Milestone ultraWAVE 3 User manual

ultraWAVE 3
Operator Manual
MA245
MILESTONE
HELPING
CHEMISTS

Milestone Srl MA245-003 –ultraWAVE 3 –User Manual
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Thank you for selecting our microwave system.
We are sure that you will be completely satisfied with the performance of this new unit entering your
laboratory. We invite you to carefully read this user manual and to keep it in reach for convenient and
fast consulting. The person who will be using this unit should have received an appropriate training from
a Milestone trained technician. For any possible clarification or any request for assistance please contact
either our Representative in your country:
or Milestone at the following address:
Milestone Srl
Via Fatebenefratelli, 1/5
24010 Sorisole (BG) Italy
Tel [phone]
Fax [phone]
Website www.milestonesrl.com
E-mail [email protected]
The instruments commercialized by Milestone are intended for the use in strict compliance with
all applicable laws and in a manner that promotes public safety and/or linked to approved
scientific or medical research purposes.
Milestone does not endorse, encourage or promote the use of its instruments for any illegal
activities.
No liability for any consequences, direct or indirect, is accepted if the ultraWAVE 3 is used in
any way in which the instrument is not intended to be used.
Pubblication date (dd/mm/yyyy) 27/09/2023

Milestone Srl MA245-003 –ultraWAVE 3 –User Manual
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1QUICK START - START USING YOUR
ULTRAWAVE 3.........................................................9
Switch on and login............................................................9
Closing and starting of the system ......................................9
Set a Program ................................................................. 10
Pressure load................................................................... 11
Open the system ............................................................. 12
Maintenance after each run .............................................. 13
2WARNING FOR SAFE OPERATION OF
MILESTONE MICROWAVE UNITS..........................14
Symbols used in this manual ............................................ 14
Do not use the system unattended ................................... 14
High temperature - long reaction times ............................. 14
Type of materials............................................................. 14
Type of reagents ............................................................. 14
Metal parts ...................................................................... 14
Cleaning.......................................................................... 15
Service............................................................................ 15
Safety ............................................................................. 15
Basic rules of microwave chemistry................................... 16
ultraWAVE 3 –chemistry guidelines .................................. 17
3SAFETY RULES...............................................18
General Information......................................................... 18
Safety Rules for Start-up .................................................. 18
Safety in operation........................................................... 18
Safety in Service Operation .............................................. 18
No Manipulations of the unit allowed................................. 19

Milestone Srl MA245-003 –ultraWAVE 3 –User Manual
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Replacement of Parts ....................................................... 19
Other Hints...................................................................... 19
Safety of operation.................................................................................. 19
Pressure Parts ........................................................................................ 20
Observance of safety regulations.............................................................. 21
Placement and movement of the unit........................................................ 21
Definition of personnel skills and capabilities ............................................. 21
How to operate with the unit ............................................ 21
Operate according to Milestone Applications.............................................. 21
Synthesis of liquids.................................................................................. 21
Digestions with aggressive Chemicals e.g. acids, caustic solutions, etc......... 21
Do not use gas phase digestion applications.............................................. 22
Base load and gas loading pressure.......................................................... 22
Aggressive Media .................................................................................... 22
Pre-loading Pressure ............................................................................... 22
Spontaneous reactions ............................................................................ 22
Pressure line........................................................................................... 22
Care and Maintenance............................................................................. 23
4DESCRIPTION OF THE SYSTEM .....................24
Unpacking/Check-list........................................................ 24
Installation site ................................................................ 24
Technical Specifications.................................................... 24
Unit ....................................................................................................... 24
Pressure Vessel....................................................................................... 25
Cooling water ......................................................................................... 26
Instrument Sensors................................................................................. 26
Proximity sensors for lifting system........................................................... 26
General Information ................................................................................ 27
Microwave Heating.................................................................................. 27
Description of the ultraWAVE 3 ports and connections ....... 28
Front view .............................................................................................. 28
Operating elements and connections on the back panel ............................. 29
Exhaust system....................................................................................... 30
Emergency vent valve ............................................................................. 30
UltraWAVE 3 built in touch screen terminal........................ 31
Description ............................................................................................. 31
easyCONTROL ........................................................................................ 31

Milestone Srl MA245-003 –ultraWAVE 3 –User Manual
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Transfer of Settings between Terminal and Interface ................................. 32
5SENSORS AND ACCESSORIES .......................34
Temperature Sensors ....................................................... 34
Pressure sensor ............................................................... 34
Overpressure protection .......................................................................... 34
Position Sensors .............................................................. 34
Recirculation water chiller................................................. 34
Recirculation water chiller installation ....................................................... 35
Gas filter ......................................................................... 36
6PRESSURE LINE INSTALLATION ...................38
Connection of ultraWAVE 3 to the Nitrogen or Argon gas line
38
Direct connection to the gas cylinder................................. 38
Pneumatic Booster (Optional) ........................................... 41
Installation of the Pneumatic booster (optional)......................................... 42
Setup of the pneumatic booster ............................................................... 44
High pressure compressor (Optional) ................................ 45
Installation of the High-pressure compressor............................................. 46
Setup of the High-pressure compressor .................................................... 49
Employment of a longer supply line .................................. 49
7FIRST USE AFTER INSTALLATION.................50
Check-up before first start................................................ 50
Switch-on the ultraWAVE 3............................................... 50
Opening of the cover ....................................................... 50
Pre-conditioning of ultraWAVE 3 before the use................. 52
8ULTRAWAVE 3 OPERATION...........................53
Sample handling and weighing ......................................... 53
Samples tray ................................................................... 55

Milestone Srl MA245-003 –ultraWAVE 3 –User Manual
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Acid mixtures................................................................... 55
Addition of Reagents........................................................ 57
Addition of base load in the main PTFE vessel ................... 57
Handling of sample rack................................................... 59
Locking of clamps ............................................................ 60
Pressure load before the microwave run............................ 61
Microwave run................................................................. 62
Pressure release after microwave run................................ 62
Opening of reactor after digestion run............................... 63
System status indicator .................................................... 64
Emergency Stop of UltraWAVE 3....................................... 65
9MAINTENANCE AND CLEANING PROCEDURES
67
Cleaning after each run .................................................... 67
Cleaning of reactor and checking of the main PTFE vessel .......................... 67
Cleaning of reactor and cover with protective oil and grease
69
How to apply the PFPE grease with anticorrosion additive........................... 70
NOx decontamination of the main PTFE vessel .................. 71
Cleaning before long operational Breaks............................ 71
Cleaning of the metal cover.............................................. 72
Cleaning instructions in case of spilt acids ......................... 73
Vessel Covering ............................................................... 75
Leak Test of the main reactor ........................................... 75
Measures in case of fast pressure release.......................... 76
Maintenance of High-pressure compressor (optional) ......... 76
Check Oil Level ....................................................................................... 76
Condensate draining................................................................................ 77
10 EASYCONTROL SOFTWARE............................78

Milestone Srl MA245-003 –ultraWAVE 3 –User Manual
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Program start .................................................................. 78
General Operation tip....................................................... 79
Graphic color .......................................................................................... 79
Numeric input via touch-screen ................................................................ 80
Text input via touch-screen .............................................. 80
Editable fields with numeric values and defined range........ 81
Generally used icons ........................................................ 83
Methods .......................................................................... 86
Method selection from Milestone library .................................................... 86
Create new methods ............................................................................... 88
How to start a microwave program ................................... 90
Opening of the reactor when the microwave program has
finished ..................................................................................... 93
Open the front cover........................................................ 94
Program sequence ........................................................ 94
Run file opening / saving / deleting .......................................................... 96
Graphical representation.......................................................................... 97
Sample table................................................................. 98
Open new sample table ........................................................................... 98
Adding lines.......................................................................................... 100
Delete record........................................................................................ 100
Direct connection with balance............................................................... 101
Automatic tare...................................................................................... 101
Enter Chemicals .................................................................................... 101
Sample Table open / save / delete ......................................................... 102
System PAGE .............................................................. 103
SETTINGS................................................................... 105
Terminal page ...................................................................................... 105
Settings page ....................................................................................... 107
Other setup windows............................................................................. 110
11 21CFR –PART 11 SOFTWARE......................112
Activation of the 21CFR –part 11 ................................... 112
Create, Edit, Delete the User Profiles............................... 113

Milestone Srl MA245-003 –ultraWAVE 3 –User Manual
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First Steps ............................................................................................ 113
Overview of user profiles and access levels ............................................. 114
Create a new ID user profile .................................................................. 115
Edit or Delete an existing ID user profile ................................................. 119
Switch on the unit and create new microwave method..... 120
Save and export the final digestion temperature profiles .......................... 123
How to save a temperature digestion profile............................................ 124
Files format and auto-save option (Administrator, Service)124
Continuous recording ............................................................................ 125
Save of the run file................................................................................ 125
The Audit Trail............................................................... 126
12 MILESTONE CONNECT .................................128
13 LIST OF QUERIES AND (ERROR) MESSAGES
130
Login ............................................................................ 130
Sensors, Settings and Twist............................................ 130
File and Data ................................................................. 131
Program ........................................................................ 132
Sample table ................................................................. 132
Internal memory, disks and signature ............................. 132
14 ULTRAWAVE 3 CLEANING PROCEDURE ......134
15 APPENDIX 1 –ANALYTICAL INDEX OF
SOFTWARE SCREENS ..........................................137
16 APPENDIX 2 - DECLARATION OF COMPLIANCE
"EASYCONTROL SOFTWARE" WITH FDA-
21CFRPART11 .....................................................144
17 APPENDIX 3 - TIPS & TECHNIQUES ............151
Applications................................................................... 151

Milestone Srl MA245-003 –ultraWAVE 3 –User Manual
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Standard base load ............................................................................... 151
Microwave program guidelines ............................................................... 151
Cleaning/ Maintenance ................................................... 152
Maintenance of the PTFE vessel ............................................................. 152
Protective oil or grease.......................................................................... 152
Cleaning before long operational breaks.................................................. 153