Analytik Jena InnuPure C96 User manual

InnuPure®C96
User Manual



2015 III

Registered trademarks:
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Serial number Refertoproductnameplate



2015 V
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2015 VII
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VIII 2015


2015 IX

Table of contents
1 General Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1.1 GeneralUserManualAdvice.....................................1
1.2 TargetGroup................................................1
1.3 Conventions.................................................2
1.3.1 TextualMarkups ...........................................2
1.3.2 WarningSigns .............................................3
1.4 IntendedPurpose.............................................4
1.5 ConformingUse..............................................4
1.6 Warranty&Liability............................................6
1.7 ScopeofDelivery.............................................7
2 Technical Specifications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
2.1 InnuPure®C96...............................................9
2.2 SummaryTableofOperatingData&Conditions.....................10
3 Safety Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
3.1 General....................................................11
3.2 Standards&Guidelines........................................11
3.3 SafetyLabelingProvidedattheSystem............................12
3.4 MechanicalDangerZones&SafetyMechanisms.....................14
3.5 GeneralSafetyNotes..........................................15
3.6 RequirementsforOperatingPersonnel............................16
3.7 SafetyRequirementsforTransportation&
Installation16
3.8 SafetyNotesforOperation.....................................17
3.8.1 GeneralAdvice ...........................................17
3.8.2 ExplosionProofness,FirePrevention............................17
3.8.3 Electrical ................................................17
3.8.4 FundamentalMaintenance&CareRules ........................18
3.8.5 HandlingofDangerousSubstances ............................18
3.8.6 ChemicalResistance........................................18
3.9 RulesofConductinCasesofEmergency...........................20
4 Technical Description . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
4.1 Setup.....................................................21
4.1.1 BasicUnit................................................21

X2015

4.1.2 Nameplate ...............................................22
4.1.3 Directions&CoordinatesofMotion ............................23
4.1.4 FrontDoors..............................................24
4.2 SystemVersions.............................................24
4.3 ComponentsDescription.......................................25
4.3.1 PipettingHead96/1000 μl...................................25
4.3.2 Stackers .................................................26
4.3.3 TouchSensorwithLED .....................................27
4.3.4 HeatingMagnetModule....................................28
4.3.5 UVLamp*...............................................28
4.3.6 ConnectionPoints.........................................29
4.4 ModeofOperation/Functionality.................................30
5 Packaging, Transportation & Storage. . . . . . . . . . . . . . . . . . . . . . . 33
5.1 SafetyNotes................................................33
5.2 Description.................................................34
5.2.1 Packaging ...............................................34
5.2.2 Storage.................................................34
5.3 Transportation&PackagingInstructions...........................35
5.3.1 InstallationofShippingRetainers ..............................35
5.3.2 Packaging ...............................................36
6 Routine Start-Up Procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
6.1 SiteRequirements............................................37
6.1.1 InstallationRequirements ....................................37
6.1.2 FootprintRequirements.....................................37
6.1.3 EnergySupplies...........................................38
6.2 StartingUp.................................................39
6.3 SoftwareInstallation..........................................40
7 Operation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
7.1 TurningOn(ReadinessforOperation).............................43
7.2 SoftwareFunctions...........................................44
7.3 TurningOff.................................................47
8 “What to do if...“ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
8.1 SafetyNotes................................................49
8.2 Description.................................................49
8.2.1 FurtherErrors.............................................49

2015 XI

8.3 FaultRemovalInstructions......................................50
8.3.1 ReplacementofInletFuse(s)..................................50
8.3.2 RestoringReadinesstoOperateAfterBreakEvents(Expl.PowerFailure).51
9 Maintenance & Care. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
9.1 SafetyNotes................................................53
9.2 MaintenanceWork...........................................54
9.2.1 Overview ................................................55
9.3 Maintenance/InspectionInstructions..............................56
9.3.1 CleanSystem .............................................56
9.3.2 SealingPlate .............................................57
9.3.3 CheckingforProperFrontDoorFunction ........................58
10 Shutting Down . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
11 Accessories & Spare Parts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61
11.1 Accessories.................................................61
11.1.1 UpgradeKits.............................................61
11.2 SpareParts.................................................62
12 Waste Disposal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
12.1 Consumables...............................................63
12.2 Reagents...................................................63
12.3 System&Accessories.........................................63

XII 2015


2015 1
GeneralInformation
1 General Information
1.1 General User Manual Advice
ThisUserManualinformsaboutthesetupandfunctionofthesystem.Itprovides
qualifiedoperatingpersonnelwiththeknowledgethatisrequiredtohandlethesystem
inasafemanner.
ThisManualfurthercontainsinstructionsandadviceaboutgeneralsystemcareandthe
Manufacturer’sdefinedscopeofmaintenanceworkitems.
Inaddition,youmayusethisManualtoanalyzefaultsituationsforpotentialcausesand
takeappropriatemeasuresforfaultremoval.
ThisUserManualmustbereadilyavailabletooperatingandmaintenancepersonnelat
alltimes!
1.2 Target Group
ThisUserManualaddresses:
Qualifiedandproperlytrainedexpertpersonnelwhoareabletooperatethe
systemandprovidegeneralcare
(“Requirements for Operating Personnel” on page 16).
Employeeswithresponsibilityfor:
–theplanningofprocesssequences/operatingprocedures,
–preventivemaintenance&cleaningwork,
–safetydevices,etc.
NOTE
Theinformationcontainedhereinreflectsthelateststateofknowledgeatthemoment
ofgoingtopress.AnalytikJenaAGreservestherighttomakechangesifdeemednec-
essaryintheinterestoftechnicalprogress.

22015
GeneralInformation
1.3 Conventions
1.3.1 Textual Markups
Work instructions involvingatimedsequencearenumberedandmergedtoaction
unitstospecifyrelatedresults.
Enumerationinvolvingnotimedsequenceisshownasabullet-stylelist,sub-level
numberingorasadash-stylelist.
Safetynotesaremarkedbyapictogramandasignalword
(“Warning Signs” on page 3).
Specificaction-relatedsafetynoteswillprecedetheactualinstruction.
Instructions,commands,controlbuttons,textfields,checkboxesandthelikeare
markedasshownfor”Load“commandsample.
Optionaloutfitcomponentsorversionsaremarkedwith*.
Forgraphicdesignstylesofcross-references,youarereferredtothetablebelow:
Table 1: Graphic design styles of cross-references
Type of cross-referenceGraphic style Explanatory note
Referencetoanillustration Fig. 1 Illustrationisonthe
samepage
Referencetoanillustration
andapage
Fig. 1 on page 17 Illustrationisonanother
page
Referencetoaposition
(withinanillustration)
Pos. 2,Fig. 1 Providesreferencetoa
positionwithinaspeci-
fiedillustration–illustra-
tionisonthesamepage
Referencetoaposition
(withinanillustrationanda
page)
Pos. 2,
Fig. 1 on page 17
Referencesaposition
withinaspecifiedillus-
tration–illustrationis
onanotherpage
Referencetoapagepage 1 Referencesagivenpage
Referencetoaheadlineand
apage
“Conventions” on
page 2
Referencesagiven
page,supplementedby
aheadline
Referencetoatableanda
page
Table 2, “Scope of deliv-
ery (depending on selected
model option)”, on page 7
Referencesagiventable

2015 3
GeneralInformation
1.3.2 Warning Signs
WARNING
Indicatesapotentiallyhazardoussituation.
Mayresultindeathorseriousinjury(crippling)ifnotavoided.
CAUTION
Dangeroussituation!
Potentialconsequences:lightormoderatephysicalinjury.
NOTICE
Dangeroussituation!
Potentialconsequences:materialdamage.
NOTE
Usefulapplicationadvice,nopotentialdangerinvolved.
NOTE
Noteregardingenvironmentalprotection.

42015
GeneralInformation
1.4 Intended Purpose
TheInnuPure®C96providesanextractiontoolthatisintendedforcompleteisolation
andpurificationofnucleicacids.
Theavailablerangeofapplicationsisrestrictedbythescopeofincludedfunctionalsoft-
wareandfirmware,aswellasthescopeofdelivery.Forthisreason,theuseris
prohibitedfromoperatingthesysteminanywayotherthanspecifiedinthisUser
Manual.
1.5 Conforming Use
ConforminguseoftheInnuPure®C96ismainlydistinguishedbyautomated
processingsequences(processsteps)usingliquidhandlingprinciplesandpurification
procedures,basedonmagneticparticleseparation.
Conforminguseisunderstoodtomeanoperationwith96deepwellmicroplates(stan-
dardSBSformat).
Different(tested)extractionkitsareavailableforusewiththeInnuPure®C96,
forexample:
kitforisolationofgenomicDNA,
kitforisolationofviralorbacterialnucleicacid,
kitfortheprocessingofforensicsamples.
Systemoperationwillbedeemedasconformingifsolelybasedonextractionkitsthat
havebeenapprovedbythemanufacturerandspecifiedforusewiththe
InnuPure®C96.
TheInnuPure®C96’sbasic(automated)functionsprovidepipetting,mixingand
heatingprocedures.Necessarymanualinterventionsarereducedtoaminimum.
Thetermconformingusefurtherincludessupervisedmonitoring(byqualified
personnel)ofprocessescarriedoutinautomaticmode.
Thedefinitionfornon-conforminguseincludes:
operatingthesysteminmedicallaboratoriesofanon-researchprofile
workingwithexplosivesubstances
workinginanexplosiveatmosphere–operationinapotentiallyexplosivezoneis
prohibited

2015 5
GeneralInformation
Thisshallincludecompliancewithallvalidsafetyrequirementsfortheprotectionof
personsandmaterialgoodsduringworkwithradioactive,infectious,poisonous,
corrosive,combustibleandotherhazardoussubstances.Theuserisunderobligationto
fulfilallrequirementsforlaboratoryequipmentandtheconductofpersonnelhandling
substancesofthisnatureandonthepracticesinplaceforcleanliness,sterilization,
environmentalprotectionandwastedisposal.
Theuserisadvisedtoissuespecialoperatinginstructionswherethesystemistobe
operatedwiththeinvolvementofhazardoussubstances.Accordingly,thisUserManual
containsnosafetynotewarningofpersonalinjuryormaterialdamagecausedby
substancesbeingexamined.
Processcontrolmustrelyonincludedsoftware.Alterationsordamageto
systemsoftwaremaygiverisetofaultsinprocessflowanddamagethesystemorits
components.Softwareprotectionisthesoleresponsibilityoftheuser.
NOTE
InnuPure®C96systemoperationinvolvingdangeroussubstanceswillbeatthesole
responsibilityoftheuser!

62015
GeneralInformation
1.6 Warranty & Liability
Theperiodofwarrantyandscopeofliabilitieswillbeasstipulatedunderbindinglaw
andprovidedforintheGeneralTermsofBusinessofAnalytikJenaAG.
Warrantywillbelimitedtorepairservicesorreplacementofdamagedparts.Itwill
excludeconsequentialdamageofanykind.Damagetowear&tearpartsandcasesof
glassbreakagearenotcoveredbywarranty.
AnydeviationfromconforminguseasdefinedinthisUserManual(operating
requirements,processsequences)willresultinrestrictedacceptanceofwarrantyor
liabilityclaimsintheeventofdamage.
Intheeventofpersonalinjuryormaterialdamage,noclaimforwarrantyandliability
willbeaccepted,unlessthesystemisoperatedasspecifiedinsection
“Conforming Use” on page 4.
NOTE
Thisloss-of-warrantyclauseshallapplytopotentialperiodsofinterruptioninbusiness
andtoanysystemcomponentthathadnotbeendirectlyaffectedbyauthorized
warrantywork.

2015 7
GeneralInformation
1.7 Scope of Delivery
Dependingontheselectedmodeloption,theproductcanbedeliveredin
configurationsaslistedbelow:
InnuPure®C961
– Transportingunit
–StackerA
–StackerB
Cabling
–Linepowercable
–USBcable
Documentation
–UserManual
– TranslationoforiginalUserManual*
–ECConformityDeclaration
– Accessories’catalog*
Packaging
– Shippingcase
– Shippingbrackets/fixtures
1Basicunitwithpipettinghead96/1000 μl

82015
GeneralInformation