cord appears to be damaged.
It has been stored under unfavorable conditions for a prolonged period.
It has been subjected to severe transport stresses.
If the TissueLyser III is not in use, switch it off at the power switch. If the TissueLyser III will not
be used for a prolonged period of time, unplug the power cord from the power outlet.
Environment
WARNING
Explosive atmosphere
The TissueLyser III is not designed for use in an explosive atmosphere.
WARNING
Risk of explosion
The TissueLyser III is intended for use with reagents and substances
supplied with QIAGEN kits. Use of other reagents and substances
may lead to fire or explosion.
CAUTION
Damage to the instrument
Direct sunlight may bleach parts of the instrument and cause damage
to plastic parts. The TissueLyser III must be located out of direct
sunlight.

TissueLyser III Safety Instructions and Quick Start Guide 05/2023
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Biological safety
Specimens and reagents containing materials from humans or animals should be treated as
potentially infectious. Use safe laboratory procedures as outlined in publications such as
Biosafety in Microbiological and Biomedical Laboratories , CDC (1).
Samples
Samples may contain infectious agents. You should be aware of the health hazard presented
by such agents and should use, store, and dispose of such samples according to the required
safety regulations.
WARNING
Samples containing infectious agents
Some samples used with the TissueLyser III may contain infectious
agents. Handle such samples with the greatest of care and in
accordance with the required safety regulations.
Always wear safety glasses, 2 pairs of gloves, and a lab coat.
The responsible body (e.g., laboratory manager) must take the
necessary precautions to ensure that the surrounding workplace is
safe and that TissueLyser III operators are suitably trained and not
exposed to hazardous levels of infectious agents as defined in the
applicable Safety Data Sheets (SDSs) or OSHA,* ACGIH,†or
COSHH‡documents.
Venting for fumes and disposal of wastes must be in accordance with
all national, state, and local health and safety regulations and laws.
* OSHA: Occupational Safety and Health Administration (United States of America).
†ACGIH: American Conference of Government Industrial Hygienists (United States of America).
‡COSHH: Control of Substances Hazardous to Health (United Kingdom).

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TissueLyser III Safety Instructions and Quick Start Guide 05/2023
Chemicals
WARNING
Hazardous chemicals
Some chemicals used with the TissueLyser III may be hazardous or
may become hazardous after completion of the sample disruption
process.
Always wear safety glasses, gloves, and a lab coat.
The
responsible body (e.g., laboratory manager) must take the
necessary precautions to ensure that the surrounding workplace is
safe and that TissueLyser III operators are not exposed to hazardous
levels of toxic substances (chemical or biological) as defined in the
applicable Safety Data Sheets (SDSs) or OSHA,* ACGIH,†or
COSHH‡documents.
Venting for fumes and disposal of wastes must be in accordance with
all national, state, and local health and safety regulations and laws.
* OSHA: Occupational Safety and Health Administration (United States of America).
†ACGIH: American Conference of Government Industrial Hygienists (United States of America).
‡COSHH: Control of Substances Hazardous to Health (United Kingdom).