REPLIGEN KrosFlo SYITF-2000 User manual

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KrosFlo® Systems
User Guide
For use with:
•KrosFlo® KTF Tangential Flow Filtration (TFF) System
•KrosFlo® KPS Perfusion (KPS) System
•KrosFlo® TFDF® Tangential Flow Depth Filtration (TFDF) System

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The information contained in this document is subject to change without notice.
With respect to documentation accompanying product, Repligen makes no warranty, express or
implied. Any and allwarranties related to the documentation accompanying product are expressly
disclaimed. Customer shall refer tothe terms and conditionsof sale governing the transaction for
any and all warranties for the Product.
Repligen Corporation shall not be liable for errors contained herein or for incidental or
consequential damages in connection with the furnishing, performance, or use of this material.
No part of this documentmay be photocopied, reproduced, or translated to another language
without the prior written consent of Repligen Corporation.
Products are not intended for diagnostic or therapeutic use or for use in vivo with humans or
animals.
For further information, please contact Repligen Corporation at www.repligen.com.
©2023 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property
of Repligen Corporation and/or its affiliate(s) or their respective owners.
Customer Support
customerserv[email protected]om
1-508-845-3030 (Option 1)
Repligen Corporation
111 Locke Drive
Marlborough, Massachusetts 01752
www.repligen.com

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Contents
1. Introduction.........................................................................................................................7
2. Safety Precautions................................................................................................................7
2.1 Signal Words...........................................................................................................................7
2.2 Safety Symbol Icons................................................................................................................8
3. Safety Guidelines..................................................................................................................9
3.1 Intended User Guide Audience ..............................................................................................9
3.2 Intended Use of the System.................................................................................................10
3.3 Warnings for Moving, Installing, and Storing the System....................................................10
3.4 Warning for System Preparations ........................................................................................11
3.5 Warnings for System Operation...........................................................................................11
3.6 Warnings for System Maintenance......................................................................................14
4. System Specifications .........................................................................................................15
5. System Dimensions.............................................................................................................17
6. RoHS and WEEE Compliance ...............................................................................................17
7. System Overview................................................................................................................18
7.1 Main System.........................................................................................................................18
7.2 Cassette Holder Cart (optional)............................................................................................19
7.3 Auxiliary Cart (optional)........................................................................................................19
8. Unpacking the System ........................................................................................................20
9. Performing Mechanical Installation.....................................................................................21
9.1 Main System Assembly.........................................................................................................21
9.2 Cassette Holder Assembly (optional)...................................................................................23
9.2.1 Cassettes Installation..................................................................................................23
9.2.2 Hydraulic Pump Preparation.......................................................................................24
9.3 Single-Use Flow-path Assembly............................................................................................26
9.3.1 Recirculation Pump Preparation and Connections.....................................................26
9.3.2 Feed Tank/Reservoir Connections..............................................................................30
9.3.3 Installing Auxiliary Pump Tubing.................................................................................32
10. Performing Electrical Installation ........................................................................................33
10.1 Sensor and Communication Cables......................................................................................33
10.1.1 Pressure Sensors.........................................................................................................33
10.1.2 Installing Ferrite Bead for Pressure Sensors...............................................................34
10.1.3 Installing Permeate Flow Sensors...............................................................................35
10.1.4 Other Sensor and Communication Cables..................................................................35
10.1.5 Connectingthe System Power Cables ........................................................................36
11. Using the System HMI.........................................................................................................36
11.1 Human Machine Interface (HMI) Overview .........................................................................36
11.2 Getting Started.....................................................................................................................37
11.3 Loading and Running Recipes...............................................................................................38
11.4 Home Screen.........................................................................................................................39
11.5 Process Screen......................................................................................................................40
11.6 Alarms Screen.......................................................................................................................42
11.7 Diagnostics Screen................................................................................................................43
12. Operating the System.........................................................................................................44
12.1 Executing Reports.................................................................................................................44
12.2 System Emergency Stop and Responses ..............................................................................45
12.2.1 Stopping the System Using the E-Stop Button ...........................................................45
12.2.2 Restarting the System after an Emergency Stop........................................................45
12.3 System Power Loss and Responses ......................................................................................46
12.3.1 System Power Loss......................................................................................................46
12.3.2 Restarting the System after a Power Loss..................................................................46
12.4 Shutting Down the System...................................................................................................46

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13. Performing System Maintenance ........................................................................................47
13.1 Making the System Safe for Maintenance ...........................................................................47
13.2 Cleaning the System.............................................................................................................47
13.3 Cleaning the Flow-path.........................................................................................................47
13.4 Flow-path disassembly and storage.....................................................................................48
13.5 System Moving and Storage.................................................................................................48
13.6 KrosFlo® System Spare Parts................................................................................................49
14. Troubleshooting the System ...............................................................................................52
15. Index..................................................................................................................................53

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List of Tables
Table 1. Signal words, definitions, and colors.........................................................................................7
Table 2. Safety Symbol Icons...................................................................................................................8
Table 3. KrosFlo® System Feature/Component Specifications.............................................................15
Table 4. KrosFlo® System Electrical Specifications ...............................................................................16
Table 5. KrosFlo® System Environmental Specifications ......................................................................16
Table 6. KrosFlo® System Spare Parts...................................................................................................49
Table 7. Basic System Troubleshooting Steps.......................................................................................52
List of Figures
Figure 1. Sample Machine Designation Label.......................................................................................16
Figure 2. KrosFlo® System Dimensions.................................................................................................17
Figure 3. KrosFlo® System Overview.....................................................................................................18
Figure 4. Optional Cassette Holder Cart...............................................................................................19
Figure 5. Optional Auxiliary Cart...........................................................................................................19
Figure 6. Pump Stand Assembly............................................................................................................22
Figure 7. Cassette Installation...............................................................................................................23
Figure 8. Hydraulic Pump Components ................................................................................................24
Figure 9. Typical Flow Path with HollowFiber and Cassette Filter Connections..................................26
Figure 10. Typical Feed Tank or Reservoir Connections.......................................................................30
Figure 11. Recipe SelectionScreen.......................................................................................................38
Figure 12. Sample Home Screen...........................................................................................................39
Figure 13. Sample Process Screen ........................................................................................................40
Figure 14. Sample Alarms Screen..........................................................................................................42
Figure 15. Sample Diagnostics Screen ..................................................................................................43

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Abbreviations
Amp Ampere
C Celsius
CF Concentration factor
cm Centimeter
DV Diafiltration volume
ES Electrical schematic
EU Europe
F Fahrenheit
FDS Functional design specification
ft Feet
GA General arrangement drawing
HDS Hardware design specification
HMI Human machine interface
Kg Kilograms
TFDF Tangential depth filtration system
lbs. Pounds
LCD Liquid-crystal display
lpm Liters per minute
M Meter
mA Milliampere, or milliamp
MBT Module bag tubing
NWP Normalized water permeability
P&ID Piping and instrumentation diagram
PID Proportional integral derivative (tuning)
PLC Programmable logic controller
Psi Pounds per square inch
rpm Revolutions per minute
SAS Standard alert symbol
SDS System design specification
TFF Tangential Flow Filtration
TMP Transmembrane pressure
VAC Volts AC power
VVD Vessel volumes per day (perfusion exchange rate)

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1. Introduction
KrosFlo® Systems from Repligen provide ready-to-use, flexible flow-path solutions for commercial-
scale microfiltration and ultrafiltration process operations.
Each system includes magnetic drive centrifugal pump(s), clamp-on flow meters, pressure sensors,
peristaltic pumps, custom flow path assemblies with or without filters, and connections for
additional process monitoring. Other optional components of the system include valves, external
input(s), and communication accessories.
The system includes a Human Machine Interface SCADA (Supervisory control and data acquisition
application) to initiate actions.
Additionally, there is a PLC (Programmable Logic Controller) and or Remote I/O platform contained
in a stainless steel skid that serves as the support structure. All units run on 200-240 VAC power. The
System is intended for indoor use only.
2. Safety Precautions
2.1 Signal Words
The signal word and color distinguish the severity level of a hazard. Signal worddefinitions and
colors are listed in Table 1.
Table 1. Signal words, definitions, and colors
Icon Description
Safety Alert Symbol (SAS) - used when a hazard to personnel is present.The SAS is
omitted when thehazard is related to property/equipment damageonly.
A DANGER notification indicates an imminently hazardous situation which, if not
avoided, will result in death or serious injury.
A WARNING notification indicates a potentially hazardous situation which, if not
avoided, could result in death or serious injury.
A CAUTION notification indicates a potentially hazardous situation which, if notavoided,
may result in minor or moderate injury.
A CAUTION notification without the Safety Alert Symbol indicates a potentially
hazardous situation which, if not avoided, may result in property/equipment damage.

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2.2 Safety Symbol Icons
The typical safety symbol icons - hazard, prohibition, and mandatory action - used on Repligen
Systems are listed in Table 2. The icons are pictograms that communicate hazards quickly and across
language barriers.
Table 2. Safety Symbol Icons
Safety Symbol Icons Used in this Document
Electrical Hazard Heavy Object Heat Hazard
Radiation Hazard
Crush Hazard
Pinch Hazard
Inhalation Hazard
Authorized and Qualified
Personnel Only
Read the Manual
Noise Level Hazard
UV Hazard

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3. Safety Guidelines
3.1 Intended User Guide Audience
This User Guide for KrosFlo Systems is intended to be used by experienced users, working in pilot or
production facilities. Users should have advanced understandings and working experiences of
upstream and downstream processes.
Because this User Guide only focuses on the equipment set-up and its detailed operations, users
should have the support from both Process Subject Matter Expert and Automation Expert to set-up
the process parameters and operate the System.
This User Guide is intended to act as a reference only, in conjunction with other materials, such as
application notes, automation documents, component manuals, or maintenance manuals. It should
not be used as the sole source of knowledge. Users must not expect to operate the System by just
reading this User Guide.
If users do not have the above experience or technical support, or they do not understand any
instructions in this User Guide, contact Repligen for assistance or training before proceeding.
The instructions in this user guide are not a substitute for the observance of the System owner’s
company-specific regulations and requirements.
Note:
This User Guide presents and describes a sample KrosFlo System configuration. Sample HMI screens
are included that represent this configuration. As a KrosFlo System may be customized to support a
particular bioprocessing development process, your KrosFlo System hardware, automation software,
and HMI screens may differ from this sample configuration. Safety information presented in this
user guide applies to all KrosFlo Systems.
Please refer to the following system design documents included in the electronic Turn Over Package
(eTOP) for details about your KrosFlo System software and hardware configuration, and capabilities:
•Hardware Design Specification (HDS)
•Core Standard Platform Software Operations Manual (SOM)
•KrosFlo® Systems Software Operations Manual (SOM)
•Recipe Editor Software Operations Manual (SOM)
•CFR 21 Part 11 Regulatory Compliance Guidance (REG)
•General Arrangement (GA) Drawing
•Piping and Instrumentation Diagram (P&ID)
•Electrical Specifications (ES)

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3.2 Intended Use of the System
The KrosFlo® System is designed to execute traditional batch processes for concentration, with
several buffer exchange or wash steps.
The System will be fully configured for the disposable ProConnex® flow-paths, which include
flexible tubing, Hollow Fiber module or Cassette, disposable levitating pump head, pressure
transmitters, with associated connections or thermal plastic weldable tubing.
The System is assembled, wired, configured, and tested by Repligen prior to shipping and
installation at the clientsite.
Consumables such as Hollow Fiber Filter, Cassettes, Sensors, or Flow-paths are integrated parts
of the System, but they may require specific maintenance methods. Refer to the vendor-
provided User Guides for more information on these consumables.
3.3 Warnings for Moving, Installing, and Storing the System
1. The KrosFlo System is intended to be unpacked and installed by trained service personnel
only.
2. Do not attempt to lift the System. The System should only be moved by carefully rolling the
System on its casters. The System shipping crate includes an integral ramp that allows the
Systemto be rolledout of the crate.
3. Be sureto set thebrake on each casterto prevent unintended motion.
4. The System is heavy and can cause crushing injury during a moving mishap. To prevent
injury, wear toe protection, such as steel-toe work boots.
5. Using a forklift (or other equipment moving machinery) of insufficient capacity can result in
unexpected dropping of the System, resulting in injury or death. To prevent injury or death
due to unexpecteddropping, use a forklift rated to lift the weight of the System.
6. Careless moving of the heavy System can result in workers being squeezed or crushed
against other equipment or walls. To prevent squeezing and crushing injury, move the
equipment slowly and ensure workers do not position themselves where injury could result.
7. Do not allow the wheels of the System to run-off of ramps. Use a sufficient number of
movers to maintain control of the System, particularly when the System is on ramps.
WARNING – Only Authorized and Qualified Personnelare allowed to
use this equipment. Ensure installation, maintenance, and operation
are completed by qualified and trained personnel.
WARNING – If you use the System in a manner not specified in this user
guide, you may be exposedto hazards leading to personal injury or
equipment damage.Do not operatethe System at temperatures or
pressures above those stated in this user guide.
WARNING – Alwayswear the personal protective equipment required
by the System owner’s safety program. This includes equipment to
prevent exposure to process fluids.

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3.4 Warning for System Preparations
1. Perform a risk assessment for the area in which you plan to use the System, to ensure the
classification of the area does not change.
2. To provide quick access for disconnecting power in case of emergency, do not block access
to the System power switch, receptacles where the power cords are plugged in, or the main
circuit disconnect.
3. To prevent the System from overheating, do not block the air intake or exhaust openings on
the Controller Cabinet.
4. To avoid risk of electric shock, this equipment must only be connected to AC mains with
protective earth using a twist lock connector. Nomodification of this equipment is allowed.
5. To avoid injuries from tripping, route and secure all piping and tubing sensibly and keep
them out of the user’s way.
6. Before starting up the System, inspect all mechanical and electrical components thoroughly
for potential damages. These include punctured bags and tubing, damaged connections, and
loosen electrical connections.
7. Only use the System in an indoor environment with an ambient atmosphere meeting the
operating specifications.
8. Do not plug in or introduce electricity to the System during Mechanical Assembly.
9. Do not introduce power or plug the System in a power outlet during Electrical Connections
procedure until instructed to do so.
3.5 Warnings for System Operation

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1. If the KrosFlo System is used in a manner not specified by the manufacturer, the protection
provided by the unit may be impaired.
2. Obtain work authorization and check the status of theSystem. Using the System without
physical supervision (for example, if System is remotely controlled), when it is damaged or
has malfunctioned, can led to personal injury.
3. If untrained or unauthorized personnel operate the System incorrectly, System damage can
result. To prevent System damage due to improper operations, ensure personnel are trained
appropriately for their levels of access and use secured access passwords to prevent
unauthorized operation.
4. Running the System manually without adequate training can lead to equipment damage. To
prevent equipment damage, ensure personnel do not run the System manually unless they
are adequately trained and have the correct authorization level.
5. Pressingthe emergency stop button does not disconnect power fromthe electrical control
panel and pumps.
6. The System flow-path may remain filled and slightly pressurized during power lost or
emergency-stop. Opening a line, connector, or component could release biologically or
chemically hazardous materials, resulting in injury or death.
7. To prevent exposure to hazardousmaterials, follow the procedures and appropriate
instructions for the correct assembly, setup, verification, and operation of the System.
Follow the System owner’s PPE requirements.
8. Moving the System or vibration during operation can loosen connections, resulting in a spill
of a potentially hazardous process fluid leading to injury. To prevent spills, exposure, and
injury, ensure all process connections are securely connected and all legs are leveled and
locked, then replace the appropriate components as soon as possible, for example the flow-
path.
9. Maintain a safe distance from the System during System startup or other activities that may
involve splashing.

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10. Never exceed theoperatinglimits detailedin this user guide or on the System label.
Operating the System outside of the statedlimits mayresult inequipment damage and
personal injury.
11. Using process or cleaning fluids that are incompatible with the flow-path materials can
damage the System.
12. Do not connect components that are not rated for the System, this includes owner-supplied
cassettes, flow-paths, hoses, tanks, and any other accessories.
13. Drain connections must be connected unrestrictedly to drain header and maintained at
atmospheric pressure. Any valves in this path shall be locked open with suitable owner-safe
procedures in place. Avoid pooling in drain lines.
14. Use a harmless fluid, for example water, during startup to enable detection of leaks without
exposure to hazardous fluids.
15. Set alarm limits within the specifications noted in this User Guide or within the limits
recommended in the software.
16. When alarms are triggered, address all ofthem one-by-one before continuing with System
operation.
17. Due to anoise levelof 80 decibels or greater,ear protection isrequired when the System
pumps are operated at a speed of greater than(>) 6000 RPM.
18. For Systems equipped with an optional UV photometer, note the following safety guidelines:
•WARNING: The photometer can emit light from ≈200 – 1100nm . Hazardous UV and
IR radiation are emitted from the unit. Never directly stare into the source/return
ports on the photometeror the fiberoptic cables, asthis can cause eye damage. The
viewer-related risk is dependent on how the users install and use the product.
•Ensure that both ends of the fiber optic cables (photometer and flow cell
connections) are properly secured (firmly hand tight) before powering on the
photometer.
•The photometer should always be powered off when handling the fiber optic cables.
If you must handle the fibers when the unit is powered on, protective eyewear must
be worn.
•In the event of product failure, do not attempt to open the unit or replace the LED.
There are no user-serviceable parts.

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3.6 Warnings for System Maintenance
1. Obtain work permits such as lockout/tagout and other permits—per System owner’s safety
procedures before servicing or maintaining the System.
2. Improper opening of the electrical panel and incorrectlockout/tagout can lead to electric
shock resulting in injury or death. To prevent injury or death from electric shock, follow your
company’s lockout/tagout and electrical panel entry procedures.
3. Due to anoise levelof 80 decibels or greater,ear protection isrequired when the System
pumps are operated at a speed of greater than(>) 6000 RPM.
4. If unqualified personnel open and work inside electrical power panels, injury can result from
electric shock. To prevent injury by electric shock, ensure only qualified maintenance
personnel open electrical power panels.
5. Only personnel authorized by Repligen should perform service, installation, and
maintenance inside the System’s electrical panels.
6. To ensure safe andcorrect operation, use accessories and replacement parts that are
approved or supplied by Repligen.
7. Before inspecting or working on the System using ladders, check and follow local regulations
for fall protection.
8. System must be turned off when replacing fuses to prevent electrical hazard. Any electrical
work beyond the electrical connections procedure and fuse replacement should be
performed by trained personnel only.
9. Opening the flow-paths without flushing them may result in injury from exposure to
hazardous process fluids. To prevent this, purge, flush, and decontaminate the System
before opening flow-paths. Always check the pressure readings on the System HMI to
confirm depressurization has been achieved before performingmaintenance activities.
10. Peristaltic pumps must be turned off when replacing either tubing or pump heads to prevent
crushing/pinching hazard.
11. Repligen does not recommend use of Vaporized Hydrogen Peroxide (VHP) to clean the
KrosFlo system.

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4. System Specifications
Table 3. KrosFlo® System Feature/Component Specifications
KrosFlo® System Feature/Component Specification
Typical process volumes
30 L - 5000 L
Maximum filter area
2 each up to 17.2 m2(Hollow fiber)
2 each up to 20 m2(Cassettes)
Recirculation Pumps
Up to 2 Mag Lev (100 to 2000-series)
Maximum configurable speed for the 2000SU
recirculation pumps is: 6500 RPM
Flow rate
Each pump up to85 LPM
Maximum pressure
Up to 2.0 Bar
Minimumhold up volume
200 mL to 6.0 L
Tubing
3/8 in ID to 1 in ID
Feed/Retentate flow meters
Clamp-on flow meter ultrasonic
Permeate flow meters
Clamp-on or flow through flow meter ultrasonic
Feed scale or Client signal (4 - 20 mA)
Up to 5000 Kg+
Cabinet width
30 inches (one or two recirculating pumps)
TMP control
Non-invasive/No-product contact
Pressure sensors
PS 0.25 in,0.375, 0.5 in, 1.0 in, and 1.38 in
Auxiliary pumps
Tri-lobe SS Peristaltic pump
Programmable Logic Controller
Allen Bradley
Software
AVEVA® System Platform (formerly Wonderware)
•AVEVA® InTouch
•AVEVA® Historian
•AVEVA® Historian Client
•AVEVA® Application Server
•Allen-Bradley® AVEVA® Operations Integration
DeltaV
DeltaV Connectivity Capable
GMP
21 CFR Part 11 Enabled

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Table 4. KrosFlo® System Electrical Specifications
Note:
Below is a sample System machine designation label, located on the back side ofthe controller
cabinet. Observe all listed electrical ratings and ensure those are metbefore using the System.
Figure 1. Sample Machine Designation Label
Table 5. KrosFlo® System Environmental Specifications
KrosFlo® System Model Power Utility Required
SYIPS/TF/DF-200
200-240 VAC (±10%), 1Ph (Neutral and Ground), 50/60 Hz, 20A
SYIPS/TF/DF-600
200-240 VAC (±10%), 1Ph (Neutral and Ground), 50/60 Hz, 20A
SYIPS/TF/DF-700
200-240 VAC (±10%), 1Ph (Neutral and Ground), 50/60 Hz, 20A
SYIPS/TF/DF-1000
200-240 VAC (±10%), 1Ph (Neutral and Ground), 50/60 Hz, 30A
SYIPS/TF/DF-1600
200-240 VAC (±10%), 1Ph(Neutral andGround),50/60 Hz, 30A
SYIPS/TF/DF-2000
200-240 VAC (±10%), 1Ph (Neutral and Ground), 50/60 Hz, 30A
KrosFlo® System Specification
System Weight
300 lbs./135 Kg (approximately)
Operating Temperature
0 to 40° C/32 to 104° F
Operating Humidity
≤80%
Operating Altitude
Up to 2000 m
Pollution Degree
Pollution Degree 2
Chemical Resistance
Frame and Controller Cabinet: SS-304
Casters: SS-304 and Polyurethane
Flow-path Components: Polypropylene, polycarbonate,
Polysulfone, and C-Flex/Pharmapure materials
Intended Use Environment
For Indoor Use Only

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5. System Dimensions
Figure 2. KrosFlo® System Dimensions
30-inch Controller Cabinet Models:
KTF-200, KTF-600, KTF-700, KTF-1000, KTF-1600, and KTF-2000
6. RoHS and WEEE Compliance
Repligen Corporation sources and uses only RoHS compliant materials in all
applicable product lines and has met itsobligations to the EU WEEE andBattery
Directive by registering in those countries towhich The Repligen Corporation is an
importer.
Repligen Corporation has also elected to join WEEE and Battery Compliance
Schemes insome countriesto help manage customer returns at end-of-life.
The presence of the crossed-out wheeled bin label on this product implies that the product contains
electrical or electronic materials that may be hazardous and present a risk to human health and the
environment when waste electrical and electronic equipment (WEEE) is not handled correctly.
Electrical and electronic equipment and batteries must be disposed of in an appropriate manner,
separate from standard unsorted waste streams. As legislation and disposal facilities may vary
throughout the European Union member states, please contact Repligen Corporation
([email protected]) for further information regarding the proper disposal of
products marked with the crossed-out wheeled bin label.
For disposal in countries outsideof the European Union. This symbol is only validfor use within the
European Union (EU). If you wish to discard this product, please contact your local authorities for the
correct method of disposal.

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7. System Overview
7.1 Main System
An overview of the typical System is presented below.
Figure 3. KrosFlo® System Overview
Note:
(*) The specifications and quantity of these components are subject to change depending on
System configuration.
(**) The System may come with otherkits and carts such as scales, cassette carts, tanks, etc.
Refer to individual component User Guides for more information.

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7.2 Cassette Holder Cart (optional)
Figure 4. Optional Cassette Holder Cart
7.3 Auxiliary Cart (optional)
Figure 5. Optional Auxiliary Cart

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8. Unpacking the System
Follow the high-level steps below to unpack the KrosFlo System:
1. Check and confirm that all boxes have been received. The wooden crate containsthe
System.
2. Place the forklift blades under the crate in a centered position, and transport the System
close to its intended operating location.
3. Unscrew and remove the front panel (the panel with the ramp built-in).
4. Safely set that panel down, close to the crate. This panel will act asa ramp.
5. Unscrew and remove three reinforcing bars from the crate.
6. Unlock the System two front wheels.
7. Using at least twopeople, carefully pull the System out the crate and move it off the ramp.
8. Unwrap the System.
9. Visually inspect for any possible shipping damages. If found, notify Repligen immediately.
10. Extend the leveling feet and adjust them until the System is properly leveled.
11. Check the rigidity and tightness of components to their supports, ensuring vibration during
shipping did not loosen them.
Note:
•Loose components such as auxiliary pumps, back pressure valves, flow meters, and other
miscellaneous components are packed separately in several carton boxes.
•Open all the boxes and check if all components are received.
WARNING – Refer to section 3 for complete Safety Precautions.
The KrosFlo System is intended tobe unpacked and installed by trained service personnel only.
Do not attempt to lift the System.The System should only be moved by carefully rolling the System on its
casters. The System shipping crate includes anintegral ramp that allows the System to be rolled out of the
crate. Be sure to set the brake on each caster to prevent unintended motion.