Endress+Hauser analytikjena CyBio QuadPrint HQ-M User manual

Operating Manual
CyBio QuadPrint HQ-M/L

Manufacturer Analytik Jena GmbH
Konrad-Zuse-Straße 1
07745 Jena / Germany
Phone: [phone]
Phone: [phone]
Mail: [email protected]
Technical Service Analytik Jena GmbH
Konrad-Zuse-Straße 1
07745 Jena / Germany
Phone: [phone]
Fax: [phone]
E-mail: [email protected]
General Information http://www.analytik-jena.com
Documentation Number 30-5004-026-26-BLE
Edition B (03/2023)
Technical Documentation Analytik Jena GmbH
© Copyright 2023, Analytik Jena GmbH
For a proper and safe use of this product follow the instructions. Keep the
operating manual for future reference.

CyBio QuadPrint HQ-M/L Table of contents
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Table of contents
1 General ................................................................................................................................................................. 7
1.1 Notes ................................................................................................................................................................. 7
1.1.1 Scope ................................................................................................................................................................. 8
1.2 Intended use (purpose).................................................................................................................................... 8
1.3 Standards and directives .................................................................................................................................. 9
2 Safety instructions................................................................................................................................................ 10
2.1 General.............................................................................................................................................................. 10
2.2 Safety markings ................................................................................................................................................ 10
2.3 Danger areas and protective devices............................................................................................................... 13
2.3.1 Hazard zones .................................................................................................................................................... 13
2.3.2 Protective devices ............................................................................................................................................. 14
2.4 Requirements for the operating personnel..................................................................................................... 15
2.5 Device-specific safety instructions................................................................................................................... 15
2.5.1 Safety instructions for operation ..................................................................................................................... 15
2.5.2 Safety instructions: Transport.......................................................................................................................... 16
2.5.3 Safety instructions – maintenance and service............................................................................................... 16
2.6 Safety instructions ............................................................................................................................................ 16
2.6.1 Handling hazardous substances ...................................................................................................................... 16
2.6.2 Chemical resistance .......................................................................................................................................... 16
2.7 Behavior during emergencies .......................................................................................................................... 17
3 Technical description............................................................................................................................................ 18
3.1 Layout................................................................................................................................................................ 18
3.1.1 Type plate.......................................................................................................................................................... 19
3.1.2 Barcode/label printer ....................................................................................................................................... 19
3.1.3 Ram applicator.................................................................................................................................................. 19
3.1.4 CyBioQuadStack............................................................................................................................................... 20
3.1.5 Barcode reader.................................................................................................................................................. 22
3.1.6 Compressed air control unit ............................................................................................................................. 23
3.2 Functionality ..................................................................................................................................................... 23
4 Commissioning ..................................................................................................................................................... 25
4.1 Location requirements ..................................................................................................................................... 25
4.2 Initial commissioning and configuration......................................................................................................... 26
4.3 Re-commissioning............................................................................................................................................ 26
5 Operation.............................................................................................................................................................. 27
5.1 Switching on ..................................................................................................................................................... 27
5.2 Inserting microplates........................................................................................................................................ 28
5.3 Switching off ..................................................................................................................................................... 29
6 Troubleshooting ................................................................................................................................................... 30
6.1 General information on troubleshooting ........................................................................................................ 30
6.2 Behavior after fault reports.............................................................................................................................. 30
6.3 Fault removal.................................................................................................................................................... 31

Table of contents CyBio QuadPrint HQ-M/L
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7 Maintenance......................................................................................................................................................... 34
7.1 Safety instructions ............................................................................................................................................ 34
7.2 Maintenance schedule ..................................................................................................................................... 35
7.3 Maintenance instructions ................................................................................................................................ 35
7.3.1 Cleaning the device........................................................................................................................................... 35
7.3.2 Checking compressed air.................................................................................................................................. 36
7.3.3 Changing label roll/transfer ribbon................................................................................................................. 36
8 Transport and storage.......................................................................................................................................... 38
8.1 Transport........................................................................................................................................................... 38
8.2 Storage .............................................................................................................................................................. 39
9 Putting the device out of operation ..................................................................................................................... 40
10 Disposal ................................................................................................................................................................ 41
11 Accessories, spare parts, consumables................................................................................................................. 42
11.1 Consumables and wearing parts...................................................................................................................... 42
11.2 Accessories........................................................................................................................................................ 42
11.3 Spare parts ........................................................................................................................................................ 42
12 Technical data ...................................................................................................................................................... 43
Glossary ................................................................................................................................................................ 46
Index ..................................................................................................................................................................... 47
13 Appendices ........................................................................................................................................................... 48
13.1 Software "CyBio PrintStudio"............................................................................................................................. 48
13.2 Supplier documentation................................................................................................................................... 48

CyBio QuadPrint HQ-M/L Table of figures
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Table of figures
Fig. 1 Warning labels on the device .............................................................................................................................. 11
Fig. 2 Hazard zones........................................................................................................................................................ 13
Fig. 3 STOP button ......................................................................................................................................................... 14
Fig. 4 Design (CyBio QuadPrint HQ-M) ........................................................................................................................ 18
Fig. 5 Connections.......................................................................................................................................................... 20
Fig. 6 Control unit........................................................................................................................................................... 21
Fig. 7 Barcode reader ..................................................................................................................................................... 22
Fig. 8 Compressed air control unit ................................................................................................................................ 23
Fig. 9 Control unit on the QuadStack ............................................................................................................................ 28
Fig. 10 Loading QuadPrint HQ-x ..................................................................................................................................... 29
Fig. 11 Compressed air control unit ................................................................................................................................ 36
Fig. 12 Replacing the label roll and the transfer ribbon ................................................................................................ 37
Fig. 13 QuadPrint HQ-L/M: Use handles........................................................................................................................ 38

List of Tables CyBio QuadPrint HQ-M/L
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List of Tables
Table 1 Scope of these instructions...................................................................................................................... 8
Table 2 Warning signs and warning symbols ..................................................................................................... 11
Table 3 Permissible disinfection methods and disinfectants.............................................................................. 17
Table 4 CyBioQuadStack: Faults .......................................................................................................................... 31
Table 5 Barcode/label printer: Faults................................................................................................................... 32
Table 6 Label applicator: Faults............................................................................................................................ 32
Table 7 Maintenance schedule............................................................................................................................. 35
Table 8 Wearing parts........................................................................................................................................... 42
Table 9 Consumables ............................................................................................................................................ 42
Table 10 Device component spare parts list .......................................................................................................... 42
Table 11 Operation, storage and transport conditions ........................................................................................ 44

CyBio QuadPrint HQ-M/L General
7
1 General
1.1 Notes
This document contains information about the setup and operation of the device CyBio
QuadPrint and provides the operating personnel with the necessary know-how for the
safe handling of the device.
The supplier documentation for the label printer and the label applicator is provided
with the device and is also available on the website of the manufacturer cab Produkt-
technik.
Conventions Instructions for actions occurring in chronological order are numbered and combined
into action units.
Warnings are indicated by a warning triangle and a signal word. The type, source and
consequences of the hazard are stated together with notes on preventing the hazard.
Elements of the control and analysis program are indicated as follows:
¡Program terms are in bold (e.g., the System menu).
¡Menu items are separated by vertical lines (e.g., System|Device).
Symbols and signal words used
in this manual
The user manual uses the following symbols and signal words to indicate hazards or in-
structions. These warnings are always placed before an action.
WARNING
Indicates a potentially hazardous situation which can cause death or very serious (possi-
bly permanent) injury.
CAUTION
Indicates a potentially hazardous situation which can cause slight or minor injuries.
NOTICE
Provides information on potential material or environmental damage.

General CyBio QuadPrint HQ-M/L
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1.1.1 Scope
These instructions apply for
Name CyBio QuadPrint HQ-M CyBio QuadPrint HQ-L
Type key 30-5004-027-26 30-5004-026-26
Table1 Scope of these instructions
1.2 Intended use (purpose)
The operator is responsible to use of the device as intended.
The CyBio QuadPrint barcode labeling device has been designed for the automatic pro-
cessing of labware in chemical and biological laboratories. In the field of medicine and
diagnostics its use is limited to research.
The labware that can be processed with the device are microplates in ANSI/SLAS format,
including deep-well and rigid full-skirted PCR plates. It is not possible to process flexible
full-skirted PCR plates and half-skirted PCR plates with this device.
We recommend processing only empty or sealed filled labware.
The basic functions are:
¡Picking up, temporarily holding and transferring labware
¡Automatic printing of barcode labels and attaching these labels to labware
CyBio QuadStack can be loaded and unloaded manually via the stacker shaft doors. It is
not permitted to manually transfer the labware to the access module for labeling pur-
poses.
Please observe the following:
¡The device must only be operated by qualified and trained personnel.
¡The device must only be used in accordance with this manual. This applies in partic-
ular to the adherence to the connection values, conditions of use and notes on the
maintenance, transport, and disposal.
¡The safety instructions in this manual must be observed.
It is not permissible
¡to operate this equipment in a medical laboratory,
¡to work with explosive substances in this device,
¡to operate this device in an explosive environment.
¡to smoke or use a naked flame at the installation location.
As regards the safe handling of dangerous substances (radioactive, infectious, toxic, cor-
rosive, combustible, and other hazardous substances), the owner/operator will be re-
sponsible in accordance with applicable laws and guidelines.

CyBio QuadPrint HQ-M/L General
9
The same applies in terms of compliance with environmental protection rules (e. g. for
disposal of reagents and consumables).
The device may only be used for the processes described in the user manual. Only the
specified use is regarded to be the intended use. Using the device for any other purpose
may compromise the safety of the user and the device.
1.3 Standards and directives
The device was manufactured according to the currently applicable generally recognized
codes of practice and the generally accepted safety-related regulations. The relevant
safety and health requirements of the applicable laws, standards and regulations were
applied during the construction of the device.
CE-labeling and a declaration of conformity confirm the device’s compliance with all rel-
evant safety and health requirements.
Any information regarding safety corresponds to the currently valid regulations of the
European Union. In countries outside the EU, all applicable laws and country-specific
regulations must be complied with.

Safety instructions CyBio QuadPrint HQ-M/L
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2 Safety instructions
2.1 General
For your own safety and to ensure error-free and safe operation of the device, please
read this chapter carefully before commissioning.
Screen Observe all safety instructions listed in these instructions, as well as all messages and in-
structions displayed by the control and analysis software on the monitor.
Besides the safety instructions in these instructions and the local safety regulations that
apply to the operation of the device, the general applicable regulations regarding acci-
dent prevention, occupational health and safety and environmental protection have to
be observed and complied with.
2.2 Safety markings
The warning labels and safety symbols attached to the device are part of the device and
must be strictly observed.
CAUTION
Risk of incorrect handling resulting in personal injury and material damage
due to missing warning labels!
Do not remove any warning labels or safety symbols!
Before switching on the device, check that the warning labels and safety symbols are
complete and intact.
Do not put the device into operation if warning labels or safety symbols are missing or
damaged.
Damaged or missing warning labels or safety symbols must be replaced immediately.
The “Risk of crushing injuries” and “Automatic startup” warning symbols are located on
each of the 4stacker shafts.
The following symbols are attached to the device:

CyBio QuadPrint HQ-M/L Safety instructions
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Fig.1 Warning labels on the device
Icon Meaning Comment
Hazard zone
warning!
Warning of mechanical hazard from moving device
components
Read the instruc-
tions!
These instructions contain important information on
the safe operation of the device
Wear protective
goggles
Wearing protective goggles is generally recom-
mended in a laboratory

Safety instructions CyBio QuadPrint HQ-M/L
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Icon Meaning Comment
Dangerous elec-
trical voltage
warning!
Never open the device!
All repairs must be performed by qualified personnel
only!
Only replace defective fuses with fuses of the speci-
fied type!
Hand injury
warning!
Warning of crushing injuries caused by moving device
components (stacker shafts, turn-lift-turn module,
printer, label applicator)
Automatic start
warning!
Warning of automatically rotating stacker shaft dur-
ing ongoing processes
Crushing injuries
warning.
It is forbidden to
reach into the de-
vice.
Unplug the power
cord before carry-
ing out any main-
tenance work on
the device.
Risk of irreversible hand injuries due to shearing and
crushing caused by moving device components in the
area of the lower stacker shaft opening on the CyBio
QuadStack and the vertical lifter of the access module.
Unplug the power cord before carrying out any main-
tenance work on the device.
Table2 Warning signs and warning symbols

CyBio QuadPrint HQ-M/L Safety instructions
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2.3 Danger areas and protective devices
2.3.1 Hazard zones
1
2
3
Fig.2 Hazard zones
1 CyBio QuadStack, stacker shafts
2 CyBio QuadStack, shaft opening (bottom of the stacker shafts)
3 Label applicator
The rotation of the stacker shaft can put the operating personnel at risk. The 4-fold
stacker shaft is equipped with a transparent protective housing for process security. The
protective housing can be opened on the main operating side via a monitored door.
The lift-turn-lift module and the label applicator are located underneath a transparent
access guard. There is a risk of crushing and shearing fingers and hands at the lower
stacking shaft opening and in the travel range of the applicator.
The operation of the CyBio QuadPrint without the protective housing and the access
guard is not compliant with the intended use and is thus prohibited. Failure to observe
warning information can result in crushing injuries to hands. Any interference with the
device during operation can result in damage to the device and to the samples.
Warning labels

Safety instructions CyBio QuadPrint HQ-M/L
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¡In the event of malfunction, first switch off the device. Unplug the power cord be-
fore, for example, removing microplates that got stuck or clamped inside the device.
¡Never reach into the range of movement of the stacker shaft with your hands or
with any type of object during operation. There is a particular risk of injury at the
gaps at the four stacker shaft doors and at the lower stacker shaft opening. There is
a risk of irreversible hand injuries caused by crushing or shearing.
¡Never operate the CyBio QuadPrint without the protective housing and the access
guard for the lift-turn-lift module and the label applicator.
¡To abort a program, press the STOP button. All drives stop.
¡The stacker shaft will only rotate when the stacker shaft doors are closed. The de-
vice monitors the position of the stacker shaft doors.
¡Always correct any incorrect movement with the aid of the PC. Incorrect handling
and operation can result in material damage and personal injury.
¡Ensure proper compressed-air connection.
The printer’s cover must only be opened to carry out one of the following installation
or maintenance tasks:
– Setting up the printer
– Replacing the label roll or the transfer ribbon
– Troubleshooting
¡Always close the housing of the printer before operating the CyBio QuadPrint. When
the housing is open, it is possible to access hazard zone2 (shaft opening of the Cy-
Bio QuadStack) as well as the print head which puts the operator at risk and may re-
sult in injuries.
¡If the applicator is running, moving components are accessible. This particularly ap-
plies to the area in which the applicator is moved back and forth between its basic
position and the labeling position. During operation, do not reach into this area and
keep hair, loose clothing and jewelry away from this area. When working in this
area, shut off the compressed-air supply.
¡Hot surfaces: The printer (the print head in particular) can heat up during printing
(approx. 50°C); for this reason, do not touch it (during operation) and only carry out
material change or removal after the printer has cooled down.
See also
2Technical data [}43]
2.3.2 Protective devices
1
Fig.3 STOP button
Press the STOP button (1 - see figure) to bring all drives to an immediate stop.

CyBio QuadPrint HQ-M/L Safety instructions
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2.4 Requirements for the operating personnel
The device may only be operated by trained specialist personnel instructed in technical
safety. The operating personnel must have read and understood the operating instruc-
tions.
The personal protective equipment must be worn to operate or service the device.
The operating personnel must be familiar with the dangers arising from the substances
used.
2.5 Device-specific safety instructions
The system must be installed by the service personnel of the manufacturer or duly
trained and authorized expert personnel under any circumstances.
Do not use aggressive substances of a type that may compromise the stable perfor-
mance of the system
Before connecting to the mains, check the electrical requirements of the device.
Observe prescribed maintenance intervals!
Only use the accessory items, consumables and spare parts specified in this document or
provided or recommended by the manufacturer!
2.5.1 Safety instructions for operation
The operator of the device must ensure that the device is in sound condition before each
use. This applies especially after any modification or adaptation of the device or any re-
pair.
Do not operate the system with defective safety devices or with improperly installed
safety and protection devices.
Do not remove, modify or disable any safety and protection devices during operation.
Ensure easy access to the main power switch, as well as to any emergency shutdown
systems and locks at all times during operation.
Ensure that all ventilation devices on the device are in proper functional condition. Cov-
ered ventilation grates or slots, etc. can result in malfunctions or device damage.
Only operate the device when connected to a power socket with grounding conductor.
The grounding conductor must not be interrupted (e.g., when using a voltage regulating
transformer). Only use extension cables equipped with grounding conductors!
When replacing the power cable, ensure that the new power cable has the proper di-
mensions for the intended operating voltage (see technical data).
Do not insert any objects into any device openings, and ensure that no liquid can get
into the device through openings or joints.
Do not short-circuit the device fuses and only use fuses corresponding to the informa-
tion in these instructions when replacing these.

Safety instructions CyBio QuadPrint HQ-M/L
16
2.5.2 Safety instructions: Transport
Only transport the device and its components in the original packaging! Ensure that all
transport locks and safety devices have been fitted and that the device components are
fully emptied and decontaminated if applicable.
2.5.3 Safety instructions – maintenance and service
Service and repairs and work for the commissioning or dismantling the device for trans-
port must only be carried out by authorized service personnel!
The operator may only carry out the tasks listed in the chapter "Maintenance and care".
Only carry out maintenance and service work on the device when it is switched off. Dis-
connect the power cord from the mains socket beforehand.
2.6 Safety instructions
2.6.1 Handling hazardous substances
Even with intended use there is a risk of health damage when handling hazardous sub-
stances. The operator is solely responsible for the compliance with all safety require-
ments to protect individuals and property when handling radioactive, infectious, toxic,
caustic, flammable and other hazardous substances.
¡Control the handling of hazardous substances in accordance with the safety category
of the lab, the details in the safety data sheets of the respective substances, the
manufacturer recommendations for use and additional national and international
regulations (WHO, “Laboratory Biosafety Manual").
¡Wear personal protective equipment when working with the device.
¡Observe all notices on the cleaning and decontamination of the device.
2.6.2 Chemical resistance
Aggressive substances may damage the device. Although the materials used are resis-
tant to most of the commonly used substances, material damage from aggressive sub-
stances cannot be completely excluded.
¡Before using any aggressive substances (e.g., bases, acids or organic solutions):
Check that the materials with direct contact to these substances are resistant.
¡When in doubt, consult the manufacturer.
Prohibited substances
Hydrofluoric acid (HF/hydrofluoric acid)
Highly concentrated acids
Cleaning powder
Paint thinner
Naphtha (crude gasoline)
Gasoline
Acetone
Cleaning spray
Ozone
¡Substances not listed in this table are not necessarily suitable.

CyBio QuadPrint HQ-M/L Safety instructions
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¡Do not use solvents (thinners), aggressive detergents, flammable liquids or caustic
alkaline solutions for cleaning. These can lead to damage to the housing compo-
nents.
Disinfection method Disinfectant Can be used for
Wipe disinfection Incidin Liquid (ECOLAB) – Housing parts
– Accessories
Table3 Permissible disinfection methods and disinfectants
2.7 Behavior during emergencies
Emergency or dangerous situation:
}Switch off main switch
}Unplug power cord

Technical description CyBio QuadPrint HQ-M/L
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3 Technical description
3.1 Layout
Fig.4 Design (CyBio QuadPrint HQ-M)
1 Protective housing 2 Operating panel with STOP button and
LED
3 CyBio QuadStack with 4-fold
stacker shaft
4 Handles
5 Lift-Turn-Lift module 6 Barcode reader
7 Label applicator 8 Type plate
9 Basic frame 10 Printer
11 Touchscreen display
The CyBio QuadPrint HQ-x is a device for printing labels with 1D/2D barcodes, text or
other information with subsequent labeling of microplates. Labels can be applied to all
four sides of the microplates.
In the CyBio QuadStack with a rotating 4-fold stacker shaft, unlabeled microplates are
prefilled in 3 shafts (shafts 2–4) and stored in shafts 1–3 after labeling.

CyBio QuadPrint HQ-M/L Technical description
19
The label height is automatically adjusted to the microplate type via the Lift-Turn-Lift
module. A sensor monitors the stacking/dispensing process; a second sensor detects
empty stacker shafts. The printing process settings are made via the CyBio QuadPrint
Studio control software.
Rotation of the stacker shafts on the CyBio QuadStack can also be triggered manually. A
control panel with buttons and a status LED is located on the main operating side of the
CyBio QuadStack.
3.1.1 Type plate
The type plate contains this information:
¡Manufacturer specifications
¡Product designations (type designation, trade name)
¡Identification data (model, serial number)
¡Year of manufacture
3.1.2 Barcode/label printer
NOTICE
Observe the associated manufacturer's documentation.
The barcode/label printer is used to print the barcodes/labels using the thermal printing
method.
The printer is connected directly to the mains socket via its mains connection socket.
For control, the printer is connected to the CyBio QuadStack via its interface.
3.1.3 Ram applicator
NOTICE
Observe the information in the corresponding documentation provided by the manufac-
turer. In particular, read the safety instructions that must be observed when operating
the label applicator.
The label applicator removes the labels from the printer.
After the label applicator has picked up a label, it moves into the labeling position.
The label is then attached to the specified position on the microplate.
The transport lock must be released before putting the device into service. For this pur-
pose, customer service removes the cover and moves the end position as far to the right
as required for the label applicator to reach all microplates in all positions.

Technical description CyBio QuadPrint HQ-M/L
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3.1.4 CyBioQuadStack
Connections
1
2
2
3
4
5
6
7
8
9
10
11
12
13
14
Fig.5 Connections
1 ESTOP 1 -
Connection of the STOP button to the
previous CyBio QuadStack
2 SENS2 -
External sensor
3 SENS1 -
External sensor
4 COM2 -
Main device
5 COM1 -
Previous device
(e.g. CyBio QuadStack)
6 LED -
Status (service only)
7 SW -
Switch output
8 INPUT - Power socket
9 Service -
Service interface
10 ESTOP2 -
Connection of the STOP button to the
subsequent CyBio QuadStack
11 SENS3 -
External sensor
12 COM3 -
Subsequent device
(e.g. CyBio QuadStack)
13 BC -
Barcode reader
14 Mains switch