Diesse VES-MATIC CUBE 30 User manual

INSTRUCTIONS MANUAL
Software Release N°3.0
Rev.2.0 issued on February 2016
Automatic instrument for the determination
of the Erythrocyte Sedimentation Rate (ESR)
(Patented)
For In vitro Diagnostic Use Only

Instructions Manual
2/50 Rev 2.0 of 02/2016
MANUFACTURER
DIESSE DIAGNOSTICA SENESE S.p.A.
Via delle Rose 10, 53035 Monteriggioni (SI), Italy
Tel. [phone] Fax. [phone]
www.diesse.it
LEGAL REPRESENTATIVE
PRESIDENT
Dr. Francesco Cocola
REGISTERED AND ADMINISTRATIVE OFFICE
Via A. Solari 19, 20144 MILANO, Italy
Tel. [phone] Fax. [phone]
For Technical Assistance please contact your distributor:
The information contained in this manual may be subject to modifications without notice. No page in
this manual may be reproduced in any form or by any means; neither electronic nor mechanical, for
any use whatsoever without prior written permission from DIESSE Diagnostica Senese S.p.A.

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Standard applied in this document:
- 98/79/EEC “directive relevant to the In Vitro Medical-Diagnostic Devices (IVD)”
- EN 61010-1 (CEI 66-5) “Safety requirements for electrical equipment for measurement,
control laboratory use –Part1: General requirements”. The instrument is classified in
Class I
- EN 61326-1 “Electrical Equipment for Measurement, Control, and Laboratory Use –
Electromagnetic compatibility requirements-Part 1: General requirements”
- EN 61326-2-6 “Electrical Equipment for Measurement, Control, and Laboratory Use –
Electromagnetic compatibility requirements-Part 2-6: In Vitro Diagnostic (IVD) medical
equipment”
- 2006/95/EEC “Low Voltage Directive”
- 2004/108/EEC “Electromagnetic Compatibility Directive”
- 2011/65/EU “Restriction of Hazardous Substances in Electrical and Electronic
Equipment Directive –RoHS2”
LIST OF MANUAL REVISIONS
APPLICATION OF THE MANUAL
This manual applies to the following models of the VES-MATIC CUBE 30:
DIESSE Code
Model description
10390
VES-MATIC CUBE 30
MANUAL
REVISIONS
VERSION SW VES-
MATIC CUBE 30
DESCRIPTION OF MODIFICATION
0.00
of
10/09
2.06
of
10/09
Initial revision
1.00
of
03/10
2.06
of
10/09
Restyling of the document after its creation by the research
department
1.01
of
07/10
2.06
of
10/09
Changed the customer care address with those of the technical
support
1.02
of
11/10
2.06
of
10/09
Adding of the plate unlocked procedure
1.03
of
02/11
2.06
of
10/09
The Annex about warranty is deleted
1.04
of
11/11
2.17
of
11/11
Modified only the German version as requested by a customer
1.05
of
01/12
2.17
of
11/11
Changed the EC Declaration and deleted the references to
Customer Care
1.06
of
10/14
3.00
of
10/14
Changed software release 3.0
2.00
of
02/16
3.00
of
10/14
Complete restyling

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SYMBOLS
Legend of graphic symbols used on the instrument.
Instrument satisfying requirements of European directive on in vitro diagnostic medical devices
(98/79/EC).
In Vitro Diagnostic medical device.
Date of manufacturing of the unit.
Serial number of the unit.
Manufacturer.
Legend of Electrical and Safety symbols used on the instrument.
Protective conductor terminal.
WEEE: - Obligation of separate waste collection according to L.D. 25/07/2005 no. 151 (Italy),
enforcement of the 2002/96/EC and 2003/108/EC directives.
Warning, read the Manual and pay attention to the safety symbols.
Warning, risk of electric shock.
Legend of symbols used in this document.
ATTENTION, potential hazard of personal injuries, all conditions indicated in the text have to be
read and understood before proceeding.
CAUTION, potential danger of damage to the machine, all conditions indicated in the text have
to be read and understood before proceeding.
NOTE, important information
BIOHAZARD, danger of contamination with possibly infected materials.
Instrument satisfying CSA standards for the Canadian and U.S.A. market.

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WARNINGS AND LIMITS
Before installation and use of the instrument, for proper and safe use, it is advised to carefully read
the warnings and instructions contained in this user manual. It is important that this user manual is
stored together with the instrument for future reference.
In case of sale or transfer make sure that this manual accompanies the VES-MATIC CUBE 30 to allow
new users to know about the instrument functionality and the related warnings.
Use of this instrument is advised for only qualified and able personnel. The installation has to be
carried out by an authorized DIESSE Diagnostica Senese S.p.A. technician who will create an
Installation Report supplied separately with the Installation Check Guide.
This report has to be transmitted to the DIESSE Diagnostica Senese S.p.A. Technical Service
Department to allow the possibility for more effective technical interventions and assistance after
installation.
The safety requirements and instrument performance are no longer guaranteed if to power
the machine, a model of cable other than the supplied one (compatible with the voltage of the
country of installation) is used.
BIOHAZARD
Potentially infected material is handled.
When an analysis system like the VES-MATIC CUBE 30 is used, all precautions
have to be used regarding biological risks. The samples do not require preparation.
The samples have to be disposed off in accordance with the laboratory instructions
and with local laws.
Observe the individual and collective security measures as appropriate for the
operator and for the working spaces. Comply with directives in security matters and
with the current legal regulations
In case of leakage of biological material, during the working cycle, clean external
surfaces of the instrument using appropriate laboratory safety procedures in order to
assure personnel safety (see paragraph 5.2)
All supplied materials have to be disposed off in accordance with the local laws.

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CONTENTS
CHAPTER 1...........................................................................................................................................8
1.0 INTENDED USE OF THE INSTRUMENT......................................................................................8
1.1 PRESENTATION OF THE INSTRUMENT.....................................................................................8
1.2 GENERAL DESCRIPTION OF THE INSTRUMENT ....................................................................10
1.3 MATERIAL SUPPLIED WITH THE INSTRUMENT......................................................................11
1.4 LIST OF MATERIAL REQUIRED BUT NOT PROVIDED.............................................................12
1.5 TECHNICAL SPECIFICATIONS..................................................................................................12
1.6 BLOCK DIAGRAM.......................................................................................................................13
1.7 TECHNICAL DESCRIPTION OF THE INSTRUMENT.................................................................14
1.8 INFORMATION REGARDING DISPOSAL...................................................................................15
CHAPTER 2.........................................................................................................................................16
2.1 STORAGE AND TRANSPORT....................................................................................................16
2.2 PREPARATION AND CHECKS PRIOR TO INSTALLATION.......................................................16
2.3 UNPACKING ...............................................................................................................................17
2.4 POSITIONING.............................................................................................................................18
2.5 INSTALLATION...........................................................................................................................19
2.6 RESTRICTIONS AND WARNINGS.............................................................................................19
2.7 SHUTTING DOWN AND SHIPPING............................................................................................20
CHAPTER 3.........................................................................................................................................21
3.1 TURNING ON THE INSTRUMENT..............................................................................................21
3.2 KEYBOARD.................................................................................................................................21
3.3 MAIN MENU................................................................................................................................22
3.4 QUERY TO HOST.......................................................................................................................23
3.5 DISPLAYING (AND PRINTING) OF THE STORED ANALYSES .................................................23
3.6 INSTRUMENT SETUP ................................................................................................................25
RECHARGE CD..........................................................................................................................28
CHAPTER 4.........................................................................................................................................30
4.1 DESCRIPTION OF THE ANALYSIS CYCLE ...............................................................................30
4.2 PREPARATION OF THE SAMPLE..............................................................................................32
4.3 TEST TUBE TYPES ....................................................................................................................34
CHAPTER 5.........................................................................................................................................35
5.1 GENERAL RECOMMENDATIONS..............................................................................................35
5.2 CLEANING/DISINFECTION OF THE INSTRUMENT ..................................................................35
5.3 REPLACEMENT OF PRINTER PAPER.......................................................................................35
5.4 SUBSTITUTION OF THE FUSES................................................................................................36
5.5 CHECKING THE SAFETY DEVICES (MICRO-SWITCHES) AND ACOUSTIC DEVICES ...........37
CHAPTER 6.........................................................................................................................................38
6.1 AUTODIAGNOSTICS..................................................................................................................38
CHAPTER 7.........................................................................................................................................39
7.1 INTRODUCTION: TECHNICAL INFORMATION..........................................................................39
7.2 INTRODUCTION: HEX-ASCII REPRESENTATION ....................................................................39
7.3 GENERAL NOTE: RESPONSE DELAY.......................................................................................39

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7.4 MESSAGE REQUESTING TEST TUBES TO BE PROCESSED: COMMAND 0X50....................39
7.5 REPLY MESSAGE WITH COMMAND DATA...............................................................................41
7.6 RESULT SENDING MESSAGE: COMMAND 0X51 .....................................................................42
7.7 QC (QUALITY CONTROL) SAMPLE DATA SENDING MESSAGE: COMMAND 0X52................44
7.8 EXAMPLE OF SERIAL PROTOCOL............................................................................................47
BIBLIOGRAPHY................................................................................................................................. 48
ATTACHMENT A: EC COMPLIANCE CERTIFICATE........................................................................ 49
ATTACHMENT B: ACCESSORIES, SPARE PARTS AND CONSUMABLES.................................... 49

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CHAPTER 1
1.0 INTENDED USE OF THE INSTRUMENT
Automatic instrument for the determination of erythrocyte sedimentation rate (ESR).
1.1 PRESENTATION OF THE INSTRUMENT
VES-MATIC CUBE 30 is a bench instrument designed and programmed to measure the
Erythrocyte Sedimentation Rate (ESR) of up to a maximum of 30 blood samples contained in test
tubes coming from the blood cell counter used in the laboratory, therefore, neither double
sampling nor biological material transfer is necessary.
The analysis is performed fully automatically (agitation and reading) and the results are
comparable with those obtained using the Westergren method, and if obtained at room
temperature, can automatically be corrected to a temperature of 18°C according to the Manley’s
Nomogram4(Fig. 1.1). VES-MATIC CUBE 30 allows obtaining results equivalent to the
Westergren method (1 hour) in just 33 minutes, including sample agitation.
Fig 1.1 Manley’s Nomogram4
Clinical concept of the ESR
The Erythrocyte Sedimentation Rate test (ESR) is performed measuring the distance travelled by red
cells in autologous plasma over a fixed period of time. In normal conditions, red cells tend to repel
each other by virtue of the negative membrane net charge, due to the presence of numerous sialic acid
residues at the level of membrane glycoproteins.
When the protein composition of the plasma is changed, with the production of so-called "acute phase
proteins", as a result of an inflammatory process or tissue damage, thanks to the binding of these
proteins (fibrinogen, immunoglobulins) to the surface of red blood cells, the negative charge of
membrane potential (Z) is altered and the red blood cells can pile-up, to form the so-called rouleaux,
which then aggregate to form microspheres of uniform radius, that begin to sediment when their
density exceeds that of the plasma in which they are immersed. The value of the ESR is then
increased in all of those situations in which there is an increase in acute phase proteins and in
particular fibrinogen (which is thought to contribute for 70% to the total phenomenon of sedimentation)
and immunoglobulins (that will increase in case of onco-haematological diseases and acute infections).
ESR is therefore an indirect not specific measure of an inflammatory state and is elevated in various
pathological conditions such as inflammatory diseases (infections, rheumatic diseases),

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relative/absolute increase of globulins (nephrotic syndrome, myeloma), tissue necrosis (myocardial
infarction, tumors). ESR is useful for predicting the prognosis of some diseases such as polymyalgia
rheumatica, giant cell arteritis, rheumatoid arthritis and Hodgkins disease and is useful as a marker of
treatment efficacy in many diseases such as rheumatoid arthritis, vasculitis, collagenosis, septic
arthritis.
The erythrocyte sedimentation rate is usually higher in females than males and is increased in
pregnancy and it has also a tendency to increase in both sexes with increasing age.
In the classical formulation of Westergren the test is performed on blood anti-coagulated with citrate, in
the proportion of 4 parts blood to one part of anticoagulant. The diluted blood is then aspirated inside a
special graduated pipette with inner diameter of 2.5 mm held vertically in a stand; the level of
sedimentation of the erythrocytes is recorded after one hour, measuring the distance between the
lower face of the meniscus of the plasma and the upper face of the layer of sedimented red blood cells.
General functions of the instrument
The blood obtained in the test tube for the CBC (cell blood count) exam, is accurately mixed by the
instrument; the samples then remain at rest for a predetermined amount of time, to allow the
sedimentation to occur.
Through analogue sensors (optic-electronic groups) the instrument automatically determines the
sedimentation level of the red cells at time zero and after 20 minutes, subsequently the information is
extrapolated and then automatically printed or shown on the display (in case of a Host connection,
please read paragraph 7.2).
Normal values of ESR
According to the scientific literature, normal ESR values are between 1 and 10 mm/h for men and
between 1 and 15 mm/h for women; in pathological conditions they can increase to values of up to 100
mm/h and above.
Approximate normal range of the VES-MATIC CUBE 30 instrument:
MALES up to 10 mm/h
FEMALES up to 15 mm/h
These values have to be considered as entirely approximate and vary in function of age and gender.
According to international guidelines, each laboratory should determine its own normal ranges based
on gender and divided by decades of age.

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1.2 GENERAL DESCRIPTION OF THE INSTRUMENT
1
2
3
4
5
6
7
Fig. 1.2.1 Front view
LEGEND:
1) Keypad
2) Display
3) 3) Paper drawer with printer slot
4) Instrument lid
5) 5) 30-postion test tube holding plate
6) Numbered test tube positions
7) Check device housing
8) Barcode reader
9) Housings for fitting the plate
reducer required for rubber-
capped test tubes
8
9

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LEGEND:
10) ON/OFF switch
11) Fuses and voltage changer
12) Power cable socket
13) RS-232 connector for connection to an external computer
14) USB connector
15) Forced ventilation fan
1.3 MATERIAL SUPPLIED WITH THE INSTRUMENT
VES-MATIC CUBE 30 is supplied with the following materials:
- An instruction manual.
- Two spare fast-blow fuses, 1A (5x20) each.
- A plate reducer for using rubber-capped test tubes.
- An IEC International Standard power cable.
[IEC 320 C-13 female plug; EEC 7-VII Schuko male plug; rating: 10A/250VAC].
- Packing list and installation report.
Purchasable consumables for use with the instrument
Check Device Transponder RF 1K for VES-MATIC CUBE (1000 tests) [Ref.: 10292]
Check Device Transponder RF 5K for VES-MATIC CUBE (5000 tests) [Ref.: 10291]
Check Device Transponder RF 10K for VES-MATIC CUBE (10000 tests) [Ref.: 10290]
ESR Control Cube 4x9ml (2 normal vials + 2 abnormal vials) [Ref.: 10435]
ESR Control Cube 2x9ml (1 normal vial + 1 abnormal vial) [Ref.: 10436]
Thermal paper for printer (1 roll) [Ref.: 10403]
Calibrator (TEST TUBE READER) [Ref.: 19900900]
Fig. 1.2.2 Rear view
14
13
10
12
15
11

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1.4 LIST OF MATERIAL REQUIRED BUT NOT PROVIDED
Disposable gloves
Cleaning paper
Solutions for cleaning the instrument
1.5 TECHNICAL SPECIFICATIONS
CENTRAL UNIT AND
INTERFACES
Low-dissipation RISC 8-BIT technology;
ATMEGA128 microprocessor
TEST TUBE HOLDING PLATE
With 30 numbered positions to host various types of test tube.
OPTICAL UNIT
A pair of optoelectronic devices (LED & analogue sensor).
PRINTER
Alphanumeric with 58 mm-wide thermal paper, 36 characters
per line, speed 20 mm/sec.
DISPLAY
Liquid-crystal graphic, 240x128 pixels
POWER SUPPLY
110 to 230 VAC (50 - 60 Hz)
FUSES
2 x 1.0A Fast (5 x 20 mm)
ELECTRICAL POWER
ABSORBED
65 W max
DIMENSIONS
510 x 350 x 500 mm (L x H x D )
WEIGHT
20 kg
OPERATING TEMPERATURE
+15°C to +35°C
STORAGE TEMPERATURE
+5°C to +45°C
RELATIVE HUMIDITY
20% to 80% without condensation
PLATE ROTATION SPEED
1 turn every 1.5 seconds during normal operation
CLASSIFICATION
CLASS I device (IEC classification)
The safety and performance requirements of the instrument cannot be guaranteed
anymore whenever, for the powering of the instrument, a cable model different from the
one supplied, compatible with the net power of the country of installation is used.

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1.6 BLOCK DIAGRAM
(The detailed diagrams are contained in the Service Manual)
Fig. 1.6.1 VES-MATIC CUBE 30 block diagram
LEGEND:
1) CPU board 10) Printer interface
2) Motor driver board 11) Printer
3) Power supply 12) Lid unit solenoid
4) Motor block 13) Lid micro-switch
5) Reading sensor unit 14) Forced ventilation fan
6) Check device unit 15) ON/OFF switch with mains filter
7) Display/keypad interface 16) External connections
8) Graphic display 17) Barcode reader
9) Keypad

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1.7 TECHNICAL DESCRIPTION OF THE INSTRUMENT
CENTRAL UNIT
This unit controls and processes the incoming data from the sensors and manages all the peripheral
devices; it comprises a FLASHEPROM containing the program and an EEPROM where the read and
processed data is stored.
OPTICAL READING UNIT
This unit is composed of a photodiode + phototransistor pair.
TEST TUBE HOLDING PLATE TILTING AND ROTATION MOTORS
One motor tilts the test tube holding plate by 90° and another motor rotates it by means of the shaft in
order to ensure homogeneous suspension of the red blood cells.
OPTICAL READING UNIT MOTOR
This motor raises the optical reading unit to check the presence of the test tubes, the blood level and
its sedimentation.
KEYPAD
The keypad has 5 keys which are used to activate the VES-MATIC CUBE 30 functions.
TEST TUBE HOLDING PLATE
The plate has a radial crown with 30 numbered positions into which the test tubes are inserted. These
are symmetrically tilted with respect to the rotation axis in such a way as to arrange the test tubes on
the cone generator.
The test tube holding plate is also equipped with a reducer required for use of rubber-capped test
tubes.
Use the reducer only when using rubber-capped test tubes.
BEEPER
The function of the beeper is to draw the attention of the operator during particular phases of the test
execution in the operating cycle.
It emits a beep each time a key on the keypad is pressed.
TEMPERATURE SENSOR
This sensor is fitted on the central unit in proximity of the test tube holding plate and is used to
measure the temperature.
PRINTER
The results of the analysis are printed at the end of each operating cycle.
DISPLAY
The display is used to show all the instrument messages.

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1.8 INFORMATION REGARDING DISPOSAL
VES-MATIC CUBE 30 is composed of the following materials in percentage:
IRON
20%
ALUMINIUM
20%
COPPER
8%
EPOXY RESINS and SILICON
6%
PLASTICS
46%
The VES-MATIC CUBE 30 instrument is operated by mains voltage, therefore has been
classified as Electrical-Electronic Equipment according to the European Directive 2012/19/UE
dated July 04, 2012, and subsequent amendments.
At the end of its life cycle, the instrument must be treated as separate collection, potentially
infected, waste and eliminated according to law.

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CHAPTER 2
2.1 STORAGE AND TRANSPORT
The VES-MATIC CUBE 30 is a precision instrument and must be treated as
such. Inappropriate operations could damage the internal opto-electronic
components and cause mechanical damage.
In view of the overall dimensions and weight of the machine, the transport must be carried out
manually by taking all necessary precautions in order to avoid impact or excessive tipping over that
could damage the instrument.
Fig.2.1.1 Complete packaging
Package dimensions
WIDTH (box)
cm
65
HEIGHT (box)
cm
50
DEPTH (box)
cm
70
GROSS WEIGHT
kg
26
PACKAGING WEIGHT
kg
6
Do not throw away the original packaging of the internal parts of the instrument in
case of further transportation of the instrument in the future.
2.2 PREPARATION AND CHECKS PRIOR TO INSTALLATION
In order to ensure the safety of the instrument and the operator the following conditions must be
guaranteed:
The power supply system (installation category II), must be “compatible” with the voltage
and current specifications indicated on the nameplate attached to the back of the
instrument; and it is recommended checking the efficiency of the electrical system
periodically.

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The electrical system and relative sockets must all be fitted with efficient ground connections according
to the regulations in force with regard to electrical installations.
The instrument is fitted with an internal power supply that supports voltage surges as per the
specifications indicated on the nameplate on the back side of the device; in the event of the line being
very disturbed, use a saturated iron stabiliser (65 W minimum) for minimising the power surges.
Before making connections with external instruments (PCs, Barcode readers), it will be necessary to
check the compatibility (refer to the relative instruction manuals) with the specifications indicated in
chapter 7 and check that there is continuity between the grounding connection and the external
instruments.
The operator must be trained to be familiar with the procedures, restrictions and warnings indicated in
this manual, as well as those pertaining to safety in the work place.
The material for the operator’s safety (gloves, containers for disposing of used expendable items,
detergent solutions for cleaning the instrument) must always be available.
The positioning of the instrument must comply with the instructions indicated in paragraph 2.4.
IT IS STRICTLY PROHIBITED TO:
- cover the rear grids (fan) of the instrument
- remove or modify the safety and protection devices.
2.3 UNPACKING
During the handling of the device, avoid impact and excessive tipping over that
could damage the instrument.
Unpacking the instrument.
a. Open the box from the top (see packaging label) and remove the polyethylene mould that holds
the upper section of the instrument in place.
Fig.2.3.1
b. Remove the manual and the accessories contained on the sides of the instrument.
Fig.2.3.2

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c. Lift the instrument out of the box.
Remove the protective bag wrapped around the instrument.
Check that the supplied material complies with the packing-list.
In case when supplied instrument and/or accessories has been damaged during
transportation notify the Transport Company and Technical Assistance.
In case of any missing items notify Technical Assistance.
2.4 POSITIONING
The laboratory of analysis is the best site for the installation of this instrument.
For normal safety requirements and in view of the type of examination to be performed, the instrument
must be positioned away from heat sources, in areas that cannot be reached by liquids, in dust-free
environments, on perfectly clean, level surfaces that are not subjected to shocks or vibrations.
Moreover, it is recommended placing the instrument as far away as possible from any electromagnetic
waves generators (e.g. refrigerators, laboratory centrifuges) and instrumentation lacking in the CE
mark, as these could compromise its correct functioning.
In order to avoid overheating of the instrument (blocking of the fan) and to be able to act quickly on the
switch and power supply cable; the safety distances described in the figure 2.4.1 must be respected
(rear panel 20 cm from the wall, front panel free, left and right side panels 10 cm space).
Fig.2.4.1 Positioning of the VES-MATIC CUBE 30
It is strictly prohibited to place anything on top of the instrument.
Choose a position near a power point, which is free from interference and voltage surges.
Never move the instrument while in use. If moving the instrument is necessary it is
compulsory to recheck the conditions listed in this paragraph before turning it on again.
If the instrument is not used for longer periods of time it should be disconnected from the
power supply and covered.

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2.5 INSTALLATION
The installation must be performed by an authorised DIESSE Diagnostica Senese S.p.A. technician as
confirmed by the Installation Report.
a. Place the instrument on a solid surface as described in the previous paragraph.
b. Open the door of the printer compartment and remove the elastic band holding the roll of thermal
paper in place (used to prevent it from coming out of its housing during transport).
c. Open the lid of the sample-holder compartment and remove the adhesive tape used to keep the
plate still during transport.
d. After following the instructions described in paragraph 2.2., connect the instrument to the power
supply:
Make sure that the power supply switch is in the OFF position « 0 » before proceeding. Connect the
power supply plug (use exclusively the power supply cable supplied with the instrument) to the
socket located to the right of the switch of the instrument (as indicated in Fig. 2.5.1). Connect the
plug of the power supply cable to the power point.
Fig. 2.5.1
2.6 RESTRICTIONS AND WARNINGS
IN CASE OF FIRE OR HAZARDS IN GENERAL, TURN OFF THE INSTRUMENT AND
DISCONNECT THE POWER SUPPLY CABLE.
DISCONNECT the instrument from the power supply system before performing any type
of technical operation or in the case of malfunctioning of the instrument.
It is only possible to enter the commands with a light pressure of the fingers.
It is prohibited to carry out OPERATIONS on the instrument while there are parts still
in movement (it is only possible to enter the commands on the keyboard).
It is prohibited to PLACE your fingers or other objects between the plate and the safety
guard of the instrument.
It is strictly prohibited to manually TRANSLATE the plate (from the sample-
introducing position to the mixing position and vice-versa).
Treatment of potentially infected material.
All precautions pertaining biological risks must be adopted when using the VES-MATIC
CUBE 30
The expendable material must be disposed of in compliance with the laboratory regulations
and the local laws.
Observe all the individual and collective safety laws envisaged for the operator in line with the
working environments. Observe the DIRECTIVES relating to safety and the laws in force.

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2.7 SHUTTING DOWN AND SHIPPING
Before shutting down and shipping the instrument it is recommended carrying out the
following sanitising procedure:
A) The instrument must be turned off and cleaned internally of all residues or spillages
with a liquid detergent and left to dry.
B) Use one of the ready-to-use spray cans of isopropyl alcohol available on the market.
C) Spray well inside the instrument and on top of the sample-holder plate.
D) Close the lid of the instrument and leave turned off for at least one hour before
beginning a new work cycle or any other type of operation on the instrument.
During handling avoid all impact or excessive tipping over that could damage the instrument