SCIEX ZenoTOF 7600 User manual

ZenoTOF 7600 System
System User Guide
RUO-IDV-05-10350-F July 2023

This document is provided to customers who have purchased SCIEX equipment to use in the operation of
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Software that may be described in this document is furnished under a license agreement. It is against the
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agreement. Furthermore, the license agreement may prohibit the software from being disassembled,
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Portions of this document may make reference to other manufacturers and/or their products, which may
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(GEN-IDV-09-10816-E)
For Research Use Only. Not for use in Diagnostic Procedures.
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© 2023 DH Tech. Dev. Pte. Ltd.
AB Sciex Pte. Ltd.
Blk33, #04-06 Marsiling Industrial Estate Road 3
Woodlands Central Industrial Estate, Singapore 739256
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Contents
1 Operational Precautions and Limitations...............................................................................6
General Safety Information....................................................................................................... 6
Documentation Symbols and Conventions............................................................................... 6
Regulatory Compliance.............................................................................................................7
Australia and New Zealand.................................................................................................. 7
Canada.................................................................................................................................7
Europe..................................................................................................................................7
United States........................................................................................................................8
International......................................................................................................................... 8
Electrical Precautions................................................................................................................8
Mains Supply........................................................................................................................9
Protective Earth Conductor.................................................................................................. 9
Chemical Precautions............................................................................................................. 10
System Safe Fluids............................................................................................................ 11
Ventilation Precautions............................................................................................................12
Physical Precautions ..............................................................................................................13
Environmental Precautions..................................................................................................... 13
Electromagnetic Environment............................................................................................ 14
Decommissioning and Disposal......................................................................................... 15
Qualified Personnel.................................................................................................................15
Laboratory Conditions.............................................................................................................16
Safe Environmental Conditions..........................................................................................16
Performance Specifications............................................................................................... 16
Equipment Use and Modification............................................................................................ 16
2 Principles of Operation.......................................................................................................... 18
System Overview.................................................................................................................... 18
Hardware Overview............................................................................................................19
Theory of Operation........................................................................................................... 22
3 Operating Instructions — Hardware..................................................................................... 23
Start Up the System................................................................................................................23
Shut Down and Vent the System............................................................................................ 25
Diverter Valve..........................................................................................................................27
Plumb the Diverter Valve in Injector Mode......................................................................... 27
Plumb the Diverter Valve in Diverter Mode........................................................................ 28
Calibrant Delivery System.......................................................................................................30
Replace the CDS Bottle..................................................................................................... 30
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Start the CDS..................................................................................................................... 30
Stop the CDS..................................................................................................................... 31
Flush the CDS....................................................................................................................31
4 Operating Instructions — User Workflows ..........................................................................35
5 Service and Maintenance Information ................................................................................. 37
Recommended Maintenance Schedule.................................................................................. 37
Clean the Surfaces..................................................................................................................40
Clean the Front-End................................................................................................................40
Symptoms of Contamination.............................................................................................. 40
Required Materials............................................................................................................. 41
Cleaning Best Practices..................................................................................................... 41
Prepare the Mass Spectrometer........................................................................................ 43
Clean the Curtain Plate...................................................................................................... 44
Clean the Front of the Orifice Plate....................................................................................46
Put the Mass Spectrometer Back in Service......................................................................46
Empty the Source Exhaust Drain Bottle..................................................................................46
Replace the Check Valve and Flow Module............................................................................49
Replace the CDS Bottle Intake Filters.....................................................................................50
Inspect the Roughing Pump Oil Level (Oil-Sealed Roughing Pump)......................................51
Storage and Handling............................................................................................................. 52
Move the Mass Spectrometer................................................................................................. 53
Open the Dress Panel........................................................................................................60
6 Mass Spectrometer Troubleshooting...................................................................................62
A Recommended Calibration Ions........................................................................................... 68
APCI Calibration Ions..............................................................................................................68
ESI Calibration Ions................................................................................................................ 70
B Exact Masses and Chemical Formulas................................................................................ 72
C Glossary of Symbols..............................................................................................................74
D Glossary of Warnings............................................................................................................ 80
Contact Us.................................................................................................................................. 82
Customer Training...................................................................................................................82
Online Learning Center...........................................................................................................82
SCIEX Support........................................................................................................................82
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CyberSecurity..........................................................................................................................82
Documentation........................................................................................................................82
Contents
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