Beckman Coulter Biomek NXP User manual

B20063AC
April 2019
Preinstallation Manual
Biomek NXP
Laboratory Automation Workstation
Beckman Coulter, Inc.
250 S. Kraemer Blvd.
Brea, CA 92821 U.S.A.

Biomek NXPLaboratory Automation Workstation
Preinstallation Manual
PN B20063AC (April 2019)
© 2019 Beckman Coulter, Inc.
All rights reserved.
Beckman Coulter, the stylized logo, and the Beckman
Coulter product and service marks mentioned herein are
trademarks or registered trademarks of Beckman Coulter,
Inc. in the United States and other countries.
Windows 7 and Windows 10 are registered trademarks or
trademarks of Microsoft Corporation in the United States
and/or other countries.
All other trademarks, service marks, products, or services
are trademarks or registered trademarks of their
respective holders.
May be covered by one or more pat. - see
www.beckman.com/patents
Contact Us
If you have any questions, contact our Customer Support
Center.
• Worldwide, find us via our website at
www.beckman.com/support/technical
• In the USA and Canada, call us at 1-800-369-0333.
• Outside of the USA and Canada, contact your local
Beckman Coulter Representative.
Glossary of Symbols is available at
beckman.com/techdocs (PN C24689).
Original Instructions

B20063AC iii
Revision History
Initial Issue B20063AA, 05/2013
Issue AB, 03/2018
Changes or additions were made to: CHAPTER 1, Air Supply Requirements (NX-MC and NX-S8 with
a Microplate Shaking ALP only).
Issue AC, 04/2019
Changes or additions were made to: Table1.1,SystemSpecifications; Table1.4,Electrical
Components and Requirements; Table4.1,ElectricalComponents and Requirements; Related
Documents.
Note: Changes that are part of the most recent revision are indicated in text by a bar in the margin of the
amended page.
This document applies to the latest software listed and higher versions. When a subsequent software
version changes the information in this document, a new issue will be released to the Beckman Coulter
website. For labeling updates, go to www.beckman.com and download the most recent manual or system
help for your instrument.

B20063AC
iv
Revision History

B20063AC v
Safety Notice
Read all product manuals and consult with Beckman Coulter-trained personnel before attempting
to operate instrument. Do not attempt to perform any procedure before carefully reading all
instructions. Always follow product labeling and manufacturer’s recommendations. If in doubt as
to how to proceed in any situation, contact your Beckman Coulter Representative.
Beckman Coulter, Inc. urges its customers to comply with all national health and safety standards
such as the use of barrier protection. This may include, but is not limited to, protective eyewear,
gloves, and suitable laboratory attire when operating or maintaining this or any other automated
laboratory analyzer.
Alerts for Danger, Warning, Caution, Important, and Note
DANGER
DANGER indicates an imminently hazardous situation which, if not avoided, will
result in death or serious injury.
WARNING
WARNING indicates a potentially hazardous situation which, if not avoided, could
result in death or serious injury.
CAUTION
CAUTION indicates a potentially hazardous situation, which, if not avoided, may
result in minor or moderate injury. It may also be used to alert against unsafe
practices.
IMPORTANT IMPORTANT is used for comments that add value to the step or procedure being performed.
Following the advice in the Important adds benefit to the performance of a piece of equipment or to a
process.
NOTE NOTE is used to call attention to notable information that should be followed during installation, use,
or servicing of this equipment.

B20063AC
vi
Safety Notice
Electrical Safety
Electrical Safety
To prevent electrically-related injuries and property damage, properly inspect all electrical
equipment prior to use and immediately report any electrical deficiencies. Contact a Beckman
Coulter Service Representative for any servicing of equipment requiring the removal of covers or
panels.
High Voltage
This symbol indicates the potential of an electrical shock hazard existing from a high-voltage
source and that all safety instructions should be read and understood before proceeding with the
installation, maintenance, and servicing of all modules.
Do not remove system covers. To avoid electrical shock, use supplied power cords only and connect
to properly grounded (three-holed) wall outlets. Do not use multiplug power strips.

B20063AC vii
Safety Notice
Warnings and Cautions Found in this Manual
Warnings and Cautions Found in this Manual
Please read and observe all cautions and instructions. Remember, the most important key to safety
is to operate this instrument and its supporting equipment with care.
The WARNINGS and CAUTIONS found within this document are listed below.
WARNING
Risk of operator injury if:
• All doors, covers, and panels are not closed and secured in place prior to and
during instrument operation.
• The integrity of safety interlocks and sensors are compromised.
• Instrument alarms and error messages are not acknowledged and acted upon.
•Youcontactmovingparts.
• Doors, covers, and panels are not opened, closed, removed, and/or replaced
with care.
• Improper tools are used for troubleshooting
To avoid injury:
• Keep doors, covers, and panels closed and secured in place while the
instrument is in use.
• Take full advantage of the safety features of the instrument. Do not defeat
safety interlocks and sensors.
• Acknowledge and act upon Instrument alarms and error messages.
• Keep away from moving parts.
• Report any broken parts to your Beckman Coulter Representative.
• Open/remove and close/replace doors, covers, and panels with care.
• Use the proper tools when troubleshooting.
CAUTION
System integrity might be compromised and operational failures might occur if:
• This equipment is used in a manner other than specified. Operate the
instrument as instructed in the Product Manuals.
• You introduce software that is not authorized by Beckman Coulter into your
computer. Only operate the computer of your system with software
authorized by Beckman Coulter.
• You install software that is not an original copyrighted version. Only use
software that is an original copyrighted version to prevent virus
contamination.

B20063AC
viii
Safety Notice
Warnings and Cautions Found in this Manual
CAUTION
If you purchased this product from anyone other than Beckman Coulter or an
authorized Beckman Coulter distributor, and if it is not presently under a Beckman
Coulter service maintenance agreement, Beckman Coulter cannot guarantee that
the product is fitted with the most current mandatory engineering revisions or
that you will receive the most current information bulletins concerning the
product. If you purchased this product from a third party and would like further
information concerning this topic, call your Beckman Coulter Representative.
WARNING
To prevent possible injury, wear safety glasses or safety goggles when removing
metal strapping. Strapping may spring back, causing injury.
WARNING
To prevent possible injury, use the steel strapping cutter with caution to ensure
the strap does not spring back.
CAUTION
When lifting the Biomek NXPinstrument, grasp it only from positions on the base
casting. Do not grasp the ends of the light curtain that extend across the front of
the instrument.
CAUTION
The back of the instrument is heavier than the front. Take care not to lift the front
so high that it causes the instrument to fall backward.
CAUTION
The Biomek NXPinstrument will overhang the edges of a 36 in. x 30 in. (92 cm x
77 cm) bench. Make sure there are no obstacles that will interfere with placement
of the instrument.

B20063AC ix
Safety Notice
Warnings and Cautions Found in this Manual
CAUTION
Make sure the bench can support the total installed weight of the system. Refer
to Table 1.3 to determine the total weight of the system.
CAUTION
When lifting the Biomek NXPinstrument, grasp it only from positions on the base.
Do not grasp the ends of the large cover at the top of the instrument.
CAUTION
The optical table is heavy and is cumbersome. To avoid injury, two people are
needed to unpack the optical table from the shipping crate.
CAUTION
The Cytomat weighs 176 - 311 pounds. To avoid injury, follow your safety officer's
instructions regarding lifting heavy objects.
WARNING
To prevent the side panels from falling on the person unpacking a Cytomat device,
a second person must hold each panel while the screws are removed.

B20063AC
x
Safety Notice
Warnings and Cautions Found in this Manual

xi
Contents
Revision History,iii
Safety Notice,v
CHAPTER 1: Preparing the Site,1-1
Preparation Overview,1-1
Models,1-1
Site Preparation,1-1
Biomek NXPSystem Specifications,1-2
Work Area Minimum Dimensions,1-3
Component Weights,1-5
Electrical Requirements,1-6
Air, Vacuum, and System Fluid Requirements,1-6
Air Supply Requirements (NX-MC and NX-S8 with a Microplate
Shaking ALP only),1-6
Vacuum Supply Requirements,1-7
System Fluid Requirements (NXP-S8 only),1-8
CHAPTER 2: Preparing the Biomek NXP Instrument for Setup,2-1
Overview,2-1
Moving the NXPInstrument Crate to the Unpacking Location,2-1
Unpacking the NXPInstrument,2-2
Required Tools,2-2
Unpacking the Accessories,2-3
Unpacking the Instrument,2-5
Inspecting the NXPInstrument,2-6
Moving the NXPInstrument to the Installation Site,2-6
Placing the NXPInstrument on the Lab Bench,2-8
Contacting Your Field Service Engineer,2-8
CHAPTER 3: Preparing Cytomat Devices,3-1
Overview,3-1
Cytomat Device Specifications,3-2
Estimating Required Workspace Dimensions,3-3
Setting Up Optical Tables,3-3

xii
Contents
Unpacking an Optical Table,3-3
Setting Up a 1 m x 1 m Optical Table for the Cytomat 6001,3-4
Setting Up a .6 m x .9 m Optical Table for the Biomek NXP
Instrument and the Microplate Hotel,3-6
Optical Table Layout,3-8
Unpacking Cytomat Devices,3-11
CHAPTER 4: Preparing Other Integrated Devices,4-1
Overview,4-1
Dimensions for Integrated Devices,4-1
Electrical Component Requirements,4-3
Index
Beckman Coulter, Inc.
Warranty and Returned Goods Requirement

xiii
Illustrations
Illustrations
1.1 Recommendation for an Air Pressure Regulation System
Configuration,1-7
2.1 Fully Packaged NXPInstrument,2-3
2.2 Accessories Box Contents for the NXPInstrument Model
A31840,2-4
2.3 ‘U’ Brackets,2-5
3.1 Assembled 1 m x 1 m Optical Table,3-5
3.2 Assembled .6 m x .9 m Optical Table,3-7
3.3 Layout Showing .6 m x .9 m and 1 m x 1 m Optical Tables,3-9
3.4 Layout for .6 m x .9 m Optical Table,3-10
4.1 System Layout Dimension Changes,4-1
4.2 Dimensions for a Biomek NXPInstrument with Several
Integrated Devices,4-2

xiv
Tables
Tables
1.1 System Specifications,1-2
1.2 Dimensions Required,1-4
1.3 Biomek NXPInstrument Component Weights,1-5
1.4 Electrical Components and Requirements,1-6
2.1 Accessories by Model Number,2-4
3.1 Cytomat 2C Incubator Specifications,3-2
3.2 Cytomat 6001 HS Incubator Specifications,3-2
3.3 Cytomat Microplate Hotel Specifications,3-2
3.4 Cytomat ALP Electrical Requirements,3-3
4.1 Electrical Components and Requirements,4-3

B20063AC 1-1
CHAPTER 1
Preparing the Site
Preparation Overview
This preinstallation manual details the necessary site preparation required prior to the installation
of the Biomek NXPLaboratory Automation Workstation.
For preinstallation information for optional Cytomat incubators and storage units and other
optional integrated devices, Preparing Cytomat Devices.
Models
The information in this manual generally refers to both configurations of the Biomek NXP
instrument; if specific conditions apply to only one configuration, this manual identifies these
configurations as follows:
• NX-MC — Biomek NXPMultichannel Laboratory Automation Workstation
• NX-S8 — Biomek NXPSpan-8 Laboratory Automation Workstation
Site Preparation
Pay careful attention to the specifications and requirements described in this manual. Accurate and
timely preparation allows the Beckman Coulter Field Service Engineer to install the Biomek NXP
instrument efficiently upon arrival. Appropriate site preparation includes making sure that:
• System specification requirements are met when the Biomek NXPinstrument is installed (See
Biomek NXP System Specifications).
• Adequate work space is set up for the instrument and automation controller (see Work Area
Minimum Dimensions).
• The bench holding the Biomek NXPsystem supports the total installed weight of the
Biomek NXPinstrument and any peripheral equipment (see Component Weights). The bench
must also be level and stable so that normal operations of the Biomek NXPinstrument do not
cause the bench to shift, jerk, or sway.
• Electrical supply and power quality are adequate for operation (see Electrical Requirements).
• Sufficient air and vacuum are available for operating the entire system (see Air, Vacuum, and
System Fluid Requirements).
• Appropriate degassed system fluid is available for a Biomek NXPinstrument equipped with a
Span-8 Pod (see System Fluid Requirements (NXP-S8 only)).
After you have prepared the site, unpacking the instrument and placing it on the workbench ready
for installation are your responsibilities.

B20063AC
1-2
Preparing the Site
Biomek NXPSystem Specifications
Biomek NXPSystem Specifications
Table 1.1 presents system specifications and requirements for the Biomek NXPinstrument.
Table 1.1 System Specifications
Item Description
Environment Indoor use only
Power Requirements 100–240 VAC, 50–60 Hz
Compressed Air Requirements
•NX-MC— Requires compressed air.
•NX-S8— Only Span-8 instruments that
use a Microplate Shaking ALP require
compressed air.
Air Pressure: 60 - 100 psi of compressed air
414 - 690 kPa of compressed air
Air Flow: 2.25 cfm @ 60 psi
0.064 m3/min @ 414 kPa
System Fluid Requirements
•NX-S8— Requires system fluid.
De-ionized or Distilled water
System fluid ambient operating temperature is
59°–86°F (15°–30°C).
System fluid should be degassed for 24 hours prior to use.
Dimensions base unit: •NX-MC— 36 in. (L) x 31 in. (W) x 34 in. (H); 91.44 cm (L)
x 78.74 cm (W) x 86.36 cm (H)
•NX-S8— 36 in. (L) x 31 in. (W) x 44 in. (H); 91.44 cm (L)
x 78.74 cm (W) x 111.76 cm (H)
Weight:
Biomek NXPinstrument (in packing crate)
Biomek NXPinstrument
320 lbs. (145.2 kg)
190 lbs. (86.2 kg)
Ambient Operating Temperature 41°–86°F (5°–30°C)
Humidity Restrictions <85% (non-condensing) @ 86°F (30°C)
Altitude Restrictions up to 6562 ft (2000 m)
Installation Category Category II
Pollution Degree 2
Sound Pressure Level Maximum sound pressure: 82 dB
Maximum sound pressure at 1 meter away: 75 dB
Fuses US: 250 VAC, 3.15 amp, 5x20 mm, Slow-blow, UL recognized,
CSA certified
Europe: 250 VAC, 3.15 amp, 5x20 mm, Slow-blow, CENELEC
approved
Communications to Host RS-232 port
Communications to Tip Loader
•NX-MC— Uses a Tip Loader.
CAN
Communications to Active ALPs via the
Biomek NXPinstrument
CAN

B20063AC 1-3
Preparing the Site
Work Area Minimum Dimensions 1
Work Area Minimum Dimensions
Use Table 1.2 to determine:
• Minimum dimensions required for the Biomek NXPinstrument work area.
• Location for the automation controller and stand near the instrument bench.
NOTE The minimum bench length of 25 in. necessary to hold the Biomek NXPinstrument is shorter than the
base of the instrument which is 36 in. If the bench is slightly shorter than the Biomek NXPinstrument, be
sure to allow enough space on both sides for the instrument to overhang the bench.
Biomek Controller Windows 7: Biomek Software Version 4.1
The following specifications are the minimum requirements
needed.
Processor: Intel Core i5-2400 (3.1 GHZ) or better
Memory: 2 GB
Hard Drive: 250 GB or better
Optical Drive: DVD
Additional Software: Microsoft SQL Server 2005 Edition
Operating System: Windows 7, 64-bit with scripting enabled
Internet Browser: Internet Explorer 8
Windows 10: Biomek Software Version 4.2
The following specifications are the minimum requirements
needed:
CPU: Intel Core i5-8500 (3.0 GHz)
RAM: 8 GB
Hard Drive: 500 GB
Optical Drive: DVD
Monitor: 22", 1920 x 1800
Operating System: Windows 10, 64-bit
Table 1.1 System Specifications (Continued)
Item Description

B20063AC
1-4
Preparing the Site
Work Area Minimum Dimensions
Table 1.2 Dimensions Required
Component Minimum Dimensions Required
Biomek NXPinstrument base unit •NX-MC— 36 in. (L) x 31 in. (W) x 34 in. (H); 91.44 cm (L)
x 78.74 cm (W) x 86.36 cm (H)
•NX-S8— 36 in. (L) x 31 in. (W) x 44 in. (H); 91.44 cm (L)
x 78.74 cm (W) x 111.76 cm (H)
Minimum bench necessary to adequately
hold the Biomek NXPinstrumenta
a. The dimensions for the lab bench in the above table do not include space for the automation controller or additional accessories. A lab bench
with shelving for accessories underneath the instrument is desirable.
25 in. (L) x 24 in. (W)
63.5 cm (L) x 61 cm (W)
CAUTION
The Biomek NXPinstrument will overhang the edges of
a 25” x 24”(63.5 cm x 61 cm) bench. Make sure there
are no obstacles that will interfere with placement of
the instrument.
CAUTION
Make sure the bench can support the total installed
weight of the system. Refer to Table 1.3 to determine
the total weight of the system.
Rear access clearance 4 in. (10.2 cm)
Side access clearance 12 in. (30.5 cm)

B20063AC 1-5
Preparing the Site
Component Weights 1
Component Weights
Use Table 1.3 to determine the bench load requirements for the approximate installed weight of a
Biomek NXPinstrument with ALPs.
Table 1.3 Biomek NXPInstrument Component Weights
Component Weight
Biomek NXPInstrument Approximately 190 lbs. (86.2 kg)
Tip Loader ALP 10 lbs. (4.5 kg)
1 x 1 Passive ALP 2 lbs. (.9 kg)
1 x 3 Passive ALP 4 lbs. (1.8 kg)
1 x 5 Passive ALP 6 lbs.(2.7 kg)
4 x 3 Passive ALP 15 lbs. (6.8 kg)
4 x 4 Passive ALP 24 lbs. (10.9 kg)
Stirring ALP 3 lbs. (1.3 kg)
Positive Position ALP 5 lbs. (2.3 kg)
Bar Code Reader ALP 4 lbs. (1.8 kg)
Microplate Shaking ALP 6 lbs. (2.7 kg)
Magnetic Bead ALP 5 lbs. (2.3 kg)
Orbital Shaker ALP 7 lbs. (3.2 kg)

B20063AC
1-6
Preparing the Site
Electrical Requirements
Electrical Requirements
Make sure the proper electrical supply is available at the bench for the Biomek NXPinstrument.
Table 1.4 defines the electrical requirements.
NOTE All AC devices are at 50/60 Hz.
Air, Vacuum, and System Fluid Requirements
Depending on configuration, the Biomek NXPinstrument may require compressed air, a vacuum
supply, or system fluid.
Air Supply Requirements (NX-MC and NX-S8 with a Microplate Shaking ALP only)
Make sure the site has the following available at the lab bench:
• 60 – 100 psi of clean dry air (276 - 690 kPa)
NOTE An external filter/regulator may be required to meet air pressure requirements.
• Air flow of 2.25 cfm @ 60 psi (0.064 m3/min @ 276 kPa)
NOTE Make sure the lab site has a clean, dry air supply available at the lab bench.
• A 1/4 in. or 1/8 in. NPT female fitting to connect the air supply to the quick disconnect fitting
and 1/4” OD tubing supplied with the Biomek NXPinstrument.
NOTE If house air is not available, or if house air will not consistently provide the recommended
pressure, an air compressor or air cylinder may be used to provide the required supply (see
Figure 1.1).
Table 1.4 Electrical Components and Requirements
Electrical Component Electrical Requirements
Base Unit 100–240 VAC @ 4 amps max.
Windows 7
CPU power requirements
Monitor
100–127 VAC @ 5 amps max.
200–240 VAC @ 3 amps max.
100–240 VAC @1.8 amps max
Windows 10
Automation Controller
Monitor
100-240VAC @ 2.5 amps
100-240VAC @ 1 amp
I/O Box 110–240 VAC @ 6.3 amps max