SCIEX CESI 8000 Plus User manual

CESI 8000 Plus High Performance
Separation-ESI Module
User Manual
RUO-IDV-05-3897-B
February 2019

AB Sciex LLC
500 Old Connecticut Path
Framingham, Massachusetts 01701
USA
This document is provided to customers who have purchased SCIEX equipment to use in the
operation of such SCIEX equipment. This document is copyright protected and any reproduction
of this document or any part of this document is strictly prohibited, except as SCIEX may
authorize in writing.
Software that may be described in this document is furnished under a license agreement. It is
against the law to copy, modify, or distribute the software on any medium, except as specifically
allowed in the license agreement. Furthermore, the license agreement may prohibit the software
from being disassembled, reverse engineered, or decompiled for any purpose. Warranties are as
stated therein.
Portions of this document may make reference to other manufacturers and/or their products,
which may contain parts whose names are registered as trademarks and/or function as
trademarks of their respective owners. Any such use is intended only to designate those
manufacturers' products as supplied by SCIEX for incorporation into its equipment and does not
imply any right and/or license to use or permit others to use such manufacturers' and/or their
product names as trademarks.
SCIEX warranties are limited to those express warranties provided at the time of sale or license
of its products and are SCIEX’s sole and exclusive representations, warranties, and obligations.
SCIEX makes no other warranty of any kind whatsoever, expressed or implied, including without
limitation, warranties of merchantability or fitness for a particular purpose, whether arising from a
statute or otherwise in law or from a course of dealing or usage of trade, all of which are
expressly disclaimed, and assumes no responsibility or contingent liability, including indirect or
consequential damages, for any use by the purchaser or for any adverse circumstances arising
therefrom.
For Research Use Only. Not for use in Diagnostic Procedures.
AB Sciex is operating as SCIEX.
The trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective
owners.
AB SCIEX™ is being used under license.
© 2019 AB Sciex
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Contents
CHAPTER 1: Safety, Notices and Labels, 13
Overview, 13
Alerts for Warning, Caution, Important, and Note, 14
Instrument Safety Precautions, 15
Moving Parts or Sharp Objects, 16
Electrical Safety, 16
Laser Safety (for Optional Laser Device), 17
Class 1 Laser Caution Label, 17
Chemical Precautions, 17
Safety Symbols and Labels, 18
High Voltage Electric Shock Risk Symbol, 18
Attention Safety Symbol, 18
Sharp Object Label, 18
Mobile Cart Caution Label, 19
Cancer and Reproductive Harm Label, 19
RoHS Notices, 19
China RoHS Caution Label, 19
Other Instrument Labels, 20
Recycling Label (WEEE), 20
Disposal of Devices Containing Mercury Components, 21
CE Mark Label, 21
RCM Mark Label, 21
CSA Mark Label, 21
章 2: 安全、通知和标签 , 23
综述 , 23
警告、注意、重要事项以及注释的提示 , 24
仪器安全防护措施 , 25
活动部件或尖锐物 , 26
电气安全 , 26
激光安全 （适用于可选激光设备） , 26
1 类激光小心标签 (1 级激光警告标签 ), 26

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化学品注意事项 , 27
安全符号和标签 , 27
高压电击危险符号 , 27
注意安全符号 , 27
尖锐物标签 , 28
流动车警告标签 , 28
致癌和生殖危害标签 , 28
RoHS 通知 , 28
中国 RoHS 警告标签 , 29
其他仪器标签 , 29
环保标签 (WEEE), 29
处理包含加汞组件的设备 , 30
CE 标志标签 , 30
RCM 标志标签 , 30
CSA 标识标签 , 30
CHAPITRE 3: Sécurité, Consignes et étiquettes, 31
Présentation, 31
Alertes « Avertissement, Mise en garde, Important et Remarque », 32
Précautions de sécurité pour l'instrument, 33
Pièces mobiles ou Objets tranchants, 34
Sécurité électrique, 34
Sécurité laser (pour les appareils avec laser en option), 35
Étiquette de mise en garde : produit laser de classe 1, 35
Précautions chimiques, 36
Symboles et étiquettes de sécurité, 36
Symbole « Haute tension, risque de choc électrique », 36
Symbole de sécurité Attention, 37
Étiquette Objet tranchant, 37
Étiquette de mise en garde chariot mobile, 37
Étiquette concernant les risques de cancer et de malformations
congénitales, 37
Consignes RoHS, 38
Étiquette de mise en garde RoHS (Chine), 38
Autres étiquettes de l'instrument,38
Étiquette de recyclage (WEEE), 39
Élimination des appareils contenant des composants au
mercure, 39
Étiquette marque CE, 39
Étiquette marque MRC, 40
Étiquette marque CSA, 40
CHAPTER 4: System Overview, 41
About This Manual, 41

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Optional Detectors, 41
Introduction, 42
Instrument, 43
Sample Handling System, 44
Syringe Pump, Power Supply, LEDs and Interlock, 46
Syringe Pump, 46
High Voltage (HV) Power Supply, 46
LED Indicators, 46
Cartridge and Sample Cover Interlocks, 47
OptiMS Cartridge, 48
CHAPTER 5: Integrating the CESI 8000 Plus System with a Mass
Spectrometer, 51
CESI-MS Integration Procedures, 51
CESI 8000 Plus System: Installing OptiMS Cartridge, 53
OptiMS Cartridge Installation, 53
Thermo Scientific Mass Spectrometer: Integration with the CESI 8000 Plus
System, 57
Physical Integration with the CESI 8000 Plus System, 57
OptiMS Cartridge Sprayer Tip Installation into a Thermo
Scientific NanoSpray II Ion Source, 59
Establishing Communication Between the CESI 8000 Plus
Controller and the Thermo Scientific Mass Spectrometer, 65
Aligning the CESI 8000 Plus System with a Thermo Scientific
Mass Spectrometer, 66
SCIEX TripleTOF®5600 Mass Spectrometer: Integration with the CESI 8000
Plus System, 71
Physical Connections with the CESI 8000 Plus System, 71
OptiMS Cartridge Sprayer Tip Installation into the SCIEX
Nanospray® III Source, 73
Establishing Communication Between the CESI 8000 Plus
Controller and the SCIEX Mass Spectrometer, 80
Aligning the CESI 8000 Plus System with the SCIEX TripleTOF®
5600 Mass Spectrometer, 81
CHAPTER 6: 32 Karat Software Overview, 87
Overview of 32 Karat Software, 87
System Administration, 87
Controller and Instrument Start Up, 88
Controller/Network Login, 88
License Key, 89
Demo Mode, 89
Launching 32 Karat Software, 89
Instrument Start Up, 89

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Instruments and Projects, 90
Configuration, 90
Online Versus Offline, 90
Using the Direct Control Window to Load the Cartridge and Samples, 91
TripleTOF®5600 Mass Spectrometer Using AAO, 93
Methods and Sequences, 94
Creating and Editing a Method, 95
Instrument Setup Window, 95
Instrument Setup — Initial Conditions, 95
Instrument Setup — Time Program, 97
Separate Dialog, 98
Rinse Dialog, 100
Inject Dialog, 100
Stop Data, 102
End, 102
Saving a Method, 102
Overview of Creating a Sequence, 103
Single Run and Sequence Runs, 103
Programming a Sequence, 104
Sequence Table, 108
Sequence Validation, 109
CHAPTER 7: CESI 8000 Software, 111
Overview of the CESI 8000 Software, 111
Launching the CESI 8000 Software, 112
Login and Logout, 113
Lock and Unlock, 114
About Dialog, 114
Help, 114
Users, 114
Run Application, 115
Application Selection, 115
Samples and Vials, 118
Samples/Vials Dialog,118
Insert Option, 120
Sequence Dialog, 121
Sequence Table Rows, 123
Fill Down Option, 127
Display Options, 128
Vial Legend, 129
Tray Detail View, 129
Vial Preview, 130

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Run Acquisition, 131
SCIEX TripleTOF®5600 Mass Spectrometer Using AAO, 133
Graph Options, 134
Sequence Transfer Overview, 135
Sequence Transfer, 135
Describe Sequence, 141
Sequence Verification, 144
Sequence Display Options, 144
CHAPTER 8: Using a SCIEX TripleTOF®5600 Mass Spectrometer with
the CESI 8000 Plus System, 147
Introduction, 147
Stock Reagents and Other Consumables Required, 148
Preparation of Reagent Solutions and Test Sample, 149
Preparation of 10% (v/v) HAc—Background Electrolyte
(BGE), 150
Preparation of 20% (v/v) Acetic Acid (HAc)—For LE pH
Adjustment, 150
Preparation of 200 mM LE (Leading Electrolyte) Buffer, 150
Reconstitution of 1 μM Beta-Galactosidase Digest Solution
(Beta-Galactosidase Stock Solution), 151
Preparation of Beta-Galactosidase Test Sample, 151
Preparation of Beta-Galactosidase for Auto-calibration, 152
Buffer Tray Setup, 152
Sample Tray Setup, 153
Procedure for Installation of Adapter and OptiMS Cartridge, 154
Methods for the CESI 8000 Plus System, 155
CESI-MS Beta-Galactosidase System Performance Test, 159
Capillary Conditioning, 162
Establishing a Stable Spray and Determining Optimum ESI Voltage, 165
Running CESI-MS, 172
Create a Sequence in the Analyst®TF Software, 173
Start a Sequence in the Analyst®TF Software, 176
Load Sample and Reagents on the CESI 8000 Plus System, 177
Sample Tray Setup, 177
Create a Sequence in the CESI 8000 Software,179
Start a Sequence in the CESI 8000 Software, 183
Automatic Rinse Feature, 184
Beta-Galactosidase Analysis, 185
CHAPTER 9: Using a Thermo Scientific Mass Spectrometer with the
CESI 8000 Plus System, 189
Introduction, 189

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Stock Reagents and Other Consumables Required, 190
Preparation of Reagent Solutions and Test Sample, 191
Preparation of 10% (v/v) Acetic Acid (HAc)—Background
Electrolyte (BGE), 191
Preparation of 20% (v/v) Acetic Acid (HAc) — For LE Buffer pH
Adjustment, 192
Preparation of 200 mM LE (Leading Electrolyte) Buffer, 192
Reconstitution of 1 μM Beta-Galactosidase Digest Solution
(Beta-Galactosidase Stock Solution), 193
Preparation of Beta-Galactosidase Test Sample, 193
Sample Tray Setup for System Performance Test, 193
Procedure for Installation of Adapter and OptiMS Cartridge, 194
Capillary Conditioning, 195
Buffer Tray Setup, 195
Capillary Conditioning Procedure, 196
Establishing a Stable Spray and Determining Optimum ESI Voltage, 198
Tuning, 202
Running CESI-MS, 203
Create a Method with the Xcalibur Software, 204
Create a Sequence with the Xcalibur Software, 207
Start a Sequence with the Xcalibur Software, 208
Load Sample and Reagents on the CESI 8000 System, 209
Create a Sequence in the CESI 8000 Software, 211
Automatic Rinse Feature, 212
Start a Sequence in the CESI 8000 Software, 213
Beta-Galactosidase Analysis, 214
CHAPTER 10: Shutdown Procedures and Decoupling Instruments, 217
Shutdown and Decoupling Overview, 217
Cartridge Removal and the CESI 8000 Plus System Shutdown, 217
Cartridge Removal and Instrument Shutdown, 217
Decoupling the CESI 8000 Plus System, 222
Decoupling from the Thermo Scientific Mass Spectrometer, 222
Decoupling from the SCIEX Mass Spectrometer, 225
APPENDIX A: Specifications, 229
CESI 8000 Plus System, 229
Validated Controller Configuration, 230
Cart Specifications, 230
Sample Temperature Control, 231
Capillary Temperature Control, 231
Pressure and Vacuum System, 231

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Detector Specifications, 232
UV Detector, 232
Laser Induced Fluorescence (LIF) Detector (Optional), 233
Photo Diode Array (PDA) Detector (Optional), 233
APPENDIX B: Nominal Network Configuration, 235
Overview, 235
Switching from the CESI 8000 Plus System to Different Mass Spectrometer
Systems, 236
Switching to the CESI 8000 Plus System from Different Mass Spectrometer
Systems, 236
Switching from a SCIEX Mass Spectrometer to Another Mass
Spectrometer, 237
Switching to a SCIEX Mass Spectrometer from Another Mass
Spectrometer, 239
Advanced Networking and Computer Configuration for the Analyst®TF 1.7
Software, 241
CE-MS Networking, 241
PC Configurations, 241
Network Sharing Setting for the Crossover Connection, 262
Setting the Mass Spectrometer Type, 264
Curtain Gas Patch Installation, 265
CE-MS Driver Installation, 267
Saving Network Configurations, 269
Analyst Hardware Profile Configuration, 270
To configure the Mass Spectrometer Hardware Profile, 270
Curtain Gas Setting and Verification, 276
Curtain Gas Setting, 276
Curtain Gas Verification, 278
APPENDIX C: TripleTOF®5600 Mass Spectrometer
Manual and Auto-Calibration Methods, 281
Overview, 281
Required Reagents, 281
Reagent and Sample Preparation, 281
Manual Calibration Before Auto-calibration, 282
Create a Reference Table for CE-MS Calibration, 282
Manual Calibration of the Mass Spectrometer, 285
Manual Calibration in TOF Mass Spectrometer Mode, 286
Manual Calibration in Product Ion Mode, 292
Methods for Auto-Calibration, 296
CE Method for Auto-Calibration, 296
MS Method for Auto-Calibration, 297
Executing Auto-Calibration, 300
Create a Sequence in the Analyst®TF Software, 300

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Start a Sequence in the Analyst®TF Software, 303
Load Sample and Reagents on the CESI 8000 System, 305
Sample Tray Setup, 305
Create a Sequence in the CESI 8000 Software, 306
Start a Sequence in the CESI 8000 Software, 310
Automatic Rinse Feature, 312
Auto-Calibration Data Analysis, 312
Troubleshooting Auto-Calibration Failure, 317
Auto-calibration Troubleshooting Table, 319
APPENDIX D: Auto Vial Increment Feature, 321
Overview, 321
Setting Auto Vial Increment on a Rinse Step, 321
Setting Auto Vial Increment on an Injection, 322
Setting Auto Vial Increment on a Separation Step, 324
Auto Vial Increment in a Method, 326
Reviewing Vial Positions before Running a Sequence, 327
APPENDIX E: Conductive Liquid Capillary Conditioning, 329
Conductive Liquid Capillary (CLC) Conditioning Procedure, 329
APPENDIX F: Using Vials and Hardware Maintenance, 331
Overview, 331
Using CESI-MS Vials and Caps, 332
CESI-MS Vials and Micro Vials, 332
Filling the Micro Vials, 333
Hardware Maintenance Procedures, 334
Capillary Cleaning Procedure (Short Term Storage), 334
Capillary Storage Procedure, 335
Removing and Re-installing OptiMS Interface Plate, 336
Opening Levers, Electrodes, and the Interface Block, 338
Clean Electrodes, Opening Levers, and the Interface Block, 341
Refilling Coolant, 343
Replacing Quad Rings, 344
Replacing Fuses, 346
APPENDIX G: Troubleshooting
and Mobile Cart Homing Procedure, 349
Overview, 349
Troubleshooting and Flow Diagrams, 349
Sample Preparation Considerations for Analysis with CESI-
MS, 350
Properties of a Method or Sequence Cannot be Modified or
Saved, 350
Blocked Sprayer Tip, 351

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Possible Cause, 351
Possible Solution, 351
Electrospray Cannot Be Established Between the CESI 8000 Plus
System and Mass Spectrometer, 353
Electrospray is Detected at Zero Ion Spray (IS) Voltage while
Applying CE Voltage, 354
Unstable Electrospray while Applying CE Voltage and IS
Voltage, 355
Droplet at Capillary Tip Disappeared Indicating that
Electrospray has Started, but No Mass Spectrometer Signal is
Detected, 356
Signal of Total Ion Current (TIC) is Lower Than Usual and/or
Background Signal Intensity Fluctuates More Than 40%, 357
Unstable CE Current, 358
No Analyte Signals Detected by Mass Spectrometer During a CE-
MS Separation, 359
Some Analyte Peaks are Missing or Smaller Than Expected, 360
CE Current Gradually Decreases During CE-MS Separation, 361
The Iron-Acetate Cluster m/z 537 is Suppressing the Sample
Signals, 362
High Voltage System Unable to Deliver the Required
Current, 363
Fine Tuning Sprayer Tip Position for Thermo Scientific Mass
Spectrometer, 364
Fine Tuning Sprayer Tip Position for SCIEX Mass Spectrometer, 366
CESI 8000 Plus Mobile Cart Homing Procedure, 368
Contact Us, 369
Customer Training, 369
Online Learning Center, 369
SCIEX Support, 369
CyberSecurity, 369
Documentation, 370
Index, 371

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CHAPTER 1
Safety, Notices and Labels
Overview
A description of the symbols and labels that are used on the SCIEX CESI 8000 Plus High
Performance Separation-ESI Module, or that are shown in this manual, can be found in this
section.
Do not attempt to perform any procedure before carefully reading all instructions. If in doubt as
to how to proceed in any situation, contact your SCIEX representative.
SCIEX urges its customers and employees to comply with all national health and safety standards
such as the use of barrier protection. This may include, but is not limited to, protective eyewear,
gloves, and suitable laboratory attire when operating or maintaining this or any other
automated laboratory instrumentation.
WARNING
If the equipment is used in a manner not specified by SCIEX, the protection
provided by the equipment may be impaired.

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Alerts for Warning, Caution, Important, and Note
All Warnings and Cautions in this document include an exclamation point, framed within a
triangle.
The exclamation point symbol is an international symbol which serves as a reminder that all
safety instructions should be read and understood before installation, use, maintenance, and
servicing are attempted.
WARNING
WARNING indicates a potentially hazardous situation which, if not avoided,
could result in death or serious injury. It may also be used to indicate the
possibility of erroneous data that could result in an incorrect diagnosis. May be
used to indicate the possibility of severe instrument damage.
CAUTION
CAUTION indicates a potentially hazardous situation, which, if not avoided,
may result in minor or moderate injury. It may also be used to alert against
unsafe practices. May be used to indicate the possibility of erroneous data that
could result in an incorrect diagnosis.
IMPORTANT Used for comments that add value to the step or procedure being performed. Following the
advice in the Important adds benefit to the performance of a piece of equipment or to a process.
NOTE Used to call attention to notable information that should be followed during installation, use, or
servicing of this equipment.

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Instrument Safety Precautions
WARNING
Risk of operator injury if:
• All doors, covers and panels are not closed and secured in place prior to
and during instrument operation.
• The integrity of safety interlocks and sensors is compromised.
• You contact moving parts.
• You mishandle broken parts.
• Doors, covers and panels are not opened, closed, removed and/or replaced
with care.
• Improper tools are used for troubleshooting.
To avoid injury:
• Keep doors, covers and panels closed and secured in place while the
instrument in use.
• Take full advantage of the safety features of the instrument. Do not defeat
safety interlocks and sensors.
• Acknowledge and act upon instrument alarms and error messages.
• Keep away from moving parts.
• Report any broken parts to your SCIEX representative.
• Use the proper tools when troubleshooting.

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CAUTION
System integrity could be compromised and operational failures could occur if:
• This equipment is used in a manner other than specified. Operate the
instrument as instructed in the product manuals.
• You introduce software that is not authorized by SCIEX into your computer.
Only operate your system’s computer with software authorized by SCIEX.
• You install software that is not an original copyrighted version. Only use
software that is an original copyrighted version to prevent virus
contamination.
CAUTION
If you purchased this product from anyone other than SCIEX or an authorized
SCIEX distributor, and, if it is not presently under a SCIEX Service Maintenance
Agreement, SCIEX cannot guarantee that the product is fitted with the most
current mandatory engineering revisions or that you will receive the most
current information bulletins concerning the product. If you purchased this
product from a third party and would like further information concerning this
topic, contact your SCIEX representative.
Moving Parts or Sharp Objects
WARNING
Risk of personal injury. To avoid injury due to moving parts, observe the
following:
• Never attempt to exchange labware, reagents, or tools while the
instrument is operating.
• Never attempt to physically restrict any of the moving components of the
instrument.
• Keep the instrument work area clear to prevent obstruction of the
movement.
Electrical Safety
To prevent electrically related injuries and property damage, properly inspect all electrical
equipment prior to use and immediately report any electrical deficiencies. Contact a SCIEX
representative for any servicing of equipment requiring the removal of covers or panels.

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Laser Safety (for Optional Laser Device)
WARNING
This product may contain a laser module. The laser (optional) is designated as
“Class 3B.” The “3B” classification means that “direct intrabeam viewing of
this type of laser is always hazardous to personnel.”
The laser and several other integral components are contained in a sealed
housing that together comprise the laser assembly. The laser assembly has no
user serviceable parts. Service of the laser assembly is restricted to qualified
SCIEX Field Service Employees (FSE).
Therefore, the overall laser classification of the CE Instrument is “Class 1,”
defined as “lasers which are safe under reasonably foreseeable conditions of
operation.”
To prevent users from potentially harmful laser light, observe all safety
warnings and NEVER REMOVE THE OUTER CASING OF THE LASER ASSEMBLY.
IMPORTANT The laser markings noted above can vary depending on the type of device, and will be
described in the documentation provided with the module.
Class 1 Laser Caution Label
If the instrument contains a laser system, a label reading “THIS PRODUCT CONFORMS TO
APPLICABLE REQUIREMENTS OF 21 CFR 1040 AT THE DATE OF MANUFACTURE” is found near the
Name Rating tag. The laser light beam is not visible.
Chemical Precautions
• Determine which chemicals have been used in the system prior to service and regular
maintenance. Refer to Safety Data Sheets for the health and safety precautions that must be
followed with chemicals.
• Work in a well-ventilated area.
• Always wear assigned personal protective equipment, including powder-free neoprene or
nitrile gloves, safety glasses, and a laboratory coat.
• Follow required electrical safe work practices.
CLASS 1 LASER PRODUCT
THIS PRODUCT CONFORMS TO
APPLICABLE REQUIREMENTS OF
21 CFR 1040 AT THE DATE OF
MANUFACTURE.
MANUFACTURED:
726024-C

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• Avoid ignition sources when working with flammable materials, such as isopropanol,
methanol, and other flammable solvents.
• Take care in the use and disposal of any chemicals. Potential risk of personal injury if proper
procedures for handling and disposing of chemicals are not followed.
• Avoid skin contact with chemicals during cleaning and wash hands after use.
• Comply with all of the local regulations for the storage, handling, and disposal of
biohazardous, toxic, or radioactive materials.
• The lamp in this product contains mercury. Do not put in the trash. Recycle or dispose of
according to local, state, or federal laws.
Safety Symbols and Labels
High Voltage Electric Shock Risk Symbol
This symbol indicates that there is high voltage and there is a risk of electric shock, and the
operator should use care when accessing this area.
Attention Safety Symbol
This symbol calls attention to important information to read, or is accompanied by another
symbol indicating a particular safety hazard. The information is located either on the label with
the symbol or in the CESI 8000 Plus documentation.
Sharp Object Label
This symbol indicates that there are sharp objects, and the operator should use care when
accessing this area.

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Mobile Cart Caution Label
A label cautioning users when moving the cart or adjusting the height of the cart can be found
on the CESI 8000 Plus mobile cart.
The CESI 8000 instrument is situated on the mobile cart. The OptiMS cartridge spray tip on the
CESI 8000 instrument has to be in very close proximity to a mass spectrometer when the system
is used. To avoid damage to the OptiMS cartridge, remove it from the MS adapter before
adjusting the height or moving the cart.
Cancer and Reproductive Harm Label
This label indicates there is risk of cancer and reproductive harm to the operator. This warning
is called for by the California Safe Drinking Water and Toxic Enforcement Act of 1986, commonly
referred to as Proposition 65, enacted by the State of California. A full list of harmful chemicals
is available at www.P65Warnings.ca.gov.
RoHS Notices
These labels and materials declaration table (the Table of Hazardous Substance’s Name and
Concentration) are to meet People’s Republic of China Electronic Industry Standard SJ/T11364-
2006 “Marking for Control of Pollution Caused by Electronic Information Products”
requirements.
China RoHS Caution Label
This label indicates that the electronic information product contains certain toxic or hazardous
substances. The center number is the Environmentally Friendly Use Period (EFUP) date, and
indicates the number of calendar years the product can be in operation. Upon the expiration of

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the EFUP, the product must be immediately recycled. The circling arrows indicate the product is
recyclable. The date code on the label or product indicates the date of manufacture.
Other Instrument Labels
This section provides information for some labels and symbols appearing on the CESI 8000
instrument housing. These labels and symbols may be associated with user-serviceable
procedures. Individual hazards associated with a specific procedure in this manual may use
these labels and symbols, and are included in Warnings or Cautions within the procedures for
that task.
Recycling Label (WEEE)
The symbol of a crossed-out wheeled bin on the product is required in accordance with the
Waste Electrical and Electronic Equipment (WEEE) Directive of the European Union.
The presence of this marking on the product indicates:
• That the device was put on the European Market after August 13, 2005 and
• That the device is not to be disposed via the municipal waste collection system of any
member state of the European Union.
Follow local municipal waste ordinances for proper disposal provisions to reduce the
environmental impact of WEEE (waste, electrical, and electronic equipment). To safely dispose
of this equipment, contact a local Customer Service office for complimentary equipment pick-
up and recycling.