Waters ACQUITY UPLC Operating manual

ACQUITY UPLC Quaternary Solvent
Manager
Overview and Maintenance Guide
715005050
Revision C
Copyright © Waters Corporation 2016
All rights reserved

General information
Copyright notice
© 2010 – 2016 WATERS CORPORATION. PRINTED IN THE UNITED STATES OF AMERICA
AND IN IRELAND. ALL RIGHTS RESERVED. THIS DOCUMENT OR PARTS THEREOF MAY
NOT BE REPRODUCED IN ANY FORM WITHOUT THE WRITTEN PERMISSION OF THE
PUBLISHER.
The information in this document is subject to change without notice and should not be construed
as a commitment by Waters Corporation. Waters Corporation assumes no responsibility for any
errors that may appear in this document. This document is believed to be complete and accurate
at the time of publication. In no event shall Waters Corporation be liable for incidental or
consequential damages in connection with, or arising from, its use. For the most recent revision
of this document, consult the Waters Web site (waters.com).
Trademarks
ACQUITY® is a registered trademark of Waters Corporation.
ACQUITY UPLC® is a registered trademark of Waters Corporation.
THE SCIENCE OF WHAT'S POSSIBLE® is a registered trademark of Waters Corporation.
TORX® is a registered trademark of Camcar Division, Textron Inc.
Waters® is a registered trademark of Waters Corporation.
Waters Quality Parts® is a registered trademark of Waters Corporation.
All other trademarks or registered trademarks are the sole property of their respective owners.
Customer comments
Waters’ Technical Communications organization invites you to report any errors that you
encounter in this document or to suggest ideas for otherwise improving it. Help us better
understand what you expect from our documentation so that we can continuously improve its
accuracy and usability.
We seriously consider every customer comment we receive. You can reach us at
[email protected].
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Contacting Waters
Contact Waters with enhancement requests or technical questions regarding the use,
transportation, removal, or disposal of any Waters product. You can reach us via the Internet,
telephone, or conventional mail.
Waters contact information
Contacting medium Information
Internet The Waters Web site includes contact information for Waters locations
worldwide.
Visit www.waters.com
Telephone and fax From the USA or Canada, phone [phone], or fax [phone].
For other locations worldwide, phone and fax numbers appear in the
Waters Web site.
Conventional mail Waters Corporation
Global Support Services
34 Maple Street
Milford, MA 01757
USA
Safety considerations
Some reagents and samples used with Waters instruments and devices can pose chemical,
biological, or radiological hazards (or any combination thereof). You must know the potentially
hazardous effects of all substances you work with. Always follow Good Laboratory Practice
(GLP), and consult your organization’s standard operating procedures as well as your local
requirements for safety.
Safety hazard symbol notice
Documentation needs to be consulted in all cases where the symbol is used to find out the
nature of the potential hazard and any actions which have to be taken.
Considerations specific to the QSM
Warning: To avoid electric shock, do not remove protective panels from system
modules. The components within are not user-serviceable.
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Warning: To avoid electrical shock, observe these precautions:
• Use SVT-type power cord in the United States and HAR-type power cord, or better,
in Europe. For requirements elsewhere, contact your local Waters distributor.
• Inspect the power cord for damage, and replace it, if necessary.
• Power-off and unplug each module before performing any maintenance operation
on it.
• Connect each module to a common ground.
Warning: To avoid spinal and muscular injury, do not attempt to lift a system module
without assistance.
See also: For safety considerations regarding specific system modules, consult the appropriate
information on the user documentation CD.
FCC radiation emissions notice
Changes or modifications not expressly approved by the party responsible for compliance, could
void the user's authority to operate the equipment. This device complies with Part 15 of the FCC
Rules. Operation is subject to the following two conditions: (1) this device may not cause harmful
interference, and (2) this device must accept any interference received, including interference that
may cause undesired operation.
Electrical power safety notice
Do not position the instrument so that it is difficult to disconnect the power cord.
Equipment misuse notice
If equipment is used in a manner not specified by its manufacturer, protections against personal
injury inherent in the equipment’s design can be rendered ineffective.
Safety advisories
Consult the "Safety advisories" appendix in this publication for a comprehensive list of warning
advisories and notices.
Operating this device
When operating this device, follow standard quality-control (QC) procedures and the guidelines
presented in this section.
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Applicable symbols
Symbol Definition
Manufacturer
Date of manufacture
Authorized representative of the European Community
Confirms that a manufactured product complies with all applicable
European Community directives
or
Australia EMC compliant
Confirms that a manufactured product complies with all applicable United
States and Canadian safety requirements
Consult instructions for use
Alternating current
Electrical and electronic equipment with this symbol may contain
hazardous substances and should not be disposed of as general waste.
For compliance with the Waste Electrical and Electronic Equipment
Directive (WEEE) 2012/19/EU, contact Waters Corporation for the correct
disposal and recycling instructions.
Serial number
REF
Part number catalog number
Audience and purpose
This guide is intended for individuals who install, operate, or maintain the quaternary solvent
manager (QSM). It gives an overview of the technology and operation of the QSM.
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Intended use of the QSM
Waters designed the QSM for use in liquid chromatography applications. The QSM is not
intended for use in diagnostic applications.
Calibrating
To calibrate LC systems, adopt acceptable calibration methods using at least five standards to
generate a standard curve. The concentration range for standards must include the entire range
of QC samples, typical specimens, and atypical specimens.
When calibrating mass spectrometers, consult the calibration section of the operator’s guide for
the instrument you are calibrating. In cases where an overview and maintenance guide, not an
operator’s guide, accompanies the instrument, consult the instrument’s online Help system for
calibration instructions.
Quality control
Routinely run three QC samples that represent subnormal, normal, and above-normal levels of a
compound. If sample trays are the same or very similar, vary the location of the QC samples in
the trays. Ensure that QC sample results fall within an acceptable range, and evaluate precision
from day to day and run to run. Data collected when QC samples are out of range might not be
valid. Do not report these data until you are certain that the instrument performs satisfactorily.
EMC considerations
Canada spectrum management emissions notice
This class A digital product apparatus complies with Canadian ICES-001.
Cet appareil numérique de la classe A est conforme à la norme NMB-001.
ISM classification: ISM group 1 class B
This classification has been assigned in accordance with IEC CISPR 11 Industrial Scientific and
Medical (ISM) instrument requirements.
Group 1 products apply to intentionally generated and/or used conductively coupled radio-
frequency energy that is necessary for the internal functioning of the equipment.
Class B products are suitable for use in both commercial and residential locations and can be
directly connected to a low voltage, power-supply network.
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EC authorized representative
Address Waters Corporation
Stamford Avenue
Altrincham Road
Wilmslow SK9 4AX UK
Telephone [phone]
Fax [phone]
Contact Quality manager
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Table of contents
General information .......................................................................................................ii
Copyright notice ..................................................................................................................................... ii
Trademarks............................................................................................................................................ ii
Customer comments.............................................................................................................................. ii
Contacting Waters .................................................................................................................................iii
Safety considerations.............................................................................................................................iii
Safety hazard symbol notice ...........................................................................................................iii
Considerations specific to the QSM ................................................................................................iii
FCC radiation emissions notice...................................................................................................... iv
Electrical power safety notice......................................................................................................... iv
Equipment misuse notice ............................................................................................................... iv
Safety advisories ............................................................................................................................ iv
Operating this device ............................................................................................................................ iv
Applicable symbols.......................................................................................................................... v
Audience and purpose..................................................................................................................... v
Intended use of the QSM................................................................................................................ vi
Calibrating ...................................................................................................................................... vi
Quality control................................................................................................................................. vi
EMC considerations.............................................................................................................................. vi
Canada spectrum management emissions notice.......................................................................... vi
ISM classification: ISM group 1 class B.......................................................................................... vi
EC authorized representative ...............................................................................................................vii
1 Overview....................................................................................................................12
1.1 Features ........................................................................................................................................12
1.1.1 Gradient Smart Start............................................................................................................13
1.1.2 Auto•Blend Plus...................................................................................................................13
1.2 Major components.........................................................................................................................13
1.3 Pressure flow envelope.................................................................................................................17
1.4 Pressure transducer overview.......................................................................................................17
1.5 Flow path through the solvent management system.....................................................................17
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2 Preparation and operation.......................................................................................19
2.1 Installation recommendations for fittings.......................................................................................19
2.1.1 Assembling new fittings .......................................................................................................20
2.1.2 Stainless steel (gold-plated) fitting with short flats and 2-piece stainless-steel ferrule........ 21
2.1.3 Stainless steel (gold-plated) fitting with long flats and 2-piece stainless-steel ferrule .........22
2.1.4 5/16-24 fitting with filter and stainless steel lock ring...........................................................24
2.1.5 Short 1/4-28 fitting with flangeless ferrule and stainless steel lock ring installed on 1/16-
inch OD tubing...............................................................................................................................24
2.1.6 Long 1/4-28 fitting with flangeless ferrule and stainless steel lock ring installed on 1/8-
inch OD tubing...............................................................................................................................25
2.2 Installing and routing the waste and degasser vent tubing ...........................................................25
2.3 Electricity source ...........................................................................................................................28
2.3.1 Connecting to a wall electricity source.................................................................................28
2.3.2 Connecting to a cart's electricity source ..............................................................................28
2.4 Connecting signal cables ..............................................................................................................29
2.4.1 Input/output signal connectors.............................................................................................31
2.5 Installing the leak sensor...............................................................................................................31
2.6 Priming the seal-wash system ......................................................................................................33
2.7 Priming the solvent manager ........................................................................................................35
2.7.1 Priming a dry solvent manager via the console...................................................................35
2.7.2 Priming a dry solvent manager using a syringe...................................................................36
2.8 Washing the plungers ...................................................................................................................38
2.9 Responding to a leak sensor alarm...............................................................................................39
3 Maintenance..............................................................................................................43
3.1 Contacting Waters Technical Service ..........................................................................................43
3.2 Viewing module information ..........................................................................................................44
3.3 Recommended maintenance schedule.........................................................................................44
3.3.1 Recommended maintenance schedule for the quaternary solvent manager ......................44
3.4 Spare parts....................................................................................................................................45
3.5 Safety and handling ......................................................................................................................45
3.6 Configuring maintenance warnings...............................................................................................46
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3.7 Servicing the air filter in the door...................................................................................................46
3.8 Replacing the solvent reservoir filters ...........................................................................................47
3.9 Replacing the leak sensor.............................................................................................................48
3.10 Replacing the inlet manifold ........................................................................................................51
3.11 Replacing the low-pressure inlet filters on the GPV outlet ..........................................................54
3.12 Replacing the 100-µL mixer/filter ................................................................................................56
3.13 Installing or replacing the optional 250-µL mixer/filter.................................................................57
3.14 Replacing the vent-valve cartridge..............................................................................................59
3.15 Replacing the optional solvent selection valve cartridge.............................................................61
3.16 Replacing the accumulator check valve......................................................................................63
3.17 Replacing the i2Valve actuator and cartridge..............................................................................66
3.17.1 Removing the i2Valve actuator ..........................................................................................67
3.17.2 Removing the i2Valve cartridge from the actuator .............................................................71
3.17.3 Installing the i2Valve cartridge on the actuator ..................................................................72
3.17.4 Installing the i2Valve actuator ............................................................................................76
3.18 Replacing the primary pump head's plunger and seals ..............................................................79
3.18.1 Moving the plunger backward............................................................................................80
3.18.2 Removing the i2Valve actuator ..........................................................................................81
3.18.3 Removing the primary pump head.....................................................................................84
3.18.4 Removing the pump head plunger.....................................................................................87
3.18.5 Removing the pump head seals ........................................................................................89
3.18.6 Installing the new pump head seals...................................................................................92
3.18.7 Installing the new pump-head plunger...............................................................................96
3.18.8 Reinstalling the primary pump head ..................................................................................98
3.18.9 Installing the i2Valve actuator ..........................................................................................101
3.19 Replacing the accumulator pump head's plunger and seals.....................................................105
3.19.1 Moving the plunger backward..........................................................................................106
3.19.2 Removing the accumulator pump head...........................................................................106
3.19.3 Removing the pump head plunger...................................................................................110
3.20 Cleaning the exterior of the equipment .....................................................................................125
A Safety advisories ...................................................................................................126
A.1 Warning symbols ........................................................................................................................126
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A.1.1 Specific warnings ..............................................................................................................127
A.2 Notices........................................................................................................................................128
A.3 Bottles Prohibited symbol ...........................................................................................................128
A.4 Required protection ....................................................................................................................129
A.5 Warnings that apply to all Waters instruments and devices .......................................................129
A.6 Warnings that address the replacing of fuses.............................................................................133
A.7 Electrical symbols .......................................................................................................................135
A.8 Handling symbols .......................................................................................................................136
B Specifications.........................................................................................................137
B.1 QSM and bioQSM physical specifications ..................................................................................137
B.2 QSM and bioQSM environmental specifications ........................................................................137
B.3 QSM and bioQSM electrical specifications.................................................................................137
B.4 QSM and bioQSM input/output specifications ............................................................................138
B.5 QSM and bioQSM performance specifications...........................................................................139
B.6 QSM and bioQSM wetted materials of construction ...................................................................141
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1Overview
The quaternary solvent manager (QSM) is a high-pressure pump that can simultaneously pump
four degassed solvents (A, B, C, and D) through the ACQUITY HPLC system. The pump can
deliver gradients in eleven curve shapes (one linear, two step, four convex, and four concave).
When the optional solvent-selection valve is installed, it is plumbed to solvent channel D, enabling
solvent selections D1 through D6 in addition to A, B, and C (a total of nine solvents to select from).
This document explains the operation of both the QSM and the bioQSM. For information about
ordering supplies for either device, visit the Waters website (www.waters.com), or consult your
Waters sales representative.
1.1 Features
The solvent manager includes these features:
• Ability to blend four solvents in any combination or proportion.
• Optional solvent-selection valve, to select from up to nine solvents for blending.
• Automated solvent compressibility, to run any solvent in any combination without loss in
accuracy or precision.
• A gradient proportioning valve (GPV), to dynamically blend solvents in any specified
combination. The GPV produces predictable gradient segments regardless of solvent
compressibility and system back pressure. Solvent selection and proportioning occur on the
low-pressure (intake) side of the solvent delivery system, and solvents continue to blend
under high pressure in each piston chamber.
• An integrated degasser that operates at all flow rates, including the maximum, with an
independent channel for each solvent and an additional channel to accommodate the purge
solvent for the sample manager.
• An automatic, programmable, seal wash. The seal wash pump prevents the buildup of
precipitates on the pump plungers by washing them with seal wash solvent at programmable
intervals.
• The electronically controlled Intelligent Intake Valve (I2Valve), to speed system priming and
reduce startup times. The I2Valve minimizes solvent flow disturbances in the inlet lines by
closely synchronizing the valve performance with pump operation.
• A vent valve that automatically switches to waste, for priming and rapid solvent changeover.
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1.1.1 Gradient Smart Start
Before each sample injection, a sample manager typically performs wash sequences and then
aspirates the appropriate sample volume. When these tasks are completed, the solvent manager
begins to deliver the gradient to the injection valve. The dwell volume of the system, which affects
the amount of time required for this gradient to reach the column, can be a significant component
of the overall cycle time.
The Gradient Smart Start feature adjusts when an injection is made relative to when it starts. In
this way, when you transfer methods, the feature compensates for differences in dwell volume
between chromatographic systems. Moreover, it automatically coordinates all pre-injection
operations, minimizing delays that would increase the overall cycle time. In doing so, the feature
makes it possible to begin gradient operation before or during the sample manager's pre-injection
functions, resulting in significant time savings.
1.1.2 Auto•Blend Plus
Auto•Blend Plus technology uses pure solvents and concentrated stocks to blend mobile phase
compositions at a specific pH. At the same time, it controls the concentration of salt or organic
solvent, to optimize separations. Use the Auto•Blend Plus feature to create and store buffer
systems in a solvent catalog that all users of an ACQUITY quaternary solvent manager can
share. To prepare and adjust chromatographic mobile phases, you add acid, base, salt or organic
solvent, and water to the solvent reservoirs. By doing so you can, for example, optimize protein
separations, which are especially sensitive to a buffer's pH and salt concentration. You can also
optimize reversed-phase separations that are sensitive to pH and organic-solvent composition.
See also:
•Auto•Blend Plus Technology for Ion Exchange, Size Exclusion, and Reversed-phase
Chromatography
• The Auto•Blend Plus videos on the Support tab on the Waters Auto•Blend Plus page.
1.2 Major components
The following diagrams show the solvent manager’s major components.
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Figure 1–1: Front view, with door closed
On/off switch – Powers the module on and off.
Power LED – Indicates the power-on or power-off status of the module. This LED is green
when power is on and unlit when power is off.
Flow LED – Indicates the flow status. A steady green flow LED indicates that there is a flow
through the solvent manager.
Door
Figure 1–2: Front view, with door open
1 2 3 45
6
7
8
9
1011
12131415
16
17
18
19
20
21
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Pressure transducer cable connector port (2) – Connects the pressure transducers, which
convert solvent pressure into electrical signals for monitoring.
Accumulator pump – Receives solvent from the primary pump and delivers it to the vent
valve.
Location of the sample manager's purge-solvent degasser – Degasses the sample
manager's purge solvent.
Note: Vacuum degassing can change the composition of mixed solvents.
Vent valve – Automatically switches to waste during priming and to a block position during
the leak test.
100-µL mixer/filter – Mixes and filters the solvent before it reaches the pump outlet.
Seal wash pump – Circulates solvent, to keep the actuator’s high-pressure seals and
plungers free of contaminants.
Location of degasser vent tube – Vents exhaust from the degasser pump.
Seal-wash waste fitting – Connects the tubing that directs seal-wash waste to the drip tray.
Drain fitting (to waste) – Connects the tubing that directs waste liquid to the waste
container.
Solvent vent tubing – Vents solvent to waste during priming.
Location of leak sensor – The leak sensor continuously monitors the solvent manager for
leaks and stops the system flow when its optical sensor detects approximately 1.5 mL of
accumulated, leaked liquid in its surrounding reservoir.
Location of optional solvent selection valve – The solvent selection valve enables you to
select as many as six solvents for isocratic and gradient applications. The valve is plumbed
to solvent channel D, enabling solvent selections D1 through D6.
Leak sensor cable connector port – Connects the leak sensor, which continuously monitors
the solvent manager for leaks.
Gradient proportioning valve – Blends solvents to create accurate gradients, regardless of
solvent compressibility and system back pressure. The system includes two gradient
proportioning valves, one for solvent channels A and B, and one for solvent channels C and
D.
Low pressure inlet filters (A, B, C, and D) – Removes particulates from the incoming
solvent.
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Drip tray – Collects liquid leaks.
Mobile phase degasser chamber (4) – Removes dissolved gasses from mobile-phase
solvents and exhausts them, along with any condensates, through waste tubing.
Note: Vacuum degassing can change the composition of mixed solvents.
Inlet manifold – Combines the solvents upstream of the pumps.
i2Valve – Electronically controlled ball check valve that allows flow in only one direction.
Primary pump – Draws solvent, transferring it to the accumulator pump and system as part
of the serial flow design.
Check valve – A ball check valve that allows flow in only one direction.
Figure 1–3: Rear view
Signal cable connector inputs and outputs
RS-232 cable connector (for service only)
Ethernet cable connector
Power input
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1.3 Pressure flow envelope
The QSM, a single pump with a proportioning valve, has a maximum operating pressure of
103,421 kPa (1034 bar, 15,000 psi) at flow rates to 1 mL/min. The maximum operating pressure
decreases linearly to 53,779 kPa (538 bar, 7800 psi) at flow rates up to 2.2 mL/min.
1.4 Pressure transducer overview
The absolute pressure transducer (APT), which measures the pressure on the low pressure side
of the degasser system, is unaffected by altitude or barometric changes.
Table 1–1: Absolute pressure transducer attributes
Item Absolute pressure transducer
Units displayed kPa, bar, psia
Sign of displayed unit Positive
Theoretical maximum vacuum 0.0 psia
Operating range 0.00 to 1.54 psia
Typical value 0.70 to 1.20 psia
1.5 Flow path through the solvent management system
The following image depicts the flow of solvent through the solvent manager.
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Figure 1–4: Solvent management system flow path
Solvent flow sequence:
1. The in-line vacuum degasser degasses the solvent.
2. The gradient proportioning valve meters the solvents, prior to pressurization in the pump
heads.
3. The inlet manifold blends the metered solvents.
4. The blended solvents flow through the i2Valve check valve and into the primary piston
chamber.
5. The primary piston delivers solvent to the accumulator, the vent valve, and the in-line
mixer/filter during transfer.
6. The accumulator piston delivers solvent, under pressure, to the vent valve and the in-line
mixer/filter.
7. From the in-line mixer/filter, the solvent flows to the sample-management system.
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2Preparation and operation
For optimal system performance, you must prepare the solvent manager for operation.
To do so, you must prime the seal wash and then the solvent manager. Be sure to prime all four
solvent lines, the seal wash tubing, and the solvent selection valve tubes (if installed).
Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when
working with hazardous materials. Consult the Material Safety Data Sheets regarding
the solvents you use. Additionally, consult the safety representative for your
organization regarding its protocols for handling such materials.
Requirement: To maintain the efficiency of the solvent manager and to obtain accurate,
reproducible chromatograms, use only LC/MS-grade solvents, water, and additives. For details,
see the Solvent Considerations information and Controlling Contamination in Ultra Performance
LC/MS and HPLC/MS Systems (part number 715001307).
Notice: To avoid damaging solvent manager components,
• do not use chloroform, methylene chloride, or toluene;
• do not use ethyl acetate, hexane, or tetrahydrofuran (THF) without the hexane/THF
compatibility kit for ACQUITY UPLC systems;
• do not pressurize solvent reservoirs above 34.5 kPa (0.34 bar, 5 psi).
Recommendation: For optimal solvent manager performance, ensure that solvent bottles are
elevated above the pump inlet and vented.
2.1 Installation recommendations for fittings
Warning: Observe Good Laboratory Practice (GLP) at all times, particularly when
working with hazardous materials. Consult the Material Safety Data Sheets regarding
the solvents you use. Additionally, consult the safety representative for your
organization regarding its protocols for handling such materials.
Warning: To avoid personal contamination with biohazards or compounds that are toxic, wear
clean, chemical-resistant, powder-free gloves when performing this procedure.
Requirement: Wear clean, chemical-resistant, powder-free gloves when performing
this procedure.
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Recommendations:
• To prevent band spreading, ensure that the tubing is fully bottomed in the fitting port before
tightening the compression screw.
• For easier accessibility, use compression fittings with long flats to attach tubes to the vent
valve.
• Perform the solvent manager leak test whenever you replace or loosen fittings during
maintenance (see the console online Help).
• Whenever you loosen fittings during maintenance, examine them for cracks, stripped threads,
and deformations.
• Do not reuse stainless steel fittings more than six times.
Required tools and materials
• Chemical-resistant, powder-free gloves
2.1.1 Assembling new fittings
For metallic (SST or MP35N) fitting assemblies with ferrules not previously assembled or set to
tubing, you must mark the compression screw and fitting body, and ensure that the two marks
line up when you tighten them.
Requirement: Wear clean, chemical-resistant, powder-free gloves when performing
this procedure.
Required tools and materials
• 1/4-inch open-end wrench – For tightening or loosening stainless steel (gold-plated) fittings
with 2-piece ferrule.
• Permanent marker
• Chemical-resistant, powder-free gloves
To assemble the new fittings:
1. Insert the end of a tube into the hexagonal end of the compression screw.
2. Insert the tube into the larger end of the ferrule.
3. Insert the tube into the fitting body.
4. Rotate the compression screw, clockwise, into the fitting body until the screw is finger-tight.
5. Using a permanent marker, mark the compression screw at the 12 o’clock position.
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