Thermo Scientific 7470 Series User manual

User Manual
Model 7450 and 7470 Series
CryoMed Controlled Rate Freezer
Operating and Maintenance Manual 7027452 Rev. 4
Visit us online to register your warranty
www.thermoscientific.com/labwarranty

Thermo Scientific
MANUAL NUMBER 7027452
4 30873/FR-2674 7/24/14 Corrected overlay part number in Parts List (Section 7) from 140296 to 140460 ccs
3 30873/FR-2674 7/22/14 RoHS overlay part number - wiring diagrams in Section 7 ccs
2 29779 5/27/14 New software V2.0 ccs
1 28702/FR-2371 8/29/12 Removed flatbed scanner references ccs
1 28816/FR-2371 8/29/12 Added ferrite - parts list, schematics, wiring diagrams ccs
0 28576/FR-2357 7/31/12 Original - Release 4 with new printer power supply ccs
0 28511/FR-2371 7/31/12 Original - Release 4 with new printer power supply ccs
REV ECR/ECN DATE DESCRIPTION By
Preface
Controlled Rate Freezer i
Non-IVF Units
Model Voltage
7450 120
7451 230
7452 120
7453 230
7454 120
7455 230
7472 100
7473 100
7474 100
IVF Units
Model Voltage
7456 120
7457 230
7458 120
7459 230
7475 100
7476 100
Models covered in this manual”

Thermo Scientificii Controlled Rate Freezer
Preface
Important Read this instruction manual. Failure to read, understand and follow the instructions in this manual
may result in damage to the unit, injury to operating personnel, and poor equipment performance. s
Caution All internal adjustments and maintenance must be performed by qualified service personnel. s
Material in this manual is for information purposes only. The contents and the product it describes are subject to
change without notice. Thermo Fisher Scientific makes no representations or warranties with respect to this
manual. In no event shall Thermo be held liable for any damages, direct or incidental, arising out of or related to
the use of this manual.
©2012 Thermo Fisher Scientific. All rights reserved.

Thermo Scientific Controlled Rate Freezer iii
Preface
Important operating and/or maintenance instructions. Read the accompanying text carefully.
Potential electrical hazards. Only qualified persons should perform procedures associated with this
symbol.
Equipment being maintained or serviced must be turned off and locked off to prevent possible injury.
Hot surface(s) present which may cause burns to unprotected skin, or to materials which may be
damaged by elevated temperatures.
Marking of electrical and electronic equipment, which applies to electrical and electronic equipment
falling under the Directive 2002/96/EC (WEEE) and the equipment that has been put on the market
after 13 August 2005.
This product is required to comply with the European Union’s Waste Electrical & Electronic
Equipment (WEEE) Directive 2002/96/EC. It is marked with the WEEE symbol. Thermo Fisher
Scientific has contracted with one or more recycling/disposal companies in each EU Member State
European Country, and this product should be disposed of or recycled through them. Further
information on Thermo’s compliance with this directive, the recyclers in your country and information
on Thermo products will be available at www.thermo.com.
4Always use the proper protective equipment (clothing, gloves, goggles, etc.)
4Always dissipate extreme cold or heat and wear protective clothing.
4Always follow good hygiene practices.
4Each individual is responsible for his or her own safety.

Thermo Scientificiv Controlled Rate Freezer
Preface
Do You Need Information or Assistance on
Thermo Scientific Products?
If you do, please contact us 8:00 a.m. to 6:00 p.m. (Eastern Time) at:
1-740-373-4763 Direct
1-800-438-4851 Toll Free, U.S. and Canada
1-877-213-8051 FAX
http://www.thermoscientific.com Internet Worldwide Web Home Page
[e-mail] Tech Support Email Address
Certified Service Web Page
Thermo Fisher Scientific
401 Millcreek Road, Box 649
Marietta, OH 45750
Our staff can provide information on pricing and give you quotations. We can
take your order and provide delivery information on major equipment items or make
arrangements to have your local sales representative contact you. Our products are listed on the
Internet and we can be contacted through our Internet home page.
Our staff can supply technical information about proper setup, operation or
troubleshooting of your equipment. We can fill your needs for spare or replacement parts or
provide you with on-site service. We can also provide you with a quotation on our Extended
Warranty for your Thermo Scientific products.
Whatever Thermo Scientific products you need or use, we will be happy to discuss your
applications. If you are experiencing technical problems, working together, we will help you
locate the problem and, chances are, correct it yourself...over the telephone without a service
call.
When more extensive service is necessary, we will assist you with direct factory trained
technicians or a qualified service organization for on-the-spot repair. If your service need is
covered by the warranty, we will arrange for the unit to be repaired at our expense and to your
satisfaction.
Regardless of your needs, our professional telephone technicians are available to assist you
Monday through Friday from 8:00 a.m. to 6:00 p.m. Eastern Time. Please contact us by
telephone or fax. If you wish to write, our mailing address is:
International customers, please contact your local Thermo Scientific distributor.
Sales Support
Service Support
www.unitylabservices.com

Controlled Rate Freezer vThermo Scientific
Table of Contents
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1-1
Standard Features . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1-2
Door Latch . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1-2
Sample ‘Seeding’ Access Ports (IVF) . . . . . . . . . . . . . . . . . . . . . . . .1-2
Displays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1-2
Indicators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1-3
Keys . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1-3
Alarm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1-3
Output . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1-3
Pre-set Profiles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1-4
Set-Up and Operation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-1
Supplies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-3
Electrical Connections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-3
Environmental Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-3
Sample Thermocouple Connection . . . . . . . . . . . . . . . . . . . . . . . . . .2-4
Power-Up . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-4
Access Code Security . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-5
Initiate a Profile . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-5
Stop a Profile Run . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-6
Program User Specific Profiles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-7
Manual Override . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-7
Copy and Paste Pre-set and User Profiles . . . . . . . . . . . . . . . . . . . . .2-10
Printer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-11
Chamber Thermocouple Open . . . . . . . . . . . . . . . . . . . . . . . . . .2-12
Alarms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-12
Sample Thermocouple Open . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-13
Heater Malfunction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-15
Chamber/Sample Over/Under Limit Temp . . . . . . . . . . . . . . . . . .2-15
Temperature Tracking Alarm . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-16
Run Complete . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-17
Power Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-17
IVF Sample Holders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-18
Warm Complete . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-18
Seeding Hold . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-18
Printer Buffer Full . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-18
Using the Straw Holder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-19
Using a Vial Holder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-19
Using the Cane Holder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-20
Holder Adjustment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2-21
Section 1
Section 2

vi Controlled Rate Freezer Thermo Scientific
Configuration/Calibration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3-1
Menu Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3-1
Menu Entry Definitions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3-1
Maintenance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4-1
Disinfect Controlled Rate Freezer Interior . . . . . . . . . . . . . . . . . . . . .4-1
Clean a Major Spill in the Chamber . . . . . . . . . . . . . . . . . . . . . . . .4-2
Clean Gasket/Heat Break . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4-3
Clean the Cabinet Exterior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4-3
Printer Set-Up . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5-1
Change the Paper . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5-1
Specifications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6-1
Parts List . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7-1
Exploded Parts Drawings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7-3
Wiring Diagrams . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7-15
Electrical Schematics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8-1
Troubleshooting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9-1
PC Interface Software . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-1
Installation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-2
Login . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-6
Login Error Messages . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-8
Setup . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-8
Run Operation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-9
Run File Name . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-10
Information Fields . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-11
Profile Steps . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-12
Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-12
Chamber/Sample Temperature . . . . . . . . . . . . . . . . . . . . . . . . . .10-12
Remaining Time . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-12
Mode . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-13
Remote Mode . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-13
Graph . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-13
Graph Legend . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-14
Typical Run Procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-14
Manual Override Procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-17
End Run . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-18
Table of Contents
Section 3
Section 4
Section 5
Section 6
Section 8
Section 7
Section 9
Section 10

Print . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-19
Alarms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-20
Power Failure Recovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-22
Display/Control Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-23
Edit Screen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-24
Startup . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-25
Create Profile . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-28
Edit Profile . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-29
Print a Profile Listing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-32
Display Profile Temperature Graph . . . . . . . . . . . . . . . . . . . . . . .10-32
Error Messages . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-33
Review Screen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-34
User Controls . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-35
Options Screen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-39
Plot Colors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-39
Description . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-40
Default Directories . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-40
Users . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-41
Username Policies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-42
Password Policies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-43
Anonymous User Policies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-43
Information Fields . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-43
Status Bar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-44
Help . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-45
About . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10-45
Warranty Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11-1
Handling Liquid Nitrogen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .AA-1
Controlled Rate Freezer viiThermo Scientific
Section 10 (continued)
Section 11
Appendix

Controlled Rate Freezer 1-1Thermo Scientific
Section 1 Introduction
Figure 1-1. Non-IVF Controlled Rate Freezer
Figure 1-2. IVF Controlled Rate Freezer (FDA clearance for human research)