GE AKTA ready XL User manual

ÄKTA™ ready XL
Operating Instructions
Original instructions
gelifesciences.com
*** TeDIS Valid on Date Printed Printed on: 15-09-2023 11:27:35 ***
185018004599

Table of Contents
1Introduction .............................................................................................................. 4
1.1 About this manual ..................................................................................................................................... 5
1.2 Important user information ................................................................................................................... 6
1.3 Associated documentation ................................................................................................................... 9
1.4 Abbreviations .............................................................................................................................................. 11
2 Safety instructions .................................................................................................. 12
2.1 Safety precautions .................................................................................................................................... 13
2.2 Labels ............................................................................................................................................................. 21
2.3 Emergency procedures ........................................................................................................................... 24
3 System description ................................................................................................. 30
3.1 Overview ....................................................................................................................................................... 31
3.2 Illustrations .................................................................................................................................................. 33
3.3 Flowchart ...................................................................................................................................................... 43
3.4 System components ................................................................................................................................. 47
3.4.1 Skid and electrical cabinet ................................................................................................................. 48
3.4.2 Control system components ............................................................................................................ 49
3.4.3 System pumps ...................................................................................................................................... 51
3.4.4 Valves ....................................................................................................................................................... 55
3.4.5 Transmitters and sensors ................................................................................................................. 60
3.5 Flow kits ......................................................................................................................................................... 62
3.5.1 Flow kit description ............................................................................................................................. 63
3.5.2 Flow kit parts and components ....................................................................................................... 65
3.5.3 Gradient section and components ................................................................................................. 71
3.6 Process control software ........................................................................................................................ 72
4 Installation ................................................................................................................ 76
4.1 Site requirements ...................................................................................................................................... 77
4.2 Transport and moving of the system .................................................................................................. 78
4.3 Setup ............................................................................................................................................................... 86
4.3.1 Assembly ................................................................................................................................................ 87
4.3.2 Setup of control system and network ........................................................................................... 90
4.3.3 Connect compressed air supply ...................................................................................................... 91
4.3.4 Guidelines for connections ................................................................................................................ 92
4.4 Power supply ............................................................................................................................................... 93
5 Preparation ............................................................................................................... 94
5.1 Start the system and log on to control software ........................................................................... 96
5.2 Install disposable flow kits ..................................................................................................................... 97
5.3 Perform flow kit installation test ......................................................................................................... 123
5.4 Prime to remove air from the pump and flow path ....................................................................... 126
5.5 Install filter (optional) ............................................................................................................................... 129
6 Operation .................................................................................................................. 130
6.1 Connect a column ...................................................................................................................................... 131
6.2 Run a method .............................................................................................................................................. 134
Table of Contents
2 ÄKTA ready XL Operating Instructions 29281616 AE
*** TeDIS Valid on Date Printed Printed on: 15-09-2023 11:27:35 ***

6.3 Controlled shutdown and removal of flow kit ................................................................................. 139
7Maintenance ............................................................................................................. 143
8 Troubleshooting ...................................................................................................... 146
9 Reference information ........................................................................................... 149
9.1 Specifications .............................................................................................................................................. 150
9.2 Flow kit ordering information ................................................................................................................ 152
9.3 Chemical resistance ................................................................................................................................. 153
9.4 Recycling information .............................................................................................................................. 156
9.5 Regulatory information ........................................................................................................................... 157
9.5.1 Contact information ........................................................................................................................... 158
9.5.2 European Union and European Economic Area ......................................................................... 159
9.5.3 Eurasian Economic Union
Евразийский экономический союз ........................................................................................ 160
9.5.4 Regulations for USA ............................................................................................................................ 162
9.5.5 Regulatory statements ...................................................................................................................... 163
9.5.6 Declaration of Hazardous Substances (DoHS) .......................................................................... 164
9.5.7 Additional regulations and standards .......................................................................................... 166
9.6 Health and Safety Declaration Forms ................................................................................................ 167
9.7 More information ....................................................................................................................................... 169
Index ................................................................................................................................... 170
Table of Contents
ÄKTA ready XL Operating Instructions 29281616 AE 3
*** TeDIS Valid on Date Printed Printed on: 15-09-2023 11:27:35 ***

1 Introduction
About this chapter
This chapter contains important user information, descriptions of safety notices, reg-
ulatory information, intended use of ÄKTA ready XL, and lists of associated docu-
mentation.
In this chapter
Section See page
1.1 About this manual 5
1.2 Important user information 6
1.3 Associated documentation 9
1.4 Abbreviations 11
1 Introduction
4 ÄKTA ready XL Operating Instructions 29281616 AE
*** TeDIS Valid on Date Printed Printed on: 15-09-2023 11:27:35 ***

1.1 About this manual
Purpose of this manual
The Operating Instructions provide you with the information needed to install, oper-
ate, and maintain the product in a safe way.
Scope of this manual
This manual is specific for ÄKTA ready XL and describes the safety instructions and
procedures required to operate ÄKTA ready XL together with either the ¾ inch or 1
inch disposable ÄKTA ready XL Flow kit, as well as technical information and instruc-
tions for troubleshooting and maintenance.
Only UNICORN™ software instructions are provided as examples. For other control
software instructions, refer to the software documentation.
Detailed information regarding columns, resin and buffer tanks is not covered.
Illustrations
The illustrations provided in this manual are for illustrative purposes and may not al-
ways be representative for ÄKTA ready XL.
Typographical conventions
Software items are identified in the text by bold italic text.
Hardware items are identified in the text by bold text.
In electronic format, references in italics are clickable hyperlinks.
1 Introduction
1.1 About this manual
ÄKTA ready XL Operating Instructions 29281616 AE 5
*** TeDIS Valid on Date Printed Printed on: 15-09-2023 11:27:35 ***