Endress+Hauser Analytik Jena CyBio FeliX User manual
Operating Manual
CyBio FeliX
2018 III
Registered trademarks:
CyBio®. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Analytik Jena AG, Germany
TitletoallothertrademarksorbrandswhicharereferencedinthisUserManualbelongs
totheirlegalowners.
Copyright ©Copyright2018AnalytikJenaAG
Allrightsreserved.Nopartofthisdocumentationmay
beduplicated,photocopied,savedtoastoragesystem
ortransferredtoelectronicmediawithoutpriorwritten
permissionofthepublisher.
Publisher
AnalytikJenaAG
Konrad-Zuse-Strasse1
07745Jena
Germany
Tel:
+4936417770
Fax:+493641779279
ServiceSupport
Tel:
+493641779449
E-Mail:[email protected]
Ordering code number 30-5015-100-24BLE08
Document type TranslationofOriginalUserManualversion
Serial number Refertoproductnameplate
CE-Erklärung_Maschinenrichtlinie Revision 02 (2016)
Gültig ab: 20.04.2016
EG Konformitätserklärung1
EC Declaration of Conformity
Name und Anschrift des Herstellers:
Name and address of the manufacturer:
Analytik Jena AG
Konrad-Zuse-Straße 1
D-07745 Jena
Hiermit erklären wir, dass das nachstehend beschriebene Produkt
Herewith we declare, that the product described below
CyBio
®
-/CyBi
®
-FeliX
allen einschlägigen Bestimmungen der Maschinenrichtlinie 2006/42/EG entspricht. Das
Produkt entspricht zusätzlich den Bestimmungen der europäischen Richtlinie 2014/30/EU über
elektromagnetische Verträglichkeit. Die Sicherheitsziele der Niederspannungsrichtlinie werden
berücksichtigt.
is complying with all corresponding requirements of the Machinery Directive 2006/42/EC.
In addition the product is in conformity with the EC Directive relating to electromagnetic
compatibility 2014/30/EU. The safety objectives of the Low-Voltage Directive are taken into
account.
Angewandte harmonisierte Normen:
Harmonized Standards used:
EN ISO 12100
Sicherheit von Maschinen - Allgemeine
Gestaltungsleitsätze - Risikobeurteilung und
Risikominderung
Safety of Machinery - General principles for
design - Risk assessment and risk reduction
EN 61010-1 Sicherheitsbestimmungen für elektrische
Mess-, Steuer-, Regel- und Laborgeräte
Safety requirements for electrical equipment
for measurement, control and laboratory use
Bevollmächtigter für die Zusammenstellung der relevanten technischen Unterlagen:
The person authorized to compile the relevant technical documentation:
Analytik Jena AG, Konrad-Zuse-Straße 1, D-07745 Jena
Diese Erklärung bezieht sich nur auf das Produkt in dem Zustand, in dem es in Verkehr gebracht wurde; vom Endnutzer
nachträglich angebrachte Teile und/oder nachträglich vorgenommene Eingriffe bleiben unberücksichtigt. Die Erklärung verliert ihre
Gültigkeit, wenn das Produkt ohne Zustimmung umgebaut oder verändert wird.
This declaration relates exclusively to the product in the state in which it was placed on the market, and excludes components which
are added and/or operations carried out subsequently by the final user. The declaration is no more valid, if the product is modified
without agreement.
1Inhaltliche Wiedergabe.
VIÅ2014Å
Einbauerklärung1ÅDeclarationÅofÅIncorporationÅ
Å
Name
Å
und
Å
Anschrift
Å
des
Å
Herstellers:
Å
ÅNameÅandÅaddressÅofÅtheÅmanufacturer:Å
Å
Analytik Jena AG
Konrad-Zuse-StraßeÅ1Å
D-07745ÅJenaÅ
Å
Hiermit
Å
erklären
Å
wir,
Å
dass
Å
die
Å
nachfolgend
ÅÅ
bezeichnete
Å
Åunvollständige
Å
MaschineÅ
Å
wegen
ÅÅ
ihrer
Å
Konzipierung
Å
und
Å
Bauart
Å
sowie
Å
in
Å
der
Å
von
ÅÅ
uns
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gebrachten
Å
Ausführung
Å
den
ÅÅ
folgenden
Å
grundlegenden
Å
Anforderungen
Å
der
ÅÅ
Richtlinie
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2006/42/EG
Å
über
Å
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Å
entspricht:
Å
Å
WeÅdeclareÅherewithÅthatÅtheÅfollowingÅ
partlyÅ
completedÅ
machineryÅÅ
asÅaÅresultÅ
ofÅdesign,ÅconstructionÅandÅtheÅversionÅputÅinÅ
circulationÅcompliesÅwithÅtheÅessentialÅ
requirementsÅofÅtheÅDirectiveÅ2006/42/ECÅonÅ
machinery:Å
Å
Anhang
Å
I,
Å
Artikel
ÅAnnexÅI,ÅarticleÅ
Å
1.1.2,
Å
1.1.3,
Å
1.1.5,
Å
1.1.6,
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1.2.1,
Å
1.3.1,
Å
1.3.2,
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1.5.1,
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1.5.2,
Å
1.5.8,
Å
1.6.3
Å
Å
Bezeichnung
Å
der
Å
unvollständigen
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Å
ÅDesignationÅofÅtheÅpartlyÅcompletedÅmachinery:Å
Å
CyBio
®
-FeliX
ÅÅ
(enclosure-less
Å
model)
Å
Å
Å
30-5015-401-24
Å
Å
Å
Å
Å
Å
Das
Å
Produkt
Å
entspricht
Å
zusätzlich
Å
den
ÅÅ
Bestimmungen
Å
der
Å
europäischen
Å
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Å
über
ÅÅ
elektromagnetische
Å
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ÅÅÅ
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Å
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Å
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ÅÅ
werden
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Å
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Å
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ÅÅ
auf
Å
begründetes
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die
Å
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ÅÅ
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über
ÅÅ
unsere
Å
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Å
zu
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übermitteln.
Å
Å
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Das
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unvollständige
Å
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darf
Å
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Å
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ÅÅ
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ÅÅ
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Å
II
Å
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Å
Å
Å
Bevollmächtigter
Å
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Å
die
Å
Zusammenstellung
Å
der
Å
Å
relevanten
Å
technischen
Å
Unterlagen:
Å
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Å
Å
Å
InÅadditionÅtheÅproductÅisÅinÅconformityÅwithÅtheÅ
ECÅDirectiveÅrelatingÅtoÅelectromagneticÅ
compatibility.Å
TheÅsafetyÅobjectivesÅofÅtheÅLow-VoltageÅDirectiveÅ
areÅtakenÅintoÅaccount.Å
Å
WeÅcommitÅtoÅtransmit,ÅinÅresponseÅtoÅaÅreasonedÅ
requestÅbyÅtheÅmarketÅsurveillanceÅauthorities,Å
relevantÅdocumentsÅonÅtheÅpartlyÅcompletedÅ
productÅbyÅourÅdocumentationÅdepartment.Å
Å
TheÅpartlyÅcompletedÅproductÅmustÅnotÅbeÅputÅintoÅ
serviceÅuntilÅtheÅfinalÅmachineryÅintoÅwhichÅitÅisÅtoÅ
beÅincorporatedÅhasÅbeenÅdeclaredÅinÅconformityÅ
withÅtheÅprovisionsÅofÅDirectiveÅ2006/42/ECÅonÅ
Machinery,ÅwhereÅappropriate,ÅanÅuntilÅtheÅECÅ
declarationÅofÅconformityÅaccordingÅtoÅannexÅIIÅAÅisÅ
issued.Å
Å
TheÅpersonÅauthorizedÅtoÅcompileÅtheÅrelevantÅ
technicalÅdocumentationÅ
Hersteller
Å
Å
Å
Å
1
Å
inhaltliche
Å
Wiedergabe
Å
Å
Å
Å
Å
Å
Å
Å
FB
Å
066
Å
Vs
Å
1.3_Einbauerklärung
Å
ÅÅ Å
X2018
CyBio®FeliX 2018 XI
Table of contents
1 General Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1.1 GeneralUserManualAdvice.....................................1
1.2 TargetGroup................................................1
1.3 Conventions.................................................2
1.3.1 TextualMarkups ...........................................2
1.3.2 WarningSigns .............................................3
1.4 IntendedPurpose.............................................4
1.5 ConformingUse..............................................4
1.6 Warranty&Liability............................................6
1.7 ScopeofDelivery.............................................6
2 Technical Specifications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
2.1 Generalcharacteristics.........................................7
2.2 SummaryTableofOperatingData&Conditions......................9
3 Safety Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
3.1 General....................................................11
3.2 Standards&Guidelines........................................12
3.3 SafetyLabelingProvidedattheSystem............................13
3.4 MechanicalDangerZones......................................17
3.5 ProtectiveDevices............................................18
3.6 RequirementsforOperatingPersonnel............................18
3.7 SafetyRequirementsforTransportation&Installation.................18
3.8 SafetyNotesforOperation.....................................19
3.8.1 GeneralAdvice ...........................................19
3.8.2 ExplosionProofness,FirePrevention............................19
3.8.3 Electrical ................................................19
3.8.4 FundamentalMaintenance&CareRules ........................20
3.8.5 Handlinghazardoussubstances ...............................20
3.8.6 Chemicalresistance ........................................21
3.9 RulesofConductinCasesofEmergency...........................24
4 Technical Description . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
4.1 Setup/Components...........................................25
4.1.1 CyBio®FeliX–Overview ....................................25
4.1.2 Nameplate ...............................................27
XII 2018 CyBio®FeliX
4.1.3 EnclosurewithBlind........................................27
4.1.4 Decks...................................................28
4.1.5 LED–OperatingStateIndicator ...............................31
4.1.6 HeadMount .............................................33
4.1.7 PipettingHeadVersions* ....................................34
4.1.8 Fan ....................................................35
4.1.9 Connectorpanel ..........................................36
4.2 ModeofOperation...........................................38
4.3 OperatingModes............................................38
5 Packaging, Transportation & Storage. . . . . . . . . . . . . . . . . . . . . . . 39
5.1 SafetyNotes................................................39
5.2 Packaging..................................................40
5.2.1 Placementofshippingretainer................................40
5.2.2 Packaging ...............................................41
5.2.3 Storage.................................................42
6 Routine Start-Up Procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
6.1 SiteRequirements............................................43
6.1.1 InstallationRequirements ....................................43
6.1.2 FootprintRequirements.....................................43
6.1.3 EnergySupplies...........................................44
6.2 InitialStart-Up&Configuration..................................45
6.3 FunctionTests...............................................46
6.3.1 PrecisionTest .............................................46
6.3.2 AccuracyTest.............................................46
6.3.3 LeakTest ................................................46
7 Operation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
7.1 TurningOn(ReadinessforOperation).............................47
7.2 RestoringReadinessforOperationafterBreakEvents(e.g.PowerFailure)..48
7.3 ReplacementofPipettingHead..................................49
7.3.1 MountingthePipettingHead.................................50
7.3.2 ReplacementofPipettingHead ...............................51
7.4 ManualOperation............................................52
7.4.1 MotionAxis ..............................................52
7.4.2 PipettingHeadMovementinZ-Direction........................53
7.5 DeckConfiguration...........................................55
7.6 Software-ControlledOperation..................................56
CyBio®FeliX 2018 XIII
7.6.1 GeneralCommands(SummaryTable) ..........................56
7.6.2 RemovalofTransportationLock ...............................58
7.6.3 PreparingforHeadReplacement/TurningOff .....................59
7.6.4 MoveinX-,Y-&Z-Direction .................................60
7.6.5 Load/UnloadTips–PipettingHeadT...........................62
7.6.6 TipMounting/TipReplacement–PipettingHeadR.................63
7.6.7 Pipetting ................................................67
7.7 TurningOff.................................................69
8 “What to do if...“ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
8.1 SafetyNotes................................................71
8.2 Systemdoesnotwork.........................................71
8.2.1 FurtherErrors.............................................71
8.3 Errorcodes.................................................72
8.4 FaultRemovalInstructions......................................76
8.4.1 ReplacementofInletFuse(s)..................................76
8.4.2 LEDBlinks–red ...........................................77
8.4.3 RestoringReadinesstoOperateAfterBreakEvents(Expl.PowerFailure).77
8.4.4 Manualaxismovement .....................................77
9 Maintenance & Care. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79
9.1 SafetyNotes................................................79
9.2 MaintenanceWork...........................................80
9.2.1 Overview ................................................81
9.3 Maintenance/InspectionInstructions..............................82
9.3.1 Cleaningthebasicunit(includingdecks)........................83
9.3.2 PerformHeadMountMaintenance ............................84
9.3.3 Cleaningcones ...........................................84
9.3.4 ReplacementofO-Rings.....................................85
9.3.5 CheckforCorrectBlindFunction ..............................87
10 Shutting Down . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89
11 Accessories & Spare Parts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
11.1 Accessories.................................................91
11.1.1 PipetteTips..............................................91
11.2 Pipettingheads..............................................94
11.3 Liquidhandling-/CHOICETMadapter..............................94
11.4 Support....................................................95
XIV 2018 CyBio®FeliX
11.5 FurtherAccessories...........................................96
11.6 SpareParts.................................................96
12 Waste Disposal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
12.1 Consumables...............................................97
12.2 Reagents...................................................97
12.3 System&Accessories.........................................97
2018 XV
Table of illustrations
Fig. 1: Certificationsign .............................................12
Fig. 2: Warningsignsatthesystem .....................................16
Fig. 3: Warningsignatthepipettinghead................................16
Fig. 4: Dangerzones ................................................17
Fig. 5: Basicunit...................................................25
Fig. 6: Variantwithoutenclosure/blind ..................................26
Fig. 7: Nameplate..................................................27
Fig. 8: Nameplate..................................................27
Fig. 9: Deckpositions ...............................................28
Fig. 10: Heights–DeckA,BandC......................................29
Fig. 11: Heights–DeckA,BandC......................................30
Fig. 12: LED–operatingstateindicators/arrowbuttons .......................31
Fig. 13: LED–operatingstateindicators/pushbutton .........................32
Fig. 14: Headmount .................................................33
Fig. 15: Rearsideview(rearpanelremoved,fanmarked) .....................35
Fig. 16: Terminals...................................................36
Fig. 17: Terminals...................................................36
Fig. 18: On/Offswitch ................................................47
Fig. 19: Headmount(withclampingleverinfrontposition)....................50
Fig. 20: Insertionofpipettinghead......................................50
Fig. 21: Pipettingheadreadyforoperation................................50
Fig. 22: Pipettinghead(fixed)..........................................51
Fig. 23: Removalofpipettinghead......................................51
Fig. 24: Headmount(withclampingleverinfrontposition)....................51
Fig. 25: Directionsofmoveandcoordinatepatternview ......................52
Fig. 26: Commands..................................................58
Fig. 27: Settings(Settoolinfo) .........................................58
Fig. 28: Settingsforplacingdown .......................................58
Fig. 29: Componentswindow ..........................................59
Fig. 30: Mountingthetransportationlock .................................59
Fig. 31: Positioningwindow ...........................................60
Fig. 32: Interactivepositioningscreenforsettingofshiftvalues.................61
Fig. 33: Componentswindow ..........................................62
Fig. 34: Manualreplacementmethod....................................62
Fig. 35: Componentswindow ..........................................63
Fig. 36: Example:mountingofCyBio®RoboTipTray .........................63
Fig. 37: Componentswindow ..........................................64
Fig. 38: Example:MountingofCHOICETMadapters..........................64
Fig. 39: Pipettetipmountingmethod(example) ............................65
Fig. 40: Componentswindow ..........................................66
Fig. 41: Example:Placementoftips ......................................66
Fig. 42: PlacementofLHadapter........................................66
Fig. 43: Sequenceofactions...........................................67
Fig. 44: Sequenceofactions...........................................68
Fig. 45: Fuses(two)incombisealatthebackofthepipettor...................76
Fig. 46: Covermagazine(transportprotection)attached ......................83
Fig. 47: Headmount .................................................84
XVI 2018
Fig. 1: Cleanbenchanddoormonitoringset.............................102
Fig. 2: Doormonitoringset ..........................................103
Fig. 3: Cleanbench ................................................104
Fig. 4: Safetylightcurtain...........................................104
Fig. 5: PinassignmentforconnectingESTOPIN ...........................107
CyBio®FeliX 2018 1
GeneralInformation
1 General Information
1.1 General User Manual Advice
ThisUserManualinformsaboutthesetupandfunctionofthesystem.Itprovides
qualifiedoperatingpersonnelwiththeknowledgethatisrequiredtohandlethesystem
inasafemanner.
ThisManualfurthercontainsinstructionsandadviceaboutgeneralsystemcareandthe
Manufacturer’sdefinedscopeofmaintenanceworkitems.
Inaddition,youmayusethisManualtoanalyzefaultsituationsforpotentialcausesand
takeappropriatemeasuresforfaultremoval.
ThisUserManualmustbereadilyavailabletooperatingandmaintenancepersonnelat
alltimes!
1.2 Target Group
ThisUserManualaddresses:
Qualifiedandproperlytrainedexpertpersonnelwhoareabletooperatethe
systemandprovidegeneralcare
(→“Requirements for Operating Personnel” on page 18).
Employeeswithresponsibilityfor:
–theplanningofprocesssequences/operatingprocedures,
–preventivemaintenance&cleaningwork,
–safetydevices,etc.
NOTE
Theinformationcontainedhereinreflectsthelateststateofknowledgeatthemoment
ofgoingtopress.AnalytikJenaAGreservestherighttomakechangesifdeemednec-
essaryintheinterestoftechnicalprogress.
22018CyBio
®FeliX
GeneralInformation
1.3 Conventions
1.3.1 Textual Markups
Work instructions involvingatimedsequencearenumberedandmergedtoaction
unitstospecifyrelatedresults.
Enumeration involvingnotimedsequenceisshownasabullet-stylelist,sub-level
numberingorasadash-stylelist.
Safety notes aremarkedbyapictogramandasignalword
(→“Warning Signs” on page 3).
Specificaction-relatedsafetynoteswillprecedetheactualinstruction.
Instructions, commands, control buttons, text fields, check boxesandthelikeare
markedasshownfor”Load“commandsample.
Optionaloutfitcomponentsorversionsaremarkedwith*.
Forgraphicdesignstylesofcross-references,youarereferredtothetablebelow:
Table 1: Graphic design styles of cross-references
Type of cross-reference Graphic style Explanatory note
Referencetoanillustration →Fig. 1 Illustrationisonthe
samepage
Referencetoanillustration
andapage
→Fig. 1 on page 17 Illustrationisonanother
page
Referencetoaposition
(withinanillustration)
Pos. 2,→Fig. 1 Providesreferencetoa
positionwithinaspeci-
fiedillustration–illustra-
tionisonthesamepage
Referencetoaposition
(withinanillustrationanda
page)
Pos. 2,
→Fig. 1 on page 17
Referencesaposition
withinaspecifiedillus-
tration–illustrationis
onanotherpage
Referencetoapage→page 1 Referencesagivenpage
Referencetoaheadlineand
apage
→“Conventions” on
page 2
Referencesagiven
page,supplementedby
aheadline
Referencetoatableanda
page
→Table 2, “Scope of deliv-
ery (depending on selected
model option)”, on page 7
Referencesagiventable
CyBio®FeliX 2018 3
GeneralInformation
1.3.2 Warning Signs
WARNING
Indicatesapotentiallyhazardoussituation.
Mayresultindeathorseriousinjuryifnotavoided.
CAUTION
Dangeroussituation!
Potentialconsequences:lightormoderatephysicalinjury.
NOTICE
Dangeroussituation!
Potentialconsequences:materialdamage.
NOTE
Usefulapplicationadvice,nopotentialdangerinvolved.
NOTE
Noteregardingenvironmentalprotection.
42018CyBio
®FeliX
GeneralInformation
1.4 Intended Purpose
Thesystemprovidesasimultaneouslyworkingpipettor(modelversionsorfromoneto
amaximumof384channelsdependingonthetypeofpipettinghead).Itisintended
forautomatedprocessingofmicroplates.
Theavailablerangeofapplicationsisrestrictedbythescopeofincludedfunctionalsoft-
wareandfirmware,aswellasthescopeofdelivery.Forthisreason,theuseris
prohibitedfromoperatingthesysteminanywayotherthanspecifiedinthisUser
Manual.
1.5 Conforming Use
TheCyBio®FeliXpipettorhasbeendevelopedtoallowtheautomatedprocessingof
microplatesinchemicalandbiologicallaboratories.
Inthefieldsofmedicineanddiagnosticsthesystem’sintendeduseisrestrictedtore-
search.
Itsbasicfunctionsaretheaspirationanddispensingofliquidfromandintoa
microplate,reservoir,(columnsinglewellortube).
Thetermconforming use alsopresupposesthat:
thesystemisoperatedbyqualifiedandtrainedresearchandlaboratorypersonnel
alloperatingrequirements,proceduralsequencesandrelatedsafetynotes
quotedordescribedinthisUserManualaredulyobserved
allspecificationsinthisManualregardingsystemstart-up,operation,preventive
maintenanceandcarearemet
applicablesafetystandardsorrulesarealwaysfulfilled.
Anyuseotherthanorinexcessoftheseruleswillberegardedasnon-conforming!The
userwillbesolelyliablefordamageresultingfromacaseofnon-conformance.
Thedefinitionfornon-conforming useincludes:
operatingthesysteminmedicallaboratoriesofanon-researchprofile
workingwithexplosivesubstances
workinginanexplosiveatmosphere–operationinapotentiallyexplosivezoneis
prohibited
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