Thermo Scientific thermoscientific HyPerforma Smartainer 3.0 User manual

HyPerforma Smartainer 3.0
User’s Guide
DOC0059 • Revision A
May 2020

Thermo Scientific
Contents
Warnings, safety, and warranty information 1
How to use this guide 6
Chapter 1 Smartainer 3.0 overview 7
1.1 Introduction to the Smartainer 3.0 7
1.2 BPC options 7
1.3 System components 7
Chapter 2 Hardware setup 10
2.1 Site preparation 10
2.2 Moving and stacking the Smartainer 3.0 10
2.2.1 Unlocking and locking load cells 10
2.2.2 Moving the Smartainer 3.0 16
2.2.3 Stacking Smartainer 3.0 units 17
Chapter 3 Operating information 18
3.1 Opening and closing the door (500 L units and larger) 18
3.2 Opening and closing the lid with dual-action gas
spring lever 19
3.3 Installing the port holder on the BPC 20
3.4 Using the BPC hoist and unfolding the BPC (for
500 L– 3,000 L systems) 22
3.5 Inserting the RTD 25
3.6 Filling the BPC 25
3.7 Dispensing 27
3.8 Removing the BPC 27
Chapter 4 Maintenance 29
Chapter 5 Temperature validation 30
Chapter 6 Specifications and parts information 46
6.1 Hardware features and dimensions 46
6.1.1 200 L Smartainer 3.0 design features 46
6.1.2 500 L and 1,000 L Smartainer 3.0 design features 47
6.1.3 1,500 L– 3,000 L Smartainer 3.0 design features 48

Thermo Scientific
6.2 Smartainer 3.0 specifications 49
6.3 Part numbers 56
Chapter 7 General ordering information 58
7.1 Ordering instructions 58
7.2 Ordering and support contact information 58
7.3 Technical support 59

Warnings, safety, and warranty information
Thermo Scientific
Warnings, safety, and warranty
information
Thank you for purchasing the Thermo Scientific™HyPerforma™
Smartainer™3.0. Each of our products is designed and manufactured
according to our high standards. We have included safety information
in this guide, based on our knowledge and experience. It is important,
however, for you to work with your safety management personnel to
ensure that this equipment is integrated into your safety practices.
Please take some time to perform your own job safety analysis in order
to identify and control each potential hazard.
WARNING: Read and understand this user’s guide before
operating the equipment.
Read and understand this user’s guide before operating the Smartainer
3.0. Failure to do so could result in personal injury or damage to the
system.
WARNING: Hazardous voltage inside.
If equipped, the load cell display and temperature display have
electrical components, and there is a risk of electrical shock
and injury. Disconnect power before opening electrical components.
Service should be performed only by Thermo Fisher Scientific service
personnel. We recommend using standard lockout procedures when
working on electrical components.
WARNING: Static electricity may build up in BPCs.
• BioProcess Containers (BPCs) may act as insulators for
electrostatic charge. If electrostatic charge is transferred to a BPC,
the charge may be stored in the BPC and/or the product inside.
This phenomena varies by product and use; therefore, it is the sole
responsibility of the end user to ensure a hazard assessment is
conducted and the risk of electrostatic shock is eliminated.
• Where applicable, a product contact stainless steel coupler may be
grounded to the frame to dissipate electrostatic build up from the
material within a BPC. It is good practice to dissipate electrostatic
buildup by grounding all BPCs prior to coming in contact with them.
When working with BPCs, the use of nonconductive materials, such
as nonconductive gloves, is recommended.
HyPerforma Smartainer 3.0 User’s Guide | 1

Thermo Scientific
Warnings, safety, and warranty information
WARNING: Use appropriately-rated equipment and qualified
operators for lifting and moving the Smartainer 3.0.
The use of unsuitable equipment or procedures can cause damage to
property, in addition to personal injury or death.
WARNING: Potential confined space.
Operators may enter larger Smartainer 3.0 units. Evaluate this
equipment against your confined space standards and procedures.
WARNING: Do not drill, cut, weld, or otherwise apply high heat
to the Smartainer 3.0.
Doing so can weaken the structure, resulting in damage to property, in
addition to personal injury or death.
WARNING: Burst hazard—air under pressure.
The BPC chamber is under slight pressure under normal operating
conditions. Normal passive venting prevents any excess of pressure
building up within the chamber. Chamber pressure and inlet line
pressure should be monitored for proper settings.
• BPC pressure should not exceed 0.03 bar (0.5 psi).
• Inlet BPC pressure should not exceed 0.34 bar (5 psi).
WARNING: Use ladders and elevated platforms with caution.
A few operations, such as adjusting a BPC during filling into a large
Smartainer, may require the use of a ladder or platform. Before use,
ensure the ladder has been inspected and weight-rated for its user.
When using a ladder or platform, be sure it is stable, maintain three
points of contact, and make sure the steps are clean.
WARNING: Pinch hazard.
The Smartainer hoist can be manually raised and lowered. Caution
should be used to avoid pinching an operator or causing damage to
the equipment or the BPC.
WARNING: Hot surface—do not touch.
The heating jacket is designed to heat the inner vessel wall. Normal
operating conditions generate heat and could create hot surfaces.
• Hot surface inside.
• Contact with surfaces may cause burns.
• Do not touch while in operation.
HyPerforma Smartainer 3.0 User’s Guide | 2

Thermo Scientific
Warnings, safety, and warranty information
WARNING: The Thermo Scientific HyPerforma Smartainer 3.0
may not be installed in a potentially explosive atmosphere as
set forth in the applicable EU ATEX Directive.
It is the responsibility of the end user to review and understand the
potential dangers listed in the ATEX 2014/34/EU guidelines.
Jacketed vessel information
The Smartainer hardware unit with jacket has been designed to be
operated, with temperatures not exceeding 50°C (122°F) under less
than 150 psig (1 MPa) operating pressure. For the utmost safety it is
recommended that the Smartainer 3.0 jacket be operated at 75 psig or
less.
Note: The Smartainer BPC operating limits for temperature are 5°C
to 40°C. The internal pressure should not exceed 0.5 psi. The water
jacket is not required to be registered, inspected and stamped with the
Code U symbol per section U-1(c)2(f) of the ASME Boiler and Pressure
Vessel Code and/or European Pressure Equipment Directive (PED)
97/23/EC. Upon request, a Declaration of Conformity, PED Sound
Engineering Practices can be made available.
Protective earth grounding
Protective earth grounding must be verified prior to plugging the
Smartainer into any electrical outlet. Ensure the receptacle is properly
earth grounded.
Environmental conditions
• Operating: 17°C to 27°C; 20% to 80% relative humidity, non-
condensing
• Storage: -25°C to 65°C
• Altitude limit: 2,000 meters
Warranty information
Any warranties, if applicable, covering this equipment exclude: (a)
normal wear and tear; (b) accident, disaster or event of force majeure;
(c) your misuse, fault or negligence; (d) use of the equipment in a
manner for which it was not designed; (e) causes external to the
equipment such as, but not limited to, external puncturing, power
failure or electrical power surges; (f) improper storage and handling of
the equipment; (g) use of the equipment in combination with equipment
or software that we did not supply; (h) equipment sold to you as ‘used’
products; (i) contact with improperly used or unapproved chemicals
HyPerforma Smartainer 3.0 User’s Guide | 3

Thermo Scientific
or samples; (j) installation, removal, use, maintenance, storage, or
handling in an improper, inadequate, or unapproved manner, such as,
but not limited to, failure to follow the documentation or instructions
in the deliverables or related to the equipment, operation outside of
stated environmental or other operational specifications, or operation
with unapproved software, materials or other products; (k) not
operating the equipment according to our operation and maintenance
guide; (l) installation of software or interfacing or use of the equipment
in combination with software or products we have not approved; (m)
the performance, efficacy or compatibility of specified components;
and (n) the performance of custom equipment or products or specified
components or achievement of any results from the equipment,
specified components or services within ranges desired by you
even if those ranges are communicated to us and are described in
specifications, a quote, or a statement of work.
ADDITIONALLY, ANY INSTALLATION, MAINTENANCE, REPAIR,
SERVICE, RELOCATION OR ALTERATION TO OR OF, OR
OTHER TAMPERING WITH, THE EQUIPMENT PERFORMED BY
ANY PERSON OR ENTITY OTHER THAN US WITHOUT OUR
PRIOR WRITTEN APPROVAL, OR ANY USE OF REPLACEMENT
PARTS WE HAVE NOT SUPPLIED, WILL IMMEDIATELY VOID
AND CANCEL ALL WARRANTIES WITH RESPECT TO THE
AFFECTED EQUIPMENT. IF THE EQUIPMENT IS TO BE USED
IN THE UNITED STATES, WE MAY VOID YOUR WARRANTY IF
YOU SHIP THE EQUIPMENT OUTSIDE OF THE UNITED STATES.
WE DO NOT WARRANTY OR GUARANTEE THAT THE USE OF
THE EQUIPMENT WILL MEET ANY PARTICULAR REGULATORY
REQUIREMENTS, AND WE DO NOT INTEND FOR THE
EQUIPMENT DOCUMENTATION TO BE USED IN SUPPORT OF
YOUR REGULATORY APPROVALS.
Use restrictions
You must use this equipment in accordance with our documentation
and if applicable, with our other associated instructions, including
without limitation, a “research use only” product label or “limited use”
label license. This equipment is intended for research use or further
manufacturing in bioprocessing applications and not for diagnostic
use or direct administration into humans or animals, we do not submit
the equipment for regulatory review by any governmental body or
other organization, and we do not validate the equipment for clinical or
diagnostic use, for safety and effectiveness, or for any other specific
use or application.
Warnings, safety, and warranty information
HyPerforma Smartainer 3.0 User’s Guide | 4

Thermo Scientific
Warnings, safety, and warranty information
HyPerforma Smartainer 3.0 User’s Guide | 5
Seismic guidance
The buyer of the equipment is responsible for ensuring that country-
specific codes and seismic values are assessed for suitability of
equipment installation and safety at the designated site. In addition,
it is the buyer’s responsibility to assess the building structure for
the designated equipment to ensure correct seismic anchoring and
tethering designs for both the equipment and facility. It is highly
recommended that the buyer consult with a local, licensed third party
architecture and engineering firm to provide the buyer with correct
engineering analysis and stamped documentation prior to equipment
installation at the facility. In addition, the buyer will be responsible for
rigging and anchoring of the equipment to a specified, fixed location.
Upon request, Thermo Fisher Scientific can assist with establishing
compliant seismic anchoring and tethering designs for purchased
equipment based on building and country codes, at an agreed upon
fee.
It is also noted that movable equipment (i.e. non-fixed or caster mount)
is exempt from seismic design requirements according to ASCE
7-16, Chapter 13, section 1.4. Although these units are exempt from
the seismic design requirements of ASCE 7, it should be noted that
such equipment is susceptible to overturning during a seismic event.
Therefore, it is the responsibility of the buyer to address seismic safety
for movable equipment at the designated facility.

Thermo Scientific
How to use this guide
How to use this guide
Scope of this publication
This user’s guide contains information about the Thermo Scientific™
HyPerforma™Smartainer™3.0. It is intended for use by people who
may or may not have experience with Thermo Scientific systems.
Document change information
Revision Date Section Change made Author
A05/2020 -- Initial release E. Hale
Questions about this publication
If you have any questions or concerns about the content of this
publication, please contact technicaldocumentation@thermofisher.
com and your Thermo Fisher Scientific sales team.
Related publications
Please contact your local sales representative for information about the
related publications listed below.
HyPerforma Smartainer 3.0 User’s Guide | 6
Publication Description
Smartainer 3.0 Unpacking Guide (DOC0073) Instructions for unpacking the
Smartainer unit
BioProcess Container Unpacking and
Inspection Guide (DOC0021)
Instructions for unpacking and inspecting
standard BioProcess Containers
Abbreviations/acronyms
Refer to the list below for definitions of the abbrieviations and acronyms
used in this publication.
BPC BioProcess Container
RTD Resistance temperature detector
TCU Temperature control unit

Thermo Scientific
Chapter 1 | Smartainer 3.0 overview
Smartainer 3.0 overview
1.1 Introduction to the Smartainer 3.0
The HyPerforma Smartainer 3.0 system is a durable stainless steel
container used for in-house, large-volume liquid handling operations.
Some of the key features of the Smartainer 3.0 include:
• 304 or 316 Stainless steel construction
• Design that allows bottom draining from BioProcess Containers
(BPCs)
• Modular system with optional accessories for mobility and BPC
handling
• Jacketed or non-jacketed versions available in unit volumes of
200 L, 500 L, 1,000 L, 1,500 L, 2,000 L, 2,500 L, and 3,000 L
1.2 BPC options
Catalog BPC configurations for the Smartainer 3.0 are available in unit
volumes of 200 L, 500 L, 1,000 L, 1,500 L, 2,000 L, 2,500 L, and
3,000 L. Standard and custom BPCs are available in CX5-14,
Aegis5-14, and ASI 26/77 films.
1.3 System components
Figure 1.1 and the numbered list on the following page detail the
system components of the Smartainer 3.0. Note: Figure 1.1 does not
show the optional temperature display. The temperature display will
be mounted on the opposite top corner from the load cell display (see
Figure 1.2 later in this section).
1
HyPerforma Smartainer 3.0 User’s Guide | 7

Thermo Scientific
Chapter 1 | Smartainer 3.0 overview
HyPerforma Smartainer 3.0 User’s Guide | 8
1. Lid (optional)—manual or assisted, with insulation
2. Load cell display
3. Manual BPC hoist handle (optional)—aids the operator in
handling and loading BPCs into the unit
4. Jacketed or non-jacketed Smartainer unit—supports the BPC
5. Handle—helps move the Smartainer 3.0 when empty over level
surfaces, for short distances
6. Document holder
7. Door handle
8. Port holder covers (2)
9. Forklift locations (2)
10. RTD port cutout
11. Jacket inlet/outlet ports (2)
12. Tray assembly (optional)—holds dispense pumps, tube welders,
and other items for easy access
13. Cart (optional)—helps move the Smartainer 3.0 when empty over
level surfaces, for short distances
14. Load cells (4)
Figure 1.1. Smartainer 3.0 components shown on 500 L system.
3
7
8
9
12
13
11
10
6
5
2
1
4
14

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Chapter 1 | Smartainer 3.0 overview
HyPerforma Smartainer 3.0 User’s Guide | 9
Load cells
Load cells are used to determine the weight of the contents of the
Smartainer 3.0 unit. The load cell kit includes four load cells, summing
block, wiring, and a display screen with a choice of several data
interfaces.
Several load cell display options are available for use on the Smartainer
3.0, and have the following features:
• Modular design with multiple mounting methods
• Powered by 85–264 VAC
• Support multiple PLC interfaces (4-20 mA analog output, ethernet/
IP, Profibus DP, DeviceNet, Allen Bradley RIO, Modbus TCP)
• Front panel key access to basic weighing functions
• Selectable unit of measure
Temperature display
The temperature display (Figure 1.2) features a variable intensity
display, four setpoint alarm outputs (with option card), communication
and bus capabilities (with option card), and NEMA 4X/IP65 sealed front
bezel. It is powered by 85–264 VAC.
Figure 1.2. Mounted temperature
display.

Thermo Scientific
Chapter 2 | Hardware setup 2
HyPerforma Smartainer 3.0 User’s Guide | 10
Hardware setup
2.1 Site preparation
Prior to setting up the Smartainer 3.0, ensure that all installation
procedures comply with local codes. Ensure that the site where the
Smartainer 3.0 will be filled is large enough to allow:
• At least 1.6 m (5 ft.) of frontal clearance for inserting and removing
the BPC.
• At least 1 m (3 ft.) of clearance on both the left and right sides to
enable a stepladder to access the BPC from the top, as applicable.
• Sufficient space to accommodate ancillary equipment.
• Clear access to the top of the Smartainer 3.0 unit, allowing full
extension of the Smartainer 3.0 lid. Note: See section 6.2 of this
guide for height specifications for each vessel size.
The floor must be level and able to support the full weight of the loaded
unit. Ensure that an electrical power source for accessories is nearby.
2.2 Moving and stacking the Smartainer 3.0
All Smartainer 3.0 units should only be transported when empty. See
the following sections for instructions on unlocking load cells (required
after uncrating), locking load cells (required if moving the system),
moving the unit, and stacking multiple units.
2.2.1 Unlocking and locking load cells
For Smartainer 3.0 units containing load cells, the load cells must be in
the locked position (centering washer and nut are threaded up) prior to
moving the system. For this reason, the Smartainer 3.0 is shipped

Thermo Scientific
Chapter 2 | Hardware setup
with the load cells in the locked position. A 24 mm (15/16 in.) open-end
wrench is recommended for unlocking the load cells on units with the
cart assembly. Units that are floor-mounted require the Mettler Toledo™
load cell unlocking kit (not provided; Mettler Toledo part number:
30219938) and two small adjustable wrenches.
Refer to Figure 2.1 and the following steps to unlock the load cells for
mobile units (on the optional cart).
CAUTION: Do not move the unit while the load cells are unlocked, as
this can damage the load cells.
HyPerforma Smartainer 3.0 User’s Guide | 11
1. Unlock the tri-clamp and use an open-end wrench (not supplied) to
begin loosening the bolt.
2. Continue loosening the bolt until you see a gap between the bolt
and the load cell.
If the Smartainer 3.0 unit needs to be moved, the load cells must be
locked again before transport. Use the following steps to lock load
cells for mobile units.
Figure 2.1. Components of load cells for mobile units.
Tri-clamp
Bolt
Load cell

Thermo Scientific
Chapter 2 | Hardware setup
HyPerforma Smartainer 3.0 User’s Guide | 12
1. Use an open-end wrench to tighten the bolt (Figure 2.2). Once
it begins to feel tight, tighten another 1/4-turn to ensure it is fully
tightened.
Figure 2.2. Tightening the bolt.
2. Reattach the tri-clamp and turn the clamp key clockwise to close
(Figure 2.3).
Refer to Figures 2.4–2.8 and the following steps to unlock the load
cells for stationary units.
Figure 2.3. Reattaching tri-clamp to close it.

Figure 2.4. Drawing of load cells for stationary units.
Bolt
Thermo Scientific
Chapter 2 | Hardware setup
HyPerforma Smartainer 3.0 User’s Guide | 13
CAUTION: Do not move the unit while the load cells are unlocked, as
this can damage the load cells.
Stationary units are shipped with three red plastic components locking
the load cells in place: one large locking plate, and two small centering
spacers. Use the below steps to remove these plastic pieces after
initially uncrating the unit.
1. Use an adjustable wrench (not provided; example shown in Figure
2.7) to loosen the bolt.
2. Once the bolt is loosened enough, remove the bolt, followed by
the two red plastic centering spacers (Figure 2.5). Then replace the
bolt; do not re-tighten yet.
Figure 2.5. Removing one of two centering
spacers (only required after initial uncrating).
3. Prior to inserting the screw jack (from load cell unlocking kit,
Mettler Toledo part #30219938), ensure that the bottom bolt on the
load cells is fastened tightly. Then insert the small screw jack at the
top of the bolt (Figure 2.6).

Thermo Scientific
Chapter 2 | Hardware setup
4. After inserting the screw jack, use an adjustable wrench to raise
the screw jack by turning clockwise (Figure 2.7).
HyPerforma Smartainer 3.0 User’s Guide | 14
Figure 2.6. Inserting small screw jack at top
of bolt (only required after initial uncrating).
5. Once it is raised enough, remove the large plastic locking plate
(Figure 2.8).
Figure 2.7. Using adjustable wrench to raise jack (only required after initial uncrating).

Thermo Scientific
Chapter 2 | Hardware setup
HyPerforma Smartainer 3.0 User’s Guide | 15
If the Smartainer 3.0 unit needs to be moved, the load cells must be
locked again before transport. To lock load cells for stationary units,
use the following steps.
1. Place the solid steel plate (included in the load cell unlocking
kit, Mettler Toledo part #30219938) in the former location of the
large plastic locking plate (Figure 2.9). To lower the bolt, use an
adjustable wrench to turn the bolt counter-clockwise. This will
close the screw jack.
Figure 2.8. Removing large locking plate (only
required after initial uncrating).
2. Replace the plastic centering spacers with the stainless steel
spacers (included in the load cell unlocking kit, Mettler Toledo part
#30219938). Use an adjustable wrench to tighten the bolt (Figure
2.10). Once it begins to feel tight, tighten another 1/4 turn to ensure
it is fully tightened. Both centering spacers should be below the
bolt when tightened.
Figure 2.9. Replacing red plastic locking plate
with stainless steel plate.

Thermo Scientific
Chapter 2 | Hardware setup
HyPerforma Smartainer 3.0 User’s Guide | 16
2.2.2 Moving the Smartainer 3.0
For convenient transport of the Smartainer 3.0, four casters may be
attached to the base in units 1,000 L and smaller. Use the following
steps to move Smartainer 3.0 units on casters.
1. Ensure that the load cells are locked out (see previous section).
2. Release the caster brakes found on the mounting brackets of the
casters by moving them to the Up (released) position.
3. Carefully apply even pressure to the Smartainer 3.0 to roll it to the
new desired location. Use the handle where applicable.
4. Once in position, ensure that all caster brakes have been reset to
the Down (locked) position.
5. The load cells can now be unlocked.
If lifting is required, use a forklift to move the Smartainer 3.0 unit. See
the Smartainer 3.0 drawings for information on weights in order to
select an appropriate forklift. To lift the Smartainer 3.0, ensure that
the forklift tines are sufficiently long and spaced far enough apart for
stability. Forklift tines should be placed in the forklift hole locations on
the unit (Figure 2.11) and spaced as close to the casters or stationary
feet as possible.
Figure 2.10. Using a wrench to tighten the
bolt.

Thermo Scientific
Chapter 2 | Hardware setup
HyPerforma Smartainer 3.0 User’s Guide | 17
Figure 2.11. Forklift tines inserted in cutouts.
2.2.3 Stacking Smartainer 3.0 units
Some Smartainer 3.0 units can be stacked on top of each other.
CAUTION: Units can only be stacked on top of fixed Smartainer
3.0 units that are properly attached to the floor. Proper hardware
should be used as recommended per site to attach the units to each
other.
The 200 L and 500 L units can be stacked up to three units high, and
the 1,000 L unit can be stacked up to two units high. Units 1,500 L
and larger cannot be stacked.