Leica BOND-PRIME User manual

BOND-PRIME
FULLY AUTOMATED IHC AND ISH STAINING SYSTEM
USER MANUAL
A D V A N C E D S T A I N I N G I N S T R U M E N T S
(NOT for use in China)

BOND-PRIME User Manual, 91.7500.501 A07
Copyright © 2023 Leica Biosystems Melbourne Pty Ltd 2
Table of contents
Table of contents 2
1 BOND-PRIME hardware 25
1.1 About the BOND System 26
1.1.1 BOND System ancillary materials and consumable items 27
1.2 The BOND-PRIME Processing Module 29
1.2.1 Front view 29
1.2.2 Rear view 30
1.3 The Hood 31
1.4 Preload and Unload Drawers 32
1.5 Slide Drawer Inserts, Waste Drains and Sumps, and Pickup Filter 33
1.5.1 Slide Drawer Inserts 33
1.5.2 Waste Drains 34
1.5.3 Sumps and Pickup Tube with Filter 35
1.6 Reagent Platform 36
1.7 Bulk Containers 37
1.8 Reservoir Cabinet 39
1.9 AC power switch 40
1.10 Reagent Trays 41
1.11 The Work Surface (under the Hood) 42
1.12 Work Surface (front view) 43
1.12.1 High-Speed Robot 44
1.12.2 Probe Selector 45
1.12.3 Wash Robots 46
1.12.4 ARC (Active Reagent Control) Modules 47
1.12.5 Wash/Prime Stations 49
1.12.6 Mixing Well Plate 50
1.12.7 Slide Preparation Station 51
1.13 Connect the processing module and switch on 52
1.14 Disconnect the processing module 54
1.15 Move a processing module to a new location 56
1.16 Decommission and dispose of a processing module 58

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BOND-PRIME User Manual, 91.7500.501 A07
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2 Touchscreen 59
2.1 Log in and log out 60
2.1.1 Log in 60
2.1.2 Log out 61
2.2 Navigation Bar 62
2.3 Status Screen 63
2.3.1 Slides Loaded Segment 63
2.3.2 Slides Processing Segment 65
2.3.3 Slides Processing Complete Segment 67
2.3.4 View more slide information 68
2.3.5 Unexpected events during processing 69
2.4 Action Queue and Alert Banner 71
2.4.1 Show and hide the Action Queue 71
2.4.2 Complete a task suggested in an Action Queue Item 72
2.4.3 Manually hide the Alert Banner 73
2.5 Preload slides 74
2.6 Preload Screen 76
2.6.1 Preload Drawer view 77
2.6.2 Preload Case view 79
2.7 Unload slides 81
2.8 Unload Screen 83
2.8.1 Unload Drawer view 84
2.8.2 Unload case view 85
2.9 Detailed case and slide information 87
2.9.1 View each slide in a case 89
2.9.2 Stop a slide in progress 90
2.10 Reagents Screen 91
2.10.1 Prepare Reagent Container and Reagent Trays 91
2.10.2 Load Reagent Trays 93
2.10.3 Examples of reagent system icons 94
2.10.4 Examples of Reagent Container icons 94
2.10.5 View reagent system and Reagent Container details 95
2.10.6 Unload Reagent Trays 97

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BOND-PRIME User Manual, 91.7500.501 A07
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2.11 Maintenance Screen 98
3 Quick start 99
3.1 Introduction 100
3.2 Start the processing module 101
3.3 Load the Reagent Tray and DS9824 Detection System 103
3.4 Preload, process, and unload the slides 105
4 Cleaning and maintenance 109
4.1 Maintenance schedules 110
4.1.1 Preventative service reminder 110
4.1.2 Cleaning and maintenance schedule 110
4.1.3 Cleaning and maintenance checklist 112
4.2 Refill the DI Water Container 113
4.3 Refill the Alcohol Container 115
4.4 Refill the Lot Tracked Bulk Containers 118
4.5 Empty the Waste Containers 121
4.6 Use the BOND-PRIME Cleaning Kit 123
4.7 Start Maintenance 127
4.8 Wipe internal surface of ARC Modules 129
4.9 Wipe down Reagent Platform and ARC Bank Surfaces 133
4.10 Clean the Suction Cup 137
4.11 Replace the Suction Cup 141
4.12 Clean the Slide Drawer Inserts, Waste Drains and Sumps, and Pickup Filter 145
Clean the Slide Drawer Inserts 145
Clean the Waste Drains and Sump 149
Clean the Pickup Tube and Filter 150
4.13 Clean the Wash/Prime Stations 154
4.14 Use the BOND-PRIME ARC Refresh Kit 158
4.15 Clean the Bulk DI Water Container 163
4.16 Clean the Locked Bulk Reagent Containers 166
4.17 Clean the Waste Containers 176
4.18 Clean the Sump Tray 179
4.19 Stop maintenance 181
4.20 Shutdown the processing module 183

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BOND-PRIME User Manual, 91.7500.501 A07
Copyright © 2023 Leica Biosystems Melbourne Pty Ltd 5
4.21 Replace power supply fuses 185
5 Troubleshooting 188
5.1 Failure to initialize 189
5.2 Network connectivity error 189
5.3 Manually retrieve slides from the processing module 190
5.3.1 Manually retrieve slides from Preload and Unload Drawers 190
5.3.2 Manually retrieve slides from the Work Surface 191
5.3.3 Manually retrieve slides from ARC Modules 193
5.3.4 Manually retrieve slides from ARC Modules during a power failure 196
5.4 Remove a slide fragment from an ARC Module 198
6 Specifications 200
6.1 System specifications 201
6.2 Physical specifications 201
6.3 Electrical power and UPS requirements 201
6.4 Environmental specifications 202
6.5 Operating specifications 202
6.6 Microscope slide specifications 203
6.7 Transport and storage specifications 204
Index 205

BOND-PRIME User Manual, 91.7500.501 A07
Copyright © 2023 Leica Biosystems Melbourne Pty Ltd
6
Legal notices
Trademarks
Leica and the Leica logo are registered trademarks of Leica Microsystems IR GmbH and used under license. BOND
System, BOND-III, BOND-MAX, BOND-PRIME, BOND-ADVANCE, Covertile, Bond Polymer Refine Detection, Bond
Polymer Refine Red Detection, Parallel Automation, Compact Polymer, and Oracle are trademarks of Leica
Biosystems Melbourne Pty Ltd ACN 008 582 401. Other trademarks are the property of their owners.
Copyright
Leica Biosystems Melbourne Pty Ltd owns the copyright on this document and any associated software. Under law,
our written permission is required before either the documentation or the software is copied, reproduced, translated,
or converted to electronic or other machine-readable form, in whole or in part.
Copyright © 2023 Leica Biosystems Melbourne Pty Ltd
Product identification
Doc. 91.7500.501 A07
Manufacturer
Leica Biosystems Melbourne Pty Ltd
495 Blackburn Road
Mount Waverley VIC 3149
Australia
Important information for all users
This manual contains important information on how to use BOND-PRIME. For the latest information on Leica
Biosystems products and services, please visit www.leicabiosystems.com.
Due to a policy of continuous improvement, Leica Biosystems reserves the right to change specifications without
notice.

BOND-PRIME User Manual, 91.7500.501 A07
Copyright © 2023 Leica Biosystems Melbourne Pty Ltd
7
Terminology
The following terms are used in this document:
lLeica Biosystems—refers to Leica Biosystems Melbourne Pty Ltd.
lBOND System - the Leica Biosystems platform that includes the BOND-III, BOND-MAX, and BOND-PRIME
lBOND-PRIME - a type of automated IHC and ISH staining instrument
lBOND System software - the software application through which users can configure and operate the BOND-
III, BOND-MAX, or BOND-PRIME system
Intended users
The intended users of BOND-PRIME are adequately trained laboratory personnel.
Persons operating a BOND Processing Module must have received sufficient training to ensure that it is used in
accordance with this document and be fully aware of any potential hazards or hazardous procedures, before
operating the processing module. Only trained staff are to remove any covers or parts from the processing module,
and only if instructed within this manual.
Installation and repairs
Installation and repairs must only be carried out by qualified service personnel authorized by Leica Biosystems.
Warranty claims can be made only if the product has been used for the specified application and operated according
to the instructions in this document. Damage resulting from inappropriate handling and/or misuse of the product will
invalidate the warranty. Leica Biosystems cannot assume liability for any such damage.
Serious incident reporting
The occurrence of any serious incident(s) that either has led to, or may lead to, death of a patient or user, or the
temporary or permanent deterioration in the state of health of a patient or user must be reported to a local Leica
Biosystems representative and the relevant local Regulatory Authority.
Statement for User Data Security and Privacy
Leica Biosystems respects, and is committed to protecting, personal data security and privacy. The Leica Biosystems
Privacy Notice below describes the personal data that we may collect, use and retain.
Privacy Notice
The licensee shall comply with all applicable data protection and privacy laws in processing personal data using the
BOND, without limitation, by making all required notifications to, and obtaining all required consents from, patients
and other data subjects prior to processing their personal data.

BOND-PRIME User Manual, 91.7500.501 A07
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The following types of Personal Data exist on the BOND Processing Module:
lPatient Name — is held temporarily on the BOND for tracking the run details of the slide whilst the slide is
processed.
lDoctor Name — is held temporarily on the BOND for tracking the run details of the slide whilst the slide is
processed.
lSlide ID — is held temporarily on the BOND for tracking the run details of the slide whilst the slide is processed.
lUser account details — User account details are encrypted in the data files and retained in the BOND System
Controller until deleted by a Supervisor. No user data is stored on the BOND Processing Module.
lSlide Images — Images of processed slides are collected for tracking the run details of the slide. Slide images
are encrypted in the data files and retained on the BOND System Controller indefinitely. The images are
automatically removed from the BOND Processing Module after one day.
Contacting Leica Biosystems
For service or support contact your local Leica Biosystems representative or see www.leicabiosystems.com.

BOND-PRIME User Manual, 91.7500.501 A07
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Revision record
Rev Issued Sections affected Detail
A07 January
2023
All
4.14Use the BOND-PRIME ARC Refresh Kit
6Specifications
5Troubleshooting
Legal notices
Changed layout of the manual.
Added slide count equivalency table.
Enhanced slide specifications image.
Added Service life and cybersecurity
certificate life.
Added Troubleshooting chapter.
Added Statement of Intended Use of Personal
Data.
A06 July 2022 2.10.4Examples of Reagent Container
icons
4.14Use the BOND-PRIME ARC Refresh Kit
4.1Maintenance schedules
Removed obsolete reagent container icons.
ARC Refresh kit maintenance period changed
to 4 months.
A05 April 2022 1.8Reservoir Cabinet
1.9AC power switch
1.4Preload and Unload Drawers
2.5Preload slides
2.6Preload Screen
2.7Unload slides
2.8Unload Screen
3.4Preload, process, and unload the slides
4.12Clean the Slide Drawer Inserts, Waste
Drains and Sumps, and Pickup Filter
4.14Use the BOND-PRIME ARC Refresh Kit
4.16Clean the Locked Bulk Reagent
Containers
1.12.3Wash Robots
5.3.3Manually retrieve slides from ARC
Modules
1BOND-PRIME hardware
4.21Replace power supply fuses
1.2The BOND-PRIME Processing Module
Updated images of Reservoir Cabinet.
Updated images of Preload and Unload
Drawers.
Updated image to remove and install
Covertile.
Added information about refilling the
containers.
Added notes about being able to manually
move Wash Robots.
Removed part numbers.
A04 January
2022
5.3Manually retrieve slides from the
processing module
Glossary of symbols
All
Added instructions for removing slides from
the processing module.
Updated Glossary of Symbols.
Updated Intended Use statement.
Various corrections and updates to reflect
the latest touchscreen interface and to
improve the usability of the manual.
Removed Clean the Slide Preparation
section.

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Rev Issued Sections affected Detail
A03 June 2021 Front cover
General cautions
1.1About the BOND System
1.2The BOND-PRIME Processing Module
1.7Bulk Containers
1.11The Work Surface (under the Hood)
1.12.5Wash/Prime Stations
1.12.7Slide Preparation Station
2.3Status Screen
2.3.1.1Slides not accepted
2.3.5Unexpected events during processing
2.4Action Queue and Alert Banner
2.5Preload slides
3Quick start
3.2Start the processing module
4.1Maintenance schedules
4.2Refill the DI Water Container
4.4Refill the Lot Tracked Bulk Containers
4.5Empty the Waste Containers
4.6Use the BOND-PRIME Cleaning Kit
4.8Wipe internal surface of ARC Modules
4.14Use the BOND-PRIME ARC Refresh Kit
4.11Replace the Suction Cup
4.13Clean the Wash/Prime Stations
4.12Clean the Slide Drawer Inserts, Waste
Drains and Sumps, and Pickup Filter
4.15Clean the Bulk DI Water Container
4.16Clean the Locked Bulk Reagent
Containers
4.17Clean the Waste Containers
4.18Clean the Sump Tray
6Specifications
Rebranding.
Various corrections, updates and additions
etc. in all listed sections affected.
A02 April 2021 All First release.
A01 - - Not released.

BOND-PRIME User Manual, 91.7500.501 A07
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Regulatory notices
Intended purpose
The BOND system automates clinical protocols for immunostaining of pathology specimens mounted
on microscope slides. Microscope slides subsequently undergo interpretation by a qualified healthcare
professional to aid diagnosis.
FCC compliance
This equipment has been tested and found to comply with the limits for a Class A digital device, pursuant to part 15
subpart B of the FCC Rules. These limits are designed to provide reasonable protection against harmful interference
when the equipment is operated in a commercial environment. This equipment generates, uses, and can radiate radio
frequency energy and, if not installed and used in accordance with the instruction manual, may cause harmful
interference to radio communications. Operation of this equipment in a residential area is likely to cause harmful
interference in which case the user will be required to correct the interference at his own expense.
To maintain compliance use only the cables supplied with the instrument.
WARNING: Any changes or modifications not expressly approved by Leica Biosystems could void the
user’s authority to operate this equipment.
CE marking
The CE Mark signifies compliance with the applicable EU Directives as listed on the
manufacturer declaration of conformity.
Instructions for in vitro diagnostic equipment for professional
use
This IVD equipment complies with the emission and immunity requirements of IEC 61326 part 2-6.
The electromagnetic environment should be evaluated prior to operation of the device.
Do not use this device in close proximity to sources of strong electromagnetic radiation (e.g. unshielded intentional
RF sources), as these can interfere with the proper operation.
WARNING: This equipment was designed and tested to CISPR 11 Class A. In a domestic environment
it may cause radio interference, in which case you may need to take measures to mitigate the
interference.
Computer regulatory requirements: UL Listed (UL 60950), IEC 60950 certified.

BOND-PRIME User Manual, 91.7500.501 A07
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CAUTION: Federal Law restricts this device to sale by or on the order of a licensed healthcare
practitioner.
Classification of equipment under CISPR 11 (EN 55011)
This equipment is classified as Group 1 Class A under CISPR 11 (EN 55011). The explanation for group and class is
described below.
Group 1 - This is applicable for all equipment which is not classified as group 2 equipment.
Group 2 - This is applicable for all ISM RF equipment in which radio - frequency energy in the frequency range 9kHz to
400GHz is intentionally generated and used or only used, in the form electromagnetic radiation, inductive and/ or
capacitive coupling, for the treatment of material or inspection/ analysis purposes.
Class A - This is applicable for all equipment suitable for use in all establishments other than domestic and those
directly connected to a low voltage power supply network which supplies buildings used for domestic purposes.
Class B - This is applicable for all equipment suitable for use in domestic establishments and in establishments
directly connected to a low voltage power supply network which supplies buildings used for domestic purposes.
Definitions
ISM: Industrial, Scientific and Medical
RF: Radio Frequency

BOND-PRIME User Manual, 91.7500.501 A07
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Glossary of symbols
This section describes the regulatory and safety symbols used in the product labeling.
Regulatory symbols
Explanation of the regulatory symbols used for Leica Biosystems products.
This glossary provides images of the symbols as presented in the relevant standards, however, some
of the symbols may vary in color.
The following is a list of symbols used on the product labeling and their meaning.
ISO 15223-1
Medical devices – symbols to be used with medical device labels, labeling and information to be supplied – Part1:
General requirements.
Symbol Standard/
Regulation
Reference Description
ISO 15223-1 5.1.1 Manufacturer
Indicates the medical device manufacturer.
ISO 15223-1 5.1.2 Authorized representative in the European community
Indicates the Authorized representative in the European Community.
ISO 15223-1 5.1.3 Date of manufacture
Indicates the date when the medical device was manufactured.
ISO 15223-1 5.1.4 Use by (expiration date)
Indicates the date after which the medical device is not to be used.
ISO 15223-1 5.1.5 Batch code
Indicates the manufacturer's batch code so that the batch or lot can
be identified.
ISO 15223-1 5.1.6 Catalog number / Reference number
Indicates the manufacturer's catalog number so that the medical
device can be identified.
ISO 15223-1 5.1.7 Serial number
Indicates the manufacturer's serial number so that a specific medical
device can be identified.

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Symbol Standard/
Regulation
Reference Description
ISO 15223-1 5.1.8 Importer
Indicates the entity importing the medical device into the European
Union.
ISO 15223-1 5.1.9 Distributor
Indicates the entity distributing the medical device into the locale.
ISO 15223-1 5.3.1 Fragile; handle with care
Indicates a medical device that can be broken or damaged if not
handled carefully.
ISO 15223-1 5.3.4 Keep away from rain
Indicates that the transport package shall be kept away from rain and
in dry conditions.
ISO 15223-1 5.3.7 Temperature limit
Indicates the temperature limits to which the medical device can be
safely exposed.
ISO 15223-1 5.4.2 Do not re-use
Indicates a medical device that is intended for one use, or for use on a
single patient during a single procedure.
ISO 15223-1 5.4.3 Consult instructions for use
Indicates the need for the user to consult the instructions for use.
ISO 15223-1 5.4.4 Caution
Indicates the need for the user to consult the instructions for use for
important cautionary information such as warnings and precautions
that cannot, for a variety of reasons, be presented on the medical
device itself.
ISO 15223-1 5.5.1 In Vitro Diagnostic medical device
Indicates a medical device that is intended to be used as an in vitro
diagnostic medical device.

BOND-PRIME User Manual, 91.7500.501 A07
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ISO 7000
Graphical symbols for use on equipment — Registered symbols.
Symbol Standard/
Regulation
Reference Description
ISO 7000 1135 Recycle
Indicates that the marked item or its material is part of a recovery or
recycling process.
ISO 7000 1640 Technical manual; manual for service
Identifies the location where the handbook is stored or to identify
information that relates to the servicing instructions for the
equipment. To indicate that the service manual or handbook should
be considered when servicing the device close to where the symbol is
placed.
ISO 7000 2594 Ventilation open
Identifies the control that allows outside air into interior environment.
ISO 7000 3650 USB
Identifies a port or plug as meeting the generic requirements of the
Universal Serial Bus (USB). To indicate that the device is plugged into
a USB port or is compatible with a USB port.
IEC 60417
Graphical symbols for use on equipment.
Symbol Standard/
Regulation
Reference Description
IEC 60417 5007 On
Indicates connection to the mains, at least for mains switches or their
positions, and all those cases where safety is involved
IEC 60417 5008 Off
Indicates disconnection from the mains, at least for mains switches
or their positions, and all those cases where safety is involved
IEC 60417 5009 Stand-by
Identifies the switch or switch position by means of which part of the
equipment is switched on in order to bring it into the standby
condition
ISO 60417 5016 Fuse
Identifies fuse boxes or their location.

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Symbol Standard/
Regulation
Reference Description
IEC 60417 5019 Protective earth: protective ground
A terminal that is intended for connection to an external conductor for
protection against electric shock in case of a fault, or the terminal of a
protective earth (ground) electrode.
IEC 60417 5032 Single phase alternating current
Indicates on the rating plate that the equipment is suitable for
alternating current only; to identify relevant terminals.
IEC 60417 5988 Computer network
Identifies the computer network itself or to indicate the connecting
terminals of the computer network.
IEC 60417 6057 Caution: moving parts
An instructional safeguard to keep away from moving parts.
IEC 60417 6222 Information; general
Identifies the control to examine the status of the equipment, e.g.
multifunctional copying machines

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Other symbols and markings
Symbol Standard/
Regulation
Reference Description
Only
21 CFR 801.15
(c)(1)(i)F
Prescription only
Recognized by the US FDA as an alternate to "Caution: Federal law
restricts this device to sale by or on the order of a licensed
practitioner."
The instrument
Declaration of
Conformity lists
the Directives
with which the
system complies
European Conformity
The instrument Declaration of Conformity lists the Directives with
which the system complies.
Directive
2012/19/EC EU:
waste electrical
and electronic
equipment
(WEEE)
Waste Electrical and Electronic Equipment (WEEE) Directive
The electronic product should not be discarded as unsorted waste but
must be sent to separate collection facilities for recovery and
recycling.
The presence of this label indicates that:
lThe device was put on the European Market after August 13,
2005.
lThe device is not to be disposed of via the municipal waste
collection system of any member state of the European Union.
Customers must understand and follow all laws regarding the correct
decontamination and safe disposal of electrical equipment.
AS/NZS 4417.1 Regulatory Compliance Mark (RCM)
Indicates compliance with the Australian Communications Media
Authority (ACMA) requirements (safety and EMC) for Australia and
New Zealand.
People’s
Republic of
China Electronic
Industry
Standard
SJ/T11364
Restriction of Hazardous Substances (RoHS 2)
Indicates that this electronic information product contains certain
toxic or hazardous elements, and can be used safely during its
environmental protection use period. The number in the middle of the
logo indicates the environmental protection use period (in years) for
the product. The outer circle indicates that the product can be
recycled. The logo also signifies that the product should be recycled
immediately after its environmental protection use period has
expired. The date on the label indicates the date of manufacture.

BOND-PRIME User Manual, 91.7500.501 A07
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Symbol Standard/
Regulation
Reference Description
People’s
Republic of
China Electronic
Industry
Standard
SJ/T11364
Restriction of Hazardous Substances (RoHS 2)
Indicates that this electronic information product does not contain
any hazardous substances, or they do not exceed the concentration
limits specified in GB/T 26572. It is a green environmentally friendly
product that can be recycled.
Title 47 United
States Code of
Federal
Regulations Part
15
Federal Communications Commission (FCC)
This product has been tested and found to comply with the limits
pursuant to part 15 of the FCC Rules.
N/A Underwriters Laboratory (UL) certification mark
Underwriter Laboratories have certified that the listed products
comply with both US and Canadian safety requirements.
CSA
International
Listed device with CSA Group testing agency
CSA Group have certified that the listed products comply with both US
and Canadian safety requirements.
N/A Listed device with Intertek testing agency
Intertek Testing Agency have certified that the listed products comply
with both US and Canadian safety requirements.
N/A Relative humidity range
Indicate the acceptable upper and lower limits of relative humidity for
transport and storage. This symbol is accompanied by the applicable
relative humidity limits.
N/A Unconnected port
This product has an unconnected port on the syringe pump.

BOND-PRIME User Manual, 91.7500.501 A07
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Safety symbols
Explanation of the safety symbols used for BOND.
ISO 7010
Graphical symbols — Safety colors and safety signs — Registered safety signs.
Symbol Standard/
Regulation
Reference Description
ISO 7010 W001 General warning
Indicates the need for the user to consult the instructions for use for
important cautionary information such as warnings and precautions
that cannot, for a variety of reasons, be presented on the medical
device itself.
ISO 7010 W004 Warning: laser beam
Laser hazard. Potential for severe eye damage. Avoid direct eye
contact with laser beams.
ISO 7010 W007 Warning: floor-level obstacle
Floor-level obstacle hazard. Take care when in the vicinity of a floor-
level obstacle.
ISO 7010 W009 Warning: biological hazard
Biological hazard. Potential exposure to a biological hazard. Follow
directions in the accompanying documentation to avoid exposure.
ISO 7010 W012 Caution: risk of electric shock
Electrical hazard. Potential risk of electric shock. Follow directions in
the accompanying documentation to avoid damage to persons or
equipment.
ISO 7010 W016 Warning: toxic material
Toxic hazard. Potential danger of severe health impacts if proper
chemical handling procedures are not followed. Use gloves and
protective eye wear when handling reagents.
ISO 7010 W017 Warning: hot surface
Heat hazard. Hot surfaces will cause burns if touched. Avoid touching
parts identified with this symbol.
ISO 7010 W020 Warning: Overhead obstacle
Overhead obstacle. Take care to avoid being struck by or walking into
an overhead obstacle.
ISO 7010 W021 Warning: flammable material
Flammable hazard. Flammable materials may ignite if proper
precautions are not followed.

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Symbol Standard/
Regulation
Reference Description
ISO 7010 W022 Warning: Sharp element
Sharp element. Take care to avoid injury from sharp elements (e.g.
needles, blades).
ISO 7010 W023 Warning: corrosive substance
Chemical hazard from a corrosive substance. There is a danger of
severe health impacts if proper precautions are not followed. Always
wear protective clothing and gloves. Immediately clean up spills using
standard laboratory practice.
ISO 7010 W024 Warning: crushing of hands
Crush hazard. Hands or body parts can be crushed by a closing
motion of mechanical parts of equipment.
ISO 7010 W072 Warning: Environmental hazard
Environmental hazard. Substance or mixture that can cause an
environmental hazard.
General warnings
Warnings are notifications of hazards that could lead to personal injury, or where there is the possibility of losing,
damaging, or misidentifying patient samples. Follow all safety precautions to avoid personal injury, damage, loss or
misidentification of patient samples, and damage to equipment.
Warnings use symbols with a black border and yellow background.
General BOND-PRIME warnings appear below. Other warnings appear in the relevant sections in the manual.
Instrument operation
To make sure that the BOND-PRIME Processing Module operates correctly, always
obey the approved instructions from Leica Biosystems Melbourne Pty Ltd. If you do not
obey instructions correctly, this can cause unsatisfactory performance.
BOND-PRIME does not require network access to function and perform its intended
use. To prevent malicious or unauthorized access, install BOND-PRIME without any
connection to your network / infrastructure.
If you would like network connection, the preferred method is to connect BOND-PRIME
to a fire walled Virtual Local Area Network (VLAN). Alternatively, you can implement
and validate your own network security mechanisms in accordance with your standard
operating procedures.
For more information, refer to the BOND System 7+ Information Systems Guide
(49.6539.811).