Endress+Hauser Analytik Jena multi N/C User manual

Operating Manual
multi N/C pharma UV
TOC Analyzer

Analytik Jena GmbH
Konrad-Zuse-Str.1
07745 Jena Germany
Phone + 49 3641 77 70
Fax + 49 3641 77 9279
Email [e-mail]
Analytik Jena GmbH
Konrad-Zuse-Str. 1
07745 Jena Germany
Phone + 49 3641 77 74 07
Email [e-mail]
http://www.analytik-jena.com
11-0110-003-23
A (01/2021)
Analytik Jena GmbH
© Copyright 2021, Analytik Jena GmbH
Manufacturer
Service
General information
Documentation number
Edition
Implementation of the
Technical Documentation

multi N/C pharma UV Contents
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Contents
1Basic Information ....................................................................................................... 7
1.1 User manual notes............................................................................................................ 7
1.2 Intended Use..................................................................................................................... 8
1.3 Warranty and liability....................................................................................................... 8
2Safety instructions...................................................................................................... 9
2.1 Safety markings on the analyzer ..................................................................................... 9
2.2 Technical condition .......................................................................................................... 9
2.3 Requirements for the operating personnel................................................................... 10
2.4 Safety instructions, transport and installation ............................................................. 11
2.5 Safety instructions - operation ...................................................................................... 11
2.5.1 General............................................................................................................................ 11
2.5.2 Safety instructions - Protection against explosion and fire ......................................... 12
2.5.3 Safety instructions - electrical equipment..................................................................... 12
2.5.4 Safety instructions for compressed gas containers and systems................................. 12
2.5.5 Safety notes on UV radiation ......................................................................................... 13
2.5.6 Handling of auxiliary and operating materials............................................................. 13
2.5.7 Safety instructions - service and repair ......................................................................... 14
2.6 Behavior during emergencies ........................................................................................ 14
3Function and setup................................................................................................... 15
3.1 System design................................................................................................................. 15
3.1.1 UV reactor with control gear.......................................................................................... 16
3.1.2 Components for sample preparation............................................................................. 16
3.1.3 Hose system.................................................................................................................... 17
3.1.4 Components for gas drying and cleaning...................................................................... 20
3.1.5 NDIR detector ................................................................................................................. 22
3.1.6 Indicator and control elements, connectors.................................................................. 23
3.1.7 Reagent accessories ....................................................................................................... 24
3.1.8 Autosampler for the analyzer ........................................................................................ 24
3.2 Principle of operation..................................................................................................... 24
3.3 Measuring method......................................................................................................... 26
3.3.1 TC analysis ...................................................................................................................... 26
3.3.2 TOC analysis.................................................................................................................... 26
3.3.3 TIC analysis ..................................................................................................................... 27
3.3.4 NPOC analysis ................................................................................................................. 27
3.3.5 NPOC analysis according to the NPOC plus method..................................................... 27
3.4 Calibration....................................................................................................................... 28
3.4.1 Calibration strategies ..................................................................................................... 28
3.4.2 Day factor........................................................................................................................ 28
3.4.3 Calibration method in multiWin.................................................................................... 29
3.4.4 Method characteristics................................................................................................... 30
3.4.5 Other calculations........................................................................................................... 31
3.5 Blank Values.................................................................................................................... 32
3.5.1 Blank water values ......................................................................................................... 32
3.5.2 Reagent blank value....................................................................................................... 33
3.5.3 Eluate blank value .......................................................................................................... 34
3.6 System Suitability Test (SST)......................................................................................... 34
4First commissioning ................................................................................................. 36
4.1 Site requirements ........................................................................................................... 36
4.1.1 Installation conditions.................................................................................................... 36
4.1.2 Space requirement.......................................................................................................... 36
4.1.3 Energy supply.................................................................................................................. 37
4.1.4 Gas supply ....................................................................................................................... 37
4.2 Unpacking and placing the analyzer.............................................................................. 37
5Connecting add-on devices ...................................................................................... 38

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5.1 AS vario autosampler ..................................................................................................... 38
5.2 Sampler AS 21................................................................................................................. 41
5.3 Sampler AS 10................................................................................................................. 45
5.4 EPA sampler.................................................................................................................... 47
6Operation ................................................................................................................. 52
6.1 General information for the analysis work.................................................................... 52
6.1.1 Reagents and materials required................................................................................... 52
6.2 Switching on the analyzer (standard commissioning) ................................................. 53
6.3 Switching off the analyzer.............................................................................................. 54
6.3.1 Switching to standby mode............................................................................................ 54
6.3.2 Switching off before longer periods of rest................................................................... 55
6.4 Carrying out the calibration ........................................................................................... 56
6.4.1 Preparing and starting the calibration .......................................................................... 56
6.4.2 Displaying calibration results ......................................................................................... 58
6.4.3 Editing an existing calibration ....................................................................................... 60
6.4.4 Transferring calibration parameters to a method ........................................................ 61
6.4.5 Managing calibration data............................................................................................. 64
6.5 Performing measurements ............................................................................................ 65
6.5.1 Measurement with manual sample supply................................................................... 65
6.5.2 Measurement with sampler........................................................................................... 66
7Maintenance and care.............................................................................................. 68
7.1 Maintenance intervals.................................................................................................... 68
7.2 Adjustment and setup tasks........................................................................................... 69
7.2.1 General notes for adjusting the autosampler ............................................................... 69
7.2.2 Adjusting the AS vario autosampler.............................................................................. 69
7.2.3 Adjust the NPOC purge flow .......................................................................................... 71
7.2.4 Adjusting the EPA sampler............................................................................................. 72
7.3 Replacing the water traps .............................................................................................. 74
7.4 Replacing the halogen trap............................................................................................ 77
7.5 Maintaining the UV reactor............................................................................................ 78
7.5.1 Checking the illumination of the lamp .......................................................................... 78
7.5.2 Cleaning the UV reactor.................................................................................................. 79
7.6 Cleaning the TC condensation vessel ............................................................................ 79
7.7 Cleaning and replacing the syringe pump..................................................................... 81
7.8 Removing and replacing the pump hose....................................................................... 82
7.9 Replacing the hose connections..................................................................................... 83
7.10 Checking the system for tightness................................................................................. 84
8Fault removal ........................................................................................................... 86
8.1 General information ....................................................................................................... 86
8.2 Error messages in multiWin........................................................................................... 87
8.3 Status errors – indications in the window SYSTEM STATE ............................................... 91
8.4 Equipment faults and analytical problems.................................................................... 92
9Transport and storage.............................................................................................. 95
9.1 Transport......................................................................................................................... 95
9.1.1 Preparing the analyzer for transport............................................................................. 95
9.1.2 Transport notes............................................................................................................... 96
9.1.3 Preparing the autosampler AS vario for transport ....................................................... 96
9.1.4 Moving the analyzer in the laboratory.......................................................................... 97
9.2 Storage ............................................................................................................................ 97
9.3 Recommissioning after transport or storage ................................................................ 98
9.3.1 Assembling the analyzer after transport or storage..................................................... 98
9.3.2 Connecting the analyzer................................................................................................. 98
10 Disposal .................................................................................................................. 101
10.1 Waste water ..................................................................................................................101
10.2 Halogen trap .................................................................................................................101
10.3 Analyzer.........................................................................................................................101

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10.4 UV module.....................................................................................................................101
10.4.1 Removing the UV module ............................................................................................101
11 Specifications.......................................................................................................... 104
11.1 Technical data...............................................................................................................104
11.2 Standards and directives..............................................................................................105
Figures
Fig. 1 Front view (doors open).................................................................................... 15
Fig. 2 UV reactor with control gear (right-hand side wall open) .............................. 16
Fig. 3 Syringe pump with 9 port valve ........................................................................ 17
Fig. 4 Hose diagram ..................................................................................................... 18
Fig. 5 Different FAST connector designs .................................................................... 19
Fig. 6 Fingertight screw connection............................................................................ 19
Fig. 7 Needle valve to adjust the NPOC purge flow (see arrow)............................... 19
Fig. 8 Condensate pump .............................................................................................. 20
Fig. 9 TIC condensation module.................................................................................. 21
Fig. 10 Water traps..................................................................................................... 21
Fig. 11 Halogen trap................................................................................................... 22
Fig. 12 Diode to indicate readiness for operation.................................................... 23
Fig. 13 Connections on the rear of the device.......................................................... 23
Fig. 14 Principle of operation .................................................................................... 25
Fig. 15 Layout of the AS vario autosampler ............................................................. 39
Fig. 16 Transport lock on autosampler AS vario ...................................................... 40
Fig. 17 Sleeve with 2 cannulas .................................................................................. 40
Fig. 18 Hose in Fingertight connection..................................................................... 41
Fig. 19 Layout of the sampler AS 21......................................................................... 42
Fig. 20 Connections at the bottom of the sampler AS 21........................................ 43
Fig. 21 Cannula holder for parallel purging.............................................................. 44
Fig. 22 Layout of the AS 10 autosampler ................................................................. 46
Fig. 23 EPA sampler ................................................................................................... 48
Fig. 24 Rear of the EPA sampler................................................................................ 48
Fig. 25 Electrical connections on the rear of the EPA sampler ............................... 49
Fig. 26 Transport lock ................................................................................................ 49
Fig. 27 Fitting the stirring arm to the autosampler ................................................. 49
Fig. 28 Hose in Fingertight connection..................................................................... 51
Fig. 29 Calibration window - DATA OF NEW CALIBRATION ............................................ 56
Fig. 30 Window CURRENT SAMPLE DATA (with sampler operation) ............................ 58
Fig. 31 CALIBRATION window - Data of the completed calibration ........................... 59
Fig. 32 Disabling individual measured values of a calibration ................................ 61
Fig. 33 Window Link to Method ................................................................................ 62
Fig. 34 Window LINK WITH METHOD with three areas................................................. 63
Fig. 35 Window CALIBRATION REPORT SELECTION........................................................... 64
Fig. 36 Adjustment points on the sample tray ......................................................... 70
Fig. 37 Water traps on the inside of the device, left side panel opened ................ 76
Fig. 38 Angled FAST connector with connected hose.............................................. 84
Fig. 39 Replacing the Fingertight connection .......................................................... 84
Fig. 40 Transport lock on autosampler AS vario ...................................................... 96
Fig. 41 Mains connection and gas connections at the multi N/C pharma UV........ 99

Contents multi N/C pharma UV
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multi N/C pharma UV Basic Information
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1Basic Information
1.1 User manual notes
The analyzer multi N/C pharma UV is intended for operation by qualified specialist
personnel observing this user manual.
The user manual informs about the design and operation of the analyzer and provides
personnel familiar with TC/TN analysis the necessary know-how for the safe handling
of the equipment and its components. The user manual further includes notes on the
maintenance and service of the equipment and potential causes and remedies of any
faults.
Instructions for actions which occur in chronological order are numbered and
combined in action units.
Warnings are marked by a warning triangle and a signal word. The type, source and
consequences of the danger are stated together with notes on preventing the danger.
The elements of the control and analysis program are indicated as follows:
Terms used in the program are identified with SMALL CAPS (e.g., Menu FILE).
Buttons are identified by square brackets (e.g., [OK] button)
Menu items are separated by arrows (e.g. FILE OPEN)
The user manual uses the following symbols and signal words to indicate hazards or
instructions. The safety instructions are always placed before an action.
WARNING
Indicate
s a potentially hazardous situation which might cause fatal or very serious
injuries (deformations).
CAUTION
Indicates a potentially hazardous situation which might cause minor or moderate
injuries.
ATTENTION
Indicates potential damage to
equipment or the environment.
Conventions
Symbols and signal words

Basic Information multi N/C pharma UV
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1.2 Intended Use
The analyzer multi N/C pharma UV is a device for determining the parameters TC,
TOC, NPOC and TIC in aqueous samples through the wet chemical digestion using UV
radiation and peroxodisulfate in accordance with the national and international
standards.
The analyzer is intended in particular for the detection of the parameters mentioned in
ultrapure water and water for pharmaceutical purposes.
The device must only be used for the methods described in this user manual to
determine the total carbon content in aqueous samples. Any other use is not as
intended! Only the operator is liable for any damages that result from this.
Improper use can endanger the user or third parties or damage the device. In particular
it is prohibited to use the analyzer to analyze flammable liquids or substances that
could contaminate the analyzer.
The device must only be used with nitrogen or argon as carrier gases. Oxygen or
synthetic air may not be used as carrier gas. The UV radiation would generate ozone
due to the dissociation of molecular oxygen.
The operational safety of the analyzer multi N/C pharma UV is only ensured during
proper use according to the information in this user manual. The intended use also
includes the adherence to the installation conditions prescribed by Analytik Jena GmbH
which are available from the customer service address stated above.
1.3 Warranty and liability
The warranty duration and liability comply with the legal requirements and the
provisions in the general terms and conditions of Analytik Jena GmbH.
Deviations from the intended use described in this user manual result in limitations of
warranty and liability during a damage event. Damage to wearing parts is not included
in the warranty.
Warranty and liability claims are excluded for personal injury and property damage
due to one or several of the following causes:
use of the analyzer multi N/C pharma UV other than intended
improper commissioning, operation and service of the analyzer
modifications of the equipment without prior consultation with Analytik Jena
GmbH
unauthorized intervention in the equipment
operation of the device with faulty safety equipment or improperly fitted safety and
protection equipment
inadequate monitoring of the equipment components subject to wear
use of other than original spare parts, wearing parts or consumables
improper repairs
faults due to the non-observance of this user manual

multi N/C pharma UV Safety instructions
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2Safety instructions
For your own safety and to ensure error-free and safe operation of the analyzer
multi N/C pharma UV, please read this chapter carefully before using the appliance.
Observe all safety notes listed in this user manual and all messages and displayed by
the control and analysis software on the monitor.
2.1 Safety markings on the analyzer
Safety symbols have been attached to the analyzer and accessories whose content
must always be observed.
Damaged or missing safety symbols can cause incorrect actions leading to personal
injury or material damage! The safety symbols must not be removed! Damaged safety
symbols must be replaced without delay!
The following safety symbols have been attached to the analyzer and accessories:
Fire, naked flame and
smoking prohibited!
Warning against dangerous
electrical voltage
Warning against
hazardous substances
Warning against hot
surface
Warning against corrosive
substances
Warning
mercury
The device contains restricted substances (according to
directive SJ/T 11363
-2011). Analytik Jena GmbH
guarantees, that those hazardous substances may not
leak out during the next 25 years when the device is
used in accordance with its intended purpose.
2.2 Technical condition
The analyzer corresponds in its design and construction to the current state of the art
technology. Unauthorized modifications or changes, especially such that affect the
safety of the staff and the environment, are generally not allowed.
The following has to be observed:
Any manipulation of the safety equipment is prohibited! In case of an accident
manipulations of the safety equipment will be interpreted as deliberate!

Safety instructions multi N/C pharma UV
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The operator must only operate the analyzer in a sound and operationally safe
condition. The technical condition must always comply with the legal requirements
and regulations.
Prior to every use the analyzer must be checked for damage and sound condition.
Any changes in the analyzer affecting its safety must be reported by the operating
personnel to the operator without delay.
The equipment components must only be connected to supply cables intended and
designed for this purpose.
All safety equipment and interlocks must be well accessible and regularly checked
for proper operation.
2.3 Requirements for the operating personnel
The analyzer multi N/C pharma UV must only be operated by qualified specialist
personnel instructed in the use of the analyzer. The instruction must also include
conveying the content of this user manual and the user manuals of other system
components or add-on equipment.
The analyzer may pose dangers if it is not used by trained personnel, improperly or
other than intended.
Therefore, every person tasked with the operation of the analyzer must have read and
understood this user manual and the user manuals of any additional equipment before
carrying out the respective tasks. This also applies if the respective person has already
worked with or been trained on this kind of analyzer.
It is recommended that the operator have the operating personnel confirm the
knowledge of the content of the user manual in writing. The ultimate responsibility for
the accident-free operation of the analyzer rests with the operator or the specialist
personnel authorized by him.
In addition to the safety at work instructions in this user manual the generally
applicable safety and accident prevention regulations of the respective country of
operation must be observed and adhered to. The operator must ascertain the latest
version of these regulations.
The user manual must be accessible to the operating and service personnel at any
time!
The analyzer must only be commissioned, operated and serviced by trained
personnel instructed in technical safety.
The operation or servicing of the analyzer by minors or individuals under the
influence of alcohol, drugs or medication is not permitted.
It must be ensured that only authorized personnel works at the analyzer.
The operating personnel must be familiar with the dangers arising from measuring
liquids. The appropriate protective equipment must be used.
Prior to pauses or at the end of the work appropriate skin cleaning and protection
measures must be carried out.
Eating, drinking, smoking or handling open flames in the operating room of the
analyzer is prohibited!

multi N/C pharma UV Safety instructions
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2.4 Safety instructions, transport and installation
The analyzer is always installed by the customer service department of Analytik Jena
GmbH or its authorized and trained specialist personnel. Independent assembly and
installation are not permitted. Incorrect installation can create serious hazards.
The following has to be observed:
Insufficiently secured components pose a risk of injury! During transport the
components of the equipment must be secured in accordance with the instructions
in the user manual.
Only transport the analyzer in its original packaging! Ensure that the transport
protections have been fitted and the analyzer is completely empty.
To prevent damaged to health the following must be observed when moving the
analyzer in the laboratory (lifting and carrying):
For reasons of safety 2 persons are required to transport the analyzer and must
position themselves on both sides of the equipment.
Because the analyzer does not feature any handles, firmly grip the device from
the bottom and make sure prior to simultaneous lifting the device that the
sensitive components at the front are protected by the closed doors.
The guide values and statutory limits for lifting and carrying loads without
auxiliary equipment must be observed and adhered to.
2.5 Safety instructions - operation
2.5.1 General
The operator of the analyzer must make sure before each commissioning that the
condition of the analyzers including the safety equipment is sound. This applies in
particular after each modification or extension of the analyzer or its repair.
The following has to be observed:
The analyzer must only be operated if all protective equipment (e.g. covers, drip
pans for chemicals and doors) are present, properly installed and fully operational.
The sound condition of the protection and safety equipment must be checked
regularly. Any defects must be corrected as soon as they occur.
Protective and safety equipment must never be removed, modified or
decommissioned during operation.
Free access to the power switch on the back of the enclosure has to be ensured
during operation.
The ventilation equipment on the multi N/C pharma UV and the extension modules
must be in good working condition. Covered vents or ventilation slits etc. may cause
the device to break down or may cause damage to it.
Keep all combustible materials away from the analyzer.

Safety instructions multi N/C pharma UV
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2.5.2 Safety instructions - Protection against explosion and fire
The analyzer must not be operated in an explosive environment. Smoking or handling
open flames in the operating room of the analyzer is prohibited!
The operating personnel have to be familiar with the location of the fire-fighting
equipment in the operating room of the analyzer.
2.5.3 Safety instructions - electrical equipment
Work on electrical components of the analyzer may only be carried out by a qualified
electrician in accordance with the applicable electrical engineering rules. Life-
threatening electrical voltages may occur in the right-hand side component of the
analyzer.
The following has to be observed:
Extension modules or system components must always be connected to or
disconnected from the analyzer in a deactivated condition.
Before opening the analyzer it must be switched off from the equipment switch
and the mains connector must be disconnected from the mains outlet!
Any work on the right-hand side component of the analyzer may only be carried
out by the customer service of Analytik Jena GmbH and specially authorized
technicians.
The electrical components must be checked regularly by a qualified electrician. Any
defects, such as loose connections, faulty or damaged cables, must be repaired
without delay.
The analyzer must be switched off immediately at the power switch (on the
equipment backplate) and the power supply disconnected from the mains if there is
any interference with the electric components.
2.5.4 Safety instructions for compressed gas containers and systems
The carrier gas (nitrogen/argon) is obtained from compressed gas containers or local
compressed gas systems. The required purity of the carrier gas must be ensured (→
see section "Technical data" p. 104)!
Work on compressed gas containers and systems must only be carried out by
individuals with specialist knowledge and experience in compressed gas systems.
The following has to be observed:
For gas cylinder or gas plant operation, the safety instructions and guidelines which
are valid at the operating location must be strictly complied with.
High pressure hoses and pressure reducers may only be used for the assigned
gases.
All pipes, hoses and screw connections must be checked regularly for leaks and
externally visible damage. Leaks and damaged must be repaired without delay.
Prior to inspections, service and repairs the valves must be closed and the analyzer
vented!

multi N/C pharma UV Safety instructions
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After successful repair and service of the components of the compressed air
containers or system the analyzer must be checked for sound operation prior to
recommissioning!
Independent assembly and installation are not permitted!
2.5.5 Safety notes on UV radiation
The protection of the user against UVC radiation is ensured by the protective glass
before the UV reactor. The protective glass must not be removed during operation.
Manipulations at the protective glass are not permitted!
Avoid looking into the protective glass for longer periods of time to protect your
eyesight.
No oxygen or synthetic air may be used as carrier gas! The UVC radiation of the UV
reactor would generate ozone due to dissociation of molecular oxygen. Ozone can
damage the mucous membranes.
2.5.6 Handling of auxiliary and operating materials
The operator is responsible for the selection of substances used in the process as well
as for their safe handling. This is particularly important for radioactive, infectious,
poisonous, corrosive, combustible, explosive and otherwise dangerous substances.
When handling dangerous substances local safety codes and guidelines must be
observed.
The following general notes do not replace the specific local regulations or the
regulations in the EG safety data sheets of the manufacturers for the auxiliary and
operating materials.
The following has to be observed:
The relevant regulations and the notes in the EC safety data sheets of the
manufacturers have to be observed and complied with regards to storage, handing,
use and disposal for all auxiliary and operation materials used during operation or
maintenance of the analyzer.
Auxiliary and operation materials may never be placed in containers or vessels for
food. The approved containers for the relevant material are to be used and these
have to be labelled accordingly. The notes on the labels have to be observed!
Protective goggles and rubber gloves have to be worn when handing reagents. The
notes on the labels have to be observed.
The regulations and notes on the safety data sheets for the handling of
orthophosphoric acid (H3PO4), sulfuric acid (H2SO4) and sodium peroxodisulfate
(Na2S2O8) must be observed!
Biological samples have to be handled according to local guidelines regarding the
handling of infectious material.
Caution when handing quartz glass and glass parts. Risk of broken glass and
therefore risk of injury!

Safety instructions multi N/C pharma UV
14
Auxiliary and operating materials as well as their containers may not be disposed in
domestic waste or enter the sewage system or the soil. The applicable regulations
for disposal of these materials must be meticulously observed.
The operator is responsible for ensuring that waste materials are disposed of in an
environmentally responsible manner and according to local regulations.
Ensure good room ventilation in working rooms.
2.5.7 Safety instructions - service and repair
The analyzer is usually serviced by the customer service department of Analytik Jena
GmbH or its authorized and trained specialist personnel.
Independent servicing can misadjust or damaged the analyzer. Therefore, the operator
may only carry out the tasks listed in the chapter "Service and care".
The following has to be observed:
The exterior of the analyzer may only be cleaned with a damp, not dripping, cloth
after the analyzer has been switched off.
Any service and repair work at the analyzer may usually only be carried out in the
switched-off condition (unless stated otherwise).
Prior to servicing or repair the energy and gas supplies must be disconnected and
the analyzer must be vented!
Only use original accessories and original replacement parts from Analytik Jena
GmbH. The notes in the chapter "Service and care" must be observed.
All protective equipment must be reinstalled correctly immediately after
completion of the service and repair work and be checked for operation!
2.6 Behavior during emergencies
The analyzer must be switched off from the power switch (on the equipment
backplate) and the power supply has to be disconnected from the mains in case of
dangerous situations or accidents.
Because a rapid response can save lives during an emergency, the following has to be
ensured:
The operating staff must be familiar with the location of safety equipment,
accident and danger alarms as well as first aid and rescue equipment as well as
their handling.
The operator is responsible for the respective training of the operating staff.
All equipment for first aid (first-aid kit, eyewash bottles, stretcher, etc.) as well as
equipment for firefighting (fire extinguishers) must be within reach and easy to
access. All equipment has to be in a sound condition and should be checked
regularly.

multi N/C pharma UV Function and setup
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3Function and setup
3.1 System design
The analyzer multi N/C pharma UV is a compact laboratory device with permanently
installed main components. The complete measuring design further includes accessory
parts and reagents which must be connected to the analyzer or made ready prior to a
measurement.
The control of the analyzer and the analysis of the measurements takes place via the
control and analysis software multiWin installed on an external PC.
All components of the analyzer to be operated or serviced by the user can be reached
via 2 doors at the front.
The analyzer multi N/C pharma UV consists of the following main components:
UV reactor with control gear
NDIR detector
Components for sample preparation
Accessories
Hose system
Electronic component
Components for measuring gas drying
and cleaning
Indicator and control elements,
connectors
Fig. 1 Front view (doors open)
1 Water traps
2
Cooling block
3
Syringe pump with 9 port valve
4
Reagent bottle for Na2S2O8
5
Drip trays
6 Reagent bottle for H
3
PO
4
7
TIC condensate container
8
Halogen trap
9
Needle valve to adjust the gas flow
10
Condensate pump

Function and setup multi N/C pharma UV
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3.1.1 UV reactor with control gear
The analyzer multi N/C pharma UV features a specially developed UV reactor with
integrated UV radiation source from quartz glass. The reactor directly surrounds the UV
radiation source. Wavelengths of 185 nm and 254 nm are used. This results in a very
efficient and high radiation density and thus a high digestion capability|
The reactor has two inlets and one outlet. One inlet is connected to the syringe pump
for feeding the sample and reagent. The carrier gas supply takes place via the second
inlet. At the top outlet of the reactor the measuring gas is routed via hose connections
to the TIC condensate container.
Fig. 2 UV reactor with control gear (right-hand side wall open)
3.1.2 Components for sample preparation
Sample feeding in the analyzer multi N/C pharma UV takes place via flow injection
over a syringe pump with 9-port valve. The injection volume is 0.05 to 20 ml. For
sample volumes ≤1.5 ml system water is additionally entered into the reactor with
each metering.
The hose connections are attached to the 9 port valve using Fingertight screw
connections. The syringe body is made of glass and replaceable.

multi N/C pharma UV Function and setup
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1 Fingertight connection
2
9-port valve
3
Metering syringe
Fig. 3 Syringe pump with 9 port valve
The hoses at the 9-port valve are labelled and connected to the following components:
Hose no. Connection to the component/accessory
1 TIC condensate container
2 Reagent bottle for phosphoric acid H3PO4
3 Reagent bottle for sodium peroxodisulfate Na2S2O8
4 Waste disposal
5 Ultra-pure water bottle
6 Sample
7 UV reactor
8 Waste disposal
9 not allocated
3.1.3 Hose system
The connection between the individual components is made with labelled hoses. The
encircled numbers and letters in the hose diagram correspond to the labels on the
hoses in the analyzer.
Hose diagram

Function and setup multi N/C pharma UV
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Fig. 4 Hose diagram
Within the device most gas connections have been implemented via a FAST connector
(FAST – Fast, Save, Tight). These connectors provide a tight transition between the
hoses and connections with different diameters. The soft sleeves prevent the risk of
glass fractures compared to rigid screw connections. There are different versions of the
connectors.
Connection method

multi N/C pharma UV Function and setup
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Fig. 5 Different FAST connector designs
In addition, so-called Fingertight screw connections are used in the analyzer
multi N/C pharma UV. These flangeless fittings consist of a conical nipple and a banjo
bolt. These hose connections seal purely by tightening the plastic banjo bolt finger-
tight.
1 Conical nipple
2
Banjo bolt
3
hose
Fig. 6 Fingertight screw connection
The flow of the carrier gas is adjusted automatically in the multi N/C pharma UV and
the inlet flow is controlled via an MFC (mass flow controller - IN). At the device outlet
the carrier gas flow is measured using an MFM (mass flow meter - OUT), i.e. an
automatic tightness check is carried out. The result is displayed in the control and
analysis software multiWin in the window SYSTEM STATE.
The adjustment of the NPOC purge flow and the adjustment of the purge flow for
reagents take place via needle valves below the hose pump. The NPOC purge flow is
measured using an MFM and displayed in the control and analysis software in the
window SYSTEM STATE.
1 Needle valve to adjust the NPOC purge
flow
2
Needle valve to adjust the purge flow for
reagents
Fig. 7 Needle valve to adjust the NPOC purge flow (see arrow)
Components for flow
adjustment

Function and setup multi N/C pharma UV
20
Via the condensate pump the condensate or the waste solution from TIC detection are
automatically pumped off after each measurement. The condensate pump is to the left
of the halogen trap.
Fig. 8 Condensate pump
3.1.4 Components for gas drying and cleaning
The TIC condensation module consists of a TIC condensate container and a cooling
block. In the TIC condensate container the TIC reactor and the gas/liquid separator are
combined. At the same time the measuring gas is dried via the cooling block.
The TIC condensate container has four connections. One connection at the top
connects the TIC condensate container to the UV reactor via a hose supplying the wet
measuring gas/carrier gas mixture. The gas is routed downwards on the inside and
exits via a glass drip. The integrated glass drip ensures the effective purging of the
generated CO2.
The measuring gas is dried by freezing in the cooling block. A Peltier element provides
cooling. The dry measuring gas is routed via the other connection out of the TIC
condensate container.
Another hose connection supplies the samples and reagents via the bottom connection
into the TIC condensate container. The waste from the TIC condensate container is
routed over the fourth connection via the condensate pump to the disposal.
Condensate pump
TIC condensation module